• The Korean Journal of Food And Nutrition
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• v.6 no.2
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• pp.130-136
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• 1993

• Proceedings of the Zoological Society Korea Conference
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• 1997.04a
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• pp.71.1-71
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• 1997

No Abstract, See Full Text

• Journal of Nutrition and Health
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• v.30 no.7
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• pp.743-750
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• 1997

The hypoglycemic effects of 2 mushrooms, Pleurotus ostreatus and Lentinus edodes, on streptozotocin(STZ) induced diabetic rats were investigated in this study . Diabets mellitus was induced in male Sprague-Dawley rats by the injection of STZinto the tail vein at a dose of 45mg/kg. Sprague-Dawley male rats(200-250g) were assigned to one control and three STZ-diabetic groups. Diabetic groups were assigned to STZ-control, pleurotus ostreatus and Lenitinus edodes groups. All groups were fed a AIN 76 diet. The two experimental groups were fed with each protein-bound polysaccharide(150mg/kg BW) for 14 days and with carboxymethyl cellulose for STZ-control group. The body weight gain was monitored and the blood levels of glucose and cholesterol were measured . Levels of protein triglyceride, and free fatty acid in plasma were analysed. Serum aminotransferase activity as also measured. The body weight gain was lower in the all diabetic groups than in the of normal group. The weight of spleen was reduced by adminstration of the Lentinus edodes protein-bound polysaccharides. The result suggest that orally administered Lentinus edodes protein-bound polysaccharides exhibited hypoglycemic effect in STZ -induced diabetic rats and that these protein-bound polysaccharides may be useful for the management of diabetes mellitus.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.214-219
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• 2004

This experiment was performed to investigate the effect of Sinjigolpy-tang on the diabetic rats induced by STZ. After experimental diabets was induced by 55mg/kg of STZ injection, we administered Sinjigolpy-tang extract for 14 days after STZ injection. Glucagon and insulin granules in Langerhans islets were stained by use of immunohistochemical(ABC) method and observed the relative amount of the each granules in Langerhans islet by light microscope and image analysis system. Area % of insulin granules in Langerhans islets in Sinjigolpy-tang increased and showed the statistically significant difference with the control group at 14th day. Area % of glucagon granules in Langerhans islets in Sinjigolpy-tang decreased and showed the statistically significant difference with the control group at 7th and 14th day. It can be inferred that Sinjigolpy-tang has a control effect on glucagon and insulin granules in Langerhans islets of diabetic rats induced by STZ.

• Korea journal of population studies
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• v.14 no.1
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• pp.35-46
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• 1991

Improvements in various health indices have been ushered in, along with soaring economic growth in the last few decades in Korea. Life span of Koreans at present stands at somewhere around age of seventies. It seems of worth to elucidate some facets of health profile of historic Koreans during Yi dynasty encompassing about five hundreds years between the 14th and 19th century. Datas on health of historic Koreans are meager with exception for sovereigns for whom royal archives have been preserved intact through centuries. Though the health environments for monarchs are, no doubt, incomparable to that of the grassroot levels during the same period, health profile of monarchs would facilitate to assess health indices for historic Koreans during Yi dynasty. Arithmetic average of life span of 25 consecutive Kings(omitted the last two Kings under Japanese control) is 44.6 years of age 81 year old for King Yongjo and 16 year old for King Danjong, representing two extremes. The principal causes of death are septicemia, subsequent to infections of soft tissue and ether organs(8 in number, one-thirds of all). Secondly, both epidemic disease and vascular accidents caused deaths of three Kings each. Two kings succumbed to diabets and one suicide. The causes for the remainder, eight kings are hardly ciarified. The monarchs who contributed in establishment of new Yi dynasty with highspirited and disciplined survied beyond their fifties and sixties. In contrast, those who reigned during mid - era of the dynasty at its culmination succumbed to death in their young adulthood, most likely due to their indulgence in court life.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.3
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• pp.95-101
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• 2004

Objective: The purpose of this study is to investigate the past history of the patients with peripheral type nerve palalysis. Methods: We examined the age, sex, region, month, season, past disease and cause of 692(343 male, 349 female) patients with peripheral type nerve palalysis who visited Dept. of Acupuncture and Moxibustion, Bundang Oriental Medicine Hospital, Dongguk University, from 2001-10-1 to 2004-9-30. Results: 420 patiens(60.7$\%$) were in the age between 30-59. The region, sex, and seasonal distribution didn't have a remarkable contrasts. In the past disease, Hypertension(14.5$\%$), Diabets mellitus(9.2$\%$), Gastric diseases(3.9$\%$) and Live diseases(3.8$\%$) were investigated highly than other diseases. In the distribution of cause, fatigue(36.3$\%$), unknown(34.8$\%$), stress(19.2$\%$) cold exposure(12.1$\%$) were investigated highly than other causes.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.4
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• pp.724-730
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• 1998

Effects of raw soy flour(RSY) and black(RSB) feeding on protein concentration of liver and serum, and GOT, GPT and alkaline phosphatase activities of serum in diabetic and nondiabetic rats were studied. Male rats(Sprague-Dawley), mean weight of (338.4$\pm$19.2g) were assigned to six dietary groups and fed with the assigned diet for 28 days. For each experimental, some rats were injected with streptozotocin intraperitoneally(L.P.) to induce diabets, and other rats were injected with buffer L.P. as a control group. The liver, kidney and spleen weights relative to bo요 weigth were higher in raw yellow soy flour diet diabetes(D-RSY) and black soy flour diet diabetes(D-RSB) groups than control, but the body weights were lower than control. The protein and albumin concentrations of liver and serum were lower in D-RSY and D-RSB groups than control. The albumin concentration of serum in D-RSB group was lower than control. The GOT activities of serum in RSY and RSB groups were increased compared with control, but the GPT activities were lower in diabetic control, D-RSY and D-RSB groups than control. The alkaline phosphatase activities of serum in RSY and RSB groups were higher than control, but those in D-RSY and D-RSB groups were lower than diabetic control.

