• Proceedings of the Korea Concrete Institute Conference
• /
• 1998.04a
• /
• pp.391-396
• /
• 1998

The concrete structures are hardly ever built under ideal conditions. So many defects may occur for a various reasons such as unsuitable and defective materials, construction methods, poor workmanship, particular structural form and prevailing weather conditions. Some structural form can greatly increase the risk of occurrence of defects. Therefore we investigated the actual condition of the deterioration factors for reinforced concrete apartment, which was composed of 85 apartments with various building ages in different regions with five evaluation the deterioration factors of apartment building to establish the overall evaluation system of deterioration degree for reinforced concrete apartment in Korea.

• Journal of Applied Reliability
• /
• v.15 no.3
• /
• pp.176-180
• /
• 2015

A defect on the product safety display is defined by a failure to prevent the damage caused by the inappropriate explanation, direction, and caution to warn the users of the related risks. In other words, it lacks the sufficient instructions or caution for proper use and is unable to furnish the possible danger of the product and the instructions to deal with it. The defect is the responsibility of the manufacturers who are supposed to provide the adequate information so as to prevent injuries of the users. However, in order to prove the product safety display defective, there should be a comprehensive consideration in many different ways such as social norms (such as property and expectation of the product), usage form, indication of the expected risk, and awareness of consumer about the harm and possibility of avoidance of danger. The purpose of this research is to propose the content and types of standardized indication of safety in the industrial product by collecting and analyzing domestic safety information.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.22 no.53
• /
• pp.79-88
• /
• 1999

This paper presents an integral model for product safety and product liability resulting from a defective product. The essence of the paper is the process of supply of manufacturing products which satisfy the product liability and the product safety in terms of consumers expectation levels. The main criteria of the product safety is the hazard level which involves in the severity and frequency. The proposed model shows the process to supply the manufactured products under the conditions that they are suitable in comparison of hazard level and safety level established by each company. If the product do not meet the safety level, this paper proposes that four different types of PL and PS countermeasures for the risk types are forward, respectively.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.30 no.1
• /
• pp.44-48
• /
• 2016

In this paper, we analyzed the operating characteristics of a ventilating fan due to overload and overheating. The experiment assumed the forcible restraint of the blade due to external objects and the aging process. We analyzed the experimental temperature and operating characteristics of the three places in the interior of the ventilating fan. As a result of the analysis, the temperature distribution was highest to lowest in the following order: the thermal fuse, the motor inside, and the above winding. There was smell of burning enamel in the restraint experiment. Following the thermal fuse operation, the insulation of motor winding was good. In the case of rated voltage and new ventilating fan restrained for about 4hours, and the results of restraint experiments in the presence or absence of the thermal fuse, no risk of deformation or fire due to overheating was identified. Henceforward, ignition hazard experiments will be required for additional factors of aging, pollution, and defective insulation.

• Toxicological Research
• /
• v.21 no.3
• /
• pp.195-208
• /
• 2005

Diabetes is a major cause of morbidity and mortality, and associated with a high risk of atherosclerosis, and liver, kidney, nerve and tissue damage. Defective insulin secretion in pancreas and/or insulin resistance in peripheral tissues is a central component of diabetes. It is well established that, regardless of the degree of muscle insulin resistance, glucose levels in diabetic and non-diabetic individuals are determined by the rate of hepatic glucose production. Moreover recently studies using liver-specific insulin receptor knockout mice show the paramount role of the liver in insulin resistance and diabetes. Insulin exerts a multifaceted and highly integrated series of actions via its intracellular signaling systems. The first major section of this review defines the major insulin-mediated signaling pathways including phosphatidylinositol 3-kinase and mitogen activated protein kinases. The second major section of the review presents a summary and evaluation of methods for determination of the role and function of signaling pathways, including methods for determination of kinase phosphorylation, the use of pharmacological inhibitors of kinase and dominant-negative kinase constructs, and the application of new RNA interference methods.

