• 산업융합연구
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• 제21권2호
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• pp.111-116
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• 2023

최근 바이러스 감염병 및 새로운 질병은 한 지역에 국한되는 것이 아니라 전 세계적으로 확산되어 경제적, 사회적으로 심각한 피해를 일으키고 있다. 또한, 새로운 질병의 발현 주기가 짧고, 확산 속도도 빨라지고 있다. 질병에 대한 확산을 막기 위해 격리, 폐쇄 등 질병 발생 후 수동적인 형태의 대응이 우선시 되고 있다. 이러한 형태의 대응은 질병 확산 방지에 근본적인 대응으로는 부족한 부분이 많이 있다. 이에, 본 연구에서는 새로운 질병 발생 정보를 포함한 질병 예방 모니터링 시스템을 제안한다. 본 연구에서는 IoMT 환경 구축을 통해 질병 정보와 사용자의 정보를 수집한다. devices를 이용한 정보 수집은 사용자의 생체정보와 질병 서버에 등록된 데이터를 수집하고 분류한다. IoMT 환경에서는 사용자의 데이터를 수집하여 사용자 질병 감염 여부를 평가하여 사용자에게 제공한다. 본 연구를 통해 개인의 질병 증상 정보를 제공하고, 질병 확산에 대한 능동적인 대응 방법을 제공할 수 있다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.31-34
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• 2003

The monitoring of genotoxic effect or oxidative DNA damage in workers exposed to hazardous materials is increasingly applied for hazard identification or risk assessment purposes in workplaces. The current generation of biomarkers has the potential to allow for the earlier detection of occupational disease, for the reduction of misclassification of exposure and outcome. (omitted)

• The Korean Journal of Physiology and Pharmacology
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• 제22권3호
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• pp.235-248
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• 2018

Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles. Moreover, UA can be used as an alternative medicine for the treatment and prevention of cancer, obesity/diabetes, cardiovascular disease, brain disease, liver disease, and muscle wasting (sarcopenia). In this review, we have summarized recent data on the beneficial effects and possible uses of UA in health and disease managements.

• Journal of mucopolysaccharidosis and rare diseases
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• 제3권1호
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• pp.14-19
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• 2017

Lysosomal storage diseases (LSDs) are a group of rare inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes and subsequent accumulation of substrates. Enzyme deficiency leads to progressive intra-lysosomal accumulation of the incompletely degraded substances, which cause dysfunction and destruction of the cell and eventually multiple organ damage. Patients have a broad spectrum of clinical phenotypes which are generally not specific for some LSDs, leading to missed or delayed diagnosis. Due to the availability of treatment including enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation for some LSDs, early diagnosis is important. ERT products have been approved with optimal outcomes for some LSDs in the recent decades, including Gaucher, Fabry, mucopolysaccharidosis (MPS) I, Pompe, MPS VI, MPS II, and MPS IVA diseases. ERT can stabilize the clinical condition, prevent disease progression, and improve the long-term outcome of these diseases, especially if started prior to irreversible organ damage. Based on the availability of therapy and suitable screening methods in the recent years, some LSDs, including Pompe, Fabry, Gaucher, MPS I, MPS II, and MPS VI diseases have been incorporated into nationwide newborn screening panels in Taiwan.

• 한국멀티미디어학회논문지
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• 제17권7호
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• pp.886-894
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• 2014

Recently, domestic animal disease caused tremendous damage to farmhouses and the damage stretched in nationwide with the spread of epidemic disease. To prevent animal diseases from happening again, the system development to easily measure the temperature of sick animals and identify of them is needed, thereby quickly treat them, reducing losses of farmhouses. However, a lack of related equipment and human resource hampered its effort to minimize its losses. This study tries to develop diagnosis system as part of measures to curb these domestic animal diseases. This paper present the 센서 node based on IEEE 802.15.4 which can be attached to the animal body for real-time temperature measurement. We design and implement tiny chip-type that can be attached to the body of animals. Then, we use available power only when measuring temperatures in a long term-basis. In this paper, the 센서 node was applied to horse's neck. We measure the horse's body temperature between $32.2^{\circ}C{\sim}33.7^{\circ}C$ and analyze phenomenon data for 4 months.

• The Plant Pathology Journal
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• 제32권6호
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• pp.508-518
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• 2016

Early blight of tomato caused by Alternaria solani, is responsible for severe yield losses in tomato. The conidia survive on soil surface and old dry lower leaves of the plant and spread when suitable climatic conditions are available. Macroclimatic study reveals that highest inoculum concentration of Alternaria spores appeared in May 2012 to 2013 and lowest concentration during January 2012 to 2013. High night temperature positively correlated and significantly (P < 0.01) involved in conidial spore dispersal and low relative humidity (RH) displayed significant (P < 0.05) but negative correlation with conidial dispersal. The objective of the study was to modify microclimatic conditions of tomato crop canopy which may hamper conidial dispersal and reduce disease severity. We evaluated effect of marigold intercropping and plastic mulching singly and in consortia on A. solani conidial density, tomato leaf damage and microclimatic parameters as compar to tomato alone (T). Tomato-marigold intercropping-plastic mulching treatment (T + M + P) showed 35-39% reduction in disease intensity as compared to tomato alone. When intercropped with tomato, marigold served as barrier to conidial movement and plastic mulching prevented evapotranspiration and reduced the canopy RH that resulted in less germination of A. solani spores. Marigold intercropping and plastic mulching served successfully as physical barrier against conidial dissemination to diminish significantly the tomato foliar damage produced by A. solani.

