• Journal of Microbiology and Biotechnology
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• v.33 no.5
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• pp.634-643
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• 2023

Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chain-enhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.153-153
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• 2021

Storm Storm event is one of major issues in South Korea due to devastating damage at its landfall. A series of statistical study on the historical typhoon records consistently insist that the typhoon translation speed (TS) is on slowdown trend annually, and thus provides an urgent topic in assessing the extreme storm surge under future climate change. Even though TS has been regarded as a principal contributor in storm surge dynamics, only a few studies have considered its impact on the storm surge. The landfall angle (LA), another key physical factor of storm surge also needs to be further investigated along with TS. This study aims to elucidate the interaction mechanism among TS, LA, coastal geometry, and storm surge synthetically by performing a series of simulations on the idealized geometries using Delft3D FM. In the simulation, various typhoons are set up according to different combinations of TS and LA, while their trajectories are assumed to be straight with the constant wind speed and the central pressure. Then, typhoons are subjected to make landfall over a set of idealized geometries that have different depth profiles and layouts (i.e., open coasts or bays). The simulation results show that: (i) For the open coasts, the maximum surge height (MSH) increases with increasing TS. (ii) For the constant bed level, a typhoon normal to the coastline resulted in peak MSH due to the lowest effect of the coastal wave. (iii) For the continental shelf with different widths, the slow-moving typhoon will generate the peak MSH around a small LA as the shelf width becomes narrow. (iv) For the bay, MSH enlarges with the ratio of L/E (the length of main-bay axis /gate size) dropping, while the greatest MSH is at L/E=1. These findings suggest that a fast-moving typhoon perpendicular to the coastline over a broad continental shelf will likely generate the extreme storm surge hazard in the future, as well as the slow-moving typhoon will make an acute landfall over a narrow continental shelf.

• Steel and Composite Structures
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• v.44 no.4
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• pp.503-517
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• 2022

This paper presents the mechanical buckling of bi-directional functionally graded sandwich beams (BFGSW) with various boundary conditions employing a quasi-3D beam theory, including an integral term in the displacement field, which reduces the number of unknowns and governing equations. The beams are composed of three layers. The core is made from two constituents and varies across the thickness; however, the covering layers of the beams are made of bidirectional functionally graded material (BFGSW) and vary smoothly along the beam length and thickness directions. The power gradation model is considered to estimate the variation of material properties. The used formulation reflects the transverse shear effect and uses only three variables without including the correction factor used in the first shear deformation theory (FSDT) proposed by Timoshenko. The principle of virtual forces is used to obtain stability equations. Moreover, the impacts of the control of the power-law index, layer thickness ratio, length-to-depth ratio, and boundary conditions on buckling response are demonstrated. Our contribution in the present work is applying an analytical solution to investigate the stability behavior of bidirectional FG sandwich beams under various boundary conditions.

• Korean Journal of Exercise Nutrition
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• v.23 no.4
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• pp.14-22
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• 2019

[Purpose] Here, we aimed to determine the effect of Polygonum cuspidatum stem extract (PSE) on exorbital lacrimal gland-excised rat models and hyperosmotic stress-stimulated human conjunctival cells (HCCs). [Methods] Seven week old male Wistar rats were divided into six groups. Only the rats in the control group (NOR, n=5) did not undergo surgery. Three days after the surgery, the exorbital lacrimal gland-excised rats were randomly allocated to five groups: (1) vehicle-treated dry-eyed rats (DED, n=5); (2) PSE (10 mg/kg) treated DED rats (PSE-10, n=5); (3) PSE (100 mg/kg) treated DED rats (PSE-100, n=5); and (4) PSE (250 mg/kg) treated DED rats (PSE-250, n=5). In addition, the HCC line was co-treated with hyperosmolar media (528 mOsm) and PSE (1-100 μg/ml). [Results] PSE treatment restored the tear volume and goblet cell density by inhibiting severe corneal irregularities and damage. The treatment with PSE significantly attenuated the hyperosmolar stress-induced inflammation and cell death through the suppression of mRNA expression levels of Tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), and Interferon-γ (IFN-γ), and the expression of Bcl-2-associated X protein (Bax) as well as the activation of caspase-3 in vitro. [Conclusion] The inhibitory effects of PSE treatment on dry eye disease indicate the potential of nutritional intervention by PES against inflammatory diseases without adverse effects.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.168-168
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• 2022

