• 대한수학회보
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• 제47권1호
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• pp.89-102
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• 2010

This paper concerns the problem of global robust stability of a time-delay discontinuous system with a positive-defined connection matrix under polytopic-type uncertainty. In order to give the stability condition, we firstly address the existence of solution and equilibrium point based on the properties of M-matrix, Lyapunov-like approach and the theories of differential equations with discontinuous right-hand side as introduced by Filippov. Second, we give the delay-independent and delay-dependent stability condition in terms of linear matrix inequalities (LMIs), and based on Lyapunov function and the properties of the convex sets. One numerical example demonstrate the validity of the proposed criteria.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권5호
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• pp.455-462
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• 2015

H-field EMI measurements have been performed for the single-ended, the differential, and the pseudo-differential signaling on a 11" FR4 microstrip line. The pseudo-differential signaling reduces EMI by more than 10 dB compared to the single-ended signaling if the delay mismatch is lower than 5% of a period for a 3 GHz clock signal. Empirical H-field equations for both differential and single-ended signaling showed fair agreements with measurements.

• 대한수학회논문집
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• 제34권2호
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• pp.685-699
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• 2019

This research is focused on a continuous epidemic model of transmission of Plasmodium vivax malaria with a time delay. The model is represented as a system of ordinary differential equations with delay. There are two equilibria, which are the disease-free state and the endemic equilibrium, depending on the basic reproduction number, $R_0$, which is calculated and decreases with the time delay. Moreover, the disease-free equilibrium is locally asymptotically stable if $R_0<1$. If $R_0>1$, a unique endemic steady state exists and is locally stable. Furthermore, Hopf bifurcation is applied to determine the conditions for periodic solutions.

• Kyungpook Mathematical Journal
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• 제62권1호
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• pp.119-132
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• 2022

Virotherapy is an effective method for the treatment of cancer. The oncolytic virus specifically infects the lyse cancer cell without harming normal cells. There is a time delay between the time of interaction of the virus with the tumor cells and the time when the tumor cells become infectious and produce new virus particles. Several types of viruses are used in virotherapy and the delay varies with the type of virus. This delay can play an important role in the success of virotherapy. Our present study is to explore the impact of this delay in cancer virotherapy through a mathematical model based on delay differential equations. The partial success of virotherapy is guarenteed when one gets a stable non-trivial equilibrium with a low level of tumor cells. There exits Hopf-bifurcation by considering the delay as bifurcation parameter. We have estimated the length of delay which preserves the stability of the non-trivial equilibrium point. So when the delay is less than a threshold value, we can predict partial success of virotherapy for suitable sets of parameters. Here numerical simulations are also performed to support the analytical findings.

• 대한수학회보
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• 제49권6호
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• pp.1193-1198
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• 2012

By constructing suitable Lyapunov functionals and combining with matrix inequality technique, a new simple sufficient condition is presented for the global asymptotic stability of the Cohen-Grossberg neural network models. The condition contains and improves some of the previous results in the earlier references.

• East Asian mathematical journal
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• 제36권1호
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• pp.81-90
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• 2020

Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.

• 한국수학사학회지
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• 제24권2호
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• pp.47-59
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• 2011

일정 영역에 서식하는 생물 종의 개체 수가 변화하는 역학적 과정을 이해하고 실질적인 예측을 하는데 도움을 주는 여러가지 수학적 모델이 현재 수학과 생태학 분야에서 활발하게 연구되고 있다. 영국의 경제학자 Malthus가 1798년부터 시작하여 1826년까지 출간한 An Essay on the Principle of Population에서 제안했던 세계인구 변화 모델과 1845년 Verhulst의 한계수용모델은 개체 수 변화에 대한 초기 수학적 모델로서 지수적 형태에 기초한 것이었다. 수리생물학으로 불리는 학문분야는 1920년경 Lotka의 연구에서 본격적으로 시작되었다고 할 수 있다. 이때부터 여러 가지 다양한 수학적 모델들이 제안되어지고 검증되어져 왔다. 이 논문에서는 주로 상미분방정식(ordinary differential equations)으로 표현되는 단일 생물종에 대한 개체 수 변화모델들을 살펴본다.

• International Journal of Control, Automation, and Systems
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• 제5권4호
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• pp.355-363
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• 2007

The paper deals with the Kalman stochastic filtering problem for linear continuous-time systems with both instantaneous and time-delayed measurements. Different from the standard linear system, the system state is corrupted by multiplicative white noise, and the instantaneous measurement and the delayed measurement are also corrupted by multiplicative white noise. A new approach to the problem is presented by using projection formulation and reorganized innovation analysis. More importantly, the proposed approach in the paper can be applied to solve many complicated problems such as stochastic $H_{\infty}$ estimation, $H_{\infty}$ control stochastic system with preview and so on.

• 한국추진공학회지
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• 제22권3호
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• pp.46-52
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• 2018

액체산소 및 탄화수소를 사용하는 연소기의 고주파 연소불안정을 해석하기 위해 단순모델로서 Crocco의 $n-{\tau}$ 시간지연 연소모델을 적용하고, 음향과 커플된 연소기 내 유동에 대해 선형해석을 수행하였다. 변수분리를 통해 편미분 포텐셜함수 식을 원통좌표계 미분방정식으로 만들고, 연소기의 접선방향 공진모드에 대한 고유 값을 계산하였다. 분사면 및 노즐입구를 경계조건으로 적용하여 미분식의 해를 구했다. 시스템의 안정성 판정을 위해 전달함수를 주파수 해석 하였으며, 관심 영역 주파수인 1T 모드 주변 주파수에서 시스템 게인 및 위상각으로 안정성 여유를 평가하였다. 또한 1T 모드 안정성 향상을 위해 배플 길이 및 형상에 대한 영향을 평가하였다.

• Advances in nano research
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• 제10권4호
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• pp.359-371
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• 2021

A tumor immune interaction is a main topic of interest in the last couple of decades because majority of human population suffered by tumor, formed by the abnormal growth of cells and is continuously interacted with the immune system. Because of its wide range of applications, many researchers have modeled this tumor immune interaction in the form of ordinary, delay and fractional order differential equations as the majority of biological models have a long range temporal memory. So in the present work, tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and interleukin-2 (IL-2) are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Furthermore, existence and local stability of fixed points are investigated for discrete model. Moreover, it is proved that two types of bifurcations such as Neimark-Sacker and flip bifurcations are studied. Finally, numerical examples are presented to support our analytical results.