• 한국소음진동공학회논문집
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• 제18권3호
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• pp.323-334
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• 2008

According to the delivery condition, the breakage of a product occurs when it is delivered to the customers. Therefore product's makers evaluate the durability under the delivery process by accelerated life testing. In order to conduct this accelerated life testing accurately, it is very important to identify the acceleration-factor exactly between on-road and accelerated life test condition. In this paper, the acceleration-factor is identified by applying linear damage summation law, rain-flow cycle counting and Dirlik theory under the conditions of the random vibration. And approximated FEM model of the connecting-pipe to the compressor is developed for fatigue analysis. This model is finally verified by comparing the experiment results to the numerical analysis results.

• 한국항공우주학회지
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• 제47권1호
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• pp.35-40
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• 2019

본 연구의 목적은 항공기 구조개발에 널리 적용되고 있는 탄소섬유 복합재의 피로특성을 확인하고, 실기체 피로시험에 활용되고 있는 자료를 획득하는 것이다. 복합재 구조의 내구성 및 손상허용성의 평가는 주로 피로시험을 통하여 이루어지며, 실기체 피로시험에 적용되고 있는 파라미터에는 피로수명계수와 하중증대계수가 있다. 탄소섬유/에폭시 일방향 및 직물형 복합재로 시편을 제작하였으며, 응력비와 적층패턴을 달리하여 피로시험을 수행하였다. Sendeckyj 모델을 적용한 와이블 분포와 개별적인 피로수명에 대한 와이블 분포를 이용하여 형상 파라미터를 분석하였다. 또한 신뢰도를 고려한 피로수명계수와 하중증대계수를 평가하였다.

• 한국동물위생학회지
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• 제46권2호
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• pp.107-113
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• 2023

Tenebrio molitor, rich in protein, is used as an alternative protein source. Many studies have evaluated Tenebrio molitor larvae (TML) for anti-obesity effects, fatty liver relief, antithrombosis, and antioxidant effects. In this study, we prepared an experimental diet by adding Tenebrio molitor larvae oil (TMLO) to feed and administered it to adult male ICR mice for six weeks. The study assessed the weight gain of mice, prothrombin time (PT), activated partial thromboplastin time (aPTT), blood coagulation time, and the activities of coagulation factor VII and coagulation factor XII. The weight gain of mice was suppressed in the groups fed with TMLO, indicating a potential anti-obesity effect. The blood coagulation time was delayed in the TMLO-fed groups, as evidenced by amplified PT and aPTT values. Furthermore, the activities of coagulation factor VII and coagulation factor XII were diminished in the TMLO-treated groups, indicating a potential thrombosis relieving effect. The concentrations of thromboxane B2 and serotonin declined in the TMLO-fed groups, signifying potential blood circulation effects. Finally, blood triglyceride and LDL-cholesterol concentrations were reduced in the TMLO-fed groups. In summary, TMLO supplementation may have an inhibitory effect on liver damage and blood clot formation caused by obesity.

• Fisheries and Aquatic Sciences
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• 제26권1호
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• pp.35-47
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• 2023

Myelophycus caespitosus, a brown alga belonging to genus Myelophycus, has been traditionally used as a food and medicinal resource in Northeastern Asia. However, few studies have been conducted on its pharmacological activity. In this study, we evaluated whether methanol extract of M. caespitosus (MEMC) could protect against oxidative damage caused by hydrogen peroxide (H₂O₂) in C2C12 murine myoblasts. Our results revealed that MEMC could suppress H₂O₂-induced growth inhibition and DNA damage while blocking the production of reactive oxygen species. In H₂O₂-treated cells, cell cycle progression was halted at the G2/M phase, accompanied by changes in expression of key cell cycle regulators. However, these effects were attenuated by MEMC. In addition, we found that MEMC protected cells from induction of apoptosis associated with mitochondrial impairment caused by H₂O₂ treatment. Furthermore, MEMC enhanced the phosphorylation of nuclear factor-erythroid-2 related factor 2 (Nrf2) and expression and activity of heme oxygenase-1 (HO-1) in H₂O₂-treaetd C2C12 myoblasts. However, such anti-apoptotic and cytoprotective effects of MEMC were greatly abolished by HO-1 inhibitor, suggesting that MEMC could increase Nrf2-mediated activity of HO-1 to protect C2C12 myoblasts from oxidative stress.

• 한국환경성돌연변이발암원학회지
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• 제22권2호
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• pp.83-89
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• 2002

The single cell gel electrophoresis (comet) assay is one of the useful tools for the study of genetic damage in humans exposed to environmental mutagens and carcinogens. This study was undertaken to evaluate the status of DNA damage in peripheral lymphocytes depending on their sex, age, smoking habits, and other factors in normal healthy Korean population. The 99 volunteers included in the study and out of these, 36 volunteers were smoker and 63 volunteers were non-smoker aged between 20-59 years. All individual answered a questionnaire that assessed their general information including smoking habits and the extent of the environmental tobacco smoke (ETS) exposure, and blood samples were obtained. There was a statistically significant difference in the extent of DNA damage between smoker and non-smoker (p<0.001). A significant difference was also observed between male and female (p<0.001) and amongst the different group of age (p<0.005), however, correlation analysis showed that only smoking habit was a significant factor for DNA damage. No significant effect of smoking duration, number of cigarettes smoking a day, SPY (smoke pack years) in smokers and environmental tobacco smoke exposure in non-smokers on the status of DNA damage was observed.

