• Korean Journal of Health Education and Promotion
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• v.32 no.3
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• pp.23-31
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• 2015

Objectives: The contribution of health behavior is high in the mortality variation. Mortality variation can be decreased through the policies and programs for improving health behavior. We investigated that health behaviors effected with standardized mortality in community. Methods: We examined the distribution of health determinant factors and correlation analyzed between factors and performed multiple linear regression. Data were collected from 2012 Community Health Survey in 253 communities, annual regional statistics, and statistics from Statistics Korea. Results: This study defined that the variation of standardized mortality and there are exist inequality level of health determinant factors in 253 communities. This study showed that the higher standardized mortality explained through health behavior factors of the current smoking rate, walking exercise rate and diagnosis of hypertension or diabetes rate after adjusted other factors(adjusted $R^2=0.709$, p<0.001). Conclusions: Smoking, walking exercise and diagnosis chronic disease affecting on the regional variation of standardized mortality. These factors can be improved by the local residents themselves.

• Genomics & Informatics
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• v.6 no.2
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• pp.91-94
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• 2008

Single nucleotide polymorphisms (SNPs) are the most abundant form of human genetic variation and are a resource for mapping complex genetic traits. A genome is covered by millions of these markers, and researchers are able to compare which SNPs predominate in people who have a certain disease. The International HapMap Project, launched in October, 2002, motivated us to start the Korean HapMap Project in order to support Korean HapMap infrastructure development and to accelerate the finding of genes that affect health, disease, and individual responses to medications and environmental factors. A Korean SNP and haplotype database system was developed through the Korean HapMap Project to provide Korean researchers with useful data-mining information about disease-associated biomarkers for studies on complex diseases, such as diabetes, cancer, and stroke. Also, we have developed a series of software programs for association studies as well as the comparison and analysis of Korean HapMap data with other populations, such as European, Chinese, Japanese, and African populations. The developed software includes HapMapSNPAnalyzer, SNPflank, HWE Test, FESD, D2GSNP, SNP@Domain, KMSD, KFOD, KFRG, and SNP@WEB. We developed a disease-related SNP retrieval system, in which OMIM, GeneCards, and MeSH information were integrated and analyzed for medical research scientists. The kHapMap Browser system that we developed and integrated provides haplotype retrieval and comparative study tools of human ethnicities for comprehensive disease association studies (http://www.khapmap.org). It is expected that researchers may be able to retrieve useful information from the kHapMap Browser to find useful biomarkers and genes in complex disease association studies and use these biomarkers and genes to study and develop new drugs for personalized medicine.

• Journal of Nutrition and Health
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• v.12 no.3
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• pp.9-23
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• 1979

The known risk factors for atherosclerosis include plasma low density lipoproteins (LDL)or Cholesterol, low PUFA in the diet, hypertension, and high Na intake, obesity, diabetes, lack of exercise, cigarette smoking, sugar, low fiber and nicotinic acid in the diet, sources of Protein foods, and Psychological factors. Among various dietary factors, fat is known as the most serious causative agent for atherosclerosis. The genetic factor is a18o known as an important one but is out of scope in this paper. Since atherosclerosis is a progressive disease which may develop for many years before showing any definitive symptoms, it is very important to develop preventive programs especially in the country like Korea that is not quite overdevelopted as some western countries. In this paper all the factors mentioned above were reviewed and the dietary suggestion were made on the basis of the content of polyunsaturated and saturated fat in the diet to prevent or/and to cure this disease. Most of the available data on diet therapy with emphasis. on P/S ratio were tabulated together. after tile patient's habitual dietary intake is analized the guidelines of personalized fat-controlled diet can be recommended. It is of utmost importance to develop Korean diets for beth prevention and cure of atherosclerosis emphasizing individual eating habit in the near future which can be more Practicaly used both at home and in the hospital.