According to the 5th Climate Change Report, global average temperature in 2081~2100 will increase 1.8℃ based on RCP 4.5 and 3.7℃ based on RCP 8.5 from the current climate value (IPCC Working Group I AR5). As temperature is expected to increase due to global warming and the intensity and frequency of rainfall are expected to increase, damage to crops is expected, and countermeasures must be taken. This study intends to evaluate rice growth in terms of nitrogen utilization efficiency according to future climate change conditions. In this experiment, Oryza sativa cv. Shindongjin were planted at the SPAR facility of the NICS in Wanju-gun, Jeollabuk-do on June 10, and were planted and grown according to the standard cultivation method. Cultivation conditions are high temperature, high CO₂ (current temperature+4.7℃·CO₂ 800ppm), high temperature (current temperature+4.7℃·CO₂ 400ppm), current climate (current tempreture·CO₂ 400 ppm). Nitrogen was varied as 0, 9, 18 kg/10a. The N content and C/N ratio of all rice leaves, stems, and seeds increased at high temperature, and the N content and C/N ratio decreased under high temperature and high CO₂ conditions com pared to high temperature. Compared to the current climate, NUE increases by about 8% under high temperature and high CO₂ conditions and by about 2% under high temperature conditions. This seems to be because the increase in temperature and CO₂ induced the increase in biomass. ANUE related to yield decreased by about 70% compared to the current climate under high temperature conditions, and decreased by about 45% at high temperature and high CO₂, showing a tendency to decrease compared to high temperature. This appears to be due to reduced fertility and poor ripening due to high temperature stress. However, as the nitrogen increased, the number of ears and the number of grains increased, slightly offsetting the production reduction factor.

• Journal of the Korea Fashion and Costume Design Association
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• v.25 no.3
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• pp.1-16
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• 2023

The purposes of this study were to investigate bag purchasing behaviors and design preferences of male and female adult consumers, and to find the differences depending on sex and age variable. A survey was conducted on 400 male and female adults from 20s to 50s. The questionnaire consisted of bag purchase behaviors, bag design preferences, and the subjects' demographic characteristics. The data were analyzed by Cronbach's α, factor analysis, x² test and t-test using SPSS. The results were as follows. First, as bag selection criteria, four factors (practicality, symbolism, aesthetics, and economics) were derived, and adult consumers considered economics as the most important among the factors. As for purchasing information sources, three factors (media, human resources, and store) were derived, and adult consumers considered human resources and store information sources more important than media. The main motive for purchasing bags was age and damage of the owned products, and Internet shopping malls were the most common purchasing place. The average annual cost of purchasing bags was 100,000 to 300,000 won, and the frequency of purchase was about once a year. Second, as bag preference images, four factors (individual, romantic, active, and classic image) were derived, and adult consumers preferred classic images the most. The shoulder bag was the most preferred as the bag shape, and black was the most preferred bag color. For the material, natural leather was the most preferred, and for the size, medium size was the most preferred. Third, bag purchasing behaviors and design preferences showed many significant differences according to the sex and age of the consumers. Therefore, the results of this study suggests that bag companies need to establish product development and marketing strategies in consideration of differences according to the sex and age group of adult consumers.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.640-647
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• 2023

