• BMB Reports
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• 제53권6호
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• pp.299-310
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• 2020

Chronic liver disease progresses through several stages, fatty liver, steatohepatitis, cirrhosis, and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since a large proportion of patients with HCC are accompanied by cirrhosis, it is considered to be an important factor in the diagnosis of liver cancer. This is because cirrhosis leads to an irreversible harmful effect, but the early stages of chronic liver disease could be reversed to a healthy state. Therefore, the discovery of biomarkers that could identify the early stages of chronic liver disease is important to prevent serious liver damage. Biomarker discovery at liver cancer and cirrhosis has enhanced the development of sequencing technology. Next generation sequencing (NGS) is one of the representative technical innovations in the biological field in the recent decades and it is the most important thing to design for research on what type of sequencing methods are suitable and how to handle the analysis steps for data integration. In this review, we comprehensively summarized NGS techniques for identifying genome, transcriptome, DNA methylome and 3D/4D chromatin structure, and introduced framework of processing data set and integrating multi-omics data for uncovering biomarkers.

• Nutrition Research and Practice
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• 제16권4호
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• pp.464-475
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• 2022

BACKGROUND/OBJECTIVES: Increased levels of uremic toxins and decreased antioxidant capacity have a significant impact on the progression of chronic kidney disease (CKD). However, it remains unclear whether they interact with each other to mediate the damage of kidney function. The purpose of this study was to investigate whether uremic toxins (i.e., homocysteine and indoxyl sulfate [IS]), as well as glutathione-dependent antioxidant enzyme activities are dependently or independently associated with kidney function during different stages of CKD patients. SUBJECTS/METHODS: One hundred thirty-two patients diagnosed with CKD at stages 1 to 5 participated in this cross-sectional study. RESULTS: Patients who had reached an advanced CKD stage experienced an increase in plasma uremic toxin levels, along with decreased glutathione peroxidase (GSH-Px) activity. Plasma homocysteine, cysteine, and IS concentrations were all positively associated with each other, but negatively correlated to GSH-Px activity levels after adjusting for potential confounders in all CKD patients. Although plasma homocysteine, cysteine, IS, and GSH-Px levels were significantly associated with kidney function, only plasma IS levels still had a significant association with kidney function after these parameters were simultaneously adjusted. In addition, plasma IS could interact with GSH-Px activity to be associated with kidney function. CONCLUSIONS: IS plays a more dominant role than homocysteine and GSH-Px activity in relation to kidney function.

• 한국ITS학회 논문지
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• 제19권2호
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• pp.89-103
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• 2020

고령화 사회에 접어들면서 거동이 어려운 장애인과 고령자의 개인 교통수단에 대한 수요가 증가하고 있다. 실제로 2017년 기준 전국 전동보장구 보급수는 9만여 대로 지속해서 증가하는 추세다. 하지만 장애인 및 고령자의 판단 능력과 조정 능력은 정상인보다 상대적으로 차이가 있는 관계로 주행 중 사고 발생의 가능성이 크다. 다양한 사고의 원인 중 하나는 도로 노면상태의 불균형으로 인해 개인 이동 수단 조향 제어의 간섭이다. 본 논문에서는 이 같은 사고를 예방하고자 도로 노면 상태를 고속으로 인지할 수 있는 암호화 형식 의미론적 분할 알고리즘을 소개한다. 이를 위하여 도로 노면 파손이 포함된 1,500여 장의 학습용 데이터와 150여 장의 테스트용 데이터를 새롭게 구성하였다. 그리고 이를 활용하여 기존의 Encoder와 Decoder 단계로 구성된 Auto-encoder 방식과 달리 Encoder 단계로 이루어진 심층 신경망을 제안하였다. 이 심층 신경망은 기존의 방식과 비교했을 때 평균 정확도(Mean Accuracy)는 4.45% 증가하였고 파라미터는 59.2% 감소하였으며 연산 속도는 11.9% 향상되었다. 이 같은 고속 알고리즘을 활용하여 안전한 개인 이동 수단이 확대 적용되길 기대한다.

