• Title/Summary/Keyword: deformability

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Cellular Protective Effect and Liposome Formulation for Enhanced Transdermal Delivery of Isoquercitrin (Isoquercitrin의 세포 보호 작용과 피부 흡수 증진을 위한 리포좀 제형 연구)

  • Jo, Na-Rae;Gu, Hyun-A;Park, Su-Ah;Han, Seat-Byeol;Park, Soo-Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.2
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    • pp.103-118
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    • 2012
  • In this study, the cellular protective effect of isoquercitrin against $H_2O_2$ and rose bengal-indued HaCaT cell damage was investigated. The ethosome and elastic liposome for enhanced transdermal delivery were prepared. Particle size, loading efficiency and cumulative permeated amounts of them were evaluated. Isoquercitrin didn't show any characteristic cytotoxicity at 50 ${\mu}M$. When HaCaT cells were treated with 5 mM $H_2O_2$ and 25 ${\mu}M$ rose bengal, isoquercitrin protected the cells against the oxidative damage in a concentration dependent manner (6.25 ~ 50 ${\mu}M$). The size of 0.03 % isoquercitrin loaded ethosome was 222.85 nm and the loading efficiency was 82.26 %. The ethosome loaded with 0.03 % isoquercitrin was stable and maintained the constant particle size for 2 weeks after being prepared. The ethosome exhibited more enhanced skin permeability than general liposome and ethanol solution. The optimal ratio of lipid to surfactant of 0.1 % isoquercitrin loaded elastic liposomes was observed to be 89 : 5 through evaluating particle size (341.2 nm), deformability index (59.89), loading efficiency (54.3 %), and skin permeability (54.4 %).

Hysteretic Behavior and Seismic Resistant Capacity of Precast Concrete Beam-to-Column Connections (프리캐스트 콘크리트 보-기둥 접합부의 이력거동 및 내진성능)

  • Choi, Hyun-Ki;Choi, Yun-Cheul;Choi, Chang-Sik
    • Journal of the Earthquake Engineering Society of Korea
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    • v.14 no.4
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    • pp.61-71
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    • 2010
  • Five half-scale beam-to-column connections in a precast concrete frame were tested with cyclic loading that simulated earthquake-type motions. Five half -scale interior beam-column assemblies representing a portion of a frame subjected to simulated seismic loading were tested, including one monolithic specimen and four precast specimens. Variables included the detailing used at the joint to achieve a structural continuity of the beam reinforcement, and the type of special reinforcement in the connection (whether ECC or transverse reinforcement). The specimen design followed the strong-column-weak-beam concept. The beam reinforcement was purposely designed and detailed to develop plastic hinges at the beam and to impose large inelastic shear force demands into the joint. The joint performance was evaluated on the basis of connection strength, stiffness, energy dissipation, and drift capacity. From the test results, the plastic hinges at the beam controlled the specimen failure. In general, the performance of the beam-to-column connections was satisfactory. The joint strength was 1.15 times of that expected for monolithic reinforced concrete construction. The specimen behavior was ductile due to tensile deformability by ECC and the yielding steel plate, while the strength was nearly constant up to a drift of 3.5 percent.

Shear stiffness of headed studs on structural behaviors of steel-concrete composite girders

