• 대한예방한의학회지
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• 제16권3호
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• pp.1-13
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• 2012

Objectives : This study aimed to analyze the living habits and results of health examinations of university students according to Sasang constitution. Methods : We measured the height, weight, body mass index, and blood pressure of 2,387 university students, performed laboratory examinations, and conducted a questionnaire survey of their eating, drinking, smoking, and exercise habits. Their Sasang constitution was diagnosed by using the Questionnaire of Sasang Constitution ClassII(QSCCII). All the data were analysed statistically by descriptive statistics, chi-square test, ANOVA, tukey's multiple comparisons Results : The Taeeumin group mostly ranged in overweight sector of the BMI, and this group showed significantly higher blood pressure and AST, ALT, GGT, LDH, CPK, Creatinine, Uric acid, total cholesterol, TG, and LDL levels than other groups, while having a lower HDL level. In the living habits survey, the Taeeumin group showed the highest proportion of "overeating", and the lowest proportion of "eating slowly". This group had the highest value of quantity of alcohol drinking, highest proportion of hazardous drinkers, and highest smoking rate of the three constitutions. Conclusions : In the results of this study, there were significant differences in the living habits behaviors, and the results of health examination, between the three constitutions. In particular, individuals of the Taeeumin group have a high possibility of getting chronic disease, such as hypertension, diabetes mellitus, hyperlipidemia, and obesity; and need to improve their living habits.

• 한국식품영양학회지
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• 제12권1호
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• pp.39-42
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• 1999

This study was carried out to investigate effects of nutrition education on diet program S-28 for a per-iod of 5 months. The participants in this diet program were 40 Chungkang college female students with over 30% body fat. During the first 2 weeks they were provided 800kcal a day and 1,200kcal a day for the lat 2 weeks. Since then weight maintenance program was continued. Exercise and nutrition e여-cation program for nutrition knowledge attitude and food habit were conducted during the entire test period, Results during the test period were as follows : 1) Weight loww was statistically significant from 69.5$\pm$4.9kg at the beginning to65.6$\pm$3.0kg(P<0.01) in 3 months to 63.2$\pm$3.5kg(P<0.01) in the 5th month. 2) Obesity rate was significantly decreased from 23.9$\pm$12.1% to 21.3$\pm$9.2%(P<0.05) in 3 mon-ths to 19.7$\pm$8.5% in the 5th month. 3) BMI was significantly declined from 27.3$\pm$1.5kg/m2 to 26.1$\pm$1. 2kg/m2(P<0.01) in 3 months to 25.7$\pm$0.9kg/m2(P<0.05) in 3 months to 28.2$\pm$1.8%(p<0.05) in the 5th month. 5) The mean scores of food habit were 33.4$\pm$4.5 at the beginning 35.2$\pm$3.7 in 3 mon-손 37.4$\pm$4.0 in the 5th month and each of nutrition attitude was 53.8$\pm$5.3, 58.0$\pm$6.2. There-fore these data showed that effects of nutrition education on diet program S-28 were feflected remark-ably not only in the antropmetric measurements but also in the mean scores of food habit and nu-trition attitude.

• 대한지역사회영양학회지
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• 제3권4호
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• pp.556-564
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• 1998