• 한국농공학회논문집
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• 제62권1호
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• pp.71-81
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• 2020

Enclosed pig house are creating an environment with high concentrations of gas and dust. Poor conditions in pig farms reduce pig weight and increase disease and accidents for livestock workers. In the pig house, the high concentration of harmful gas may cause asphyxiation accidents to workers and chronic respiratory disease by long-term exposure. As pig farm workers have been aging and feminized, the damage to the health of the harsh environment is getting serious, and real-time monitoring is needed to prevent the damage. However, most of the measuring devices related to humidity, harmful gas, and fine dust except temperature sensors are exposed to high concentrations of gas and dust inside pig house and are difficult to withstand for a long time. The purpose of this study is to develop an wearable based device to monitor the hazardous environment exposed to workers working in pig farms. Based on the field monitoring and previous researches, the measurement range and basic specifications of the equipment were selected, and wearable based device was designed in terms of utilization, economic efficiency, size and communication performance. Selected H₂S and NH₃ sensors showed the average error of 5.3% comparing to standard gas concentrations. The measured data can be used to manage the working environment according to the worker's location and to obtain basic data for work safety warning.

• KIEAE Journal
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• 제14권5호
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• pp.49-57
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• 2014

This research is about analysis and evaluation of biodiversity of Suwon's street tree, then understanding the problem of it and finally finding a solution. Because the increasing damage of the street trees by disease and insects, insecticide is applied to prevent further damage. However, this insecticide is found to be cancer genic and causing hygienic threat to civilians. Therefore, by gathering Suwon's internal statistics about Suwon's street tree, the trees are divided into three categories, tall evergreen trees, deciduous trees, shrubs following Frank's 30-20-10 theory(1990). Also, according to species diversity index, the problem of disease and insect is researched in terms of biodiversity, and here we suggests solutions to counter such problems. According to the results, the trees planted in Suwon was found to be 31 families, 43 genus and 58 species. The most used kinds, almost 85% of the whole species, are found to be Rhododendron indicum (L.) Sweet, Buxus koreana Nakai ex Chung & al, Euonymus japonicus Thunb, Ligustrum obtusifolium Siebold & Zucc. Besides these, the rest of 15% of street trees had little variety. Therefore, it is necessary to plant tree variously and equally in terms of biodiversity. If this Frank's 10-20-30 solution is not enough to completely solve coulure problem, then further research will be done on soil properties, and local features for improvement of Suwon street tress.

• 대한물리치료과학회지
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• 제9권4호
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• pp.105-112
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• 2002

When any damage or disease occurs, muscular strength and muscular endurance are lowered, and thus, if one is able to be restored from the damage or the disease, appropriate stimulus is required, since the muscles have to restore their proper functions. For such stimulus, the way of exercising and the way using electric stimulus are used in physical therapy. In order to examine the change in muscular strength, muscular endurance and girth of limbs for Biceps brachii, according to the lands of stimulus, in this article a total of 42 healthy male and female adults in their twenties were randomly sampled, and a series of tests were conducted for 6 weeks, for 15 minutes per once, 3 times per week, respectively, dividing them into the group for RUS(Russian Current Stimulation), PRE(Progressive Resistive Exercise) and P+R(RUS + PRE). The findings showed that the change in muscular strength was most significant as for the group for P+R, since it increased from $62.12{\pm}25.30$ before experiment to $95.78{\pm}34.07$ after 6 weeks: the change in muscular endurance was most significant as for the group for P+R, since it increased from $17.57{\pm}6.63$ to $42.86{\pm}10.24$; and the change in the girth of limbs was slightly significant only in the group for P+R, and the remaining two groups showed no significance.

• 대한의생명과학회지
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• 제26권4호
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• pp.310-318
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• 2020

The sciatic nerve is the largest nerve among the peripheral nerves, and the damage to the sciatic nerve is caused by mechanical and physical pressure. This is an important disease that consumes a lot of time and money in the treatment process. Among them, research on relieving nerve pain caused by damage to the peripheral sciatic nerve has been made efforts to prevent and treat this disease through various methods such as drugs, natural products, electrical stimulation, exercise therapy, and massage. Existing treatments are not very effective in neurological pain, and countermeasures are needed. Forsythia Fructus, used in this study, has been used as a therapeutic agent for infectious diseases and a pain reliever for cancer from the past, and in past studies, it has been known to properly control the inflammatory response. In this study, rengyolone, a physiologically active substance of Forsythiae Fructus, was administered to rats that caused chronic left nerve pain to verify the pain relief effect. As a result of the experiment, it was found that mechanical pain and cold stimulation pain were significantly reduced in the rengyolone-treated group compared to the non-administered group. In addition, it was found that nerve growth factor (NGF) mRNA expression was significantly reduced and Cyclin-dependent kinase 2 (Cdc2) expression was increased in the rengyolone administration group. This increase in NGF expression is thought to be related to rengyolone's anti-inflammatory regulatory mechanism. It is expected that the reduced NGF was directly involved in pain relief.