The skin, the largest organ in the body, undergoes age-related changes influenced by both intrinsic and extrinsic factors. The primary external factor is photoaging which causes hyperpigmentation, uneven skin surface, deep wrinkles, and markedly enlarged capillaries. In the human dermis, it decreases fibroblast function, resulting in a lack of collagen structure and also decreases keratinocyte function, which compromises the strength of the protective barrier. In this study, we found that treatment with γ-aminobutyric acid (GABA) had no toxicity to skin fibroblasts and GABA enhanced their migration ability, which can accelerate skin wound healing. UVB radiation was found to significantly induce the production of matrix metalloproteinase 1 (MMP-1), but treatment with GABA resulted in the inhibition of MMP-1 production. We also investigated the enhancement of filaggrin and aquaporin 3 in keratinocytes after treatment with GABA, showing that GABA can effectively improve skin moisturization. In vivo experiments showed that oral administration of GABA significantly improved skin wrinkles and epidermal thickness. After the intake of GABA, there was a significant decrease observed in the increase of skin thickness measured by calipers and erythema. Additionally, the decrease in skin moisture and elasticity in hairless mice exposed to UVB radiation was also significantly restored. Overall, this study demonstrates the potential of GABA as functional food material for improving skin aging and moisturizing.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.spc
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• pp.61-67
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• 2023

Special equipment used for snow removal is only used in the winter and must be moved into storage during non-winter seasons. However, when moving heavy equipment using a forklift within a limited space, safety accidents may occur due to deformation and damage due to the worker's limited visibility and excessive loading of heavy objects. In this study, the scissors boom of the developed heavy load transporter was conducted in two cases: link structural analysis and position-based structural analysis. In detail, the link structural analysis covers four cases of stress and safety factor according to material and thickness to optimize the specifications of the material selected during development, and the structural analysis according to position covers two cases before and after the lift, when maximum stress concentration is achieved. Safety was evaluated through finite element analysis. As a result of the study, when manufacturing a scissors boom type heavy load transporter that can withstand a load of 10 tons, the link showed safety at SS400 4.5mm or higher, and reinforcement is needed in the upper and lower structures, so it is judged to be useful in applying materials according to the load.

• Smart Media Journal
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• v.12 no.9
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• pp.28-37
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• 2023

The main factor affecting the decline in rice yield is damage caused by localized heavy rains or typhoons. The method of analyzing the rice lodging area is difficult to obtain objective results based on visual inspection and judgment based on field surveys visiting the affected area. it requires a lot of time and money. In this paper, we propose the method of estimation and diagnosis for rice lodging areas using a Vision Transformer-based Segformer for RGB images, which are captured by unmanned aerial vehicles. The proposed method estimates the lodging, normal, and background area using the Segformer model, and the lodging rate is diagnosed through the rice field inspection criteria in the seed industry Act. The diagnosis result can be used to find the distribution of the rice lodging areas, to show the trend of lodging, and to use the quality management of certified seed in government. The proposed method of rice lodging area estimation shows 98.33% of mean accuracy and 96.79% of mIoU.

• The Korea Journal of Herbology
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• v.39 no.3
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• pp.97-105
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• 2024

Objective : This study examined the effects of yaksun recipe on the anti-fatigue and endurance enhancement properties in the forced swimming test (FST). Methods : The treatment groups were divided randomly into three groups: water-treated FST (control), 200 mg/kg of red ginseng-treated FST (RG200), 200 mg/kg of water extract of yaksun recipe-treated FST (YS200). After FST, an autopsy was performed, and the tissue and serum were collected. Results : The swimming exhaustion time in the RG200 and YG200 groups were significantly increased compared to the control group. The YG200 group fatigue indicators, D-Lactate, LDH(lactate dehydrogenase), creatine kinase, and ammonia content, significantly decreased compared to the control group. In addition, liver glycogen content significantly increased in the YG200 and tended to increase in RG200. Likewise, the glucose contents were significantly increased compared to the control group. The muscle damage indicators GPT (glutamic pyruvic transaminase) and BUN (blood urea nitrogen), a protein metabolite, in the YG200 group significantly decreased compared to the control group. Furthermore the concentration of liver lipid peroxidation, MDA(malondialdehyde) levels significantly decreased in the RG200 and YG200 compared to control group. Conclusions : These results suggest that YG200 can increase the endurance exercise capacity by decreasing the fatigue indicators, saving glycogen, and elevating the antioxidant defense system.