• 농업과학연구
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• 제45권4호
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• pp.707-713
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• 2018

This study was done to search for positional candidate genes associated with the back fat thickness trait using a Genome-Wide Association Study (GWAS) in purebred Yorkshires (N = 1755). Genotype and phenotype analyses were done for 1,642 samples. As a result of the associations with back fat thickness using the Gemma program (ver. 0.93), when the genome-wide suggestive threshold was determined using the Bonferroni method ($p=1.61{\times}10^{-5}$), the single nucleotide polymorphism (SNP) markers with suggestive significance were identified in 1 SNP marker on chromosome 2 (MARC0053928; $p=3.65{\times}10^{-6}$), 2 SNP markers on chromosome 14 (ALGA0083078; $p=7.85{\times}10^{-6}$, INRA0048453; $p=1.27{\times}10^{-5}$), and 1 SNP marker on chromosome 18 (ALGA0120564; $p=1.44{\times}10^{-5}$). We could select positional candidate genes (KCNQ1, DOCK1, LOC106506151, and LOC110257583), located close to the SNP markers. Among these, we identified a potassium voltage-gated channel subfamily Q member gene (KCNQ1) and the dedicator of cytokinesis 1 (DOCK1) gene associated with obesity and Type-2 diabetes. The SNPs and haplotypes of the KCNQ1 and DOCK1 genes can contribute to understanding the genetic structure of back fat thickness. Additionally, it may provide basic data regarding marker assisted selection for a meat quality trait in pigs.

• 한국융합학회논문지
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• 제10권10호
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• pp.81-89
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• 2019

본 연구에서는 2013-2015년 국민건강영양조사 결과를 이용하여 우리나라 20-64세 성인 남녀 5,597명의 자료를 분석하였다. 현재 흡연자인 남성은 41.1%, 여성은 5.5%였으며, 현재 흡연자에서 대사증후군이 발생할 위험은 남성에서 연령 및 음주, 신체활동, 비만, 수면시간을 보정하였을 경우 1.785배 유의하게 증가하는 것으로 나타났지만, 여성에서는 유의하지 않았다. 흡연 및 대사증후군 유무에 따른 평균 영양소 섭취 차이를 분석 결과, 흡연자이면서 대사증후군이 있는 군에서 연령과 성별을 보정하였을 경우 에너지, 레티놀 및 비타민 C 섭취량에서만 유의한 결과를 보였다. 본 연구 결과 흡연 행태와 대사증후군 여부가 영양소 섭취와 연관이 있다는 것을 확인할 수 있었으며, 이에 따라 대사증후군의 예방과 관리를 위한 국가적인 수준의 생활습관 중재가 필요하겠다.

• 한국치위생학회지
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• 제19권5호
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• pp.699-713
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• 2019

Objectives: This study aimed to identify the relationships of oral and systemic health-related characteristics with health-related quality of life (EQ-5D) in the elderly, and factors related to quality of life were compared according to age subgroups classified as either younger (young-old) or older (old-old) than 75 years of age. Methods: Data acquired by the Sixth Korean National Health and Nutrition Examination Survey(KNHANES) from 2013 to 2015 were used, and the research target was 3,124 people aged 65 years or older. A complex samples general linear model was used to identify health-related quality of life factors. Results: Education, economic activity, depression, stress, regular walking, self-rated oral health, pronunciation problems, and unmet dental care had significant effects on quality of life in both young-old and old-old participants. Marriage, income, number of systemic diseases, sleeping, and chewing inconveniences were significant factors for the young-old but not in the old-old participants. Instead, obesity and drinking were identified as significant factors in the old-old participants. Conclusions: We reaffirmed that factors affecting health-related quality of life in older adults differed by age group. We also confirmed the impact of oral health-related characteristics on this quality. Therefore, to improve quality of life for older adults, it would be efficient to divide groups by age and develop and implement programs that take relevant factors into consideration.

• 한국보건간호학회지
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• 제33권1호
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• pp.85-97
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• 2019

Purpose: The purpose of this study was to examine the mediating effect of physical activity, dietary habit, and academic stress, as well as the moderating effect of gender on the relationship between adolescents' quality of sleep and body mass index (BMI). Methods: The data were collected from 181 adolescents and analyzed using SPSS WIN 23.0. Bootstrapping analysis was performed to analyze the mediating and moderating effects. Results: First, there was non-significant mediating effect between the quality of sleep and BMI. Second, there was significant moderating effect between the quality of sleep and BMI. Conclusion: Sleep quality should be considered as a component of an intervention program for the prevention and management of obesity. It is also necessary to consider then gender when constructing such program.