The purpose of this study was to assess the iron nutritional status of college women residing in the Kyungin area. The anthropometric parameters, nutrient intake, and biochemical status of iron were measured for 102 college women. The mean height and weight were 160.3cm and 52.4kg, respectively. The proportion of subjects whose BMI was less than 20 was 41.3%. The proportion of subjects assessed as overweight(25$\geq$25%) assessed by the fat percent(FP) was 53.9%. The mean daily intake of iron was 13.90mg(77.1% of RDA), composed of 0.97mg of heme iron and 12.44mg(69.0% of RDA). When the sources of iron were grouped as rice(including bread), noodle, soup, side dish, and snack, noodle provided, 3.95mg of iron regarded as the highest amount. Subjects were taking 6.72mg(51.4% of RDA) of iron per day from main dishes(rice, bread and noodle). The fifty five percent of the subjects showed iron depletion(serum femitin<20ng/ml)and 33.4% showed suppressed erythropoiesis with iron deficiency(serum ferritin<10ng/ml). The anemic subjects assessed with transferrin saturation (<15%) represented 33.3% of the test population, whereas 11.8% of the subjects possessed less than 12g/dl of hemoglobin. Subjects not satisfied with their body shape were having significantly lower amount of energy intake(p<0.05) than the subjects satisfied with their body shape. College women having mothers who graduated from university had a significantly decreased amount of energy, carbohydrates, fat and vitamin C(p<0.05). The mean RBC and serum iron of the subjects who were on a diet more than one month were lower than those of the subjects who were not on a diet(p<0.05).

• Journal of Nutrition and Health
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• 제35권10호
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• pp.1053-1059
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• 2002

In post-genome period, the technique for identifying gene expression has been changed to high throughput screening. In the field of molecular nutrition, the need for this technique to clarify molecular function of the specific nutrient is essential. In this study, we have tested the zinc-regulated gene expression in zinc-deficient U937 cells, using cDNA microarray which is the cutting-edge technique to screen large numbers of gene expression simultaneously. The study result can be used for the preliminary gene screening data for clarifying, using monocyte U937 cell line, molecular Zn aspect in atherosclerosis. U937 cells were cultured in Zn-adequate (control, 12 $\mu$M Zn) or Zn-deficient (experimental, 0 $\mu$M Zn) ESMI media during 2 days, respectively. Cells were harvested and RNA was extracted. Total RNA was reverse-transcriptinized and synthesized cDNA probe labeled with Cy-3. fluorescent labeled cDNA probe was applied to microarray slide for hybridization slide, and after then, the slide was scanned using fluorescence scanner. ‘Highly expressed genes’ in Zn-deficient U937 cells, comparing to Zn-adequate group, are mainly about the genes for motility protein, immune system protein, oncogene and tumor suppressor and ‘Less highly expressed genes’ are about the genes for transcription, apoptosis associated protein, cell cycle, and several basic transcription factors. The results of this preliminary study imply the effectiveness of cDNA microarray for expression profiling of a singly nutrient deficiency, specially Zn. Furthur study, using tailored-cDNA array and capillary endothelial cell lines, would be beneficial to clarify molecular Zn function, more in detail.

• 여성건강간호학회지
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• 제4권3호
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• pp.388-401
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• 1998

The purpose of this study is to investigate the relationship between the eating disorder, physical symptoms and mood status among college women. Data has been analyzed by SPSS/PC using frequency, percentage, mean, standard deviation, t-test, Pearson correlation coefficient. The results of this study are as follows : 1. The mean of body weight and height of the subjects were 52.74kg, 163.10cm. 2. Depending upon BMI, the obesity subjects were very rare(2.2%) and the rest(97.8%) were underweight or normal. 3. The total mean score of anorexia nervosa was higher than bulimia nervosa. 4. The total mean score of perceived physical symptoms was 20.68 and subjects in this study showed the tendency giving the highest core on the item of autonomic nerve system and mensural status. 5. The total mean score of mood status was 58.49. 6. The scores of eating behavior differed significantly by the BMI : The score was highest in the group of normal body weighted(t=5.75, p<.05). 7. The scores of physical symptoms differed significantly by the BMI : The score was highest in the group of the underweight(t=7.35, p<.01). 8. No significant difference was found on over all mood status scores according to the BMI. 9. There was high positive correlation between BMI and eating disorder(r=.1633, p<.01), between eating disorder and physical symptoms(r=.2497, p<.0001), between eating disorder and mood status(r=.2328, p<.0001), and between symptoms and mood status(r=.5051, p<.0001). From the results of this study, the eating disorder among college woman was very serious and the perception of their body weight was distorted. Therefore, to prevent the eating disorder, professional intervention is needed.

