• Maxillofacial Plastic and Reconstructive Surgery
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• 제20권4호
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• pp.279-283
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• 1998

The osteoporosis is a disease that represents a reduction in the volume of bony tissue relative to whole bone volume. And mandible also may be affected. Such porotic mandible may influence the result of the surgery like dental implant surgery relating mandible. So, the author examed the panoramic view of 89 persons for finding the possibility of useful diagnostic parameters of osteoporosis. To know the correlationship between the condition of vertebra and mandible, bone marrow density of lumbar spine from 2nd to 4th, and the number of residual tooth, panoramic mandibular index (PMI), angular cortical bone thickness (ACT) and ramus cortical bone thickness (RCT) were compared. The result is that PMI and ACT have similar relative weak linear correlationship, RCT have very weak linear correlationship, the number of residual tooth have not linear correlationship.

• 한국콘텐츠학회논문지
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• 제14권11호
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• pp.362-369
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• 2014

본 연구는 골다공증 환자의 Digital 요추 측부 영상을 이용하여 질감특징의 통계적 분석으로 컴퓨터 보조진단 시스템 구현과 질병의 조기진단 및 치료를 위한 실험적인 모형 연구로 신뢰성 있는 보조적 진단 정보를 제공함으로써 골다공증에 대한 정확한 진단 방향을 제시하고자 하였다. 이를 위해서 정상인의 Digital 방사선 요추 측부 영상과 골다공증 환자의 Digital 방사선 요추 측부 영상을 실험 영상으로 하여 설정된 ROI에 대한 통계적 질감특징 값을 6가지 parameter로 나타냈다. 골다공증에 대한 질감특징분석 값 중 Average Gray Level에서 95%로 최고 높은 인식률을 나타내었고, Uniformity에서 80%로 가장 낮은 인식률을 나타내었다. 또한 Average Contrast에서 82.5%, Smoothness에서 90%, Skewness에서 87.5%, Entropy에서 87.5%를 나타내어 6가지 Parameter에서 모두 80%이상의 높은 인식률을 나타내 알고리즘의 안정성을 입증하였다. 따라서 본 연구 결과를 토대로 의료영상의 컴퓨터자동진단 시스템으로 발전된 프로그램을 coding 한다면 의료영상의 병소부위 자동검출, 질병 진단을 위한 예비 진단자료, 질병의 확진을 위한 자료제공, 제한된 장비로도 진단 가능, 의료영상의 판독시간 단축에 유용하게 사용될 수 있으리라 사료된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권5호
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• pp.519-526
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• 2000

Osteoporosis has recently been recognized as a major health problem in the elderly population. The disorder is manifested as a loss of bone mass accompanied by structural alteration of bone and increased incidence of fracture. Mandible also may be affected. So, I evaluated panoramic views of 66 postmenopausal women for finding the possibility of useful diagnostic mandibular parmeters of osteoporosis. To know the correlationship between skeleton and mandible, the average of the bone mineral density of lumbar from 2nd to 4th by the dual energy X-ray absorptiometry(DEXA, LUNAR DPZ. USA), and age and mandibular parameters, that is, the number of residual teeth, alveolar ridge resorption ratio, panoramic mandibular index (PMI), mandibular cortical width (MCW), angular cortical thickness (ACT), ramus cortical thickness (RCT), morphology of mandibular inferior cortical (MIC) were compared. And I divided the all tested women to the osteoporotic group and non-osteoporotic group by the use of T-score -2.0, which was derived from skeletal bone mineral density (BMD). To find the correlationship of the each group with mandibular parameters, t-test and discriminant analysis were done. The results of the t-test were that all parameters were highly related with 2 groups (p<0.05). Especially ACT, MIC, age have had even higher correlationship than others (p<0.001). The results of the discriminant analysis by the use of these ACT, MIC and age were that the discriminant function was Z = -2.973+(-1.447)$\times$(ACT)+1.131$\times$(MIC score)+(0.052)$\times$(age), the cutting score was 0.257 and the classification accuracy was 84.8%. Therefore I suggest that the consideration of the angular cortical thickness (ACT), the age of patient and the morphology of mandibular inferior cortical(MIC) may help find the osteoporosis.