• Childhood Kidney Diseases
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• 제23권1호
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• pp.53-57
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• 2019

Renal cortical necrosis (RCN) is patchy or diffuse ischemic destruction of the renal cortex caused by significantly reduced renal arterial perfusion. It is a rare cause of acute kidney injury (AKI) and is associated with high mortality. Here, we review the case of RCN in a 15-year-old boy who developed AKI. A 15-year-old boy was referred to our hospital from a local hospital due to a sharp decrease in his renal function. He presented with acute flank pain, nausea with vomiting, and oliguria for the past two days. He had taken a single dose of antihistamine for nasal congestion. At our hospital, his peak blood pressure was 148/83 mmHg and he had a high body mass index of $32.9kg/m^2$. The laboratory data showed a blood urea nitrogen (BUN) of 28.4 mg/dL, a creatinine of 4.26 mg/dL, and a glomerular filtration rate estimated from the serum cystatin C of $20.2mL/min/1.73m^2$. Proteinuria (spot urine protein to creatinine ratio 1.66) with pyuria was observed. Kidney sonography showed parenchymal swelling and increased renal echogenicity. Due to rapidly progressing nephritis, steroid pulse therapy (750 mg/IV) was done on the second day of his admission and the patient showed complete recovery with normal renal function. However, the kidney biopsy findings revealed renal cortical hemorrhagic necrosis. Multifocal, relatively well-circumscribed, hemorrhagic necrotic areas (about 25%) were detected in the tubulointerstitium. Although RCN is an unusual cause of AKI, especially in children, pediatricians should consider the possibility of RCN when evaluating patients with rapidly decreasing renal function.

• 대한지역사회영양학회지
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• 제26권5호
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• pp.363-381
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• 2021

Objectives: This study examined the Korean elderly's dietary intake status, subjective health-related perception and chronic disease prevalence among age groups. Associations of dietary quality with subjective health-related perception and chronic diseases were also examined. Methods: Based on data from the 7th National Health and Nutrition Examination Survey, a total of 3,231 elderly were selected and categorized into 4 age groups of '65 ~ 69', '70 ~ 74', '75 ~ 79' and 'over 80'. Nutrient intakes, proportions of those with insufficient nutrient intakes, Korean Healthy Eating Index (KHEI), some subjective health-related perceptions and prevalence of major chronic diseases were compared according to the age groups. Differences in the subjective health-related perceptions and odds ratios of the chronic diseases according to the quartile levels of KHEI within the same age group were analyzed. Results: With the increase of age, several nutrient intakes (P < 0.001) and KHEI scores significantly decreased (P < 0.01). In women, activity restriction increased (P < 0.05), and EQ-5D score decreased with age (P < 0.001). Prevalence of hypertension (P < 0.0001), hypercholesterolemia (P < 0.05) and anemia (P < 0.01) significantly increased, while hypertriglyceridemia (P < 0.01) significantly decreased only in men. Obesity prevalence decreased, while underweight prevalence increased (P < 0.05). Subjective health status, EQ-5D score and PHQ-9 score significantly improved as KHEI score increased in certain age groups of women (P < 0.05). Odds ratio of hypercholesterolemia significantly increased with the increase of KHEI score in 65 ~ 69-year-old women. However, hypertension and anemia significantly decreased with the increase of KHEI score in 75 ~ 79-year-old women (P < 0.05). Conclusions: The study findings suggest that nutrition management and policy for the Korean elderly need to apply a segmented age standard that can better reflect their dynamic characteristics.

