• 대한한방소아과학회지
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• 제20권3호
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• pp.129-141
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• 2006

Objectives : The purpose of this study is to determine clinical efficacy of herbal medicine by evaluating SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis Methods : Subjects are divided into two groups : Group 1(non-differentiation children treated with Saenghyeoryunbueom) and group 2(differentiation children treated with either pyungwisan, onchungum or gamitongsungsan). We determine SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis before and after taking each of herbal treatment for 12 weeks. Results : After herbal prescription for 12 weeks, A SCORAD index of both group 1 and group 2 was decreased. However, the total level of ceramides in group 1 and group 2 was not altered after 12 weeks. When the correlation between the alteration of SCORAD index and ceramides levels was determined, the SCORAD index in group 1 was inversely correlated with the total level of ceramides(r=-0.994, p=0.006) In contrast, the alteration of SCORAD index in group 2 was not correlated with ceramide levels. Conclusions : The clinical efficacy of Saenghyeoryunbueom for non-differentiation children with atopic dermatitis is paralleled with the increased level of ceramides in skin. The clinical efficacy of pyungwisan, onchungum or gamitongsungsan for differentiation children with atopic dermatitis is not correlated with ceramide level in skin.

• 한방비만학회지
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• 제7권1호
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• pp.55-69
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• 2007

Objectives : The aim of the study was to investigate the principal symptoms and a syndrome differentiation in the obesity using surveys from Oriental medical doctors and obese patients. Methods : Seventy three Oriental medical doctors who participated in the 2006 autumn annual conference of Korean Oriental Association for Study of Obesity and 243 obese patients responded to the survey. Results : Twenty nine percent of Oriental medical doctors replied that the syndrome differentiation is the most important diagnosis index, and 21 percent of them replied they use Sasang Constitution classification during diagnostic process. The syndrome differentiations used were mainly phlegm-fluid, blood stasis, spleen vacuity, food accumulation, damp phlegm, and Gi deficiency order. In the response of doctors and patients about principle symptoms of 6 syndrom differentiation belong inside 5 place except phlegm fluid and liver stasis Conclusions : We should develop syndrome differentiation questionnaire about obese symptoms.

• 대한한의진단학회지
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• 제16권1호
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• pp.27-34
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• 2012

Objectives The purpose of this study was to find out whether if there is correlation between the pattern differentiation questionnaire and edema index of body composition analysis. Methods The authors obtained results of pattern differentiation Questionnaires and body composition analysis tests from 195 female patients who visited the Oriental gynecology department in Kyung Hee university Oriental medicine hospital at Gang-dong. The authors conducted correlation analysis between indicators of Body composition analysis and each part of the pattern differentiation Questionnaire. Pearson correlation analysis was performed on SPSS version 13.0 for windows. Results There was negative correlation between the Phlegm Questionnaire and right arm ECF, left arm ECF, and left arm ECW of the Body composition index. There was no correlation between Yin-deficiency Questionnaire and Body composition index. There was no correlation between Heat pattern Questionnaire and Body composition index. There was positive correlation between the Cold pattern Questionnaire and right leg ECF, and right leg ECW of the body composition index. There was no correlation between degree of edema self-awareness and Body composition index. Conclusions The result showed that each Questionnaire score has different correlation or even no correlation with Body composition index and degree of edema self-awareness. Further studies are needed for a better understanding and interpretation of the relationship between edema index on Body composition analysis and Questionnaires.

• 동의생리병리학회지
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• 제21권1호
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• pp.347-351
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• 2007

This study was done to report the improvement of second case report form(CRF) and standard operating procedure(SOP) of Tentative Korean Standard Differentiation of the Symptoms and Signs for Stroke. We were in charge of developing case report form(CRF) and educating the investigators. In the process of this project, we needed to develop standard operating procedure(SOP) for this CRF. So we made Tentative Korean Standard Differentiation of the Symptoms and Signs for Stroke and tried clinical application at Department of Oriental Internal Medicine of Wonkwang University and Daejeon University in 2005. And in this pilot study we can find out some problems and need to improve it. We strengthen the incision and exclusion criteria of CRF We canceled the Chief complains entry for efficiency. We reflected the decision of Stroke standard committee. We reduced the differentiation index of CRF to promote efficiency and accuracy. We rearranged the order of the differentiation index to promote rationality and practicality. We regulated detail item belonging to Differentiation index. We used a colloquialism in question. We inserted flow chart in SOP. We inserted picture of diagnostic index.

