• Journal of Korean Society of Steel Construction
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• v.21 no.5
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• pp.493-503
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• 2009

Bridge redundancy is defined as the capability of a bridge to sustain loads after one of its main members incurs damage. It is affected by many parameters, including the number of girders, span length, girder height, internal supports, and secondary members. The present AASHTO and Korean Bridge design codes, however, define bridge redundancy only as the number of girders, and neither the evaluation method nor the required level of redundancy is given. This study presented a redundancy evaluation method for plate girder bridges with severe fatigue damage based on the reliability method,by considering the essential parameters. A required level of redundancy was also proposed as a target system reliability index from the load capacity analysis and reliability analysis of the basis bridge designed by LRFD. Finally, the level of redundancy of simple and continuous plate girder bridges with a variable number of girders designed by ASD was evaluated and presented.

• Journal of Korean Biological Nursing Science
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• v.2 no.1
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• pp.49-63
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• 2000

Aflatoxin $B_1(AFB_1)$ is a potent hepatotoxic and hepatocarcinogenic mycotoxin in human beings. It is accumulated in animal tissues and injured cell through variable metabolic pathway. This study was conducted to determine the effect of antioxidant vitamins on liver function enzymes and hepatic damage of $AFB_1$ treated mice. The 6 weeks old male ICR mice were randomly separated 6 groups, vehicle solvent or vitamin C(10 mg/kg/day) and vitamin E(63.8 mg/kg/day) were administered by intraperitoneal(i.p.) injection and 1 hr later, vehicle solution(DMSO) or $AFB_1$(0.4 mg/kg) were injected. The results obtained as follow ; The levels of liver function enzymes such as GOT, GPT, LDH, and alkaline phosphatase, in sera of mice were remarkably elevated by treatment with $AFB_1$ only. However, those enzymes were significantly alleviated by co-treatment with antioxidant vitamins(p<0.01). Especially the levels of LDH and ALK phosphatase were similar to those of control groups(p<0.01). The transmission electron microscopy(TEM) image of intracellular microrganelles on the liver cell of mice was also degenerated extremely by treatment with $AFB_1$, but vitamin C and vitamin E gave good effects on cellular deformation. The intracellular microrganelles such as mitochondria, endoplasmic reticulum, nucleus and nucleic membrane were nearly disappeared the cellular deformation by antioxidant vitamins co-administration. With above results, we could estimated that antioxidant vitamins blocked AFB1 induced hepatic cell damage.

• Archives of Plastic Surgery
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• v.44 no.4
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• pp.261-265
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• 2017

Periauricular paresthesia may afflict patients for a significant amount of time after facelift surgery. When performing face and neck lift surgery, temple and posterior auricular flap dissection is undertaken directly over the auriculotemporal, great auricular, and lesser occipital nerve territory, leading to potential damage to the nerve. The auriculotemporal nerve remains under the thin outer superficial fascia just below the subfollicular level in the prehelical area. To prevent damage to the auriculotemporal nerve and to protect the temporal hair follicle, the dissection plane should be kept just above the thin fascia covering the auriculotemporal nerve. Around the McKinney point, the adipose tissue covering the deep fascia is apt to be elevated from the deep fascia due to its denser fascial relationship with the skin, which leaves the great auricular nerve open to exposure. In order to prevent damage to the posterior branches of the great auricular nerve, the skin flap at the posterior auricular sulcus should be elevated above the auricularis posterior muscle. Fixating the superficial muscular aponeurotic system flap deeper and higher to the tympano-parotid fascia is recommended in order to avoid compromising the lobular branch of the great auricular nerve. The lesser occipital nerve (C2, C3) travels superficially at a proximal and variable level that makes it vulnerable to compromise in the mastoid dissection. Leaving the adipose tissue at the level of the deep fascia puts the branches of the great auricular nerve and lesser occipital nerve at less risk, and has been confirmed not to compromise either tissue perfusion or hair follicles.

• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.115-129
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• 1994

In the present study, quantitative and qualitative histology was used to assess the effects of ibuprofen suppositories with various treatments on the rectal mucosa of rats. Two suppositories were prepared with Witepsol W35 and compared with two commercial ibuprofen suppositories Reference I (Showa Pharm.ind., Tokyo, Japan), Reference II (P.Pharm., Seoul, Korea). Single and multiple dose(dosing interval 4 hr, n=4) studies were conducted. All suppositories significantly increased epithelial cell loss, but the extent of rectal irritation was variable. These studies showed that the incorporation of ibuprofen into the suppository bases increases the morphological change in rectal tissue both for the single and multiple administrations of suppositories, but which was significantly recovered within 24 hr although the interanimal variability in scores was very substantial. Multiple administration of ibuprofen suppositories caused significant damage to rectal mucosa, but it must be considered that these were under the severe condition, that is, interval of administration (4 hr) was three times shorter than normal interval of administration and dose was fifteen times larger than usual human dose. Aluminum oxide $(Al_2O_3)$, a dispersing agent, slightly increased the irritation of rectal mucosa in rats at 5 hr and 24 hr after multiple administration, but it was possible to ignore the difference of irritation in the data at 5hr and 24hr after single administration. Finally, it was concluded that Witepsol W35 and ibuprofen had a slight rectal mucosa-irritating effect on the usual human dose, and ibuprofen suppositories prepared with Witepsol W35 or Witepsol W35, $Al_2O_3$ showed almost similar extent of rectal irritation with commercial ibuprofen products.

• Archives of Pharmacal Research
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• v.16 no.4
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• pp.259-264
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• 1993

Three cell lines, CHO, L929 and B16 which are non-tumorigenic and cancer cells, respectively, were first tested for their survival in the presence of radioprotective ginseng protein fraction(GPF0. The influence of three radioprotectors-CPF, cysteamine, and 1-Methyl-2-bis[(2-methylthio)vinyl] quinolinium iodide (MVQI) on DNA repair capacity of UV damaged cells survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was also investigated by measuring $^3H$-thymidine incorporation of PUVA treated cells. In cell survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was not high enough to consider it as an antitumorigenic agent. Variable results were obtained in the effects on DNA repair capacity depending on the protectors and cell lines used. In pretreatment, the presence of GPF and MVOI brought about a sinificant increase in the capacity in both CHO and B16 cells. However, in L929, the enhancing effect was not shown. In all three cell lines, cysteamine showed lower repair capacity than control, suggesting the primary damage reduction in stronger enhancing effects in L929 and B16 cells, while it was weaker in CHO cells. Here also cystemine hsowed a very little or no increase in the capacity in all three cell lines. These results demonstrate that GPF has mild cytotoxicity in tumorignic cells and that GPF and MVQI enhance DNA repair capacity of UV damaged cells, whether they are tumorigenic or not. On the other hand, cysteamine shows only damage reduction effect. Celles of different genetic origin seem to give different responses to the modifier and different modifiers may possibly work by different mechanisms.

• Journal of the Korean Society of Safety
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• v.24 no.1
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• pp.31-36
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• 2009

This paper focuses on techniques of improving refinery reliability, availability, and profitability. Our team developed a corrosion control document(CCD) for processing of the crude distillation unit(CDU). Recent study shows the loss due to corrosion in US is around $276 billion. It's a big concern for both managers and engineers of refinery industry. The CCD consists of numerous parts namely damage mechanism(DM), design data, critical reliability variable(CRV), guidelines, etc. The first step in the development of CCD is to build material selection diagram(MSD). Damage mechanisms affecting equipments and process need to be chosen carefully based on API 571. The selected nine DM from API 571 are (1) creep/stress rupture, (2) fuel ash corrosion, (3) oxidation, (4) high temperature sulfidation, (5) naphthenic acid corrosion, (6) hydrochloric acid(HCL) corrosion, (7) ammonium chloride(salt) corrosion, (8) wet $H_2S$ corrosion, and (9) ammonia stress corrosion cracking. Each DM related to corrosion of CDU process was selected by design data, P&ID, PFD, corrosion loop, flow of process, equipment's history, and experience. Operating variables affecting severity of DM are selected in initial stage of CRV. We propose the guidelines for reliability of equipments based on CRV. The CCD has been developed on the basis of the corrosion control in refinery industry. It also improves the safety of refinery process and reduces the cost of corrosion greatly.