• 한국학교보건학회지
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• 제20권1호
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• pp.77-90
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• 2007

Purpose : This study identified the patterns of smoking of students attending middle schools and high schools, and analyzed its related health risk behaviors. Methods: The data was based on the survey of 1,517 middle students and 911 high students residing in Kyung-Gi district. Results: The current smoking rates of male and female middle students are 5.3%, and 3.1% respectively. The rates of experiences in smoking are 21.4% and 16.0%(male/female). The current smoking rates of male and female high students are 17.9% and 8.5%, whereas the rates of experiences in smoking are 34.2% and 23.3% respectively. On the other hands, 14.1% of middle students and 12.0% of high students were exposed to smoking for at least 2 hours per day. The majority of middle and high school smokers started smoking when they were in middle or high school. And the most popular places to smoke were children's playgrounds, public open area., parks, and so on. Whether having a smoker as a friend or not and students' own perception towards smoking influenced the decisions to smoke for middle and high students. Both middle and high students, regardless of their gender, who have higher rates of drinking experiences and the hours of computer usage were found to have higher rates of smoking experiences. Meanwhile, the sleeping hours is in reverse proportion to the rate of smoking experiences. There was statistically significant difference in smoking experiences related to the degree of obesity only in the female high students: underweight and overweight students showed higher rates of smoking experiences than those falling in the normal weight range. Conclusion: For the effective prevention of adolescence smoking, it is necessary to adopt a comprehensive approach, which classifies the target population according to their age and sex and cover all health risk behaviors.

• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.177-187
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• 2021

Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type 2 diabetes mellitus. This study aimed to examine the therapeutic effects of morin, as one of the flavonoids constituents, which widely exists in many herbs and fruits, against some metabolic and hepatic manifestations observed in MBS rats and the feasible related mechanisms. MBS was induced in rats by high fructose diet feeding for 12 weeks. Morin (30 mg/kg) was administered orally to both normal and MBS rats for 4 weeks. Liver tissues were used for determination of liver index, hepatic expression of glucose transporter 2 (GLUT2) as well as both inflammatory and fibrotic markers. The fat/muscle ratio, metabolic parameters, systolic blood pressure, and oxidative stress markers were also determined. Our data confirmed that the administration of morin in fructose diet rats significantly reduced the elevated systolic blood pressure. The altered levels of metabolic parameters such as blood glucose, serum insulin, serum lipid profile, and oxidative stress markers were also reversed approximately to the normal values. In addition, morin treatment decreased liver index, serum liver enzyme activities, and fat/muscle ratio. Furthermore, morin relatively up-regulated GLUT2 expression, however, down-regulated NF-κB, TNF-α, and TGF-β expressions in the hepatic tissues. Here, we revealed that morin has an exquisite effect against metabolic disorders in the experimental model through, at least in part, antioxidant, anti-inflammatory, and anti-fibrotic mechanisms.

• Neurospine
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• 제15권4호
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• pp.376-382
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• 2018

Objective: The purpose of this study was to evaluate factors associated with inpatient admission following 2-level cervical disc arthroplasty (CDA). A secondary aim was to compare outcomes between those treated on an inpatient versus outpatient basis. Methods: Using data from the American College of Surgeons National Surgical Quality Improvement Program database, multivariate logistic regression analysis was used to assess the independent effect of each variable on inpatient or outpatient selection for surgery. Statistical significance was defined by p-values <0.05. The factors considered were age, sex, body mass index (BMI), smoking status, American Society of Anesthesiologists physical status classification, and comorbidities including hypertension, diabetes, history of dyspnea or chronic obstructive pulmonary disease, previous cardiac intervention or surgery, steroid usage, and history of bleeding. In addition, whether the operation was performed by an orthopedic or neurosurgical specialist was analyzed. Results: The number of 2-level CDA procedures increased from 6 cases reported in 2014 to 142 in 2016, although a statistically significant increase in the number of outpatient cases performed was not seen (p=0.2). The factors found to be significantly associated with inpatient status following surgery were BMI (p=0.019) and diabetes mellitus requiring insulin (p=0.043). There were no significant differences in complication and readmission rates between the inpatient and outpatient groups. Conclusion: Patients undergoing inpatient 2-level CDA had significantly higher rates of obesity and diabetes requiring insulin than did patients undergoing the same procedure in the outpatient setting. With no difference in complication or readmission rates, 2-level CDA may be considered safe in the outpatient setting in appropriately selected patients.

