• Tuberculosis and Respiratory Diseases
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• v.48 no.5
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• pp.740-747
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• 2000

Background : To compare the efficacies and side effects of etoposide, cisplatin/cyclophosphamide, adriamycin, vincristine(VPP/CAV) with those of carboplatin etoposide(CE) in extensive stage small cell lung cancer patients. Method : Patients with extensive stage small lung cancer who has measurable disease were eligible. VPP/CAV group(n=22) was treated with cisplatin(60mg/$m^2$ iv. D1) etoposide(100mg/$m^2$ iv. D1-3), and 3 weeks later cyclophosphamide(1000mg/$m^2$ iv. D1), adriamycin( 40mg/$m^2$ iv. D1), and vincristine(1.4mg/$m^2$ iv. D1), were administered alternatively. CE group(n=22) was treated with carboplatin(325mg/$m^2$ iv. D1) and etoposide (100mg/$m^2$ iv. D1-3) ; repeated treatment was performed every 3 weeks. Result : Forty four patients were eligible for the study. The overall response rate was 61.4% (complete remission rate 0%, partial response rate 61.4%, stable disease rate 25%, progressive disease rate 13.6%), and median survival was 10.8 months. In VPP/CAV group, response rate was 54.5% (complete remission rate 0%, partial response rate 54.4%, stable disease rate 27.3%, progressive disease rate 18.2%), and, in carboplatin/etoposide group, the response rate was 68.2%(complete remission rate 0%, partial response rate 68.2%, stable disease rate 22.7%, progressive disease rate 9.1%). The median survival time was 9.5 months in the VPP/CAV group and 11 months in CE group. The toxicity of both group was moderate, and anemia was more frequent in the CE group. Conclusion : VPP/CAV regimen and CE regimen produced similar response rates and survival times in extensive stage small cell lung cancer patients. CE regimen may be effective as part of the initial therapy for extensive stage small cell lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4157-4160
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• 2013

Objectives: Understanding the situation of cancer awareness which doctors give to patients might lead to prognostic prediction in cases of of colorectal cancer (CRC). Methods: Subsets of 10,779 CRC patients were used to screen the risk factors from the Cancer Registry in Pudong New Area in cancer awareness, age, TNM stage, and gender. Survival of the patients was calculated by the Kaplan-Meier method and assessed by Cox regression analysis. The views of cancer awareness in doctors and patients were surveyed by telephone or household. Results: After a median observation time of 1,616 days (ranging from 0 to 4,083 days) of 10,779 available patients, 2,596 of the 4,561 patients with cancer awareness survived, whereas 2,258 of the 5,469 patients without cancer awareness and 406 of the 749 patients without information on cancer awareness died of the disease. All-cause and cancer-specific survival were poorer for the patients without cancer awareness than those with (P < 0.001 for each, log-rank test). Cox multivariate regression analysis showed that cancer concealment cases had significantly lower cancer-specific survival (hazard ratio (HR) = 1.299; 95 % confidence interval (CI): 1.200-1.407)and all-cause survival (HR = 1.324; 95 % CI: 1.227-1.428). Furthermore, attitudes of cancer awareness between doctors and patients were significantly different (P < 0.001). Conclusion: Cancer concealment, not only late-stage tumor and age, is associated with a poor survival of CRC patients.

• Journal of Korean Foot and Ankle Society
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• v.13 no.2
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• pp.223-226
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• 2009

Freiberg disease is a osteochondrosis of the lesser metatarsal heads. Various surgical treatment have been recommanded including joint debridement and metatarsal head reshaping, metatarsal dorsal wedge osteotomy, metatarsal head excision and joint arthroplasty. Autogenous osteochondral graft for the treatment of Freiberg disease is an effective restorative procedure that provides early range of motion exercise, weight bearing, and reduces other morbidity. We report a case of late stage Freiberg disease treated with arthrotomy, removal of loose body and autogenous osteochondral graft.