• Journal of Preventive Medicine and Public Health
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• v.50 no.1
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• pp.10-17
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• 2017

Objectives: The purpose of this study was to examine the relationship of meeting the recommended levels of physical activity (PA) with health status and preventive health behavior in adults. Methods: A total of 5630 adults 18 years of age or older were included in this study. PA was assessed using a series of questions that categorized activities based on their metabolic equivalent values and then categorized individuals based on the reported frequency and duration of such activities. Participants reporting 150 minutes or more of moderate-intensity PA per week were considered to have met the PA guidelines. Multiple logistic regression was used to model the relationships between meeting PA guidelines and health status and preventive health behavior, while controlling for confounding variables. Results: Overall, 53.9% (95% confidence interval [CI], 51.9 to 55.9%) of adults reported meeting the recommended levels of PA. Among adults with good general health, 56.9% (95% CI, 54.7 to 59.1%) reported meeting the recommended levels of PA versus 43.1% (95% CI, 40.9 to 45.3%) who did not. Adults who met the PA guidelines were significantly more likely not to report high cholesterol, diabetes, chronic obstructive pulmonary disease, arthritis, asthma, depression, or overweight. Furthermore, adults meeting the PA guidelines were significantly more likely to report having health insurance, consuming fruits daily, consuming vegetables daily, and not being a current cigarette smoker. Conclusions: In this study, we found meeting the current guidelines for PA to have a protective relationship with both health status and health behavior in adults. Health promotion programs should focus on strategies that help individuals meet the current guidelines of at least 150 minutes per week of moderate-intensity PA.

• Journal of the Korean Society of Food Culture
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• v.15 no.3
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• pp.201-213
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• 2000

The aim of this study is to survey the eating habits and nutritional knowledge of children in Pusan, with a view to uncovering problems and their underlying causes and cultivating desirable dietary habit and nutrition for children. Three hundred and fifty six elementary school students were asked questions about their eating habits and nutritional knowledge as well as general information about their personal characteristics. The results showed: 1. Only 53.5% of the subjects had breakfast every day. Seventy-six percent of the subjects had dinner every day. Only 40% of the children took meals and talked with family at both breakfast and dinner. Thus there was little opportunity for dietary guidance by parents. 2. About half of the subjects answered that their appetite decreased after eating snack foods between meals. A third of the subjects liked the baked goods as snacks. Because of their high sugar and fat content, they can damage children's health, resulting in child diabetes and tooth decay. For this reason, careful education is necessary to allow children to be able to select snack foods that are appropriate in kind and quantity. 3. About 85% of the subjects had an unbalanced diet. Therefore systematic nutrition education at school is necessary to instill in children the value of balanced diet. 4. Children preferred rice to other cereals as a staple food. They disliked kimchi, seasoned and blanched foods and salads as subsidiary foods. It is therefore necessary to teach children systematically the nutritional advantage of cereals and vegetables and to heighten their awareness of Korean food culture. 5. Children had a low level of nutritional knowledge. The knowledge of specific nutrients was lower than that of foods. In conclusion, systematical educational programs need to be developed at elementary school. These should include information about achieving a balanced diet, good eating habit, meal management and Korean dietary culture. Nutritional education at home must be emphasized.

• Bulletin of the Korean Chemical Society
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• v.29 no.5
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• pp.921-927
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• 2008

Discovery of $\alpha$-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and the other carbohydrate mediated diseases. As a method for the discovery of new novel inhibitors of $\alpha$-glucosidase, we have addressed the performance of the computer-aided drug design protocol involving the homology modeling of $\alpha$-glucosidase and the structure-based virtual screening with the two docking tools: FlexX and the automated and improved AutoDock implementing the effects of ligand solvation in the scoring function. The homology modeling of $\alpha$-glucosidase from baker’s yeast provides a high-quality 3-D structure enabling the structure-based inhibitor design. Of the two docking programs under consideration, AutoDock is found to be more accurate than FlexX in terms of scoring putative ligands to the extent of 5-fold enhancement of hit rate in database screening when 1% of database coverage is used as a cutoff. A detailed binding mode analysis of the known inhibitors shows that they can be stabilized in the active site of $\alpha$- glucosidase through the simultaneous establishment of the multiple hydrogen bond and hydrophobic interactions. The present study demonstrates the usefulness of the automated AutoDock program with the improved scoring function as a docking tool for virtual screening of new $\alpha$-glucosidase inhibitors as well as for binding mode analysis to elucidate the activities of known inhibitors.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.414-425
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• 2015

