• 한국치위생학회지
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• 제8권4호
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• pp.127-139
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• 2008

The purpose of this study was to examine the awareness of people in general about halitosis. The subjects in this study were 184 people who visited the clinical practice lab at J health college to get their teeth scaled. After a survey was conducted from May 1 to June 3, 2008, the analyzable answer sheets from 178 respondents were analyzed after four different areas were selected, which included smoking/nonsmoking, scaling experience, toothbrushing frequency and the use of oral hygiene supplies. SPSSWIN 12.0 program was utilized to make a frequency analysis and crosstabs analysis. The findings of the study were as follows: 1. Concerning subjective feelings of halitosis, 55.3 percent(99 people) of the respondents found themselves to have a moderate level of bad breath. 28.5 percent(51) deemed themselves to have a little foul breath, and 14 percent(25) didn't feel they had any bad breath. 2. As to the subjective level of halitosis, 89.8 percent(168) thought that their bad breath was a little perceived only by themselves, regardless of smoking, scaling experience, toothbrushing frequency and the use of oral hygiene supplies. 3. In regard to the cause of halitosis, 31 percent(56) cited plaque in the mouth as the cause, and 28.5 percent(51) pointed out the other causes that weren't mentioned in the questionnaire. 18.4 percent(33) cited decayed tooth, and 11.2 percent(20) pointed out gastroenteric disorder. 10.6 percent(19) viewed diabetes as the cause. 4. As to the time when they had the subjective symptom of halitosis, 114 respondents(63.7%) felt their own bad breath the most immediately after they got up 21.8 percent(39 respondents) did it when they were hungry 5.5 percent(9) did that before breakfast, and 4.5 percent(8) did that after having breakfast. 5. Regarding view of how to prevent halitosis, 52.5 percent(94) brushed their teeth frequently 21.2 percent(38) got their teeth scaled on a regular basis at a dentist's office, and 17.9 percent(32) drank water often. The above-mentioned finding seemed to suggest that the respondents weren't well aware of the fact halitosis was a sort of oral and systemic disease. Therefore the development of halitosis prevention and care programs geared toward practice lab visions were required.

• 대한유전성대사질환학회지
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• 제15권1호
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• pp.35-39
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• 2015

중쇄 acyl-CoA 탈수소효소 결핍증은 미토콘드리아에 존재하는 효소 중 하나인 MCAD의 부족으로 인하여 적절한 지방산 산화가 이루어지지 못하는 대사질환으로 지방산 산화와 관련된 대사 질환 중 가장 흔한 형태이다. 다양한 임상증상으로 저혈당, 발달지연, 발작, 돌연사 등이 나타날 수 있다. 저자들은 신생아 선별검사상 C6, C8, C10:1 acylcarnitine, C8/C2 ratio 혹은 C8/C10 ratio의 증가를 보이는 무증상의 신생아에서 유전자 분석검사를 통해 MCAD 결핍증을 진단하였다. 생후 10개월 경, 고열을 동반한 전신 강직성간대경련 발생하였으나 혈액검사 상 저혈당은 관찰되지 않았고 발열 호전된 후 추가적인 경련은 없었다. 이후 생후 25개월까지 추적관찰 하였을 때 경련을 포함한 증상 없었고, 정상적인 성장과 발달을 보였다. 무증상의 신생아에서 신생아 선별검사를 통해 우연히 MCAD 결핍증으로 진단된 후 1회의 열성경련 발생하였으나 대사성 위기없이 정상적인 성장 및 발달을 보이고 있는 환아가 있어 이에 증례를 보고하는 바이다.

• 대한소아치과학회지
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• 제32권4호
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• pp.703-708
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• 2005

쇄골두개 이형성증은 구강내에서 치아의 맹출 지연과 함께. 두개골 쇄골 및 안면의 비정상적인 성장을 보이는 상염색체 우성 유전 증후군이다. 이 증후군의 특징적인 소견으로, 쇄골이 양측성으로 존재하지 않거나 혹은 불완전한 구조로 존재하는 것을 들 수 있다. 또한 두개골 성장에 있어서 전두골, 후두골판은 다른 골과는 다르게 크기가 증가하여 비정상적 인 형태의 머리모양을 보인다. 두개골의 어떤 부위에는 충분한 골성장이 결여되어 봉합선이 매우 넓어져 있으며 방사선 사진상에서 봉합이 열려있는 상태로 관찰된다. 코는 대개 편평하고 넓으며, 일반적으로 상악의 성장이 부족하여 상대적으로 하악이 커 보인다. 구강내 소견으로는, 유치의 흡수가 늦어지며, 그 결과 영구치도 정상인보다 늦게 맹출되는 양상이 관찰된다. 20세 이상의 쇄골두개 이형성증 환자의 구강내에서 유치를 흔히 발견할 수 있다. 또한 다수의 과잉치가 존재하는데, 이는 구강내 전체에 걸쳐 존재할 수도 있다. 대부분의 쇄골두개 이형성증 환자는, 영구치 맹출 장애가 일어날 때까지 자신의 치과적 문제점을 인식할 수 없기 때문에, 적절한 치료시기를 지나서 치과병원에 내원하는 경우가 많다. 소아환자를 치료하는 치과의사는 쇄골두개 이형성증 환자의 치열 발육에 관한 지식을 숙지하여, 이러한 환자들이 적절한 시기에 치료를 받을 수 있도록 한다.

