• Journal of Genetic Medicine
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• v.9 no.1
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• pp.38-41
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• 2012

A 32-year-old female patient and her sister show high levels of high density lipoprotein (HDL) cholesterol in regular health checkups, since female patient was 11 years old. The patient's serum total cholesterol was 285 mg/dL and HDL cholesterol was 113 mg/dL. Her sister's total cholesterol was 240 mg/dL and the HDL cholesterol measured to be 90 mg/dL. Lipoprotein pattern and cholesteryl ester transfer activity gene analysis were examined in these patients. We found c.1321+1G>A (IVS14+1G/A) hetero mutation in cholesteryl ester transfer protein (CETP) genes. Generally, CETP mediates transfer and exchange of triglycerides and cholesteryl ester between plasma lipoproteins. Also we investigated a key role of HDL-CE and Apo A-1 metabolism. Patients with low levels of CETP have increased serum HDL levels. We hereby report two Korean cases of CETP deficiency in a family. Brief literature review ensues with the cases.

• Journal of Nutrition and Health
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• v.25 no.2
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• pp.150-161
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• 1992

The purpose of this study was to evaluate the riboflavin status of primary school children. Fiftyone subjects were selected as obese group and fiftyfive subjects were selected as control group according to Body Mass Index(BMI) of fifth-graders at a primary school in Taegu. For each subject information on nutrient intake and daily activity pattern were obtained by questionnaire. The riboflavin status was evaluated by urinary riboflavin exvretion The daily energy expenditure per kilogram of body weight was significantly lower in obese group(=47kcal/day) than in control group(=58kcal/day) (p<0.001) However the entire energy consumption was siginificantly greater in the obese children(=2005kcal/day) than their nono-baser peers(=1837kcal/day)(p<0.001). Riboflavin intake was 0.67mg/100kcal in the control group and 0.61mg/1000kcal in the obese group. Thus intakes for both groups met the current group and control group were 86.9$\mu\textrm{g}$/day and 98.7$\mu\textrm{g}$/day. repectively. There was no significnat Assesment of clinical signs of riboflavin deficiency indicated that angular lesion was 4.7% and glossitis was 6.6% of all subjects. Thirty one percent of subjects excrete riboflavin below 78$\mu\textrm{g}$/g creatinine which is defined as deficient. Therefore this group would be considered at high risk for developing riboflavin deficiency. From this study current recommendation of 0.6mg/1000kcal of riboflavin intake may not be adequate during growth and associated stress.

• The Journal of Korean Medical History
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• v.34 no.2
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• pp.25-43
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• 2021

Among the ancient ideas of East Asia, there is a myth about the symbol of the Four Gods who commands all directions in the east, south, west, and north, and this is also reflected in the medical field. However, although there is discussion about Qinglong Decoction (青龍湯), Baihu Decoction (白虎湯) and Xuanwu Decoction (玄武湯) in the 『Shanghan Lun (傷寒論)』, there is no content focusing on Zhuniao decoction (朱鳥湯). Considering the consistent perspective of 『Shanghan Lun』, which recognizes the disease-syndrome and seeks prescriptions based on yin and yang thinking, this is very unusual. Therefore, in this study, it was revealed that the concept of 'Sishen Decoction (四神湯)' itself was a concept that emerged when the authors of 『Shanghan Lun』 established the 'eight-principles syndrome differentiation (八綱辨證)' system in their recognition and response to diseases-syndromes. Based on this, I considered the following possibilities: They were able to present Qinglong decoction, Baihu Decoction and Xuanwu decoction, as appropriate prescriptions for 'exterior cold excess syndrome (表寒實證)', 'interior heat deficiency syndrome (裏熱虛證)', and 'interior cold deficiency syndrome (裏熱實證)'. However, it is possible that the name of the prescription 'Zhuniao decoction' was not intentionally used, because it was not possible to provide an appropriate prescription for 'exterior cold excess syndrome (表熱實證)'.