• Tuberculosis and Respiratory Diseases
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• v.79 no.3
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• pp.121-126
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• 2016

Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.291-300
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• 2024

Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a notable contributor to the prevalence of chronic kidney disease worldwide. Despite the absence of a complete cure, ongoing research aims for early diagnosis and treatment. Although agents such as tolvaptan and mTOR inhibitors have been utilized, their effectiveness in managing the disease during its initial phase has certain limitations. This review aimed to explore new targets for the early diagnosis and treatment of ADPKD, considering ongoing developments. We particularly focus on cell polarity, which is a key factor that influences the process and pace of cyst formation. In addition, we aimed to identify agents or treatments that can prevent or impede the progression of renal fibrosis, ultimately slowing its trajectory toward end-stage renal disease. Recent advances in slowing ADPKD progression have been examined, and potential therapeutic approaches targeting multiple pathways have been introduced. This comprehensive review discusses innovative strategies to address the challenges of ADPKD and provides valuable insights into potential avenues for its prevention and treatment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37C no.12
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• pp.1263-1270
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• 2012

Livestock disease that decreases the farm productivity and income leads to not only financial loss but also national loss from the spread of contagious disease. The purpose of this paper is to propose a livestock disease forecasting system that can diagnose disease of livestock at an early stage based on the livestock activity and body temperature. The proposed livestock disease forecasting system collect data on livestock activity and body temperature using a acceleration sensor and thermal imaging camera and comparing the data with control according to disease. It is expected that, this system can be accurately identify and prevent spread of livestock disease beforehand to minimize damages caused by disease to improve the productivity and the rate of return of livestock farms.

• Journal of Korean Academy of Nursing
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• v.37 no.4
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• pp.459-466
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• 2007

Purpose: This study was to identify predictors of quality of life in breast cancer patients. Physical and pscyhological factors like stress, mood, and fatigue with sociodemographic factors like education, income, job and stage of disease were used to predict quality of life. Methods: One hundred eleven patients with breast cancer participated in this study? The functional Assessment of Cancer Therapy-Breast(FACT-B) was used to assess quality of life. Results: The mean age of the patients was 46.7 years. The FACT-B mean score was 89.89(SD:17.31) Education, income, job and stage of disease were significantly associated with QOL. In a regression analysis, mood, income, and fatigue were significant predictors for QOL where as, stress was not significant. Among the subscales of QOL, physical well-being, functional well-being, emotional well-being, and the breast cancer subscale were included as predictors of QOL Conclusion: Physical and psychological factors were strong predictors of QOL. These results demonstrate the need for interventions to improve QOL in breast cancer survivors.

• Clinical and Experimental Pediatrics
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• v.61 no.7
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• pp.205-209
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• 2018

Kidney transplantation (KT) is the gold standard for renal replacement therapy in pediatric patients with end-stage renal disease. Recently, it has been observed that the outcome of pediatric KT is nearly identical to that in adults owing to the development and application of a variety of immunosuppressants and newer surgical techniques. However, owing to several differences in characteristics between children and adults, pediatric KT requires that additional information be learned and is associated with added concerns. These differences include post-KT complications, donor-recipient size mismatch, problems related to growth, and nonadherence to therapy, among others. This review was aimed at elucidating the clinical characteristics of pediatric KT that differ from those observed in adults.

• Journal of Haehwa Medicine
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• v.13 no.1
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• pp.197-210
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• 2004

Objective : This study was designed to investigate causes, symptoms and treatments for the Chronic rhinorrhea of children with oriental medical literatures. Methods : We surveyed the oriental and western medical books from to recent published books that have articles on Chronic rhinorrhea. Results and Conclusions : The Chronic rhinorrhea are classified to Bigu and Biruan(鼻淵). Bigu is similar to Allergic Rhinitis and Biyan(鼻淵) is similar to Chronic Sinusitis. The external cause of disease is the invasion of Poong han(風寒) etc a wrong air and the internal causes of disease are the deficiency of the spleen, lung and kidney and inner heat caused by stress. Treatment in Oriental medicine consists of herbal-therapy, acupuncture and moxa. The methods of treatment are expelling of Poong han(風寒) in the early stage and helping the vital energy in the late stage.

• Korean journal of applied entomology
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• v.19 no.4 s.45
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• pp.240-242
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• 1980

Recently, a powdery mildew on the leaves of Capsium spp., Pimento and pepper, occurred greatly in the vinyl-house at Seungchon area, Chonnam province. According to the field survey, the disease is severe at high temperature and high humidity conditions in the vinyl house. Diseased loaves were severely fallen and remained only several top leaves, thus the setting and thickening of fruits were greatly depressed. The pathogenic fungus was identified as Oidiopsis taurica(Lev.) Arn., imperfect stage of Leveillula taurica (Lev.) Arn., The perfect stage of fungus was not observed. Optimum temperatures for conidial germination ranged at $25-30^{\circ}C$ with high humidity.