• 문화기술의 융합
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• 제7권1호
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• pp.570-575
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• 2021

인간은 오감을 풍요롭게 느끼면서 생활하기 때문에 인간의 행복한 삶을 영위하기 위해서는 청력이 손상되지 않도록 주의하여야 한다. 생활환경에서 입게 되는 청력손상은 특정 주파수대역이 먼저 손상되는 부분대역에서 청력손상이 일반적이다. 그러나 청력손상의 초기 통증이 별로 나타나지 않아서 그 증세를 초기단계에는 알아내기가 어렵다. 본 연구에서는 간단한 어플 등을 통해 손쉽고 빠르게 청력손상을 자가 측정할 수 있는 고속 측정법을 제안하였다. 이 방법은 voice soub-band별 이득 보상된 pure tone 9개를 번갈아 양쪽 귀에 들려줌으로써 자신의 청력손상을 스스로 고속 판별하게 된다. 1인당 27초 동안 18번의 톤 펄스를 들려주었을 때, 12명의 피험자들 중에서 1명이 부분청력손상 의심자로 확인되었다. 그리고 피험자들에게 들린 횟수 청력판별법을 알려주니, 실험참가자들 스스로가 자신의 청력손상여부를 바로 판별해 내었다. 이러한 측정방법은 스마트 폰으로 27초 내에 양쪽 귀의 청력을 간단히 판단함으로서 병원에서는 10분 이상 소요되었던 청력측정이 비교적 정확하게 이루어져서, 시간과 비용을 줄이면서 청력건강을 유지할 수 있음을 파악하였다.

• 한국구조물진단유지관리공학회 논문집
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• 제10권4호
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• pp.135-144
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• 2006

지진에 대한 구조물의 특성, 지반과의 상호작용, 현장 조건 등의 예측에 다수의 불확실성이 존재하는 경우 그 취약성 또는 손상도를 평가하는 방법이 필요하다. 본 연구에서는 범용구조해석 프로그램과 일반적인 확률밀도함수를 사용하여 면진 콘크리트 교량의 손상도 곡선을 구하는 방법을 제시하였으며, 제시된 방법을 교량에 적용하여 교량의 손상도를 평가하였다. 손상도 곡선을 작성하는 데에는 2변수를 갖는 대수정규분포를 사용하였으며, 지진의 여러 특성인 최대지반가속도(PGA), 최대지반속도(PGV), 스펙트럼가속도(SA), 스펙트럼속도(SV), 스펙트럼강도(SI) 등에 대해 납 면진받침(LRB)이 설치된 면진교량의 손상도 곡선을 구하였다. 또한 손상도 곡선의 합성 방법을 사용하여 합성된 면진교량의 손상도 곡선을 유도하였다.

• 콘크리트학회지
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• 제6권5호
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• pp.183-192
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• 1994

지진하중을 받는 철근콘크리트 구조물의 안전성은 확정적 이론에 의한 평가보다 지진하중이 가지는 불확실성과 철근콘크리트의 이력특성을 고려하여 평가하는 것이 합리적이다. 확정적 이론에 의한 내진 구조물의 안전성 평가는 확률변수의 영향 등을 충분히 고려하기가 쉽지 않은데, 이러한 것들을 고려하기 위해서는 신뢰성이론 및 랜덤진동이론을 도입할 필요가 있으며 이에 의해 합리적으로 안전성을 검토하거나 확보할 수 있다. 본 연구에서는 철근콘크리트 뼈대구조물의 이력거동을 고려한 추계적 지진응답을 이용하여 지진손상정도와 위험성을 평가하고자 하였으며, 지진하중을 받는 뼈대구조물의 파괴확률을 계산하는 과정을 제시하였다.