• Journal of Periodontal and Implant Science
• /
• v.33 no.3
• /
• pp.457-474
• /
• 2003

The ultimate objective of periodontal treatment is to get rid of an on-going periodontal disease and further regenerate the supporting tissue, which is already destroyed, functionally. Currently, the bone grafting operation using various kinds of bone grafting materials and the operation for induced regeneration of periodontal tissue using the blocking membrane are performed for regeneration of the destroyed periodontal tissue. However, there are respective limitations Galenical preparations, which are used for regeneration of periodontal of tissue, has less risk of rejective reaction or toxicity that may be incidental to degradation and their effect is sustainable. Thus, in case they are applicable to a clinic, they can he used economically. Chitosan has such compatibility, biological actions including antibacterial activity, acceleration of wound treatment, etc., and excellent mechanical characteristics, which has recently aroused more interest in it. Also, it has been reported that it promotes osteogenesis directly or indirectly by functioning as a matrix to promote migration and differentiation of a specific precussor cell (for example, osteoblast) and further inhibiting the function of such a cell as fibroblast to prevent osteogenesis. In this study, the pure chitosan solution, which was obtained by purifying chitosan, was used. However, since this chitosan is of a liquiform, it is difficult to sustain it in a defective region. It is, therefore, essential to use a carrier for delivering chitosan to, and sustaining it gradually in the defective region. In the calvarial defect model of the Sprague-Dawley rat, it is relatively easy to maintain a space. Therefore, in this study, the chitosan solution with which ACS was wetted was grafted onto the defective region, For an experimental model, a calvarial defect of rat m s selected, and a critical size of the defective region was a circular defect with a diameter of 8 mm. A group in which no treatment was conducted for the calvarial defect was set as a negative control group. Another group in which treatment was conducted with ACS only was set as a positive control group (ACS group). And another group in which treatment was conducted was conducted with by grafting the pure chitosan solution onto the defective region through ACS which was wetted with the chitosan solution was set an experimental group (Chitosan/ACS group). Chitosan was applied to the Sprague-Dawley rat's calvarial bone by applying ACS which was wetted with the chitosan solution, and each Sprague-Dawley rat was sacrificed respectively 2 weeks and 8 weeks after the operation for such application. Then, the treatment results were compared and observed histologically and his tometrically. Thereby, the following conclusions were obtained. 1. In the experimental group, a pattern was shown that from 2 weeks after the operation, vascular proliferation proceeded and osteogenesis proceeded through osteoblast infiltration, and at 8 week after the operation, ACS was almost absorbed, the amount of osteogensis was increased and many osteoid tissue layers were observed. 2. At 2 weeks after the operation, each amount of osteogenesis appeared to be 8.70.8 %, 13.62.3 % and 4.80.7 % respectively in the experimental group, the positive control group and the negative control group. Accordingly, it appeared to be higher in the Experimental group and the positive control group than in the negative control group, but there was no significant difference statistically (p<0.01). 3. At 8 weeks after the operation, each amount of osteogenesis appeared to be 62.26.1%, 17.42.5 % and 8.21.4 % respectively in the experimental group, the positive control group and the negative control group. Accordingly, it appeared to be substantially higher in the experimental group than in the positive control group and the negative control group, and there was a significant difference statistically (p<0.01). As a result of conducting the experiment, when ACS was used as a carrier for chitosan, chitosan showed effective osteogenesis in the perforated defective region of the Sprague-Dawley rat's calvarial bone.

• CRM연구
• /
• v.1 no.1
• /
• pp.23-48
• /
• 2006

Internet B2C marketplace such as 'Auction', 'G Market', 'Daum onket' etc.(called open market) has grown sharply in sales about yearly 100% rate increase in recent 1-2 years in Korea. Although Open marketplace has much reputation and the customer loyalty, almost of merchants participated in open market, which size in sales are medium/small, has poor reputation and trust. Consumers, who have to get in touch with untrustworthy merchants for trade in openmarket, perceive high trade risk which undergo the monetary damages such as 'merchandise never received'. This examines what factors consumer trust develop in online marketplace. This study explores several perceived risk factors in an open market by factor analysis and multi-regression to prove the relationships between the degree of trust for the merchants and the perceived trade risk. 133 data collected from the open market user data in this survey. In this study, the consumer's trade satisfaction in open market is low by 4.2 point degree of 7 point likert scale. and perceives 4 trade risk factors such as (1) 'failure to honor warranty or guarantee' (2) 'defective/poor goods in quality' (3) 'merchandise never received or received late' (4) 'poor information'. the degree of merchant's trust has significant relationship with the degree of perceived risk(sig. = 0.0000, $R^2=.327$) We find that the open market has to enhance the relationship marketing of trust by developing the strategies.