• Nutrition Research and Practice
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• 제13권1호
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• pp.3-10
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• 2019

BACKGROUND/OBJECTIVES: The $NAD^+$ precursor nicotinamide riboside (NR) is a type of vitamin $B_3$ found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents hearing loss, high-fat diet-induced obesity, Alzheimer's disease, and mitochondrial myopathy. The objective of this study was to investigate the effects of NR on inflammation and mitochondrial biogenesis in AML12 mouse hepatocytes. MATERIALS/METHODS: A subset of hepatocytes was treated with palmitic acid (PA; $250{\mu}M$) for 48 h to induce hepatocyte steatosis. The hepatocytes were treated with NR ($10{\mu}M$ and 10 mM) for 24 h with and without PA. The cell viability and the levels of sirtuins, inflammatory markers, and mitochondrial markers were analyzed. RESULTS: Cytotoxicity of NR was examined by PrestoBlue assay. Exposure to NR had no effect on cell viability or morphology. Gene expression of sirtuin 1 (Sirt1) and Sirt3 was significantly upregulated by NR in PA-treated hepatocytes. However, Sirt1 activities were increased in hepatocytes treated with low-dose NR. Hepatic pro-inflammatory markers including tumor necrosis factor-alpha and interleukin-6 were decreased in NR-treated cells. NR upregulated anti-inflammatory molecule adiponectin, and, tended to down-regulate hepatokine fetuin-A in PA-treated hepatocytes, suggesting its inverse regulation on these cytokines. NR increased levels of mitochondrial markers including peroxisome proliferator-activated receptor ${\gamma}$ coactivator-$1{\alpha}$, carnitine palmitoyltransferase 1, uncoupling protein 2, transcription factor A, mitochondrial and mitochondrial DNA in PA-treated hepatocytes. CONCLUSIONS: These data demonstrated that NR attenuated hepatic inflammation and increased levels of mitochondrial markers in hepatocytes.

• Nutrition Research and Practice
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• 제13권2호
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• pp.134-140
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• 2019

BACKGROUND/OBJECTIVES: Excessive sugar consumption may increase the risk for development of several diseases. Although average dietary sugar intake of Koreans is within the recommended level, an increasing trend has been found in all age groups. This study aimed to evaluate the population attributable fractions (PAF) to dietary sugar for disease and death in Korea, and to estimate the socioeconomic effects of a reduction in dietary sugar. MATERIALS/METHODS: The prevalence of sugar-sweetened beverages (SSB) overconsumption (${\geq}20g$ of sugar from beverages) was analyzed using the Korean National Health and Nutrition Examination Survey 2015. Disease-specific relative risks of excessive SSB consumption were obtained through reviewing previous studies. Using the prevalence of SSB overconsumption and each relative risk, PAFs for morbidity and mortality were calculated. Socioeconomic costs of diseases and death attributable to SSB overconsumption were estimated by using representative data on national medical expenditures, health insurance statistics, employment information, and previous reports. RESULTS: Disease-specific PAF to SSB consumption ranged from 3.11% for stroke to 9.05% for obesity and dental caries, respectively. Costs from disease caused by SSB overconsumption was estimated at 594 billion won in 2015. About 39 billion won was estimated to be from SSB consumption-related deaths, and a total of 633 billion won was predicted to have been saved through preventing SSB overconsumption. CONCLUSIONS: Sugars overconsumption causes considerable public burdens, although the cost estimates do not include any informal expenditure. Information on these socioeconomic effects helps both health professionals and policy makers to create and to implement programs for reducing sugar consumption.