• Journal of the Korean Society of Radiology
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• v.11 no.3
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• pp.147-151
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• 2017

Potentially lethal damage repair (PLDR) in HFL-I was investigated by delayed plating experiments. The surviving fraction data were fitted to the linear Quadratic equation ($LogSn=-n{\gamma}({\alpha}d+{\beta}d^2$) where ${\gamma}=1$ for immediate plating). And a repair factor ${\gamma}$ was developed to compare survival for immediate and delayed plating. When we only took into account the repair factor of PLDR ${\gamma}$ which was derived from the delay assay, the cell survival response th fractionated carbon ion irradiation was not fully matched. This gap suggested that consideration of another repair process is necessary. So this suggests that the various repair process plays an important role in the fractionated irradiations.

• Elastomers and Composites
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• v.47 no.3
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• pp.194-200
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• 2012

Rubber components have been widely used in automotive industry as anti-vibration components for many years. These subjected to fluctuating loads, often fail due to the nucleation and growth of defects or cracks. To prevent such failures, it is necessary to understand the fatigue failure mechanism for rubber materials and to evaluate the fatigue life for rubber components. The objective of this study is to develop the durability analysis process for vulcanized rubber components, which is applicable to predict fatigue life at initial product design step. The determination method of nonlinear material constants for FE analysis was proposed. In order to investigate the applicability of the commonly used damage parameters, fatigue tests and corresponding finite element analyses were carried out and strain energy density was proposed as the fatigue damage parameter for rubber components. The fatigue analysis for automotive rubber components was performed and the durability analysis process was reviewed.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.9 no.1
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• pp.25-34
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• 2010

Fretting damage reduces fatigue life of the material due to low amplitude cyclic sliding and changes in the contact surfaces of strongly connected machine and structures such as bolt, key, fixed rivet and connected shaft, which have relative slip of repeatedly very low frequency amplitude. In this study, the fretting fatigue behavior of 7050-T7451 aluminum alloys used mainly in aircraft and automobile industry were evaluated. The plain fatigue test and fretting fatigue test under cyclic bending load carried out commercial bending fatigue tester and specially devised equipments to cause fretting damage. From these experimental work, the following results obtained: (1) The plain fatigue limit for stress ratio R=-l was about 151MPa. (2) In case of fretting fatigue, fatigue limit for stress ratio R=-l about 72MPa, the fatigue limit for R=0 about 81MPa, and the fatigue limit for R=0.3 about 93MPa. (3) The fatigue limit reduction rates by the fretting damage were about 52%(R=-1), 46%(R=0) and 38%(R=0.3) respectively. (4) The fatigue limit reduction rate decreased with stress ratio increase. In fretting bending test, as stress ratio increased, occurrence of initial oblique crack by fretting decreased or phased out, so that fracture surfaces were formed by plain fatigue crack occurrence, and such tendency was notable as stress amplitude increased. (5) Tire tracks and rubbed scars were observed in the fracture surface and contacted surface.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.15 no.4
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• pp.319-324
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• 2002

In this study, the reduce of plasma etching damage in PZT thin film with addictive gas and re-annealing after etching have been investigated. The PZT thin films were etched as a function of $Cl_2/CF_4$ with addition of Ar and $O_2$ with inductively coupled plasma. The etch rates of PZT thin films were 1450 ${\AA}/min$ at 30% additive Ar and 1100 ${\AA}/min$ at 10% auditive $O_2$ into $Cl_2/CF_4$ gas mixing ratio of 8/2. In order to reduce plasma damage of PZT thin films after etching, the etched PZT thin films were re-annealed at various temperatures at $O_2$ atmosphere. From the hysteresis curries, the ferroelectric properties are improved by $O_2$ re-annealing process. The improvement of ferroelectric behavior at annealed PZT films is consistent wish the increase of the (100) and (200) PZT peaks revealed by x-ray diffraction (XRD). From x ray photoelectron spectroscopy (XPS) analysis, the intensity of Pb-O, Zr-O and Ti-O peak are increased and the chemical residue peak is reduced by $O_2$ re-annealing. The ferroelectric behavior consistent with the dielectric nature of $Ti_xO_y$ is recovered by $O_2$ recombination during rapid thermal annealing process.

• Journal of Animal Reproduction and Biotechnology
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• v.35 no.1
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• pp.58-64
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• 2020

This present study was conducted to investigate protective effect of discontinuous Percoll gradient containing alpha-linolenic acid (ALA) before freezing process on viability, acrosome damage, mitochondrial activity, and oxidative stress of frozen-thawed boar spermatozoa. The separation of spermatozoa by discontinuous Percoll gradient was performed by different concentration of Percoll solution (45/90%) containing ALA combined with bovine serum albumin (BSA), and collected sperm in each Percoll layer was cryopreserved. To evaluate viability, acrosome damage, mitochondrial activity, and reactive oxygen species (ROS) level of frozen-thawed sperm, flow cytometry was used. Morphological abnormalities were observed under light microscope. In results, viability of sperm from 90% Percoll layer was higher than control and 45% Percoll group (p < 0.05). Separated sperm in 90% Percoll layer had lower acrosome damage and morphological abnormalities than control as well as viability, whereas 45% Percoll group was higher (p < 0.05). Similar with acrosome damage and abnormalities, mitochondrial activity was slightly enhanced and the population of live sperm with high ROS level was decreased by 90% Percoll separation, however, there was no significant difference. Supplementation of 3 ng/mL ALA into Percoll solution increased sperm viability and decreased population of live sperm with high ROS compared to control (p < 0.05). In conclusion, discontinuous Percoll gradient before freezing process could improve efficiency of cryopreservation of boar sperm through selection of sperm with high freezing resistance, and supplement of ALA during Percoll gradient might contribute suppression of ROS generation via stabilizing of plasma membrane during cryopreservation.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.6
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• pp.745-752
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• 2018

