• Journal of The Korean Society of Inherited Metabolic disease
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• v.3 no.1
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• pp.86-93
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• 2003

Background : The SCL began screening of newborns and high risk group blood spots with tandem mass spectrometry (MS/MS) in April 2001. Our goal was to determine approximate prevalence of metabolic disorders, optimization of decision criteria for estimation of preventive effect with early diagnosis. This report describes the ongoing effort to identify more than 30 metabolic disorders by MS/MS in South Korea. Methods : Blood spot was collected from day 2 to 30 (mostly from day 2 to 10) after birth for newborn. Blood spot of high risk group was from the pediatric patients in NICU, developmental delay, mental retardation, strong family history of metabolic disorders. One punch (3.2 mm ID) of dried blood spots was extracted with $150{\mu}L$ of methanol containing isotopically labelled amino acids (AA) and acylcarnitines (AC) internal standards. Butanolic HCl was added and incubated at $65^{\circ}C$ for 15 min. The butylated extract was introduced into the inlet of MS/MS. Neutral loss of m/z 102 and parent ion mode of m/z 85 were set for the analyses of AA and AC, respectively. Diagnosis was confirmed by repeating acylcarnitine profile, urine organic acid and plasma amino acid analysis, direct enzyme assay, or molecular testing. Results : Approximately 31,000 neonates and children were screened and the estimated prevalence (newborn/high risk group), sensitivity, specificity and recall rate amounted to 1:2384/1:2066, 96.55%, 99.98%, and 0.73%, respectively. Confirmed 28 (0.09%) multiple metabolic disorders (newborn/high risk) were as follows; 13 amino acid disorders [classical PKU (3/4), BH4 deficient-hyperphenylalaninemia (0/1), Citrullinemia (1/0), Homocystinuria (0/2), Hypermethioninemia (0/1), Tyrosinemia (1/0)], 8 organic acidurias [Propionic aciduria (2/1), Methylmalonic aciduria (0/1), Isovaleric aciduria (1/1), 3-methylcrotonylglycineuria (1/0), Glutaric aciduria type1 (1/0)], 7 fatty acid oxidation disorders [LCHAD def. (2/2), Mitochondrial TFP def. (0/1), VLCAD def. (1/0), LC3KT def. (0/1). Conclnsion : The relatively normal development of 10 patients with metabolic disorders among newborns (except for the expired) demonstrates the usefulness of newborn screening by MS/MS for early diagnosis and medical intervention. However, close coordination between the MS/MS screening laboratory and the metabolic clinic/biochmical geneticists is needed to determine proper decision of screening parameters, confirmation diagnosis, follow-up scheme and additional tests.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.566-572
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• 2021

A methodology for the identification and coordinates estimation of air cavities under urban ground or sandy soil using its natural poles and natural resonant frequencies is presented. The potential of this methodology was analyzed. Simulation models of PEC (Perfect Electric Conductor)s with various shapes and dimensions were developed using an EM (Electromagnetic) simulator. The Cauchy method was applied to the obtained EM scattering response of various objects from EM simulation models. The natural poles of objects corresponding to its instinct characterization were then extracted. Thus, a library of poles can be generated using their natural poles. The generated library of poles provided the possibility of identifying a target by comparing them with the computed natural poles from a target. The simulation models were made assuming that there is an air cavity under urban ground or sandy soil. The response of the desired target was extracted from the electromagnetic wave scattering data from its simulation model. The coordinates of the target were estimated using the time delay of the impulse response (peak of the impulse response) in the time domain. The MP (Matrix Pencil) method was applied to extract the natural poles of a target. Finally, a 0.2-m-diameter spherical air cavity underground could be estimated by comparing both the pole library of the objects and the calculated natural poles and the natural resonant frequency of the target. The computed location (depth) of a target showed an accuracy of approximately 84 to 93%.