• Earthquakes and Structures
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• 제10권4호
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• pp.867-891
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• 2016

This paper addresses numerically the behavior of steel structures under Fire-after-Earthquake (FAE) loading. The study is focused on a four-storey library building and takes into account the damage that is induced in structural members due to earthquake. The basic objective is the assessment of both the fire-behavior and the fire-resistance of the structure in the case where the structure is damaged due to earthquake. The combined FAE scenarios involve two different stages: during the first stage, the structure is subjected to the ground motion record, while in the second stage the fire occurs. Different time-acceleration records are examined, each scaled to multiple levels of the Peak Ground Acceleration (PGA) in order to represent more severe earthquakes with lower probability of occurrence. In order to study in a systematic manner the behavior of the structure for the various FAE scenarios, a two-dimensional beam finite element model is developed, using the non-linear finite element analysis code MSC-MARC. The fire resistance of the structure is determined using rotational limits based on the ductility of structural members that are subjected to fire. These limits are temperature dependent and take into account the level of the structural damage at the end of the earthquake and the effect of geometric initial imperfections of structural members.

• International journal of advanced smart convergence
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• 제9권3호
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• pp.227-231
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• 2020

Recently, the importance of user experience (UX) has been rapidly increasing. Its utilization is emphasized for development of systems, products, and services. User experience is widely used across industries including services, products, processes, society, and culture. Therefore, if it is unsatisfactory, it is likely to have a direct negative impact on the corresponding system, product, or service. The failure to analyze user experience causes significant damage to the project, which may lead to its failure or redevelopment; it is hence necessary to prioritize the verification of UX in the earliest stages of development. The requirements development stage, which is a preceding stage, is an appropriate stage for the verification of user experience because the identification of user needs is completed and prototypes can be implemented. In this paper, we proposed a systematic requirements development stage; it adds user experience verification activities to the requirements development stage, using the Honeycomb model, which is a widely used tool for verifying the overall UX. User experience verification was added to the existing requirements development activities, which consisted of three steps: model definition and requirements placement, discussions between external and internal stakeholders, and review by internal stakeholders. By easily validating the user experience through this systematic requirements development stage, we expect to minimize the damage to the project due to the failure of the user experience analysis and increase the possibility of success.

• 한국환경과학회지
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• 제15권11호
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• pp.1003-1010
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• 2006

It is very difficult to forecast accurately a damage from the natural disasters which occurs frequently. If the significant weather event was forecasted one or two days ago, we will be able to minimize a damage from the severe weather event through the suitable prevention activities. It said that 2000's our country's total damages from the meteorological disasters was several trillion won(Park et al, a, b, 2005). Therefore, we analyzed the Korea Meteorological Administration(KMA) and television broadcasting's reports, information contents, and transmission system, an ex post facto valuation about typhoon Nabi which struck the Korean peninsula from September 5 to 7, 2005. Through these investigations, we want to present the basic data to rises the application effect of disaster prevention meteorological information. We think KMA must present many information report to promote a citizen's understanding about the meteorological information and the serious disaster situation. And also we think the KMA and television broadcasting must present an advisable reports, the contents which is suitable to disaster response stages. And we must grasp the problem of disaster prevention meteorological information through an ex post facto examination, improve it effectively.

• 한국전문물리치료학회지
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• 제22권3호
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• pp.98-105
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• 2015

Muscular dystrophy is a hereditary musculoskeletal disorder caused by a mutation in the dystrophin gene. Duchenne muscular dystrophy (DMD) is one of the most common, and progresses relatively faster than other muscular dystrophies. It is characterized by progressive myofiber degeneration, muscle weakness and ultimately ambulatory loss. Since it is an X-linked recessive inheritance, DMD is mostly expressed in males and rarely expressed or less severe in females. The most effective measurement tool for DMD is magnetic resonance imaging (MRI), which allows non-invasive examination of longitudinal measurement. It can detect progressive decline of skeletal muscle size by measuring a maximal cross-sectional area of skeletal muscle. Additionally, other techniques in MRI, like $T_2$-weighted imaging, assess muscle damage, including inflammation, by detecting changes in $T_2$ relaxation time. Current MRI techniques even allow quantification of metabolic differences between affected and non-affected muscles in DMD. There is no current cure, but physical therapist can improve their quality of life by maintaining muscle strength and function, especially if treatment (and other forms of medical intervention) begins in the early stages of the disease.