• 한국임상약학회지
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• 제3권1호
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• pp.15-20
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• 1993

The ability to precisely predict serum digoxin concentration using 7 published methods in a group of 50 patients was undertaken. Two methods of estimating creatinine clearance and two estimates of lean body weight were employed as input variables using the 7 dosing methods. TDX was used to determine the nadir SDCs(serum digoxin concentrations) in 50 in patients meeting predetermined study criteria. All patients, whose ages ranged 19-71 years, had steady-state digoxin levels, were in oral digoxin, and were free from liver dysfunction, thyroid dysfunction and renal failure. The correlation coefficients(r) of predicted versus observed SDCs were determined,. and mean error(ME) was determined for each method to reflect bias, respectively. No substantial differance in predictive reliabliity was evident among the methods studied in total group. Poor correlations existed between predicted and observed SDCs(r<0.4) and these correlations were not significantly affected by age and gender. But relatively higher correlation and lower ME was founded for the CHF group in Jelliffe method(r=0.5, p<0.05).

• Archives of Pharmacal Research
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• 제24권5호
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• pp.377-384
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• 2001

The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of the latter products towards chemical reagents was studied to give heterocyclic derivatives with potential biological activities.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1978년도 제17차 학술대회
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• pp.60-60
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• 1978

• Clinical and Experimental Pediatrics
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• 제45권7호
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• pp.928-932
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• 2002

저자들은 재태 연령 $38^{+6}$주에 태아 심초음파 검사에 의해 태아 심방 조동이 발견되어 산모에게 digoxin을 투여하였으나 효과가 없어 제왕 절개술을 통해 분만한 후, digoxin, 전기적 심율동 전환에 의해서도 치료되지 않아 propafenone을 복용하여 정상 동율동으로 회복된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한임상독성학회지
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• 제4권1호
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• pp.58-60
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• 2006

The venom gland of Toad contains large quantities of cardiac glycosides, and toad venom poisoning is similar to digitalis toxicity and carries a high mortality. Sometimes after ingestion of aphrodisiac pills which contain dried toad, a patient develops gastrointestinal symptoms and bradycardia, psychoneurologic symptoms. We have experienced 2 cases of toad venom intoxication, who ingested asian toads. Patients were presented to our ED with nausea, vomiting, and abdominal pain. The patients were peformed monitoring and conservative treatment and were fully recovered. Toad venom intoxication should be considered in patients with clinical manifestation of gastrointestinal irritation, cardiac arrhythmias, hyperkalemia, and detectable serum digoxin level without current medication of digoxin.

• KSBB Journal
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• 제13권4호
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• pp.352-356
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• 1998

Addition of cyclodextrin in the biotransformation of digitoxin into digoxin by Digitalis lanata cell suspension cultures enhanced the conversion yield. Presence of cyclodextrin also supported good stability of the intermediate product, digoxin, for long time. Among several kinds of cyclodextrins, ${\beta}$-cyclodextrin provided the best results. It was found that the optimum form of cyclodextrin utilization was the external addition of iclusion complexes between digitoxin and ${\beta}$-cyclodextrin at 1: 2 molar ratio from the beginning of biotransformation. With the optimized conditions, addition of ${\beta}$-cyclodextrin enhanced the production of digoxin up to 1.55 fold. In this case, not only digitoxin consumption was increased, but also the production of by-product was reduced.

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 2002년도 제11차 추계학술대회
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• pp.7-7
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• 2002

• Journal of Yeungnam Medical Science
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• 제6권1호
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• pp.99-107
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• 1989