  • He, Jun;Lin, Zhaofei;Liu, Yuqing;Xu, Xiaoqing;Xin, Haohui;Wang, Sihao
    • Steel and Composite Structures
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    • v.36 no.5
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    • pp.553-568
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    • 2020
  • Steel-concrete composite structures have been extensively used in building, bridges, and other civil engineering infrastructure. Shear stud connectors between steel and concrete are essential in composite members to guarantee the effectiveness of their behavior in terms of strength and deformability. This study focuses on investigating the shear stiffness of headed studs embedded in several types of concrete with wide range of compressive strength, and their effects on the elastic behavior of steel-concrete composite girders were evaluated. Firstly, totally 206 monotonic push-out tests from the literature were reviewed to investigate the shear stiffness of headed studs embedded in various types of concrete (NC, HPC, UHPC etc.). Shear stiffness of studs is defined as the secant stiffness of the load-slip curve at 0.5Vu, and a formulation for predicting defined shear stiffness in elastic state was proposed, indicating that the stud diameter and the elastic modulus of steel and concrete are the main factors. And the shear stiffness predicted by the new formula agree well with test results for studs with a diameter ranging from 10 to 30 mm in the concrete with compressive strength ranging from 22.0 to 200.0MPa. Then, the effects of shear stiffness on the elastic behaviors of composite girders with different sizes and under different loading conditions were analyzed, the equations for calculating the stress and deformation of simply supported composite girders considering the influence of connection's shear stiffness were derived under different loading conditions using classical linear partial-interaction theory. As the increasing of shear stiffness, the stress and deflection at the most unfavorable section under partial connected condition tend to be those under full connected condition, but the approaching speed decreases gradually. Finally, the connector's shear stiffness was recommended for fully connection in composite girders with different dimensions under different loading conditions. The findings from present study may provide a reference for the prediction of shear stiffness for headed studs and the elastic design of steel-concrete composite girder.

A Proposition on Landscape Restoration of Joseon Dynasty's Palace Gardens (조선시대 궁궐정원의 원형경관 복원을 위한 제안)

  • Ahn, Gye-Bog;Lee, Won-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.32 no.3
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    • pp.10-20
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    • 2014
  • The purpose of this study is to define criteria for landscape restoration of palace gardens. The case study on Gyeongbokgung and Changdeokgung was used not only to evaluate effectiveness of the criteria, but also to propose solutions to issues of current restoration process of both palace gardens. Following three pairs of different concepts were chosen as criteria to determine on the original form: Diachrony vs. Synchrony, Originality vs. Contemporary Characteristics, and Invariance vs. Deformability. Gyeongbokgung has been restored based on its contemporary characteristics of Year 1888 and the main focus is on its architectural features rather than both architecture and landscape. However, in-depth complementary work on landscape restoration is necessary to restore its originality in Year 1395 such as analyzing photos of Gyeongbokgung taken in modern era. In case of Changdeokgung, we analyzed separately by region or landmark such as Jondeok-Pavilion(尊德亭), Yeonkyung-Hall(演慶堂), and Okryu-Stream(玉流川). Original form of Jondeok-Pavilion Area was changed in 1884. Since diachronic invariance that lasted for 240 years is more important criterion than its contemporary characteristics, it should be restored as how it was painted in Donggwoldo(東闕圖). In Yeonkyung-Hall Area, both original characteristics at the time of Hyomyung Crown Prince and contemporary characteristics of Emperor Kojong Era appear. Therefore, different solution is required for such area to be restored appropriately. Starting from era of King Injo(1636), diachrony and invariance of Okryu-Stream Area were continued throughout the era of King Sukjong and King Jeongjo(1800). It is more than 250 years before Okryu-Stream Area was altered under the rule of Emperor Kojong in 1884. In fact, alterations made to Okryu-Stream Area after 1884 doesn't hold much significance. Therefore, water landscape of Okryu-Stream Area, which was altered in the era of Emperor Kojong, needs to be restored based on Donggwoldo.

Flexural Behavior and Design of Concrete-filled U-shape Hybrid Composite Beams Fabricated from 570MPa High-strength Steel (570MPa급 고강도강을 적용한 콘크리트 채움 U형 하이브리드 합성보의 휨거동 및 설계)

  • Lee, Cheol Ho;So, Hyun Joon;Park, Chang Hee;Lee, Chang Nam;Lee, Seung Hwan;Oh, Ha Nool
    • Journal of Korean Society of Steel Construction
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    • v.28 no.2
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    • pp.109-120
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    • 2016
  • Flexural tests of full-scale concrete-filled U-shape hybrid composite beams were conducted. Ordinary (SS400) and high-strength (SM570) steel plates were used in the web and in the bottom flange of U-shape steel section respectively. The primary objectives were to develop the hybrid section configuration with maximized flexural capacity and to investigate its flexural strength and deformation capacity. All the hybrid test specimens in this study exhibited the plastic moment capacity and resonable deformability. It is shown that the plastic stress distribution can be assumed in calculating the flexural strength of the proposed hybrid composite beams if the plastic neural axis is located within 15% of the total beam depth from the top of the composite slab. The procedure for computing the effective flexural stiffness of hybrid composite beams is also recommended based on test results.

