• Investigative Magnetic Resonance Imaging
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• 제1권1호
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• pp.66-74
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• 1997

혈액의 산소화와 불 산소화에 따른 국부적인 자화율 효과의 변화에 의한 자장의 불 균일성에 민감한 경사 자장 에코 기법은 현재의 뇌기능 MR 영상의 기본이 되고 있다. 일반적으로 이러한 경사 자장 에코기법은 $T2^{*}$ 혹은 BOLD효과에 의한 자장의 불 균일성의 증가가 신호의 감소로 나타난다. BOLD 효과는 주자장에 대한 핏줄의 방향이나 영상 형식, 즉, 횡단면, 관상면, 또는 시상면에 따라 달라진다. 그래서 영상 형식과 영상면에 대한 기울임 각에 따른 신호의 변화와 BOLD 효과의 변화에 대한 정량적인 연구를 하였다. 연구는 자화율 효과에 대해 다른 민감도를 가지는 TRFGE 와 CGE 기법으로 이루어졌다. 컴퓨터 모의 실험과 실험 결과를 본 논문에 나타내었다.

• 아시안잔디학회지
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• 제25권2호
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• pp.177-183
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• 2011

벤트그라스 3종류의 품종에 대한 감수성을 잎 조각 검정와 전체식물에 대하여 9개의 Microdochum nivale 균주를 이용하여 온도가 조절된 공간에서 평가 하였다. 위스콘신 골프장에서 감염된 병반에서 얻은 자주색 설부병 균주에 대하여 온도와 살균제에 대한 반응시험을 하였다. 잎 조각 검정과와 전체식물을 이용한 시험은 80일된 잔디로 평가하였다. 9균주는 2종류의 살균제에 감수성이 었으며, 온도에 대하여 균주간에 차이를 보였다. 잎조각을 이용한 검정에서도 벤트그라스 품종과 종간에도 뚜렸한 차이를 보였다. 전체식물을 이용한 시험에서도 품종과 종간에 병 심각성에 차이를 보였는데, 특별히 4배수체인 크리핑과 콜로니얼 벤트그라스와 2배체인 벨벧벤트그라스 종과 품종간에 M. nivale 균주에 대한 감수성 차이를 보였다. 이 연구는 자주색 설부병에 대한 벤트그라스 평가에 응용될 수 있고, 육종을 하는데도 품종간에 전망적인 예측 평가을 하는데 필요한 자료로 쓰일 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3691-3698
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• 2014

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A (RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis was here performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to November 2013 on the association between RASSF1A Ala133Ser polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Bothfixed-effect and random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) by using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 10 studies including 4,572 cancer cases and 4,320 controls were included in the meta-analysis. Overall, significantly increased cancer risk was associated with the variant Ser133 when all studies were pooled (Ser vs Ala: OR=1.51, 95% CI=1.08-2.12, $P_{heterogeneity}{\leq}0.001$; Ser/Ser+Ala/Ser vs Ala/Ala: OR=1.55, 95% CI=1.08-2.22, $P_{heterogeneity}{\leq}0.001$). Moreover, in subgroup analyses by cancer types, a significant association between RASSF1A Ala133Ser polymorphism and lung cancer risk was found (Ser vs Ala: OR=2.27, 95% CI=1.29-4.02, $P_{heterogeneity}$=0.61; Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.42, 95% CI=1.33-4.42, $P_{heterogeneity}=0.75$). In addition, in subgroup analyses by ethnicity, it was found that the RASSF1A Ala133Ser polymorphism was associated with overall cancer risk in Asians (Ser vs Ala: OR=1.37, 95% CI=1.06-1.77, $P_{heterogeneity}=0.06$) and Caucasians (Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.21, 95% CI=1.01-4.82, $P_{heterogeneity}{\leq}0.001$). Conclusions: This meta-analysis suggests, for the first time, that RASSF1A Ala133Ser polymorphism may contribute to cancer susceptibility, especially for lung cancer. Besides, additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• 한국항공우주학회지
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• 제39권3호
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• pp.242-253
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• 2011