• 한국산림과학회지
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• 제86권2호
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• pp.158-166
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• 1997

본 연구에서는 임분구조의 다양성 또는 동질성을 계량화시키는 방법을 제시하였다. 우선 인접목과의 직경비율에 의해 임분구조를 파악할 수 있는 Gadow의 직경차이율을 소개하였고, 직경급별 본수비율과 단면적 또는 재적비율에 의해 형성되는 Lorenz곡선형태로 부터 임분구조의 다양성지수를 유도하는 새로운 방법을 제시하였다. 본 연구에서 제시한 Lorenz곡선원리에 의한 횡적 임분구조지수는 Gadow의 직경차이율과 마찬가지로 0에서 1사이의 값을 가지며, 임분구조가 다양할수록 1에 접근하는 특정을 지니고 있다. 이러한 Lorenz곡선원리에 의한 횡적 임분구조지수를 Gadow의 직경차이율과 비교한 결과, 본 연구에서 제시한 새로운 형적 임분구조지수는 Gadow의 직경차이율과 비슷하게 임분구조를 설명하는 것으로 나타났다.

• 산업기술연구
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• 제18권
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• pp.233-240
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• 1998

In this study, ride sensitivity analysis of train with non-linear suspension elements is performed. Non-linear characteristics of springs and dampers for primary and secondary suspensions of a train is parameterized. Equation of motion of the train model is derived, and using the direct differentiation method, sensitivity equations are obtained. For a nominal ride quality performance index, sensitivity analysis with respect to various design parameters regarding non-linear suspension parameters is carried out.

• Asian-Australasian Journal of Animal Sciences
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• 제20권3호
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• pp.432-439
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• 2007

Thiazolidinediones (TZDs) act as potent activators of the adipose differentiation program in established preadipose cell lines. TZD's have also been investigated in diabetic patients and reported to act as PPAR-${\gamma}$ ligands. In this report, the effects of TZDs on the differentiation pathway of myoblasts have been investigated. C2C12 mouse myoblasts were grown in Dulbecco's Modified Eagles medium for 4-5 days until they reached almost 100% confluency. Post-confluent cells (day 0) were further exposed to adipogenic induction medium along with TZDs for 48 hours. Thereafter, cells were exposed only to TZDs every 48 h until day 10. The control was provided with differentiation medium without any treatment. Alterations in the cells during the differentiation programme were analyzed on the basis of fusion index, oil-red-o staining, adipocyte index, adipocyte stain uptake measurement, immuno-histochemistry and western blotting. Exposure of C2C12 mouse myoblasts to TZDs prevented the expression of myosin heavy chain with parallel increase in the expression of C/EBP-${\alpha}$ and PPAR-${\gamma}$ and acquisition of adipocyte morphology, thus abolishing the formation of multinucleated myotubes. TZDs exert their adipogenic effects only in non-terminally differentiated myoblasts; myotubes were insensitive to the compound. Continuous exposure (at least 4-5 doses) to inducers after the growth arrest was essential to provide a sustained environment to the cells converting to fully matured adipoctyes. The results indicate that TZDs specifically converted the differentiation pathway of myoblasts into that of adipoblasts.

