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Detection, Identification and Characterization of In vitro GSH Metabolites Formed by 1-and 2-Bromopropane

  • Moon, Yoon-Soo;Kim, Eun-Kyung;Basnet, Arjun;Zhao, Long-Xuan;Kim, Dae-Ok;Kim, Nam-Hee;Chae, Whi-Gun;Jeong, Tae-Cheon;Lee, Eung-Seok
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.174.3-175
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    • 2003

  • 1-and 2-Bromopropane were reported as the causative agents for reproductive toxicity and immunotoxicity. The glutathione (GSH) metabolites resulting from in vitro treatment of 1- and 2-bromopropane were detected, identified and characterized. For the facile identification, expected GSH metabolites rormed by 1- and 2-bromopropane were chemically synthesized as reference materials (positive controls) and characterized by $^1H$-NMR, $^13C$-NMR, HPLC and LC/MS/MS. The treatment of GSH and S-9 fraction with 1- or 2-bromopropane at a physiological condition (pH 7.4, $37^\times$) for 1hr produced GSH metabolites, which were identified by UV, HPLC and ESI LC/MS/MS analyses. (omitted)

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