• Bulletin of the Korean Chemical Society
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• v.18 no.9
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• pp.939-945
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• 1997

Several types of 4-substituted-quinoline-2-carboxylic acid derivatives possessing different substituents at C4-position such as sulfonyl, phosphonyl, carbonyl groups, or a flexible alkyl chain have been synthesized and evaluated for their in vitro antagonistic activity at the glycine site on the N-methyl-D-aspartate (NMDA) receptor. Of them, 5,7-dichloro-4-(tolylsulfonylamino)-quinoline-2-carboxylic acid 9 was found to have the best in vitro binding affinity with IC50 of 0.57 μM. On the other hand, in compounds 21 and 22 the introduction of flexible alkyl chains on C4 of the quinoline mother nuclei caused a significant decrease of the in vitro binding affinity. In addition, replacement of polar carboxylic acid group on C2 by neutral bioisosteres in compounds 23a-d also seems to be disadvantageous to in vitro activity. In the structure-activity relationship (SAR) study of the 4-substituted quinoline-2-carboxylic acid acid derivatives, it was realized that the substitution pattern on C4 significantly influences on the binding affinity for the glycine site of NMDA receptor and the binding affinity might be increased by the introduction of a suitable electron rich substituent at C4 which has the ability of H-bonding donor.

• Nuclear Engineering and Technology
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• v.42 no.6
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• pp.704-711
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• 2010

Modal testing requires measuring the vibration of many points, for which an accelerometer, a gab sensor and laser vibrometer are generally used. Conventional modal testing requires mounting of these sensors to all measurement points in order to acquire the signals. However, this can be disadvantageous because it requires considerable measurement time and effort when there are many measurement points. In this paper, we propose a method for modal testing using a camera image. A camera can measure the vibration of many points at the same time. However, this task requires that the measurement points be classified frame by frame. While it is possible to classify the measurement points one by one, this also requires much time. Therefore, we try to classify multiple points using pattern recognition. The feasibility of the proposed method is verified by a beam experiment. The experimental results demonstrate that we can obtain good results.

• Nuclear Engineering and Technology
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• v.52 no.5
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• pp.889-896
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• 2020

The vertically inverted U-tube steam generator (UTSG) is widely used in the pressurized water reactor (PWR). The reverse flow behavior generally exists in some U-tubes of a steam generator (SG) under both single- and two-phase natural circulations (NCs). The behavior increases the flow resistance in the primary loop and reduces the heat transfer in the SG. As a consequence, the NC ability as well as the inherent safety of nuclear reactors is faced with severe challenges. The theoretical models for calculating single- and two-phase flow pressure drops in U-tubes are developed and validated in this paper. The two-phase reverse flow characteristics in two types of SGs are investigated base on the theoretical models, and the effects of the U-tube height, bending radius, inlet steam quality and primary side pressure on the behavior are analyzed. The conclusions may provide some promising references for SG optimization to reduce the disadvantageous behavior. It is also of significance to improve the NC ability and ensure the PWR safety during some accidents.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.116-123
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• 2018

The purpose of this study is to analyze the trend of the prize money and the performance factors, based on the data of 1,000 pro golf players provided by KLPGA(Korea Ladies Professional Golf Association) for the past 10 years from 2008 to 2017. First, in terms of the prize money, it increased a lot if we compare the data from 2008 and from 2017. However, it is still disproportionally favorable to the top players and is extremely disadvantageous to the middle-low players. Therefore, it is necessary to considerately care middle-low players. Second, in terms of performance factors, the players' skill has been improved steadily based on all of the factors considered: the scoring average, average putting, the birdie average, par save, par break, and recovery for the past 10 years from 2008 to 2017. Despite the fact that both players' performance and income have increased, it is prominent that the inequality between the players in terms of prize money becomes severe, which should be mitigated by external systematic support to maintain the current level of world-class players of Korea.

• Design & Manufacturing
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• v.13 no.2
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• pp.22-29
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• 2019

This study conducted a research as to condensation heat transfer by using three types of flat micro multi-channel tubes with different processing of micro-fin and number of channels inside the pipes and different sizes of appearances. In addition, identical studies were conducted by using smoothing circular tubes with 5mm external diameter to study heat transfer coefficient. The condensation heat transfer coefficient showed an increase as the vapor quality and mass flux increased. However, each tube shows little differences compared to 400kg/m2s or identical in case the mass flux are 200kg/m2s and 100kg/m2s. The major reason for these factors is increase-decrease of heat transfer area that the flux type of refrigerant is exposed to the coolant's vapor with the effect of channel aspect ratio or micro-fin. In addition, the heat transfer coefficient was unrelated to the heat flux, and shows a rise as the saturation temperature gets lower, an effect that occurs from enhanced density. The physical factor of heat transfer coefficient increased as the channel's aspect ratio decreased. Additionally, the micro pin at the multi-channel type tube is decided as a disadvantageous factor to condensation heat enhancement factor. That is, due to the effect of aspect ratio or micro-fin, the increase-decrease of heat transfer area that the flux type of a refrigerant is exposed to the vapor is an important factor.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.6
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• pp.76-81
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• 2019