종래의 stand-off 무인항공기가 감시와 정찰에 초점이 맞춰져 있었다면, 무인전투기는 여기서 더 발전하여 극한상황에서의 전투임무를 수행한다. 미래의 전장에서 무인전투기는 유인전투기가 수행하였던 적 방공망제압임무(SEAD)와 같은 극한상황의 임무를 수행할 것이며, 임무 수행 중 지대공 미사일등과 같은 각종 위협에 직면하게 될 것이다. 현재 항공기의 전투생존성에 대하여 많은 연구가 진행되고 있지만 이것은 대부분 유인전투기의 위약도와 취약도를 개선하는 방안에 대한 것이다. 무인전투기의 생존성을 고려한 설계는 일반적으로 유인전투기와 유사할 수 있으나, 임무수행환경 및 형상과 성능에 있어 유인전투기와 차이가 존재하므로 생존성에 영향을 미치는 변수들에 있어 정량적, 정성적인 차이가 존재 한다. 본 논문에서는 무인전투기의 생존성 요소 중 위약도에 영향을 주는 요소를 유인전투기인 F-16C/D와 무인전투기 X-45A를 예제로 하여 식별하고 그 민감도를 몬테카를로 모사법을 이용하여 분석하였다

• Geomechanics and Engineering
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• 제24권5호
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• pp.407-418
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• 2021

Due to the complexity of the causes of the sliding mass instabilities, landslide susceptibility and hazard evaluation are difficult, but they can be more carefully considered and regionally evaluated by using new programming technologies to minimize the hazard. This study aims to evaluate the landslide hazard zonation in the Tabriz region, Iran. A fuzzy logic-based multi-criteria decision-making method was proposed for susceptibility analysis and preparing the hazard zonation maps implemented in MATLAB programming language and Geographic Information System (GIS) environment. In this study, five main factors have been identified as triggering including climate (i.e., precipitation, temperature), geomorphology (i.e., slope gradient, slope aspect, land cover), tectonic and seismic parameters (i.e., tectonic lineament congestion, distribution of earthquakes, the unsafe radius of main faults, seismicity), geological and hydrological conditions (i.e., drainage patterns, hydraulic gradient, groundwater table depth, weathered geo-materials), and human activities (i.e., distance to roads, distance to the municipal areas) in the study area. The results of analyses are presented as a landslide hazard map which is classified into 5 different sensitive categories (i.e., insignificant to very high potential). Then, landslide susceptibility maps were prepared for the Tabriz region, which is categorized in a high-sensitive area located in the northern parts of the area. Based on these maps, the Bozgoosh-Sahand mountainous belt, Misho-Miro Mountains and western highlands of Jolfa have been delineated as risk-able zones.

• 농업과학연구
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• 제43권4호
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• pp.507-521
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• 2016

Landslides are one of the most common natural hazards causing significant damage and casualties every year. In Korea, the increasing trend in landslide occurrence in recent decades, caused by climate change, has set off an alarm for researchers to find more reliable methods for landslide prediction. Therefore, an accurate landslide-susceptibility assessment is fundamental for preventing landslides and minimizing damages. However, analyzing the stability of a natural slope is not an easy task because it depends on numerous factors such as those related to vegetation, soil properties, soil moisture distribution, the amount and duration of rainfall, earthquakes, etc. A variety of different methods and techniques for evaluating landslide susceptibility have been proposed, but up to now no specific method or technique has been accepted as the standard method because it is very difficult to assess different methods with entirely different intrinsic and extrinsic data. Landslide prediction methods can fall into three categories: empirical, statistical, and physical approaches. This paper reviews previous research and surveys three groups of landslide prediction methods.

• 자원환경지질
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• 제46권4호
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• pp.301-312
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• 2013