• Journal of Ginseng Research
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• 제32권3호
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• pp.244-249
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• 2008

Vascular inflammation is an important step in the development of cardiovascular disorder. Since it has not been known whether Korean red ginseng has a role to play on the vascular inflammation, we investigated the effects of Korean red ginseng extract (KRGE) on monocyte adhesion and its underlying signaling mechanism. Monocyte adhesion assay and Western blot were conducted on the human umbilical vein endothelial cells to study monocyte adhesion and the expression of adhesion molecules. Intracellular calcium was measured with Fura-2 fluorescent staining, and superoxide production was measured with lucigenin chemiluminescence in the endothelial cells. KRGE inhibits tumor necrosis factor (TNF)-alpha-induced monocyte adhesion on the endothelial cells at the range of $0.03{\sim}1$ mg/ml. TNF-alpha-induced vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1 expression were inhibited by the pretreatment of KRGE in the endothelial cells. KRGE also inhibits TNF-alpha-induced intracellular calcium and the superoxide production in the endothelial cells. This study first demonstrated that KRGE inhibits TNF-alpha-induced monocyte adhesion by inhibiting the adhesion molecule expression, intracellular calcium and superoxide production in the endothelial cells. Therefore, the anti-inflammatory function of KRGE may be contributed to protecting the endothelial dysfunction in the vascular inflammatory disorders.

• 생명과학회지
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• 제24권3호
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• pp.311-317
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• 2014

Rimed vacuole을 가진 원위 근육병(distal myopathy with rimmed vacuoles, DMRV)은 제2형 유전성 봉입체 근육병으로도 불리며 초기 성인기에 발병하여 원위부의 근력약화를 보이는 임상양상과 rimmed vacuole의 근육병리소견을 특징으로 하는 상염색체 열성의 근육병이다. 이러한 DMRV의 원인은 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) 유전자의 돌연변이임이 밝혀져 있다. 저자들은 원위부 근력약화를 호소하는 환자에서 전체 엑솜 염기서열분석을 이용하여 GNE 유전자의 복합 이형접합성 돌연변이(p.Asp176Val 및 p.Val572Leu)를 확인하여 DMRV를 진단할 수 있었다. 본 연구는 근육병의 정확한 분자진단에 있어서 전체 엑솜 염기서열분석의 유용성을 보여주었기에 이를 보고하는 바이다.

• 혜화의학회지
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• 제4권2호
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• pp.335-336
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• 1996