Purpose: This study was conducted to explore the experience of smart-home healthcare among older adults who had participated in the smart-home technology development project. Methods: Data were collected by focus group interviews with 7 hypertension or diabetes participants(mean age 75 years). Qualitative contents analysis was used to analyze the verbal data. Results: The results were composed of 27 meanings units, 10 categories and 6 themes. The 6 themes are: 'improvement of health conditions through anytime anywhere self-monitoring', 'attractive experience to be counselling at home', 'frequent system and telecommunication problems', 'unfamiliar devices for elderly users', 'complementary strategies for activation', 'advancement of elderly-friendly devices and programs'. Conclusion: The smart-home healthcare system should be developed based on older adults' preferences. It is essential to make progress with professional resources and organizational supports in the future.

• Journal of Digital Convergence
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• v.16 no.10
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• pp.343-350
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• 2018

The purpose of this study was to identify the effect of nutrition related factors on mortality risk among community-residing older adults in Korea. We analyzed data from 8,532 older adults who took part in the 2008 living profiles of older people survey and 2011 death mortality data. According to Cox regression analysis, male (Hazard Ratio [HR], 2.03; 95% Confidence Interval [CI], 1.74~2.37), diabetes mellitus (HR, 1.35; 95% CI, 1.12~1.64), underweighted (HR, 2.68; 95% CI, 2.16~3.31), dysphagia (HR, 1.23; 95% CI, 1.02~1.47), chewing ability (HR, 1.33; 95% CI, 1.11~1.59), and undernutrition (HR, 1.47; 95% CI, 1.23~1.75) significantly affected mortality risk. Systematic nutrition support programs should be developed to decrease the mortality among Korean older adults.

• Korean Journal of Community Nutrition
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• v.18 no.1
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• pp.65-76
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• 2013

The purpose of this study was to investigate the effects of a nutrition education and personalized lunch service program in a senior welfare center. A total of 30 elderly (14 males, 16 females) aged 62~89 years participated in this study. Nutrition education lessons (2 hour/lesson/week) were provided for 4 weeks. Also, ten weeks from week 3rd to week 12th, personalized lunch providing 1/3 personal needed energy was served 5 times for a week. After the nutrition intervention program, we compared anthropometric characteristics, blood biochemical characteristics, nutrition knowledge, dietary attitude and dietary intake using 24 hr recall with those before the intervention. The body weight (p < 0.001) and body mass index (BMI) (p < 0.001) were decreased. There were significant increases in score of nutrition knowledge (p < 0.01) and consumption of milk & milk products for snacks. There was a positive effect on fasting blood sugar (FBS) showing significant decreases in portion of impaired fasting glucose and diabetes mellitus (p < 0.05). Also, serum triglyceride (TG) was significantly decreased (p < 0.05). In evaluation of nutrient intake by Dietary Reference Intakes for Koreans (KDRIs), riboflavin (p < 0.01), vitamin C (p < 0.001), calcium (p < 0.05) were positively improved. The index of nutritional quality (INQ) and intakes of vitamin C (p < 0.001), riboflavin (p < 0.05), Ca (p < 0.01) and Fe (p < 0.05) were increased. In conclusion, this nutrition education and lunch service program providing 1/3 personal needed energy can be used to develop and implement a tailored nutritional intervention programs in the setting of a community senior welfare center to improve health and nutritional status of Korean elderly.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.1-9
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• 2021

This study aimed to find out the factors influencing the fall of middle-aged women aged 40 to 64 and to use it as basic data for the development of a fall prevention program. The study was based on raw data from the 2019 Korea Community Health Survey. To establish the impact of fall experience of middle-aged women, descriptive statistics, chi-square test, and multiple logistic regression were used. Of the 43,917 people surveyed, 11.9% of middle-aged women said that they had experienced a fall. Falls were more common among women with increasing age or without a spouse. Those who experienced a lot of depression and perceived stress and were diagnosed with diabetes also had a higher fall experience. In the case of drinking, women who drank more than non-drinkers were more likely to fall. The results of this study can lead to a better understanding middle-aged women who have experienced falls, and they can be used as basic data for the development of related health programs.