• Molecules and Cells
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• 제25권4호
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• pp.457-461
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• 2008

DNA damage checkpoint is an important self-defense mechanism for the maintenance of genome stability. Defects in DNA damage signaling and repair lead to various disorders and increase tumor incidence in humans. In the past 10 years, we have identified many components involved in the DNA damage-signaling pathway, including the product of breast cancer susceptibility gene 1 (BRCA1). Mutations in BRCA1 are associated with increased risk of breast and ovarian cancers, highlighting the importance of this DNA damage-signaling pathway in tumor suppression. While it becomes clear that BRCA1 plays a crucial role in the DNA damage responsive pathway, exactly how BRCA1 receives DNA damage signals and exerts its checkpoint function has not been fully addressed. A series of recent studies reported the discovery of many novel components involved in DNA damage-signaling pathway. These newly identified checkpoint proteins, including RNF8, RAP80 and CCDC98, work in concern in recruiting BRCA1 to DNA damage sites and thus regulate BRCA1 function in G2/M checkpoint control. This review will summarize these recent findings and provide an updated view of the regulation of BRCA1 in response to DNA damage.

• 동의생리병리학회지
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• 제19권4호
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• pp.993-999
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• 2005

This research was peformed to investigate protective effect of Sophora Subprostrata fractions against focal ischemic brain damage after middle cerebral artery(MCA) occlusion using intraluminal suture. Rats were divided into six groups: MCA-occluded group(Control): each administered groups with Sophora Subprostrata total phase(Total), Sophora Subprostrata Aqueous phase (Aqueous), Sophora Subprostrata BuOH phase(BuOH), and Sophora Subprostrata Alkaloid phase(Alkaloid) after MCA-occlusion; sham-operated group(Sham). The right MCA was occluded by A poly-L-lysine coated 4-0 nylon suture thread through the internal carotid artery permanently. Sophora Subprostrata and fractions were administered orally(Smg/ml) for 7 days after MCA-occlusion. The Drain tissue was stained with $2\%$ triphenyl tetrazolium chloride on ischemic brain tissue(2mm section). The results showed that 1) Sophora Subprostrata total phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 2) Sophora Subprostrata Aqueous phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 3) Sophora Subprostrata Alkaloid phase reduced infarct size compared to the control group at 24 hours after MCA-occlusion, but 4) at 7 days after MCA-occlusion, Sophora Subprostrata did not show effective recovery compared with control group. Sophora Subprostrata has protective effects against brain damage at the early stage of focal cerebral ischemia. Sophora Subprostrata total and Aqueous phase produced more pronounced protective effect against focal ischemic brain damage.

• Environmental Analysis Health and Toxicology
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• 제23권4호
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• pp.315-323
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• 2008

In this study, the backs with a hair cut of 6-week-old healthy ICR male mice were once exposed to a dose of $400\;mJ/cm^2$ UVB. An acute dermal inflammation was observed, and the certified 100% pure and natural lavender essential oil were applied to the UVB-exposed mice skin twice a day. It was observed that the mice exposed to UVB resulted in an acute inflammation, and when treated with lavender oil the degree of inflammation was much alleviated, and the inflamed skins of both the control and lavender oil-treatment groups were cured almost completely after 6 days of the UVB exposure. At 24 hours after UVB exposure, the epidermal keratinocytes in the control group showed a cell-membrane damage with the destruction of intercellular junctions, agglutination of tonofilaments within the cytoplasm and nucleus damage, while the lavender oil-treatment group had much less cell damage than the control group. While the control group showed a significant increase (p<0.05) in the activity of XO up to 144 hours, the lavender oil-treatment group did not show any significant increase except for 48 hours after the UVB exposure. Both the control and lavender essential oil-treatment groups had a significant decrease in the activities of CAT and SOD up to 96 hours. Particularly, the CAT activity was significantly lower(p<0.05) in the lavender oil-treatment group than the control group up to 48 hours, and higher than the control group at and after 96 hours. The GST activity was significantly decreased in both the control and lavender oil-treatment groups up to 96 hours after the UVB exposure except for the control group at 24 hours, and that of the lavender oil-treatment group was higher than the control group at and after 96 hours. Therefore, it is assumed that the application of the lavender oil to the ultraviolet-damaged mice skin can be effective in treatment for the damaged skin.