저자들은 1987년 9월부터 1989년 4월사이 약 19개월간 영남대학병원 내과에 입원하여 만성 심방세동 진단하에 치료받고 있던 환자 34명을 대상으로 digoxin치료를 받은 20명과 치료를 받지 않은 10명에 대한 24시간 ambulatory ECG를 시행하여 두 집단간의 심박수의 변화 및 가장 긴 정지기등을 비교 분석한 결과 다음과 같은 성적을 얻었다. 1) 대상환자 34례의 평균 심박수의 평균치는 $75.7{\pm}13.8$회/min.($mean{\pm}S.D.$), 가장 빠른 심박수는 $148.0{\pm}32.4$/min.($mean{\pm}S.D.$), 가장 느린 심박수는 $48.1{\pm}8.4$회/min.($mean{\pm}S.D.$)이었고 가장 빠른 심박수와 가장 느린 심박수의 차이의 평균치는 $99.9{\pm}29.0$회/min.($mean{\pm}S.D.$), 가장 긴 정지기는 $2.95{\pm}1.06sec.$($mean{\pm}S.D.$)이었으며 이중 4명은 가장 긴 정지기가 4.0sec.이상으로 sick sinus syndrome을 배제할 수 없어서 비교대상집단에서는 제외시켰다. 2) 대상환자 34례중 27례에서 심실성 기외수축이 있었으며 100회/24hours이내가 11례(40.7%)로 가장 많았고, 변성전도(aberrant conduction)는 전례에서 다 나타났다. 3) Digoxin(0.25mg/day)으로 치료받은 20례의 평균 심박수의 평균치는 $78.4{\pm}13.7$회/min.($mean{\pm}S.D.$), 가장 빠른 심박수는 $152.5{\pm}33.1$회/min.($mean{\pm}S.D.$), 가장 느린 심박수는 $48.9{\pm}8.5$회/min.($mean{\pm}S.D.$) 이었고 가장 빠른 심박수와 가장 느린 심박수의 평균치는 $103.6{\pm}31.7$회/min.($mean{\pm}S.D.$), 가장 긴 정지기는 $2.55{\pm}0.50$sec.($mean{\pm}S.D.$)이었다. 4) Digoxin으로 치료받지 않은 10례의 평균 심박수의 평균치는 $78.0{\pm}10.7$회/min.($mean{\pm}S.D.$), 가장 빠른 심박수는 $154.5{\pm}26.8$회/min($mean{\pm}S.D.$), 가장 느린 심박수는 $50.6{\pm}7.1$회/min.($mean{\pm}S.D.$)이었고 가장 빠른 심박수와 가장 느린 심박수의 평균치는 $103.9{\pm}22.2$회/min.($mean{\pm}S.D.$), 가장 긴 정지기는 $2.66{\pm}0.39sec.$($mean{\pm}S.D.$)이었다. 5) Digoxin으로 치료받은 20명과 치료받지 않은 10명의 두 집단간의 평균 심박수, 가장 빠른 심박수, 가장 느린 심박수, 가장 빠른 심박수와 가장 느린 심박수의 차이, 가장 긴 정지기의 차이는 통계학적으로 유의하지 않았다(P>0.05). 이상을 요약하면 하루 0.25mg의 digoxin투여로 만성 심방세동 환자의 심박수는 잘 조절되었으며 만성 심방세동 환자의 치료유무 결정 및 치료약제에 대한 반응등을 평가하는데 ambulatory ECG가 유용하고 안전한 검사법으로 사료된다.

• 한국임상수의학회지
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• 제33권4호
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• pp.205-209
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• 2016

A 6-year-old male domestic shorthair cat was referred to Gyeongsang National University Animal Medical Center for labored breathing. According to the patient's history, the client had fed him commercial dog foods. The patient's hematological, radiographic, and echocardiographic examinations were evaluated for diagnosis. Echocardiography results showed marked dilations of ventricles and atriums and mitral regurgitation. A systolic dysfunction was detected. Plasma taurine concentration was lower than the reference range. Based on these results, the patient was diagnosed with feline dilated cardiomyopathy associated with taurine deficiency. Treatment included feline commercial foods, taurine, digoxin, furosemide, and clopidogrel. Digoxin was changed to pimobendan when normal blood pressure was achieved. Clinical signs improved gradually and no abnormalities were detected on echocardiograms at 10 weeks following onset of treatment.

• Journal of Chest Surgery
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• 제25권6호
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• pp.672-677
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• 1992

This is a clinical review of the results from electric cardioversion and pharmacological therapy used in our hospital for reverting cardiac arrythmia in patients with mitral valve surgery between Jan. 1990 and Jun. 1991. Of 62 evaluated patients, 16 patients had regular sinus rhythm and the other 46 had arrhythmias [42; atrial fibrillation 1; atrial flutter 1; premature ventricular contraction] preoperatively. In 2 of patients with sinus rhythm, atrial fibrillation newly developed after surgery and was converted into sinus rhythm soon by intravenous administration of digoxin. Remaining 14 patient resumed sinus rhythm spontaneously. In patients with preoperative arrythmia, 3 patients reverted into sinus rhythm from atrial fibrillation by electric cardioversion at operative field, 1 patient by lidocain and mexiletine, 4 patients by combined use of digoxin and verapamil, 4 patients by 2 times of oral quinidine and 9 patient by long term use of oral amiodarone. Throughout this consecutive trials of anti-arrhythmic drugs and electric cardioversion, Conversion into normal sinus rhythm occurred in 48% of patients with arrhythmia developed after mitral valve surgery.