• Childhood Kidney Diseases
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• 제27권2호
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• pp.70-75
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• 2023

Dent disease is a rare inherited kidney tubulopathy caused by mutations in either the CLCN5 (Dent disease 1) or OCRL1 (Dent disease 2) genes, and which is often underdiagnosed in practice. A diagnosis is clinically suspected in patients with low-molecular-weight proteinuria, hypercalciuria, and one of the following: hematuria, nephrolithiasis, nephrocalcinosis, hypophosphatemia, or chronic kidney disease. Inheritance is X-linked recessive, meaning, these symptoms are generally only found in males; female carriers may have mild phenotypes. Genetic testing is only a method to confirm the diagnosis, approximately 25% to 35% of patients have neither the CLCN5 nor OCRL1 pathogenic variants (Dent disease 3), making diagnosis more challenging. The genotype-phenotype correlations are not evident with the limited clinical data available. As with many other genetic diseases, the management of patients with Dent disease concentrates on symptom relief rather than any causative process. The current treatments are mainly supportive to reduce hypercalciuria and prevent nephrolithiasis. Chronic kidney disease progresses to end-stage between the ages of the third to fifth decades in 30% to 80% of affected males. In this review, we aimed to summarize the literature on Dent disease and reveal the clinical characteristics and molecular basis of Korean patients with Dent disease.

• Annals of Clinical Neurophysiology
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• 제17권1호
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• pp.17-23
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• 2015

Background: Sleep-related disturbances and sleep disorders are common in Parkinson's disease (PD) and have a great impact on daily life of PD patients. This study was done to find the sleep characteristics and sleep disturbing factors in PD patients according to disease severity through clinical interview and polysomnographic (PSG) study. Methods: Fifty patients with PD (22 males, age $60.6{\pm}6.4$, Hoehn and Yahr (HY) stage $2.7{\pm}1.0$) were recruited and thoroughly interviewed about their sleep. PSG was performed on the patients taking routine antiparkinsonian medications. Patients were grouped into mild and moderate/severe group according to HY stage, and the results were compared between each group. Results: Ninety-four percent of total patients had one or more sleep-related disturbances based on the interview or PSG. On interview, the moderate/severe group complained more insomnia and REM sleep behavior disorder (RBD) than mild group. In PSG findings, the moderate/severe group showed lower sleep efficiency, longer sleep latency, REM sleep latency, waking time after sleep onset, and higher prevalence of RBD. Conclusions: In this study, most patients with PD had sleep disturbances. Clinical interview and PSG findings revealed deterioration of sleep quality along the disease severity. Our results suggest that sleep disturbances in PD patients are prevalent and warrant clinical attention, especially to the patients with advanced disease.

• 한국동물위생학회지
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• 제42권4호
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• pp.275-278
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• 2019

Blindness was observed in five calves born from cattle fed only a commercial feed of growing stage and dried rice straws for about two years in a farm in Gyeongsangbuk-do province. Three of them died within a month after birth, and a body and sera of his mother and other 19 cattle were submitted for diagnosis. At necropsy, the calf was very weak and filled with cerebrospinal fluid in the cerebrum. Any histopathological lesion including atrophy of death of optic nerve cells was not observed, but the irregular proliferation such as lace pattern of choroidal cells and lymphocytic infiltration just below choroid was observed. No pathogen was detected as a result of the etiological tests on the internal organs of calves and bloods. In addition, the levels of serum vitamin A in different affected and his mother cattle were all lower than normal. Finally, we determined this case as an encephalopathy caused by maternal vitamin A deficiency in a calf. This report is an extreme example of how important it is to supply adequate s diets and a good quality of hay for each stage of growth in cattle.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5639-5644
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• 2014

Objective: This study aimed to determine effects of doctor-patient communication on the quality of life among breast cancer survivors in 16 communities in southern China. Methods: Multistage random sampling was to use to recruit 260 females from the Guangzhou Cancer Registry Database who were diagnosed with breast cancer. A questionnaire provided data on the doctor-patient communication (including the doctor's attitude, the patient's participation with the medical decision and information about the disease) and QOL (quality of life), as measured using FACT-B. Univariate analysis, non-conditional logistic regression was used to evaluate the associations between the doctor-patient communication and QOL. Results: Females who received good attitudes from doctors demonstrated higher FACT-B (OR=4.65, 95% CI: 1.68-12.86), social well-being (OR=5.88, 95% CI: 2.16-16.05), emotional well-being (OR=4.77, 95% CI: 1.92-11.88), and functional well-being ((OR=5.26, 95% CI: 1.90-14.52) compared to the females who encountered worse attitudes from their doctor, adjusting for age, education, marriage, employment, family income, years since diagnosis, TNM stage, radiation therapy, chemotherapy and side effects, particularly when the TNM stage was 0-II and the patients exhibited no side effects. Regardless of the length of time after diagnosis, doctors' good attitudes resulted in higher QOL scores. Conclusions: This study demonstrated that the doctor-patient communication has a significant association with the QOL of breast cancer survivors, mainly dependent on the doctors' attitude. Effective intervention is required to develop optimal doctor-patient communication.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.3007-3013
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• 2016