• 한국콘텐츠학회논문지
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• 제12권6호
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• pp.353-360
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• 2012

본 연구는 근위대퇴골 정면 영상에서 골다공증 측정을 위한 영상지표가 이중에너지흡수계측법(DEXA)으로 측정한 골밀도 결과와 관련성이 있는지 알아보고자 하였다. 총 112명을 대상으로 근위대퇴부 정면 영상을 촬영하였고, 영상 지표인 대퇴골관비(CCR)와 피질골 두께지표(CTI)를 측정하여 DEXA 골밀도 결과와 비교하였다. T-score를 이용하여 골다공증군과 비골다공증군으로 나누었고, 영상지표와 평균비교분석 및 상관관계분석, 진단일치도를 비교하였다. 영상계측에서 골다공증군의 골수강내 대퇴관과 골단 대퇴관 간격은 비골다공증군보다 유의하게 컸다. CCR은 골밀도와 음의 상관관계(r=-0.340)가 이었고, CTI는 양의 상관관계(r=0.624)가 있었다. 골다공증에 대한 CCR의 진단일치도는 63.4%이었고, kappa 값은 0.271이었다. CTI의 진단일치도는 67.0%이었고, kappa 값은 0.258 이었다. 결론적으로 근위대퇴골 영상에서 비골다공증군보다 골다공증군의 CCR이 더 크고, CTI는 더 좁게 나타났다. 이는 근위대퇴골 정면영상을 평가할 때 대퇴골의 골단간 피질의 두께가 얇은 환자는 골다공증에 대한 추가적인 검사를 추천할 수 있다.

• The Journal of the Acoustical Society of Korea
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• 제22권2E호
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• pp.69-77
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• 2003

Correlations between acoustic properties and bone density have been investigated in bovine cancellous bone. Speed of sound (SOS), broadband ultrasonic attenuation (BUA), and broadband ultrasonic reflection (BUR) were measured in 10 defatted bovine cancellous bone specimens in vitro. SOS showed a significant correlation with the apparent density of the bone. A comparable correlation was observed between BUA and the apparent density. BUR was rather highly correlated with the apparent density. It was shown that BUR had a weak correlation with BUA and a significant correlation with SOS. This indicates that the parameter BUR can provide important information that may not be contained in BUA and SOS and, therefore, can be useful as an alternative diagnostic parameter of osteoporosis. As expected, a linear combination of all three ultrasonic parameters in a multiple regression model resulted in a significant improvement in predicting the apparent bone density.

• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.213-222
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• 2012

While much has been learned about the mechanisms of metastatic spread of cancer to bone, there has been little headway in establishing guidelines for monitoring the alteration in bone quality and estimating fracture risk. The aims of this study are, therefore, 1) to evaluate bone quality induced by metastatic bone tumor by analyzing the characteristics on bone microarchitecture and degree of bone mineralization and 2) analyze fracture risk increased secondary to the bone quality changes by metastatic bone tumor through calculating mechanical rigidities based on in-vivo micro CT images. For this study, eighteen female SD rats (12 weeks old, approximate 250 g) were randomly allocated in Sham and Tumor groups. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was inoculated in the right femur (intraosseous injection) in Tumor group, while 0.9% NaCl (saline solution) was injected in Sham group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters and degree of bone mineralization at 0 week, 4 weeks, 8 weeks, and 12 weeks after surgery. At the same time, urine was collected by metabolic cages for a biochemical marker test in order to evaluate bone resorption. Then, bone metastasis had been directly identified by positron emission tomography. Finally, axial, bending and torsional rigidities had been calculated based on in-vivo micro CT images for predict fracture risk. The results of this study showed that metastatic bone tumor might induce significant decrease in bone quality and increase of fracture risk. This study may be helpful to monitoring a degree of bone metastasis and predicting fracture risk due to metastatic bone tumor. In addition, this noninvasive diagnostic methodology may be utilized for evaluating other bone metabolic diseases such as osteoporosis.