• Archives of Pharmacal Research
• /
• v.15 no.4
• /
• pp.333-335
• /
• 1992

Hofmann rearrangement of a series of primary aliphatic and aromatic carboxamides 1a-1m with HgO-NBS (or dibromantin)R'OH-DMF gives corresponding carbamates 2a-2m in excellent yields.

• YAKHAK HOEJI
• /
• v.33 no.3
• /
• pp.206-210
• /
• 1989

Bromolactonization of 2-Substituted-1-cyclohexenyl-1-acetic acid (1) with 1,3-dibromo-5,5-dimethylhydantoin (dibromantin) in N,N-dimethylformamide gave the corresponding ${\gamma}-bromo-{\beta}-lactone$ (2) and ${\beta}-bromo-{\gamma}-lactone$ (3). The effect of the substituents, the reaction temperature, and the solvent on the regioselectivity was discussed.