Background: Gastrointestinal cancers are common malignancies associated with high mortality rates. Healthcare systems are always faced with high costs of treatment of gastrointestinal cancers including stomach cancer. Identification and prioritization of these costs can help determine economic burden and then improve of health planning by policy-makers. This study was performed in 2015 in Kerman City aimed at estimating the direct hospital costs for patients with gastric cancer. Materials and Methods: In this cross-sectional study, the medical records of 160 patients with stomach cancer admitted from 2011 to 2014 to Shafa Hospital were examined, the current stage of the disease and the patients' health status were identified, and the direct costs related to the type of treatment in the public and private sectors were calculated. SPSS-19 was used for statistical analysis of the data. Results: Of the patients studied, 103 (65%) were men and 57 (35%) were women. The mean age of patients was 65 years. Distribution into four stages of the disease was 5%, 20%, 30%, and 45%, respectively. Direct costs in four stages of the disease were calculated as 2191.07, 2642.93, 2877, and 2674.07 USD (63,045,879, 76,047,934, 82,783,019, and 76,943,800 IRR), respectively. The highest percentage of costs was related to surgery in Stage I and to medication in Stages II, III, and IV. According to the results of direct costs of treatment for stomach cancer in Kerman, the mean total cost of treating a patient in the public sector was estimated at 74,705,158 IRR, of which averages of 60,141,384 IRR and 14,563,774 IRR were the shares of insurance and patients, respectively. Conclusions: The high prevalence and diagnosis of disease in old age and at advanced stages of disease impose great costs on the patients and the health system. Early diagnosis through screening and selecting an appropriate treatment method might largely ameliorate the economic burden of the disease.

• 기본간호학회지
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• 제13권2호
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• pp.249-256
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• 2006

Purpose: To investigate the influence of clinical and demographical variables on depression, instrumental activities of daily living (IADL), and cognitive function in patients with Parkinson's disease. Method: Using a structured questionnaire data were collected from 100 participants registered in the neurology department of C university hospital. Duration and stage of disease, fall history, vision impairment, duration and quality of sleep, orthostatic hypotension, ambulation impairment, and use of walking aid were included in clinical variables. Depression, IADL, and cognitive function were assessed using Kee's GDSSF-K, Cho's scale, and K-MMSE. Collected data were analyzed using the SAS program. Results: The depression score for the participants was 7.78, higher than cut-off score(5). Participants who were male, living with spouse, above high school education, high economic status, with no vision impairment, and no ambulation impairment revealed high cognitive scores. Average IADL score were significantly higher for participants who were male, who had high economic status, low stage of disease, and no ambulation impairment. Depression IADL & cognitive function scores were significantly different according to ambulation impairment. Scores for ADL and cognitive function were positively correlated. Conclusion: It is recommended that make programs for patients with Parkinson's disease, clinical and demographic variables should be considered according to their individual needs.

• The Journal of Korean Physical Therapy
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• 제31권2호
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• pp.122-128
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• 2019

Purpose: This study examined the effects of sagittal spinopelvic alignment on the clinical parameters, motor symptoms, and respiratory function in patients with mild to moderate Parkinson's disease (PD). Methods: This study was a prospective assessment of treated patients (n=28, Hoehn and Yahr (H&Y) stage 2-3) in a PD center. Twenty-eight subjects ($68.5{\pm}5.7yrs$) participated in this study. The clinical and demographic parameters, including age, sex, symptoms duration, treatment duration, and H&Y stage, were collected. Kinematic analysis was conducted in the upright standing posture with a motion capture system. A pulmonary function test (PFT) was performed in the sitting position using a spirometer. The motor symptoms were assessed on part III of the movement disorder society sponsored version of the unified Parkinson's disease rating scale (MDS-UPDRS). SPSS 18.0 was used to analyze the collected data. Results: The exceeding 12 degrees group of the lower trunk showed significantly higher on the clinical parameters than the below 12 degrees group. In addition, the exceeding 12 degrees group of the lower trunk showed a significantly lower forced expiratory volume at one second (FEV1) / forced vital capacity (FVC) (%) and 25-75% forced mid-expiratory flow (FEF) (L/s) than in the below group. On the other hand, there was no difference in the upper trunk and the cervical pelvis between the groups. Conclusion: These findings suggest that the sagittal balance in the lower trunk is related to the clinical parameters and respiratory function, but not the motor symptoms in patients with mild to moderate PD.