Artemisinin, a new antimalarial to treat patients infected with strains of Plasmodium jalciparum, derived from the plant Artemisia annua Linn, has immunopharmacologic actions such as enhence the PHA -induced lymphocyte transformation rate, increased the weight of spleen but reduced the weight of thymus, reduced phagocytic function of peritoneal macrophage, remarkably reduced the level of serum IgG and hemolysin fonning capacity (sentitized with SRBC), inhibited the activity of Ts cells of donor mice by supraoptimal immunuization(SOI), but enhenced activity of Ts cells of recipient mice by SOI. These results suggested that Ts cells may be the target cells of artemisinin. To the serum complement C3 level of plasmodium berghei-infeted mice, artemisinin (i. m,) could remarkly increase it. The artemisinin also obviously reduced the prostaglandin E(PGE) in the mouse hind paw swelling induced by carrageenin. Numerous studies have demonstrated that pharmacologic doses of PGE attenuate the development of immunocomplex nephritis. Some autologous immune mechanisms may be invoolved In the pathogensis of some types of glomurulonephritis. Glomerular abnormalities can be induced in animals by variety of immunological manipulations. The resulting disorder has many clinical and pathogical similarities to the disease in human. Our purpose was therefore to test the ability of the artemisinin to lessen the severity of rabbit IgG accelerated nephrotoxic serum glomerulonephritis in mice model. Mice which had treated with rabbit IgG and NTS, administrated with saline, showed Significant inceases of urinary protein, cholesterol level, and decrease of serum albumin in NS group. On the contrary, By i.g. adminstration of artemisinin at dose of 12.5, 25 and 50 mg/kg for 14 days after NTS injection, shown that artemisinin inhibited the nephritic changes in some parameters by means of urinary protein(p<0.05, p<0.01) and serum choleterol(p<0.05, p<0.01) and albumin (p<0.05, p<0.01), blood urea nitrogen (p<0.05, p<0.01), serum albumin(p<0.05, p<0.01); Cyclophosphamide(i.p. 10mg/kg for 14d) had almost same effect as the artemisinin had. Morphological studies shown that The picture of kidney from the mouse with NTS-nephritis accerated with rabbit IgG, treated with i.g. saline as the control, the mesangiocapillary were enlarged and proliferated; There were inflammatory cells infiltrating around the glomeruli; The ethelial cell were proliferated in the wall of Bowman's capsule. Histopatholological picture of kidney from the NTS-nephritis accerated with rabbit IgG mouse treated with i.p. 10mg/kg cyclophosphamide as the positive control. No siginicant histopathological evidence were found. Treaded with i.p. 12.5mg/kg artemisinine, the picture shown that mesangiocapillary were lightly proliferated; There were inflammatory cells infiltrating around the glomeruli; Treaded with i.p. 25mg/kg artemisinine, The picture shown that the mesangiocapillary were lightly proliferated; Treaded with i.p. 50mg/kg artemisinine, The picture shown that both the mesangiocapillary proliferated and the inflammatory cells infiltrating around the glomeruli are less than treated with saline, 12.5 and 25 mg/kg artemisinine. On the basis of these studies we conclude that the artemisinin can relieve pathological change caused by NTS-nephritis aacerated with rabbit IgG.

• International Journal of Oral Biology
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• 제32권4호
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• pp.119-125
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• 2007

Dlx3 is a homeodomain protein and is known to play a role in development and differentiation of many tissues. Deletion of four base pairs in DLX3 (NT3198) is causally related to tricho-dento-osseous (TDO) syndrome (OMIM #190320), a genetic disorder manifested by taurodontism, hair abnormalities, and increased bone density in the cranium. The molecular mechanisms that explain the phenotypic characteristics of TDO syndrome have not been clearly determined. In this study, we examined phenotypic characteristics of wild type DLX3(wtDlx3) and 4-BP DEL DLX3 (TDO mtDlx3) in C2C12 cells. To investigate how wtDlx3 and TDO mtDlx3 differentially regulate osteoblastic differentiation, reporter assays were performed by using luciferase reporters containing the promoters of alkaline phosphatase, bone sialoprotein or osteocalcin. Both wtDlx3 and TDO mtDlx3 enhanced significantly all the reporter activities but the effect of mtDlx3 was much weaker than that of wtDlx3. In spite of these differences in reporter activity, electrophoretic mobility shift assay showed that both wtDlx3 and TDO mtDlx3 formed similar amounts of DNA binding complexes with Dlx3 binding consensus sequence or with ALP promoter oligonucleotide bearing the Dlx3 binding core sequence. TDO mtDlx3 exhibits a longer half-life than wtDlx3 and it corresponds to PESTfind analysis result showing that potential PEST sequence was missed in carboxy terminal of TDO mtDlx3. In addition, co-immunoprecipitation demonstrated that TDO mtDlx3 binds to Msx2 more strongly than wtDlx3. Taken together, though TDO mtDlx3 acted as a weaker transcriptional activator than wtDlx3 in osteoblastic cells, there is possibility that during in vivo osteoblast differentiation TDO mtDlx3 may antagonize transcriptional repressor activity of Msx2 more effectively and for longer period than wtDlx3, resulting in enhancement of osteoblast differentiation.

• Journal of Oral Medicine and Pain
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• 제31권4호
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• pp.365-373
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• 2006