• Journal of Nutrition and Health
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• v.27 no.3
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• pp.228-235
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• 1994

The purpose of this study was to investigate the effect of vitamin B6 deficiency on the concentration of energy metabolite in streptozotocin-induced diabetic rats. Thirty rats were fed a vitamin B6 deficient diet(-B6) or a control diet(+B6) for 5 weeks and then subdivided into 3 groups respectively ; base group, one day diabetic group and three day diabetic group. Diabetes of rats were induced by streptozotocin injection into the tail vein. Glucose, glycogen, protein, alanine, triglyceride and free fatty acids were compared in plasma, liver skeletal muscle of rats. Also, the total urinary nitrogen and glucose excretion were compared. Compared with +B6 rats, the increase of plasma glucose in -B6 rats due to the diabetes was smaller. After diabetes was induced, the level of plasma alamine was not changed in -B6 rats while increased significantly(p<0.05) in +B6 rats. The increase of urinary nitrogen excretion was smaller and the increase of muscle protein was larger in -B6 rats at the first day diabetes was induced. The levels of plasma free fatty acid and liver triglyceride were significantly (p<0.05) higher in -B6 rats after diabetes was induced. These results suggest that vitamin B6 deficiency may impair the adaptation of animals to the energy metabolism related due to a decrease of the body protein catabolism of fatty acid oxidation in diabetes and aggravate fatty liver which is one of the chronic complications of diabetes.

• Journal of agricultural medicine and community health
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• v.23 no.2
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• pp.269-274
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• 1998

The purpose of this study is to establish the basic consultation data for diabetes in adults and to demonstate the necessity of preventive regular medical examinations. The study was carried out at Chungyang County, Chungchungnam-Do from the first of January, 1996 to the end of December. Below is the statistical data of this study which concerns the distinction of sex, ages, and occupations from the 600 examinees. 1. According to the distinction of sex, there are 12 males and 11 females among the 300 examinees in each group. That means, the diabetic percentage is 4.0% versus 3.6% and male/female diabetic ratio is 1.1:1 2. According to the distinction of ages, there is one people 0.25% aged 20years old and 5 peoples 1.3% aged 30 years old among the 400 examinees. There are 6 peoples 1.0% aged 40 years old and 6 peoples 1.0% aged 50 years old among the 600 examinees. There are 4 peoples 2.0% aged 60 years old among the 200 examinees. 3. According to the distinction of occupations, there are 13 white collar workers 6.5% among the 200 examinees, and there are 8 blue collar workers(4%) among the 200 examinees. There are 2 government employees 1% among the 200 examinees. This show that there is less diabets in government employees than other occupational groups of the same number. 4. Among the white and blue collar workers, 7 diabetis's blood glucose levels are 140mg%--200 mg% and 6 are 200mg%. 5. Among the community medical insurance holders, 7 diabetic's blood glucose levels are 140 mg%--200mg% and 1 is 200mg%. 6. Among the government employees, 2 diabetic's bleed glucose levels are 140mg--200mg% and there is no 200mg%.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.2
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• pp.313-318
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• 1998

This study investigated the effect of raw soybean yellow(RSY) and raw soybean black(RSB) on body weights, pancreas weights, serum glucose and lipid concentrations of boty normal and diabetic male rats(Sprague-Dawley, body weight 338.8$\pm$19.2g). For each experimental, some rats were injected with streptozotocin intraperitoneal(i.P.) to induce diabets, and other rats were injected with buffer i.P. as a control group. Body weight gain(BWG) was lower in rats fed both RSY and RSB diet(3.4~5.0g BWG) than in those fed control diet(58.1g BWG). The diabetic rats showed significant decrease of bo요 weight (-50~-67g) compared with the control rats. RSY and RSB feeding resulted in greater pancreatic weight relative to body weight, and diabetic rats fed RSY and RSB had heavier pancreatic weights relative to body weight than control rats. The levels of fasting serum glucose in diabetic rats fed both RSY and RSB decreased by 42 and 31%, respectively, compared with the diabetic control rats, but they increased by 80 and 110% compared with the normal control rats. The concentrations of total lipid, triglyceride, phospholipid and total cholesterol in serum of diabetic rats fed RSB diet were lower than those in control rats, but serum HDL-cholesterol, HDL-cholesterol/total cholesterol ratio were not affected by raw soybeans feeding. Atherogenic index wa lower in diabetic rats fed RSY and RSB diet than those in control rats. The concentrations of total lipid, triglyceride and phospholipid in liver were lower in raw soybean groups than those in control group. The concentrations of cholesterol in liver of groups treated raw soybean were decreased compared with the control group.