• Journal of Korean Medical classics
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• v.36 no.1
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• pp.45-78
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• 2023

Objectives : Based on the Zangfuyaoshibuzheng of Zhang Shanlei, this paper examines the tip/root division of the Zangfu, features of medicinal application according to deficiency/excess or cold/heat, and erroneous cases in the Zangfuxushibiaobenyongyaoshi of Zhang Jiegu. Methods : Categorization according to tip/root, cold/heat, deficiency/excess and respective medicinal applications in the Zangfuxushibiaobenyongyaoshi were organized, followed by thorough analysis based on the annotations in the Zangfuyaoshibuzheng. Results : First, in the treatment principle of the Zangfu diseases, each of their physiological function and pathological mechanism were analyzed so that the disease patterns are understood accurately and treated accordingly. Second, in categorizing treatment methods, terminology application was modified in overlapping or ambiguous cases so that they could be better distinguished. Third, medicinal categories that were designated to treat each Zangfu disease were explained well based on unique features. In cases where medicinals were falsely included, they were identified and corrected based on sound reasoning. Conclusions : The pattern diagnosis in the Zangfuyaoshibuzheng is clear, and medicinal application analysis is intelligible. As it thoroughly corrects and revises errors in Zhang Jiegu's theories, it could provide valuable assistance in selecting each medicinals when treating disease patterns of the Five Zang.

• 대한상한금궤의학회지
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• v.10 no.1
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• pp.115-124
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• 2018

Objective : The purpose of this paper is to report the improvements of a patient who has suffered from aftereffects following stroke such as dysgraphia and articulation disorder, which is treated by herbal medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed as Taeyang-byung Gyeolhyung and number 138 provision, and was administered Sohamhyung-tang for 90 days. We recorded the progress of improvements based on the patient's statement and documented the patient's writing Results : The patient can write the letters such as U, 2, ㄹ,ㅇ more clearly and become confident on both writing and speaking. Conclusions : This case shows the effects of Sohamhyung-tang on aftereffects following stroke such as dysgraphia and articulation disorder. It was induced according to the 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions' so that it suggest a potential interpretation, which is different with it of the text books Herbal Formula Science and Sanghallonjeonghae, on the provision no. 138. Also the usage of Sohamhyung-tang in this case may support the way far from the diagnosis of oriental neurological medicine, which explain the pathology of stroke as fire-heat(火熱), dampness-phlegm(濕痰), static blood(瘀血) and dual deficiency of qi and blood(氣血兩虛).

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.1094-1098
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• 2010

With the high prevalence of functional dyspepsia in the world, it was difficult to get objective diagnosis, treatment and assessment for the reason that there were many different symptoms and signs. The purpose of this study is to develop a standard instrument of pattern identification for functional dyspepsia which will be applied to clinical research. The items and structure of the instrument were based on review of published literature. The advisor committee on this study was organized by 11 oriental division of gastroenterology professors of oriental medical colleges nationwide. The experts discussed developing the instrument, and we also took professional advices by e-mail. We divided the symptoms and signs of functional dyspepsia into 6 pattern identification, such as disharmony of liver and stomach, retention of undigested food, damp-heat in the spleen and stomach, simultaneous occurrence of cold and heat syndromes, deficiency and cold of the spleen and the stomach, and insufficiency of stomach eum. We got the mean weights to each symptom of six pattern identification which had been scored on a 5-point scale ranging from 1 to 5 by the 11 experts. We made out the Korean instrument of the pattern identification composed of 45 questions for functional dyspepsia. Although there are some limitations in our study, the instrument is meaningful and certain worth of its own. We hope to improve the instrument through the further clinical studies and discussions.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.111-123
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• 2017

Objectives: To develop and investigate the reliability of the pathologic aging scale based on korean medical theory and korean medical pattern identification for dementia. Methods: We searched the textbook of korean neurophychiatry and Donguibogam and selected items through professional consensus. We compared between dementia(n=40) and normal elderly(n=38) and tested the reliability of two scales. Results: After professional consensus, we drafted the Korean Medical Pathologic Aging Scale(12 items, Likert 3 scale) and Korean Medical Pattern Identification for Dementia(4 patterns, 28 items, Likert 5 scale). On Korean Medical Pathologic Aging Scale, There is no significant difference between two groups. We had good internal consistency(Cronbach's alpha = 0.6) and test-retest reliability(r=0.631) but low inter-rater reliability(r=0.430). On Korean Medical Pattern Identification for Dementia, dementia patients diagnosed with Qi deficiency are significantly more than those in normal group. We had fairly good internal consistency(Cronbach's alpha = 0.574) and excellent test-retest(kappa= .800) and inter-rater reliability(kappa = .733). Conclusions: Korean Medical Pattern Identification for Dementia is appropriate for diagnosing korean medical pattern. But Korean Medical Pathologic Aging Scale isn't appropriate to discriminate dementia from normal elderly because of many subjective items. Therefore objective measurement of sensory dysfunction would be needed to measure pathologic aging based on korean medical theory.