이 연구는 경찰사회에서의 측두장애환자의 교합상태를 평가하여 습관적인 최대교합시에 교합접촉 시기와 접촉수, 접촉힘을 분석하여 과도한 개구나 이악물기등의 악습관 교정을 제시 하는데 있다. 경찰사회에서는 일반 사회에는 다른 양상의 최대 개구, 습관적인 긴밀한 최대 교합상태 등으로 인하여 측두하악장애에 영향을 미칠 수 있다. 반복적인 훈련이나 일상생활에서의 변화는 그동안 유지되어 오던 저작근을 비롯한 악구강계 평형 상태에 변화를 초래하여 측두하악관절과 그에 따른 구조물에 동통을 유발 내지는 악화 시킬 수 있다. 본 연구는 측두하악장애에 영향을 미칠 수 있는 교합상태를 조사하기 위하여 T-scan II system(Tekscan Co., USA)을 이용하였으며, 최대 교합력을 발휘하기 위하여 약 20 mm 정도의 개구 상태에서 최대교합시까지 물었다. 경찰종사자의 측두하악장애환자는 일반 측두장애환자보다 최초 접촉부터 최대 접촉까지 걸리는 시간은 오래 걸리며, 최종 접촉까지의 시간은 보다 짧았으며, 최종 교합접촉력은 더 강하여, 더 짧은 시간에 강한 힘을 유지한 채 폐구가 이루어져 측두하악관절에 더 많은 잔존한 부하를 전달하였다. 이환 측과 교합접촉 시간, 교합 접촉 힘등의 교합양상과는 관계가 미약하였으며, 최대 접촉력이 가해진 시기에서 우측이 이환 측이면 우측 악궁에, 좌측이 이환측일 경우 좌측 악궁에 집중되는 좌, 우 악궁간 불균형을 보였다. 이상의 결과에서 측두하악장애를 가진 경찰 종사자들의 하악 운동에 보다 부드러운 움직임과 습관적인 최대 교합상태에서의 보다 적은 힘을 유지해야 할 것으로 생각되어진다.

• Advances in pediatric surgery
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• 제8권2호
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• pp.113-118
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• 2002

The etiology of several motility disorders, including persistent megacolon after definitive surgery for Hirschsprung's disease, meconium ileus which is not associated with cystic fibrosis and idiopathic megacolon, is still unclear. Interstitial cells of Cajal (ICC) are thought to modulate gut motility as gastrointestinal pace maker cells. The aim of this study was to evaluate the role of ICC in the bowel walls of the patients (n=15) who had variable motility disorders. The ICC were identified by immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. The ICC were immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. Whereas ICC were evenly distributed in the ganglionic bowels of G2, they were not seen or scarecely distributed in the ganglionic bowels of G3. Two patients (G4) who suffered from idiopathic megacolon showed absence or decrease of ICC in spite of presence of ganglion cells in their colons. Four neonates (G5) who underwent ileostomy because of meconium obstruction showed absent or markedly decreased ICC in the the colon at the time of ileostomy and the distribution of ICC was changed to a normal pattern at the time of ileostomy closure between 39-104 days of age and their bowel motility were restored after that. The results suggest that lack of ICC caused reduce motility in the ganglionic colons and it may be responsible for the development of various motility disorders. Delayed maturity of ICC may also playa role in the meconium obstruction of neinates.

• 디지털융복합연구
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• 제11권11호
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• pp.753-766
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• 2013

오늘날 인류의 문명은 빠른 속도로 발전해 가고 있음에도 불구하고 인간과 삶의 환경의 모습은 더 행복해지고 있는 것처럼 보이지 않는다. 문명이 인간의 정신, 즉 마음의 산물이고 마음은 육체뿐만 아니라 사회 및 자연환경과 연결되어 서로 상호작용하며 변화되어 간다는 점에서 오늘날 인간의 마음이 바람직한 방향으로 변화되고 있다고 보기 어렵다. 이 논문은 불행한 현상들의 근원으로서의 인간의 마음을 이해하기 위해 인간의 모든 다양한 마음이 생성되어 나오는 두뇌 인지 메커니즘을 통해 본연의 마음이 무엇이고 또 그것이 어떻게 변화되어 가는지, 마음의 전체적 변화 패러다임과 그 원인을 밝혔다. 논문의 결과에 따르면 자유롭고 평온한 인간 본연의 처음 마음은 인지 근원지의 구성요소 중 하나인 내부 인지 공간의 진화에 따라 중간 마음을 거쳐, 극단적으로 내부 인지 공간 안에 갇힌 자폐상태가 되어 감각 기억에 극단적으로 강하게 구속되고(극단적 집착) 내적으로만 사고(극단적 번뇌)하는 끝 마음으로 변화할 수 있다. 오늘날 지나친 문명 발달을 포함한 인간, 사회, 자연환경의 부정적인 변화의 모습들은 모두 이런 마음의 변화과정의 산물로 해석된다. 이 논문은 본연의 처음 마음, 변화되고 있는 중간 마음, 극단적인 모습의 끝마음의 특징들을 기술하고 현재 개인들의 마음이 어디에 있으며 어디로 변화해가고 있는지를 논의하며, 마지막으로 두뇌 인지 메카니즘을 통해 인간의 본연의 첫 마음을 회복할 수 있는 구체적인 방법을 제시하고 있다.