• Korean Chemical Engineering Research
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• v.60 no.3
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• pp.356-362
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• 2022

Research related to hydrogen technology is being actively conducted around the world. Korea is also making great efforts to develop technology to leap forward as a hydrogen economy powerhouse. In particular, the world's No. 1 hydrogen vehicle penetration rate is proof of this. However, the construction of hydrogen refueling stations is being delayed. The biggest delay factor is the public opposition. As such, policies without public support cannot be successfully implemented and are not sustainable. Therefore, this study intends to analyze the factors affecting the acceptability of hydrogen refueling stations in favor of and against them. As a research method, the basic factors affecting acceptability were identified by reviewing previous studies, and a questionnaire was designed and investigated based on the established factors. The validity and reliability of the questionnaire were verified, and the hypothesis was verified through correlation analysis. And, using structural equation modeling, a factor model was developed on the acceptability of hydrogen refueling stations. As a result of the study, acceptability defined private acceptability and public acceptability. In the case of private acceptability, it was confirmed that the higher the attitude toward the environment, the higher the level of knowledge about the hydrogen charging station, and the lower the degree of feeling the risk of the hydrogen charging station, the higher the acceptability. In the case of public acceptability, it was confirmed that the higher the benefit, the better the attitude toward the environment, and the lower the risk-taking characteristics of the individual, the higher the acceptability. Therefore, in this study, based on the potential factors verified in previous studies, the main factors affecting the acceptance on hydrogen refueling stations were identified. And the acceptance model was developed using structural equation modeling. This study is expected to provide basic data to seek ways to improve the acceptance of public when implementing national policies such as hydrogen refueling stations, and to be used analysis data for scientific communication.

• The Journal of the Acoustical Society of Korea
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• v.29 no.7
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• pp.458-467
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• 2010

In this paper, a new audio reproduction system was developed in which the cross-talk signals would be reasonably cancelled at an arbitrary listener position. To adaptively remove the cross-talk signals according to the listener's position, a method of tracking the listener position was employed. This was achieved using the two microphones, where the listener direction was estimated using the time-delay between the two signals from the two microphones, respectively. Moreover, room reverberation effects were taken into consideration where linear prediction analysis was involved. To remove the cross-talk signals at the left-and right-ears, the paths between the sources and the ears were represented using the KEMAR head-related transfer functions (HRTFs) which were measured from the artificial dummy head. To evaluate the usefulness of the proposed listener tracking system, the performance of cross-talk cancellation was evaluated at the estimated listener positions. The performance was evaluated in terms of the channel separation ration (CSR), a -10 dB of CSR was experimentally achieved although the listener positions were more or less deviated. A real-time system was implemented using a floating-point digital signal processor (DSP). It was confirmed that the average errors of the listener direction was 5 degree and the subjects indicated that 80 % of the stimuli was perceived as the correct directions.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.1
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• pp.1-10
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• 1982

Degree of grain shattering which is of varietal character is an important determinant for the magnitude of field loss of grains during harvest and threshing. Seven Indica \times Japonica progeny varieties and four Japonica varieties were subjected to measurements of tensile strength of grains, degree of grain shattering when panicles were dropped at 1.5m above concrete floor, and moisture content of grains (wet basis) during a period 35 to 63 days after heading. In addition, two varieties were tested for the relation of tensile strength of grains to the magnitude of field loss of grains in actual binder harvest. The 11 varieties differed conspicuously in tensile strength of grains and the degree of grain shattering: the weakest average tensile strength of grains of a variety was about 90g and the strongest about 250g with varying standard deviation of 30 to 60g. Three Indica \times Japonica varieties and one Japonica variety shattered I to 30% of the grains under the falling test. The threshold tensile strength of grains allowing grain shattering was estimated to be 180g on average for a sampling unit of 10 panicles, but only the grains having tensile strength weaker than 98g within the samples shattered. A decrease in average tensile strength by 10g below the threshold value corresponded to an increase of 3 to 5% in grain shattering. Most varieties did not change appreciably the tensile strength of grains and degree of grain shattering with delay in time of harvest and showed a negative correlation between the tensile strength and the moisture content of grains. The average tensile strength of grains was negatively correlated linearly with field loss in binder harvest. The average tensile strength for zero field loss in binder harvest was estimated to be 174g and a decrease in the average tensile strength by 10g corresponded to an increase of 40kg per hectare in field loss of grains. Instead of the average tensile strength of grains, the percentage of grains having tensile strength weaker than 100g is recommended as a criterion for the estimation of field loss of grains during harvesting operations as well as a basis of variety classification for grain shattering, since the standard deviation of tensile strength of grains varies much with variety and time of harvest, and individual grains having tensile strength stronger than 98 did not shatter practically.