• 한국안전학회지
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• 제31권2호
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• pp.119-126
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• 2016

Across the world, the industrialization has increased the frequency of climate anomaly. The size of damage due to recent natural disasters is growing large and fast, and the human damage and economic loss due to disasters are consistently increasing. Urbanization has a structure vulnerable to natural disasters. Therefore, in order to reduce damage from natural disasters, both hardware and software approaches should be utilized. Currently, however, the development of a statistical access process for 'analysis of disaster occurrence factor' and 'prediction of damage costs' for disaster prevention and overall disaster management is inadequate. In case of local governments, overall disaster management system is not established, or even if it is established, unscientific classification system and management lead to low utility of natural statistics of disaster year book. Therefore, in order to minimize disaster damage and for rational disaster management, the disaster damage survey process should be improved. This study selected gale as the focused analysis target among natural disasters recorded in disaster year book such as storm, torrential rain, gale, high seas, and heavy snow, and analyzed disaster survey process. Based on disaster year book, the gale damage size was analyzed and the issues occurring from the correlation of gale and damage amount were examined, so as to suggest an improvement plan for reliable natural disaster information collection and systematic natural disaster damage survey.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.1409-1416
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• 2010

It is essential to predict a blasting-induced excavation damage zone (EDZ) beyond the proposed excavation line of a tunnel because the unwanted damage area requires extra support system for tunnel safety. Complicated blasting process which may hinder a proper characterization of the damage zone can be effectively represented by two loading mechanisms. The one is a dynamic impulsive load generating stress waves outwards immediately after detonation. The other is a gas pressure that remains for a relatively long time. Since the gas pressure reopens up the arrested cracks and continues to extend some cracks, it contributes to the final formation of EDZ induced by blasting. This paper presents the simple method to evaluate EDZ induced by gas pressure during blasting in rock. The EDZ is characterized by analyzing crack propagation from the blasthole. To do this, a model of the blasthole with a number of radial cracks of equal length in an infinite elastic plane is considered. In this model, the crack propagation is simulated by using three conditions, the crack propagation criterion, the mass conservation of the gas, and the adiabatic condition. As a result, the stress intensity factor of the crack generally decreases as crack propagates from the blasthole so that the length of the crack is determined. In addition, the effect of rock properties, initial number of cracks, and the adiabatic exponent are investigated.

• Journal of Ginseng Research
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• 제47권2호
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• pp.311-318
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• 2023

Background: The beneficial effects of compound K (CK) on different chronic diseases have been shown to be at least related to antioxidant action. Nevertheless, since its antioxidant activity in human retinal pigment epithelial (RPE) cells is still unknown, here we investigated whether CK alleviates oxidative stress-stimulated damage in RPE ARPE-19 cells. Methods: The cytoprotective consequence of CK in hydrogen peroxide (H₂O₂)-treated cells was evaluated by cell viability, DNA damage, and apoptosis assays. Fluorescence analysis and immunoblotting were performed to investigate the inhibitory action of CK on reactive oxygen species (ROS) production and mitochondrial dysfunction. Results: H₂O₂-promoted cytotoxicity, oxidative stress, DNA damage, mitochondrial impairment, and apoptosis were significantly attenuated by CK in ARPE-19 cells. Furthermore, nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation level and its shuttling to the nucleus were increased, which was correlated with upregulated activation of heme oxygenase-1 (HO-1). However, zinc protoporphyrin, a blocker of HO-1, significantly abrogated the preventive action of CK in H₂O₂-treated ARPE-19 cells. Conclusion: This study indicates that activation of Nrf2/HO-1 signaling by CK plays an important role in rescuing ARPE-19 cells from oxidative cellular damage.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1992년도 가을 학술발표회 논문집
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• pp.240-244
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• 1992

The values of a linguistic variable are words, phrases, or sentences in a given language. For example, structural damage can be considered as linguistic variable with values such a 'severely damaged', 'moderately damaged', which are meaningful classifications but not clearly defined, This paper is to evaluate reasonably the correction factor of bridge capacity with the aid of fuzzy sets theory. By using the above mentioned fuzzy measure, the concept of fuzzy integral and linear membership function can be defined. It is concluded that the fuzzy sets theory cam be applied to determine reasonably the correction factor of bridge capacity.

• Structural Engineering and Mechanics
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• 제22권3호
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• pp.351-370
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• 2006

In this study, the earthquake damage response of the concrete arch dams was investigated including dam-reservoir interaction. A continuum damage model which is a second-order tensor and includes the strain softening behavior was selected for the concrete material. Fluid-structure interaction problem was modeled by Lagrangian approach. Sommerfeld radiation condition was applied to the truncated boundary of reservoir. The improved form of the HHT-${\alpha}$ time integration algorithm was used in the solution of the equations of motion. The arch dam Type 5 was selected for numerical application. For the dynamic input, acceleration records of the 10 December 1967 Koyna earthquake were chosen. These records were scaled with earthquake acceleration scale factor (EASF) and then used in the analyses. Solutions were obtained for empty and full reservoir cases. The effects of EASF and damping ratio on the response of the dam were studied.