Effects of Annealing Temperature on Interface Properties for Al/Mild Steel Clad Materials (어닐링 온도 변화가 Al/연강 클래드재의 계면 특성에 미치는 영향)

  • Jeong, Eun-Wook;Kim, Hoi-Bong;Kim, Dong-Yong;Kim, Min-Jung;Cho, Young-Rae
    • Korean Journal of Materials Research
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    • v.22 no.11
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    • pp.591-597
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    • 2012
  • For heat exchanger applications, 2-ply clad materials were fabricated by rolling of aluminum (Al) and mild steel sheets. Effects of annealing temperature on interface properties, especially on inter-layer formation and softening of strain hardened mild-steel, for Al/mild steel clad materials, were investigated. To obtain optimum annealing conditions for the Al/mild steel clad materials, annealing temperature was varied from room temperature to $600^{\circ}C$. At the annealing temperature about $450^{\circ}C$, an inter-layer was formed in an island-shape at the interface of the Al/mild steel clad materials; this island expanded along the interface at higher temperature. By analyzing the X-ray diffraction (XRD) peaks and the energy dispersive X-ray spectroscopy (EDX) results, it was determined that the exact chemical stoichiometry for the inter-layer was that of $Fe_2Al_5$. In some samples, an X-layer was formed between the Al and the inter-layer of $Fe_2Al_5$ at high annealing temperature of around $550^{\circ}C$. The existence of an X-layer enhanced the growth of the inter-layer, which resulted in the delamination of the Al/mild-steel clad materials. Hardness tests were also performed to examine the influence of the annealing temperature on the cold deformability, which is a very important property for the deep drawing process of clad materials. The hardness value of mild steel gradually decreased with increasing annealing temperature. Especially, the value of hardness sharply decreased in the temperature range between $525^{\circ}C$ and $550^{\circ}C$. From these results, we can conclude that the optimum annealing temperature is around $550^{\circ}C$ under condition of there being no X-layer creation.

Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract (마디풀 추출물의 경피 전달을 위한 탄성 리포좀의 물리적 특성 및 In Vitro 피부 투과 연구)

  • Han, Saet Byeol;Kwon, Soon Sik;Jeong, Yoo Min;Kong, Bong Ju;Yu, Eun Ryeong;Park, Soo Nam
    • Polymer(Korea)
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    • v.38 no.6
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    • pp.694-701
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    • 2014
  • In this study, Polygomun aviculare L. (P. aviculare L.) extract loaded elastic liposomes (ELPs) were investigated to enhance the transdermal delivery of P. aviculare L. extract composed of various flavonoids. ELPs were composed of egg phospholipids (PC) and edge activator ($Tego^{(R)}$ care 450) and the physical properties and in vitro permeation studies of ELPs were performed. Particle size ranged from 148.1 to 262.2 nm and deformability index was recorded as 11.5~25.4. Loading efficiency was from 53.1 to 66.3%. In vitro skin permeation studies using Franz diffusion cell demonstrated that ELP-4 having ratio of 85:15 for PC to $Tego^{(R)}$ care 450 exhibited the higher skin permeability than ELP-1, the general liposome without $Tego^{(R)}$ care 450. It was visually seen by fluorescence image restoration microscopy. The findings suggest that ELP-4 selected as the optimal formulation could be used as useful formulation for transdermal delivery of the extract.