In the mold-manufacturing field, various methods of advanced production technology are being used in the production of industrial-grade gear pulleys. Among the current methods are injection molding, hoop molding, insight molding, two-material molding, compound-mold molding, as well as engineering plastic mold. Currently, casting pulleys are inexpensive because they are produced in small quantities. However, they produce complications during the manufacturing process, are very unreasonable for mass production, and are disadvantageous in cost competitiveness. Pulleys are divided into hundreds of kinds and thousands of kinds, so the production methods vary. As these pulleys are made of a single material by a casting and welding method, they are not manufactured using injection molds consisting of different materials. In this research, pulleys, shafts, and reinforced plastic materials were incorporated using ANSYS software, and a low-cost, lightweight technology was applied for trial production with optimum design and extrusion technology.

• Philosophy of Education
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• no.66
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• pp.105-132
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• 2018

This study analyzes and compares the contents of the prohibited history textbooks to the officiated curriculum textbooks during the Japanese Intervention period. By doing so the study will discuss the curriculum regulation through the new educational sociology aspects. The results are as follows. First, the Residency-General placed Japanese advisors in educational faculties to prepare a foundation for colonial education. It was intended to influence the educational system and its contents by displaying their superiority represented by their group of elites. Second, In 1908, the authorities issued the textbook regulation, which controlled the contents of the education before the book was published. The standard for the regulation was to exclude contents that are disadvantageous to Japan, and is favorable to colonial rules. Third, The prohibited textbooks contained contents that violate the standards. This shows that during the Residency -General period the textbook examination system was a tool to control school curriculum. Fourth, after comparing the contents of both prohibited textbooks and regulated textbooks, the prohibited history textbooks included the national independence, the victory over the Japanese, patriotism, and unfavorable relations with Japan. On the other hand, the regulated textbooks omitted patriotism and ethnicity-independent content, and instead filled its content with a friendly relationship Korea had with Japan at the time. This phenomenon proves that knowledge and the way of thinking are favorable towards superior groups of society and have an influence in determining the content of school education. This is the new education sociology theology.

• The Journal of Information Systems
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• v.31 no.4
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• pp.47-73
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• 2022

Purpose The purpose of this study is to select the electronic architecture concept of the powertrain domain of the electronic platform to be applied to electric vehicles after 2025. Previously, the automotive electrical and electronic architecture was determined only by trend analysis, but the purpose was to determine the scenario based on the data and select it with clear evaluation indicators. Design/methodology/approach This study identified the function to be applied to the powertrain domain of next-generation electric vehicle, estimated the controller, defined the function feature list, organized the scenario candidates with the controller list and function feature list, and selected the final architecture scenario. Findings According to the research results, the powertrain domain of electric vehicles was selected as the architectural concept to apply the DCU (Domain Control Unit) and VCU (Vehicle Control Unit) integrated architecture to next-generation electric vehicles. Although it is disadvantageous or equivalent in terms of cost, it was found to be excellent in most indicators such as stability, security, and hardware demand.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.6
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• pp.365-368
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• 2023

The mentum plays an important role in the aesthetics of the face, and genioplasty is performed to improve an unbalance of the mentum. Among the various surgical approaches, setback genioplasty is used to create an aesthetic jaw-end appearance by moving the mentum backward when it protrudes more than normal. However, conventional setback genioplasty may be aesthetically disadvantageous because the profile of the mentum could become flat. This case study attempted to overcome the limitations of conventional setback genioplasty by rotating the position of the menton and pogonion. We devised a new method for setback genioplasty by rotating the segment anteroinferiorly. Using virtual surgery, we were able to specify the range of surgery more accurately and easily, and the surgery time was reduced. This case report showed the difference in chin soft tissue responses between conventional setback genioplasty and setback genioplasty with rotation.

• Elastomers and Composites
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• v.59 no.1
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• pp.17-21
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• 2024

Solution styrene-butadiene rubber (S-SBR) is used to improve the wet grip and rolling resistance properties of tire treads. As blending of SBRs can improve the physical properties of tire treads, we investigated the effects of SBR type and blending ratio on the physical properties. Twelve SBR/SBR biblend composites were prepared using four SBRs with different microstructures. The glass transition temperature (T_g), tanδ at 0℃ (wet grip predictor), and tanδ at 60℃ (rolling resistance predictor) were obtained from dynamic mechanical analysis, and were compared to the expected values obtained from the results of single SBR samples. Most of the SBR/SBR biblend composites exhibited crosslink densities lower than the expected values. The tanδ values at 0℃ and 60℃ of the SBR/SBR blend composites deviated from the expected values, with many of the deviations being disadvantageous. Of the twelve composites, six samples had higher 0℃ tanδ values than the corresponding expected values, and four exhibited superior wet grip properties to those of the SBR single samples. In addition, two of the twelve samples exhibited improved rolling resistance properties as compared with the single SBR samples. Finally, four samples exhibited lower T_g values than expected, and the T_g of one composite was lower than those of the single SBR samples.