• Title/Summary/Keyword: diseases

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Prognosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases in Korea

  • Kwon, Jae-Cheol;Kim, Si-Hyun;Park, Sun-Hee;Choi, Su-Mi;Lee, Dong-Gun;Choi, Jung-Hyun;Yoo, Jin-Hong;Kim, Yoo-Jin;Lee, Seok;Kim, Hee-Je;Lee, Jong-Wook;Min, Woo-Sung
    • Tuberculosis and Respiratory Diseases
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    • v.72 no.3
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    • pp.284-292
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    • 2012

  • Background: The aim of this study was to investigate therapeutic outcomes and assess factors associated with therapeutic outcomes in hematologic patients with invasive pulmonary aspergillosis (IPA). Methods: We analyzed all consecutive cases of IPA in adults with hematologic diseases from January 2008 to January 2009 at a Catholic Hematopoietic Stem Cell Transplantation (HSCT) Center in Seoul, Korea. Results: A total of 54 patients were identified. Underlying diseases were acute myelogenous leukemia (n=25), acute lymphoblastic leukemia (n=10), myelodysplastic syndrome (n=7), chronic myelogenous leukemia (n=3), multiple myeloma (n=3), severe aplastic anemia (n=2) and other hematologic diseases (n=4). Twenty six patients (48.2%) were assessed as having a favorable response, of which 16 patients (29.6%) showed complete response. Overall 12-week mortality and IPA attributable mortality were 38.9% (n=21) and 33.3% (n=18), respectively. In multivariate analysis, uncontrolled underlying disease (odds ratio [OR], 7.31; 95% confidence interval [CI], 1.49~35.94; p=0.014) was associated with an unfavorable response, and for 12-week mortality, uncontrolled underlying disease (OR, 11.79; 95% CI, 1.49~93.46; p=0.020) and hypoalbuminemia (OR, 9.89; 95% CI, 1.42~68.99; p=0.021) were significantly poor prognostic factors. Conclusion: IPA still remains as a poor therapeutic outcome, especially in patients with refractory hematologic diseases.

  • https://doi.org/10.4046/trd.2012.72.3.284 인용 PDF KSCI

Relationship between arteriosclerosis and Oriental medical diagnosis in ischemic stroke patients (뇌경색 환자의 동맥경화와 한방변증과의 관련성 연구)

  • Shin, Won-Jun;Park, Young-Min;Jeong, Dong-Won;Hong, Jin-Woo;Sun, Jong-Joo;Lee, Jun-Woo;Jung, Woo-Sang;Park, Seong-Uk;Moon, Sang-Kwan;Park, Jung-Mi;Ko, Chang-Nam;Cho, Ki-Ho;Kim, Young-Suk;Bae, Hyung-Sup
    • The Journal of Internal Korean Medicine
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    • v.27 no.1
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    • pp.197-207
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    • 2006

  • The object of this study was to examine the relationship between arteriosclerosis and oriental medical diagnosis of the patients who had suffered ischemic stroke. The degree of arteriosclerosis of the patients was assessed by cardio-ankle vascular index(CAVI), and diagnostic criteria used for all patients were deficiency of ki, deficiency of blood, blood stasis and stagnation of water. One hundred four patients were included and their general characteristics, CAVI and oriental diagnosis were evaluated. Results showed a significantly strong correlation between CAVI and blood stasis. These results suggest a close relationship between arterioslcerosis and blood static syndrome as defined by oriental medicine. If so, diagnosis of blood static syndrome is a reilable predictor of arteriosclerosis.

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