• Journal of Korean Medical classics
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• v.37 no.1
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• pp.57-75
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• 2024

Objectives : The objective of this paper is to study the literature on stagnation pattern, to further determine reasoning for the emphasis on Liver-qi stagnation out of all the Five Zang stagnation patterns. Methods : Stagnation patterns in literature from the Xian-Qin/Liang-Han period, Sui-Tang-Song period, Jin-Yuan period and Ming-Qing period were studied and analyzed. Results & Conclusions : Based on chronological analysis on discussions of stagnation pattern, the Five stagnation in the Neijing were related to the excessiveness and deficiency of the Five circuits. After the discussions of the Four Masters of the Jin-Yuan period, WangAndao explained that stagnation could happen without relation to external contraction in his discussion of Benqiziyubing. Yutuan focused on the inter-relationship between the six stagnation patterns, emphasizing qi stagnation, while Sunyikui discussed stagnation pattern within the framework of the Five Zang stagnation. Zhaoxianke argued for the first time that one of the treatment methods of Wood stagnation could replace the five treatment methods, focusing on Wood stagnation which could be the clue to stagnation pattern. Of current Zangfu diagnostic terminology, the influential Liver qi stagnation remains to this day.

• Korean Journal of Oriental Medicine
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• v.13 no.2 s.20
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• pp.59-63
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• 2007

The purpose of this study was to diagnosis that what patterns identification using the statistical method. Discriminant analysis using the medical specialist and resident pattern identification agree case in stroke patients within 1 month of onset. The agreement rate of dificiency of Gi(75%), heat-transformation(74%), dampphlegm syndrome(69%), deficiency of Eum(51%) and syndrome of blood stagnation(43%) are respectively 0.75, 0.74, 0.69, 0.51 and 0.43 in medical specialist and using linear discriminant function pattern identification are same. The study of inspection, pulse feeling and palpitation will be continued to evaluate concordance rate. Discrimination model will be make to get higher Accuracy and prediction, it means becomes the help in pattern identification diagnosis objectivity and scientific.

• The Journal of Korean Medicine
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• v.27 no.2 s.66
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• pp.253-261
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• 2006

Backgrounds : Hyperlipidemia is a major cause of cardiovascular disease (CVD). Lowering serum cholesterol levels could reduce the risk of CVD. Insamsansa-eum (Renshenshanzha-yin, ISE), composed of Ginseng Radix and Crataegii Fructus, is a new medicine developed to treat hyperlipidemia and CVD. Objectives : In this study, we intended to explore the clinical effects of ISE on patients with hypercholesterolemia, and moreover we also compared its effects according to the pattern identification. Methods : Subjects were administered ISE with the dose of 600 mg three times a day for 4 weeks. Patterns of subjects were identified with diagnostic scoring system for Yin-Yang and the condition of Excess-Deficiency before treatment. Serum lipids were measured at baseline and after 4 weeks of medication. Results : ISE lowered total cholesterol(TC), triglyceride(TG), total lipid(TL), phospholipid(PL) and low density lipoprotein cholesterol(LDL) significantly. Compared with the data of our previous study, it was less effective than Atorvastatin but showed equal lipids-lowering effect to Chunghyul-dan (Qingxue-dan, CHD). In Yang pattern group, ISE was less effective in lowering TG and LDL than it was in not-Yang-not-Yinpattern group. On safety assessment, there was no adverse effect, hepatic or renal toxicity. Conclusions : We suggest that ISE is a safe and useful herbal medicine for hypercholesterolemia, and moreover it could be more useful when it is used for patients with not Yang pattern.