• The Korea Journal of Herbology
• /
• v.31 no.2
• /
• pp.39-45
• /
• 2016

Objectives : Abnormal regulation of glucose and impaired lipid metabolism that result from a defective or deficient insulin are the key etiological factor in type 2 diabetes mellitus. The our study investigated the effects of Gamioknyeo-jeon (GO) on blood glucose and lipid metabolism improved by it in db/db mice (a murine model of type 2 diabetes mellitus).Methods : The animals were divided into 3 groups: Normal groups were not-treated C57BL/6 mice; Control groups were treated orally with DW in db/db mice; GO groups were treated orally with GO (200 ㎎/㎏/day) in db/db mice. After mice were treated with GO for 5 weeks, we measured AST, ALT, creatinine, BUN, body weight, food intake, blood glucose, insulin and lipid levels (total cholesterol, HDL cholesterol, and LDL cholesterol and atherogenic index(AI) and cardiac risk factor(CRF).Results : Serum AST, ALT, creatinine, BUN levels were not changed by GO do not show any toxic effects. GO groups were decreased in body weight, food intake and blood glucose level among compared to Control groups. Also, GO groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol and LDL cholesterol decrease). Finally, GO groups were increased the insulin compared to Normal and control groups.Conclusions : We suggest that GO may have the control effects of diabetes mellitus by improving blood glucose control and lipid metabolism.

• Clinical and Experimental Pediatrics
• /
• v.50 no.6
• /
• pp.519-523
• /
• 2007

Aplastic anemia is a rare disease, which is characterized by pancytopenia and hypocellular bone marrow without infiltration of abnormal cells or fibrosis. The incidence in Asia is higher than in the West and new cases are diagnosed at a rate of 5.1 per million pediatric populations per year in Korea. The pathophysiology is understood roughly by defective hematopoiesis, impaired bone marrow micro-environment and immune mechanism. Treatments are performed on basis of pathogenesis and selected depending on the severity. Immunosuppressive therapy with antilymphocyte or antithymocyte globulin and cyclosporine is effective in the majority of patients but has some problems including relapse or clonal evolution. Recently, there have been clinical trials of immunosuppression with hematopoietic growth factors or other drugs. Allogeneic hematopoietic stem cell transplantation (HSCT) is curative in children with severe aplastic anemia. The overall survival in HSCT from HLA-identical sibling is higher than alternative donor, including HLA matched unrelated donor or cord blood. We have to consider quality of life after HSCT because of high survival rate. However, chronic graft versus host disease and graft failure are important factors that affect the quality of life and overall survival. We need further investigation to make new regimens aimed at overcoming these risk factors and perform clinical trials.

• Journal of the Korean Society of Systems Engineering
• /
• v.15 no.2
• /
• pp.57-65
• /
• 2019

The weapon system applies the rule that the system engineering procedure must be applied at the acquisition stage. Naval ships, which are one of the important naval weapon systems, take a long period of time to acquire, and the leadership must be commissioned. Therefore, in order to acquire a naval ship, high risk management is necessary, and it is necessary to promote business success through effective application of system engineering which is a scientific management method. However, in the case of naval ships, there are no specific procedures and methods for applying the system engineering. Therefore, research on application method of system engineering which can be easily used by person in charge is necessary. This should have a simple approach to ensure effective business performance by systematically refining and simplifying existing works. QFD (Quality Function Deployment) is a way to improve product satisfaction, impress customers, reduce defective products, reduce design errors, and reduce costs. This systematically develops these mutual relationships by converting the needs of customers into quality characteristics of products and defining them as the design quality of products considering the functions, quality, and process elements of parts. The purpose of this research is to present concrete methodology at the practical level using QFD in a way to ensure traceability of requirements which is an important element of system engineering.