• 한국융합학회논문지
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• 제12권3호
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• pp.317-323
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• 2021

본 연구의 목적은 청소년의 체질량지수에 따른 구강증상 경험을 분석하고자 함이다. 청소년건강행태조사 자료를 이용하여 총 55,728명을 대상으로 복합표본분석을 실시하였다. 민감성 치아, 치아통증, 치은출혈 및 부종의 경험은 각각 과체중 그룹(36.8%, 23.9%, 19.2%)에서 가장 높고 저체중 그룹(34.6%, 20.8%, 17.0%)은 가장 낮았으며, 구취경험은 비만 그룹이 26.7%로 가장 높고 저체중 그룹은 18.8%로 가장 낮았다(p<0.001). 정상체중을 기준으로 했을 때 치아통증 경험은 과체중 그룹이 1.08배(95%CI: 1.01-1.15) 유의하게 높았고 치은출혈 및 부종 또한 과체중 그룹에서 1.08배(95%CI: 1.01-1.16) 유의하게 높았다. 구취경험은 과체중 그룹에서 1.19배(95%CI: 1.11-1.27), 비만 그룹에서 1.43배(95%CI:1.35-1.52) 유의하게 높았다. 차후 전신건강과 구강건강에 관한 보다 다양한 연구가 필요할 것이다.

• Journal of Korean Biological Nursing Science
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• 제23권1호
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• pp.31-42
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• 2021

Purpose: This study was performed to assess the level of blood glucose and to identify poor glycemic control groups among patients with type 2 diabetes mellitus (DM). Methods: Data of 1,022 Korean type 2 DM patients aged 30-64 years were extracted from the Korea National Health and Nutrition Examination Survey VII. Complex samples analysis and a decision-tree analysis were performed using the SPSS WIN 26.0 program. Results: The mean level of hemoglobin A1c (HbA1c) was 7.22±0.25%, and 69.0% of the participants showed abnormal glycemic control (HbA1c≥6.5%). The characteristics of participants associated with poor glycemic control groups were presented with six different pathways by the decision-tree analysis. Poor glycemic control groups were classified according to the patients' characteristics such as period after DM diagnosis, awareness of DM, sleep duration, gender, alcohol drinking, occupation, income status, low density lipoprotein-cholesterol, abdominal obesity, and number of walking days per week. Period of DM diagnosis with a cut-off point of 6 years was the most significant predictor of the poor glycemic control group. Conclusion: The findings showed the predictable characteristics of the poor glycemic control groups, and they can be used to screen the poor glycemic control groups among adults with type 2 DM.

• 디지털융복합연구
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• 제19권3호
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• pp.371-378
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• 2021

본 연구의 목적은 클로로겐산이 함유된 피부 패치를 피부에 부착하여 체지방과 체중에 미치는 변화를 규명하여, 유용성을 평가하는 것이다. 시험군 8명, 대조군 8명으로 총 16명의 대상자가 연구에 참여하였고, 연구 기간은 2020년 08월 03일부터 2020년 08월 31일까지 4주간 실시하였다. 군-간 효과검정 결과 체지방의 변화는 전체적으로 유의한 차이가 없었으나(F=4.38, p<.055), 1주 후와 4주 후 검사에서는 의미있는 변화(p<.001)가 있었다. 또한, 체중은 유의미한 차이로 시험군이 대조군보다 체중 감소가 큰 것으로 나타났다(F=9.43, p<.008). 이번 연구의 결과는 비만 관련 연구에 패치를 적용한 예비연구로써 의미가 있다고 할 수 있으며, 연구의 결과가 향후 연구될 피부 패치 연구의 기초 자료로 활용될 수 있을 것으로 판단된다.

• 동의생리병리학회지
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• 제35권1호
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• pp.36-41
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• 2021

Many prior studies on neck pain after a traffic accident (TA), but there is a lack of research on risk factors for post-TA neck pain in Korea. The purpose of this study was to examine the relationship between post-traffic neck pain and the demographic characteristics of TA patients and to find any factors affecting the neck pain after TA. In this study, 120 TA patients in a Korean medicine hosipital were analysized. The Korean version of the Neck disability Index (NDI) and Numeral Rating Scale (NRS) were used. Data were summarized by frequency(%) and mean(standard deviation). Pearson correlation test, Independent sample t-test, chi-squre test, one-way ANOVA and two-way ANOVA were performed. The IBM SPSS Advanced Statistics for window, version 20.0 was used for statistical processing. All p-values less than 0.05 were considered statistically significant. NDI and NRS were highly correlated. NRS and NDI showed higher scores for women, those in 30s, BMI≥25, and side collisions, but there were no statistically significant differences. For women, the direction of collision was observed to affect NDI. In this study, it was confirmed that the NDI and NRS had a high correlation. However, it was confirmed that sex, degree of obesity, direction of traffic accident collision are not factors that significantly affect the intensity of neck pain and the functional disorder by neck. It is necessary to conduct an additional study by larger scale.