ICs(Integrated circuits) for nuclear power plant exposed to radiation environment occur malfunctions and data errors by the TID(Total ionizing dose) effects among radiation-damage phenomenons. In order to protect ICs from the TID effects, this paper proposes a radiation-hardening of the logic circuit(D-latch) which used for the data synchronization and the clock division in the ICs design. The radiation-hardening technology in the logic device(NAND) that constitutes the proposed RH(Radiation-hardened) D-latch is structurally more advantageous than the conventional technologies in that it keeps the device characteristics of the commercial process. Because of this, the unit cell based design of the RH logic device is possible, which makes it easier to design RH ICs, including digital logic circuits, and reduce the time and cost required in RH circuit design. In this paper, we design and modeling the structure of RH D-latch based on commercial $0.35{\mu}m$ CMOS process using Silvaco's TCAD 3D tool. As a result of verifying the radiation characteristics by applying the radiation-damage M&S (Modeling&Simulation) technique, we have confirmed the radiation-damage of the standard D-latch and the RH performance of the proposed D-latch by the TID effects.

• Journal of Life Science
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• v.33 no.7
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• pp.586-592
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• 2023

Oxidative stress is a critical factor affecting the quality and viability of sperm during boar semen storage. Oxidative stress is also a significant concern during the process of freezing semen. The process of semen storage involves exposing the sperm to various stressors, including temperature changes, cryoprotectants, and extended periods of incubation. In addition, oxidative stress can lead to the production of reactive oxygen species (ROS) within the sperm, resulting in oxidative damage to cellular components, such as lipids, proteins, and DNA. Striking a balance between ROS production and the antioxidant defense system is crucial for maintaining sperm viability and functionality during semen storage. Moreover, the prolonged storage of boar semen leads to an increase in ROS levels, which can impair sperm motility, membrane integrity, and DNA integrity. ROS-induced lipid peroxidation affects the fluidity and stability of sperm membranes, leading to decreased sperm motility. Moreover, oxidative damage to the DNA can result in DNA fragmentation, compromising the genetic integrity of the sperm. In conclusion, oxidative stress is a significant challenge in maintaining sperm quality during boar semen storage. Understanding the mechanisms underlying oxidative stress and their impacts on sperm function is crucial for developing effective strategies to minimize oxidative damage and improve sperm storage outcomes.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.3
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• pp.237-248
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• 2016

As OPB and IPB moment-induced fatigue damage on mooring chain links were reported for a offloading buoy, verification of OPB and IPB fatigue has been a key engineering item in offshore structure mooring design. Mathematical and physical features of the conventional approach which was mainly explained in BV guideline are reviewed and disadvantages of the conventional approach are addressed in terms of stress proportionality and nonlinearity of OPB and IPB moments. In order to eradicate these disadvantages, a novel approach is newly proposed which is able to dispel apprehension on stress proportionality and is not dependent of nonlinearities of OPB and IPB moments. Significant differences between two approaches are suggested by comparing relations of OPB moment versus OPB interlink angle and IPB moment versus IPB interlink angle. For periodic OPB tension angle processes having three different OPB angle ranges with a simple irregular tension process, fatigue damage calculation reveals that OPB moment-induced fatigue damage has dominant portion to total fatigue damage. Comparative studies between two approaches also show that the conventional approach based on BV guideline predicts fatigue damage far conservatively since it assume unrealistic high stress concentration factor for tension load. Meanwhile IPB moment-induced fatigue damage is negligible compared to tension-induced fatigue damage.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.5
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• pp.343-348
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• 2009

53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage response proteins, including ${\gamma}$-H2AX, MDC1, and BRCA1. The recruitment of 53BP1 requires a tandem Tudor fold which associates with methylated histones H3 and H4. It has already been determined that the majority of DNA damage response proteins are phosphorylated by ATM and/or ATR after DNA damage, and then recruited to the break sites. 53BP1 is also phosphorylated at several sites, like other proteins after DNA damage, but this phosphorylation is not critically relevant to recruitment or repair processes. In this study, we evaluated the functions of phosphor-53BP1 and the role of the BRCT domain of 53BP1 in DNA repair. From our data, we were able to detect differences in the phosphorylation patterns in Ser25 and Ser1778 of 53BP1 after neocarzinostatin-induced DNA damage. Furthermore, the foci formation patterns in both phosphorylation sites of 53BP1 also evidenced sizeable differences following DNA damage. From our results, we concluded that each phosphoryaltion site of 53BP1 performs different roles, and Ser1778 is more important than Ser25 in the process of DNA repair.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.4 s.19
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• pp.95-105
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• 2005

Korea is located away from plate boundaries which are not safe from earthquakes. However, having witnessed the large-scale earthquake in the Tangshan region in 1976 deemed as a safe plate, it should not be assured that Korea is absolutely safe from earthquakes. In addition, many seismologists have claimed that there indeed is a high possibility of earthquakes above mid scale that would occur in Korea. Because it is impossible to prevent earthquake, studies on seismic design and earthquake disaster control system are widely being conducted. However, studies on early response to earthquakes or recovery process are still very limited, and only a few studies for establishing earthquake damage evaluation system are being conducted. Thus, this study aimed to present essential data for establishing earthquake damage evaluation system that takes into account the real situation of structures in Korea. In this study, a nonseimically reinforced concrete apartment structure in Gangnamgu was selected as an standard type of such structures and its earthquake damage was estimated. The result of damage evaluation based on the derivation of vulnerability function and realtive story displacement was compared to that abtained using HAZUS Program Vulnerability Function.