• Journal of KSNVE
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• v.10 no.1
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• pp.41-48
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• 2000

Evaluation model for damage consciousness was established through the survey of 2,210 residents' consciousness on aircraft noise near Taegu Airport. There were none who replied that the level of the aircraft noise was as los as it was quiet. 77(3.5%) people replied the noise was normal, and 2,133(95.5%) people said it was noisy. As to the period of time when the aircraft noise occurred, 51%, 97%, 86%, 0.6% of the residents pointed out the morning time, the day time, the evening time, and the night time, respectively. Because of aircraft noise, 73%, 88%, 70%, 77%, 78%, and 33% of the residents felt it disturbing indoor conversation, telephoning, watching TV or listening to the ratio, reading or meditating, working, sleeping, and studying, respectively. It was examined that the bad effects of aircraft noise on the health were severe : 43% of the resident said they experienced embarrassment. 52% astonishment, 66% absence of mind, 61% heart-beating. 77% headaches, 78% earache, and 93% displeasure. For the survey of the residents' damage consciousness about aircraft noise, the level of aircraft noise was set as an objective variable, and gender, age, occupation. Education, the type of house, the structure of windows, the consciousness of settlement in the district, and the period of residence were set as explanatory variables. And the quantification theory I was applied to the analysis. The most influencing factor of the damage consciousness on aircraft noise was the education, the second occupation, the third age, the forth the consciousness of settlement, the fifth the period of residence, the sixth gender, the seventh the type of house, and the least influencing factor among them was the structure of windows. These findings will be a useful guideline when the government seeks to set up policies which will help solve the resident's noise problems near Taegu Airport.

• Journal of Ocean Engineering and Technology
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• v.33 no.5
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• pp.435-446
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• 2019

Because offshore structures are affected by various environmental loads, the risk of damage is high. As a result of ever-changing ocean environmental loads, damage to offshore structures is expected to differ from year to year. However, in previous studies, it was assumed that a relatively short period of load acts repeatedly during the design life of a structure. In this study, the residual life of an offshore wind turbine support structure was evaluated in consideration of the timing uncertainty of the ocean environmental load. Sampling points for the wind velocity, wave height, and wave period were generated using a central composites design, and a transfer function was constructed from the numerical analysis results. A simulation was performed using the joint probability model of ocean environmental loads. The stress time history was calculated by entering the load samples generated by the simulation into the transfer function. The damage to the structure was calculated using the rain-flow counting method, Goodman equation, Miner's rule, and S-N curve. The results confirmed that the wind speed generated at a specific time could not represent the wind speed that could occur during the design life of the structure.

• Health Policy and Management
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• v.32 no.3
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• pp.293-303
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• 2022

Background: Coronavirus disease 2019 (COVID-19), which has occurred since the end of 2019, has caused tremendous damage not only in terms of disease and death but also in terms of economy. Accordingly, governments implemented health and quarantine policies to prevent the transmission and spread of COVID-19 and minimize economic effects, and implemented various countermeasures to reduce social and economic damage. However, the damage varies from country to country, and there are differences in the response of each government. Methods: Using 2020 data from the Organization for Economic Cooperation and Development countries, the effectiveness of governments' quarantine and economic policies in response to COVID-19 was calculated, and what factors determine the effectiveness were analyzed. While most of the previous studies analyzed the relationship between the government's quarantine policy and corona transmission and death, this study is characterized by considering the economic aspect in addition. Results: As a result of the analysis, the following results were obtained. First, when economic aspects are not considered, Asian and European countries have similar levels of efficiency, but when economic aspects are taken into account, Asian countries have higher efficiency. Second, population density had a negative effect on the efficiency of each country's policy, and long-term orientation was found to have an important impact when considering the economic aspect. Conclusion: We found that the governance index is an important variable influencing the efficiency, which shows that the effectiveness of government policies in response to the coronavirus depends heavily on the trust relationship between the government and the people.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.10a
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• pp.433-436
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• 2009

This study is concerned with an effect of frictional condition in a forward/backward combined extrusion process. Generally, the material flow of the billet is influenced by the corners of the die cavity, the ratio in reduction in area, and thickness ratio of backward can thickness to forward can thickness. In addition, the frictional condition in contact area between the billet and the punch/die also affect the material flow. This paper investigated the effect of frictional condition for variable friction factors. The FEM simulation has been carried out in order to examine the effect of frictional condition. Deformation patterns and flow characteristics were examined in terms of design parameters such as extruded length ratio etc. Die pressure exerted on the die-workpiece interface is calculated by the simulation results and analyzed for safe tooling. Therefore the numerical simulation works provide a combined extrusion process of stable cold forging process planning to avoid the severe damage on the tool.