산사태는 지형, 지질, 임상, 토양 등과 같은 다양한 요인들이 복합적으로 작용하여 발생한다. 따라서 산사태 발생위치와 산사태 유발 요인 사이의 상관관계를 파악할 수 있는 다양한 분석 기법이 사용되고 있으며 본 연구에서는 산사태 위험지역을 정량적으로 예측할 수 있는 효과적인 기법을 제안하고자 퍼지관계 기법과 인공신경망 기법을 이용하여 포항지역의 산사태 취약성을 분석하였다. 취약성 분석을 위해 먼저 산사태 위치를 파악하여 현황도를 작성하였으며, 산사태 발생과 관련 있는 11개의 요인들에 대한 공간 데이터베이스를 구축하였다. 퍼지관계 기법에서는 cosine amplitude method를 이용해 각 요인 별 퍼지 소속 함수 값을 획득하고 퍼지관계 함수 연산을 이용하여 취약성도를 작성하였다. 인공신경망 기법에서는 오류 역전파 알고리즘을 이용하여 산사태와 관련 요인들 간의 상대적 가중치를 결정하고 취약성도를 작성하였다. 두 기법으로 도출된 산사태 취약성도의 ROC(Receiver Operating Characteristic)와 AUC(Area Under the Curve)를 통한 검증 결과는 82.18%와 87.4%로 나타났다. 퍼지 관계 및 인공신경망 기법 모두 높은 예측 정확도를 보여 취약성 분석 기법으로서의 적용 가능성이 있는 것으로 분석되었다. 한편 본 연구지역의 경우 인공신경망 기법이 퍼지관계 기법에 비해 좀 더 나은 예측 정확도를 보이는 것으로 분석되었다.

• 대한의생명과학회지
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• 제23권2호
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• pp.89-95
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• 2017

Tuberculosis (TB), mainly disseminated by infection of the respiratory tract, remains an unsolved community health problem by Mycobacterium tuberculosis (MTB). However, because of the different susceptibility to MTB, people infected with MTB do not all develop TB. These differences of disease arise from individual genetic susceptibility as well as the property of the microorganisms itself. CD226, one of the genetic factors that influences TB, interact with its ligand PVR and ITGB2. It is induced various cellular responses that contribute multiple innate and adaptive responses. In a previous study, CD226 enhanced immune efficacy induced by Ag85A DNA vaccination that is secreted protein by MTB. The aim of this study was to investigate the association between six genetic polymorphisms of CD226 gene and TB status with Korean population. Our results show that two SNPs of CD226 were identified to associate with tuberculosis. The highest significant SNP was rs17081766 (OR=0.70, CI: 0.54~0.90, $P=5.4{\times}10^{-3}$). According to this study, polymorphisms of CD226 gene affect the outbreak of TB in MTB-infected patients. It is suggested that polymorphism of other genes also associated with immune responses results in susceptibility to TB. The results from this study suggest that not only the characteristics of the microorganism itself but also the genetic background of the individual may affect progression of TB in MTB-infected patients.

• 대한의생명과학회지
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• 제22권4호
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• pp.215-219
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• 2016

The problems of tuberculosis and its drug resistance are very severe. Therefore, rapid and accurate drug susceptibility assay is required. Recently, there has been an increased understanding of the genetic mechanism of Mycobacterium tuberculosis (MTB) drug resistance as well as advancement of molecular technologies. While many gene mutations correlate well with drug resistance, many genes do not show a strong correlation with drug resistance. For this reason, the current study assessed the utility of rpoB mRNA as a target to detect live mycobacteria. In this study, RT-PCR targeting of rpoB mRNA in BCG treated with rifampin was performed. Conventional RT-PCR and real-time PCR targeting rpoB mRNA as well as 85B mRNA was performed to determine whether these two methods could distinguish between viable and non-viable MTB. The levels of rpoB and 85B mRNA detected by RT- PCR were compared in parallel with colony forming unit counts of BCG that were treated with rifampin for different periods of time. The data suggests that that even though both mRNA levels of rpoB and 85B decreased gradually when rifampin-treatment increased, the rpoB mRNA seemed to represent live bacteria better than 85B mRNA. This study clearly indicates that RT-PCR is a good method to monitor viable cell counts in the liquid culture treated with the anti-tuberculosis drug.

• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.618-626
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• 2016

Pleural effusion lymphoma (PEL) is a rare B-cell lymphoma that has a very poor prognosis with a median survival time of around 6 months. PEL is caused by Kaposi's sarcoma-associated herpesvirus, and is often co-infected with the Epstein Barr virus. The complement system is fundamental in the innate immune system against pathogen invasion and tumor development. In the present study, we investigated the activation of the complement system in PEL cells using human serum complements. Interestingly, two widely used PEL cell lines, BCP-1 and BCBL-1, showed different susceptibility to the complement system, which may be due to CD46 expression on their cell membranes. Complement activation did not induce apoptosis but supported cell survival considerably. Our results demonstrated the susceptibility of PEL to the complement system and its underlying mechanisms, which would provide insight into understanding the pathogenesis of PEL.