Evaluation and Modification of Tensile Properties of Carbon Fiber Reinforced Polymer(CFRP) as Brittle Material with Probability Distribution (확률분포를 이용한 취성재료 특성의 탄소섬유보강폴리머 인장물성평가 및 보정)

  • Kim, Yun-Gon
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.23 no.3
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    • pp.17-24
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    • 2019
  • Carbon Fiber Reinforced Polymers(CFRP) has widely utilized as a material for rehabilitation because of its light-weight, deformability and workability. Because CFRP is brittle material whereas steel is ductile, it is inappropriate to apply conventional design approach for steel reinforcement. For ductile material, the behavior of combined elements is on average of that of unit element due to the stress redistribution between elements after yielding. Therefore, the mean value of the stress of combined elements is equal to that of unit element and the standard variation is smaller. Therefore, although the design value can increase, it is used as constant value because it is conservative and practical approach. However, for brittle material, the behavior of combined elements is governed by the weaker element because no stress redistribution is expected. Therefore, both the mean value and standard variation of the stress of combined elements decreases. For this reason, the design value would decrease as the number of element increases although it is eventually converged. In this paper, in brittle material, it is verified that the combination of unit element with normal distribution results in combined element with weibull distribution, so the modifying equation of mechanical properties is proposed with respect to the area load applied.

Evaluation of Strength and Deformability of a Friction Material Based on True Triaxial Compression Tests (진삼축압축시험을 통한 마찰재료의 강도 및 변형 특성 평가)

  • Bae, Junbong;Um, Jeong-Gi;Jeong, Hoyoung
    • The Journal of Engineering Geology
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    • v.32 no.4
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    • pp.597-610
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    • 2022
  • Knowledge of the failure behavior of friction materials considering their intermediate principal stress is related to an understanding of situations where these materials might be used: for example, the stability of deep-seated boreholes and fault slip analysis. This study designed equipment for physically implementing true triaxial compression and used it to assess specimens of plaster, a friction material. The material's mechanical behaviors are discussed based on the results. The applicability of the 3D failure criteria are also reviewed. The tested specimens were molded cuboids of width, length, and height 52, 52, and 104 mm, respectively. A total of 24 true triaxial compression tests were performed under various combinations of 𝜎3 and 𝜎2 conditions. Conventional uniaxial and triaxial compression tests were employed to estimate the mechanical properties of the plaster for use as parameters for 3D failure criteria. Examining the stress-strain relations of the plaster materials showed that a large difference between the intermediate principal stress and the minimum principal stress indicated strong brittle behavior. The mechanical behavior of the plaster used here reflects the change of intermediate principal stress. Nonlinear multiple regression analysis on the test data in the principal space showed that the modified Wiebols-Cook failure criterion and the modified Lade failure criterion were the most suitable 3D failure criteria for the tested plaster.

Rock Mechanics Site Characterization for HLW Disposal Facilities (고준위방사성폐기물 처분시설 부지에 대한 암반역학 부지특성화)

  • Um, Jeong-Gi;Hyun, Seung Gyu
    • Economic and Environmental Geology
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    • v.55 no.1
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    • pp.1-17
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    • 2022
  • The mechanical and thermal properties of the rock masses can affect the performance associated with both the isolating and retarding capacities of radioactive materials within the deep geological disposal system for High-Level Radioactive Waste (HLW). In this study, the essential parameters for the site descriptive model (SDM) related to the rock mechanics and thermal properties of the HLW disposal facilities site were reviewed, and the technical background was explored through the cases of the preceding site descriptive models developed by SKB (Swedish Nuclear and Fuel Management Company), Sweden and Posiva, Finland. SKB and Posiva studied parameters essential for the investigation and evaluation of mechanical and thermal properties, and derived a rock mechanics site descriptive model for safety evaluation and construction of the HLW disposal facilities. The rock mechanics SDM includes the results obtained from investigation and evaluation of the strength and deformability of intact rocks, fractures, and fractured rock masses, as well as the geometry of large-scaled deformation zones, the small-scaled fracture network system, thermal properties of rocks, and the in situ stress distribution of the disposal site. In addition, the site descriptive model should provide the sensitivity analysis results for the input parameters, and present the results obtained from evaluation of uncertainty.