• Strategy21
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• 통권44호
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• pp.213-253
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• 2018

The Russo-Japanese War(1904-1905) in the early 20th century greatly influenced the international politics in Northeast Asia and the destiny of both countries. There are many studies on the cause of the outbreak and its effect on the Korean peninsula. The victory and defeat of the battle of Tsushima also the subject of research by renowned scholars and navy officers. Many previous studies have analyzed the process of engagement. However, There was a lack of research that analyzed at the tactical level of naval commanders. Therefore, this study tries to review the battle of Tsushima in terms of tactical level, that is formation, maneuvering, damage control. Naval operations at sea with many variables are not always done as planned. The intuitive judgement and readiness have had a decisive impact on victory and defeat. The analysis of the naval warfare on the basis of formation, maneuvering, and damage control makes the cause of the win more clearly. The conclusion of the this study can be summarized in five ways. First, victory would be achieved through the suppression of the beginning. The destiny of the Tsushima battle was determined by an 1 hour after first firing. The Japanese fleet caught fire by paralyzing the command and control capabilities of the Russian fleet. Second, the Japanese fleet's power was superior to the Russian fleet. In general, Japan and Russia had similar powers, and Admiral Togo's "T crossing tactics" decisively contributed the victory. However, when compared to the weapon system level, formation and maneuvering, Japan was much more dominant. Third, people realized that one side to be annihilated in the battle between similar powers after the Tsushima battle. The common perception before the Battle of Tsushima was that the battle ship would not sunken, and that the result of wiping out was difficult. However, there is s time for one sided victory and defeat depending on the early suppression nad the destruction of the command and control ability. Fourth, it is the importance of damage control ability. The main cause of the Russian fleet's loss of command and control ability was thick smoke from fire, and maneuverability was greatly deteriorated due to coal overload. In this way, importance is still valid after more than 100 tears. Fifth, the area of uncertainty. In the navy battles, one or two shots of clear firing in the beginning and small misconception and minor mistakes decide win or loss. Ultimately, this area of fortune can be linked to mindset of the commander. I hope this research will be help to naval researchers and naval commanders at the sea.

• Journal of Microbiology and Biotechnology
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• 제19권10호
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• pp.1122-1126
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• 2009

The exogenously added cadaverine is effective in protecting Vibrio vulnificus from methyl viologen (MV)-induced superoxide stress at pH 8.5. Such a protective effect by cadaverine was not observed at pH 7.5. Consistently, the accumulated level of intracellular cadaverine at pH 8.5 is approximately four times as much as that of the control cell at pH 7.5. Cadaverine accumulation is not affected by MV. The protection of V. vulnificus by cadaverine from superoxide stress was abolished when cadB coding for the lysine-cadaverine antiporter was interrupted. However, the cadaverine-mediated protection was complemented with cadB DNA. Therefore, CadB of V. vulnificus not only acts as a lysine-cadaverine antiporter at acid pH to neutralize the external medium, but also mediates cadaverine uptake at alkaline pH to result in cell protection from superoxide stress.

• 대한한의학회지
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• 제22권4호
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• pp.79-89
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• 2001

Objectives : This study has been carried out to investigate the effects of the Saengjinyanghyutang-gamibang and Rosa rugosa extracts on pancreas of the hyperglycemia mice induced with streptozotocin. Methods : We examined immunohistochemistry for insulin and COX-2, ultrastructural changes of acini by electron microscope, and changes of the blood glucose and BUN levels. Results : The ${\beta}-cells$ on Langerhnan's islet were destructed by administration of streptozotocin, so that few insulin-positive cells were observed in the control group. However, a lot of insulin-positive cells were observed in the experimental groups. These cells had recovered from the damage. As a result of COX-2 immunostain, COX-2 expression were highest in the control group other than the Saengjinyanghyutang-gamibang and Rosa rugosa extracts administered groups. As the electron microscopical observation, the centroacinar cells and acini of pancreas were destructed or damaged by administration of streptozotocin in the control group, but these recovered !Tom the damage in the other experimental groups. The levels of serum glucose were decreased remarkably on the Rosa rugosa and Saengjinyanghyutang-gamibang extracts administered groups compared with control group. Conclusions : These results suggest that administration of the Rosa rugosa and Saengjinyanghyultang-gamibang extracts to the mice reduced the damage induced by streptozotocin.