• Radiation Oncology Journal
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• 제10권1호
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• pp.69-76
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• 1992

국소진행된 자궁경부암에 있어서의 예후인자를 알아보기 위하여 1979년 3월부터 1986년 12월까지 서울대학교병원에서 근치적방사선치료를 시행받은 154명의 환자를 대상으로 후향적 분석을 시행하였다. FIGO 병기 IIIA, IIIB, IVA의 환자 수는 각각 8, 134, 12명 이었고 병기에 따른 5년 국소치료율은 각각 $58\%$, $51\%$, $27\%$이었으며 5년 무병생존율은 각각 $57\%$, $40\%$, $25\%$, 5년 생존율은 각각 $67\%$, $51\%$, $33\%$이었다. 단변수분석에 의하면 임신 횟수, 혈색소치, 전산화단층촬영상 골반측벽 침범소견이 국소치료율에 영향을 미치는 인자 이었고 임신 횟수, 혈색소치, 전산화단층촬영상의 골반측벽 침범소견과 함께 요로조영술상의 요로패쇄증, 전산화단층촬영상의 골반임파절 비대가 무병생존율에 영향을 미치는 인자 이었으며 생존율에 영향을 미치는 인자는 전산화단층촬영상의 골반측벽 침범소견 및 방광침범소견 이었다. 다변량분석에 의하면 국소치료율에 영향을 미치는 인자는 없었고 무병생존율에 영향을 미치는 인자는 전산화단층촬영상의 골반임파절 비대이었으며 생존율에 영향을 미치는 인자는 원발병소의 크기였다.

• Tuberculosis and Respiratory Diseases
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• 제71권4호
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• pp.271-277
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• 2011

Background: A chronic obstructive pulmonary disease (COPD) assessment test (CAT) has recently been developed as a short and simple method for assessing the quality of life in COPD patients. The object of this study was to assess the usefulness of the Korean version of the CAT for assessing COPD patients in an outpatient clinic. Methods: The study included 60 COPD patients in a stable state from an outpatient clinic. The authors investigated the frequency of acute exacerbation during aprevious year through reviewing medical records. We evaluated the spirometry test, a 6-min walk distance test, and obtained the MMRC dyspnea scale, the Korean version of the CAT, and the BODE index at the time of visit. To assess the usefulness of the CAT, correlations between the CAT and other methods were evaluated. Results: The mean age of patients was $68.3{\pm}8.6$ years and 95% of patients were male. There was a significant correlation between the CAT score and $FEV_1%$ (r=-0.323, p=0.012), the frequency of acute exacerbation (r=0.292, p=0.024), the MMRC dyspnea scale (r=0.554, p<0.001), the BODE index (r=0.380, p=0.003), and 6 MWD (r=-0.372, p=0.004). The mean CAT score increased according to the GOLD stage (stage 1, $10.7{\pm}4.5$; stage 2, $13.1{\pm}7.9$; stage 3, $16.3{\pm}6.2$; stage 4, $16.5{\pm}14.8$; p=0.746). Conclusion: The CAT was shown to be useful for the assessment of COPD severity. Therefore, the CAT is an easily applied and simple method for assessing COPD severity in an outpatient clinic.

• Radiation Oncology Journal
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• 제16권3호
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• pp.245-250
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• 1998

목적 : 조기 성문암의 방사선 치료 후 생존율, 실패 양상, 그리고 예후 인자에 대해 분석하였다. 대상 및 방법 : 1985년 6월부터 1992년 11월까지 방사선 치료를 위해 의뢰된 57례의 성문암환자를 대상으로 후향적 분석을 실시하였다. 연령 분포는 17세부터 71세까지 광범위했고 (중앙값 39세), 남자 55례와 여자 2례로 남성에서 호발하였다. 방사선 치료는 6 MV X-ray를 이용하여 1회 선량 2 Gy씩, 주 5회, 총선량 66 Gy를 조사하였다. 결과 : 방사선 치료에 대한 반응은 완전 관해 89.5% (51/57), 부분 관해 혹은 무반응 10.5%(6/57) 였다. 51례의 완전관해 환자 중에서 7례의 재발이 관찰되었고 7례 모두 수술로 구제되었다. 부분 관해 혹은 무반응 6례 중 4례에 대하여 구제수술을 시행하였고 2례에서는 수술을 시행하지 못하였다. 구제수술을 시행한 4례 중 3례가 구제되었고 1례는 다시 국소재발하였다. 3년 및 5년 무병생존율은 각각 72.9% 및 63.8%였다. 병소의 위치에 따른 5년 무병생존율은 후방인 경우 85.5%, 전방인 경우 61.6%였다 (P<0.05). 방사선치료에 대해 부분 관해 혹은 무반응을 보인 5례를 포함하여 13/57 (22.8%) 례의 치료 실패가 관찰되었고 그 중 10/13 (76.9%) 례가 수술로 구제되었다. 최종 5년 국소제어율은 92.3%였고 전체적으로 47/57 (82.5%) 례에서 음성을 보존할 수 있었다. 결론 : 높은 음성 보존율을 고려하면 초기 성문암에서 방사선치료가 우선적으로 고려되어야 한다.