• 대한한방내과학회지
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• 제29권3호
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• pp.574-581
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• 2008

Objective : Functional dyspepsia is a common disease impeding subjective quality of life. The present study aimed to analyze syndrome differentiation of functional dyspepsia to help with development of oriental therapeutics. Methods : Sixty-eight subjects diagnosed with functional dyspepsia were analyzed and classified into one of five syndrome differentiations. We compared symptomatic characteristics according to the Nepean Dyspepsia Index (NDI), such as severity, kinds of dyspepsia-related complaints and functional dyspepsia quality of life (QOL) among groups. Results : Patients with disharmony between liver and stomach were most prevalent (52.9%), but no patients with complex of fever and cold. The scores of symptom severity and QOL were not significantly different between groups. Each group had a specified pattern of complaints. Conclusions : Clinical-study based analysis of functional dyspepsia constructed by this study, could be useful in objectively developing Oriental medicines for this disease.

• 한국심리학회지 : 문화 및 사회문제
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• 제8권2호
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• pp.33-49
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• 2002

본 연구에서는 성인기 자녀 381명을 대상으로 가족분화수준, 가족관계의 질 및 친밀감간의 관계를 살펴보았다. 첫째, 가족분화수준과 가족관계의 질간의 관계를 통하여 가족분화의 개념이 원가족에 대해 지각하는 정서적 건강과 실제 가족관계에서 심리적 안녕감을 나타내는 개념인지 알아보았다. 그 결과, 가족분화수준과 가족관계의 질간에는 유의한 정적 상관을 보였다. 둘째, 원가족의 가족분화수준과 성인기 자녀의 이성파트너와의 친밀감간의 관계를 토대로 원가족의 부모와의 정서적 역동이 성인기 자녀의 현재 이성파트너와의 관계에 영향을 미치는지 살펴보았다. 연구결과, 성인기 자녀는 모든 하위체계에서 원가족의 가족분화수준과 이성파트너와의 친밀감간의 관계에서 유의한 정적 상관을 보였으며, 아들이 딸보다 부모의 가족분화수준에 민감한 것으로 나타났다.

• 대한기관식도과학회지
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• 제9권2호
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• pp.36-43
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• 2003

Background and objectives; Esophageal cancer is one of the most malignant tumors and has a poor prognosis. Many clinical studies have been tried for improving prognosis of esophageal cancer. Some clinical studies used molecular markers as the predictor of prognosis & the indicator for the choice of multimodality treatments. We investigated the relationship between some molecular markers, including p53 mutation, expression of bc12, Ki67 index, expression of E-Cadherin and the prognosis of esophageal cancer, Materials and Method; The materials used in this study were the tumor specimens from 72 esophageal cancer patients who underwent esophagectomy from 1987 to 2002 in our institute. The mutation of p53, expression of bc12, Ki67 index, and expression of E-cadherin were examined by using the tissue array and immunohistochemical staining method. The patients were subgrouped into higher Ki67 index group if the index was higher than 30. The patients were also subgrouped into grade 1(>90%), grade 2(50∼90%), grade 3 (10∼50%), and grade 4(<10%) according to the rate of E-Cadherin expression. We studied the relationship between the rates of immunohistochemical staining and the survival rate. Results: Seventy two tumor specimens from 72 patients were studied. (mean age ; 59.6 years, male female = 69 : 3) The histologic type of the specimens was all squamous cell carcinoma. The patient's number of stage IIA, IIB, and Ⅳ was 30, 37, and 7 respectively, Thirty patients were alive and overall 5 year-survival rate was 28%. The mutation of p53 was shown in 54.2% of the patients. Five year survival rates of negative and positive groups were 29% and 28% respectively.(p=0.4) Expression of bc12 gene was found in 13.9% of the specimens. Five year survival rates of negative and positive groups were 30% and 21%.(p=0.3) Higher Ki67 index was correlated to poorer differentiation.(p=0.05) Five year survival rates of higher and lower groups of Ki67 index were 47% and 30%.(p=0.15) Higher expression rate of E-Cadherin showed better differentiation.(p=0.04). However we couldn't find any survival differences between these 4 groups.(p=0.23) Conclusion; We could not find any molecular markers meaningful in the prognosis of esophageal cancer patients. We just found the tumor markers correlated to the differentiation of esophageal cancer. However, we knew that we need further study with some more samples to stratify other important prognostic factors of esophageal cancer.