• 한국안전학회지
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• 제36권4호
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• pp.1-11
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• 2021

Piping systems comprising pumps and valves are essential in the power plant, oil, and defense industry. Their purpose includes a stable supply of the working fluid or ensuring the target system's safe operation. However, piping system accidents due to leakage of toxic substances, explosions, and natural disasters are prevalent In addition, with the limited maintenance personnel, it becomes difficult to detect, isolate, and reconfigure the damage of the piping system and recover the unaffected area. An autonomous recovery piping system can play a vital role under such circumstances. The autonomous recovery algorithms for the piping system can be divided into low-pressure control algorithms, hydraulic resistance control algorithms, and flow inventory control algorithms. All three methods include autonomous opening/closing logic to isolate damaged areas and recovery the unaffected area of piping systems. However, because each algorithm has its strength and weakness, appropriate application considering the overall design, vital components, and operating conditions is crucial. In this regard, preliminary research on algorithm's working principle, its design procedures, and expected damage scenarios should be accomplished. This study examines the characteristics of algorithms, the design procedure, and working logic. Advantages and disadvantages are also analyzed through simulation results for a simplified piping system.

• 자원환경지질
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• 제54권6호
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• pp.649-657
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• 2021

This paper aims to study the impact of natural disasters on per capita income in Vietnam both the short and long-term, specifically impact loss of income caused by the extreme drought 2013 for agriculture, forestry and fishery in Phu Yen Province, Central Vietnam. The study valued economic damage by applying the synthetic control method (SCM), which is a statistical method to evaluate the effect of an intervention (e.g. natural disasters) in different case studies. It estimates what would have happened to the treatment group if it had not received the treatment by constructing a weighted combination of control units (e.g. control provinces). The results showed that the 2013 drought caused a decrease in income per capita, mainly in the agriculture, forestry, and fishery sector in Phu Yen. The reduced income was estimated to be VND 160,000 (1 USD = 23,500 VND (2021)) for one person per month, accounting for 11% of total income per capita and continued to affect the income 6 years later. Therefore, authorities need to invest in preventive solutions such as early and accurate warnings to help people to be more proactive in disaster prevention.

• 한국환경과학회지
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• 제14권11호
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• pp.1071-1079
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• 2005

Using single cell gel electrophoresis, DNA single strand breaks were determined in various marine organisms. DNA damage on fish blood cells was detected to know whether there was a difference between Incheon, Pohang, Masan, and Tongyeong as a control site. Tongyeong showed the lowest DNA damage among the study areas. Mussels, transplanted to Masan Bay for one month, revealed high DNA damage at sites with high economical activity. In two weeks exposure of polychaete to Incheon sediments, higher DNA damage was detected in the sediment adjacent to Incheon harbor than open sea. These results suggested that the marine organism from the polluted area revealed a relatively high DNA damage. In addition, these areas might be contaminated with genotoxic compounds and comet assay was useful as a bioassay to detect DNA damage in marine organisms.

• 한국정밀공학회지
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• 제19권6호
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• pp.145-154
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• 2002

CMP (Chemical mechanical polishing) process was used to control the fine grinding process induced mechanical damage of Cz Silicon wafer. Characterization of mechanical damage was carried out using Nomarski microscope, magic mirror and also using angle lapping and lifetime scanner evaluation after heat treatment. Magic mirror and lifetime scanner were very useful for the residual damage pattern characterization and CMP process was effective on the reduction of fine grinding induced mechanical damage.