• 제목/요약/키워드: cyclotron center

검색결과 122건 처리시간 0.019초

RADIATION SAFETY STUDIES AT TOHOKU UNIVERSITY CYRIC

  • Yamadera M. Baba A.;Miura T.;Aoki T.;Hagiwara M.;Kawata N.
    • Journal of Radiation Protection and Research
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    • 제26권3호
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    • pp.231-236
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    • 2001
  • A brief introduction is presented on the radiation safety studies at Tohoku University Cyclotron & Radioisotope Center. Studies on two subject are described; (1) measurement of the thick target neutron yield and radioisotope production / activation cross section for ten's of MeV neutrons and ions using K=110 Tohoku University cyclotron to provide basicdata for accelerator shielding, and (2) development of techniques for high sensitive radiation detection and profile measurement using an Imaging Plate which is a high sensitive two-dimensional radiation sensor. Application of the Imaging Plate techniques to localization of very weak radioactivity and to neutron profile measurement is described.

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Facile Synthesis and Radioiodine Labeling of Hypericin

  • Kim, Sang-Wook;Park, Jeong-Hoon;Yang, Seung-Dae;Hur, Min-Goo;Kim, Yu-Seok;Chai, Jong-Seo;Kim, Young-Soon;Yu, Kook-Hyun
    • Bulletin of the Korean Chemical Society
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    • 제25권8호
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    • pp.1147-1150
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    • 2004
  • Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.

Synthetic approaches toward [18F]Fluoromisonidazole as a hypoxia imaging maker

  • Kwon, Young-Do;Lim, Seok Tae;Jeong, Hwan-Jeong;Sohn, Myung-Hee;Kim, Hee-Kwon
    • 대한방사성의약품학회지
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    • 제1권1호
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    • pp.9-14
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    • 2015
  • Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about physiological and biological events such as diseases. In order to use the PET technique for healthcare, promising molecular probes such as PET tracers required. [$^{18}F$]Fluoromisonidazole ([$^{18}F$]FMISO) is the most widely used in PET tracers for hypoxia. In this review, major developments of the synthetic method of [$^{18}F$]FMISO are discussed.

L-3-[$^{123}I$iodo-${\alpha}$-methyltyrosine 합성과 9L Glioma 이식 백서 분포조사 (Synthesis of L-3-[$^{123}I$]iodo-${\alpha}$-methyltyrosine and Biodistribution in 9L Glioma Bearing Rats)

  • 양승대;임상무;우광선;정위섭;전권수;서용섭;임종석;박현;윤용기;이종두
    • 대한핵의학회지
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    • 제29권1호
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    • pp.105-109
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    • 1995
  • Tyrosine의 유도체인 [$^{123}I$]IMT를 각종 악성종양의 SPECT에 이용하기 위하여 표지시 반응조건과 뇌종양이식 백서에서의 체내 동태를 연구하여 다음과 같은 결과를 얻었다. AMT의 [$^{123}I$] 표지에 chloramine-T 보다 Iodobead를 이용하는 것이 훨씬 간편하고 수율이 높았으며, Iodobead 1개, AMT $200{\mu}g/100{\mu}L$ phosphate buffer, PH 5.5, 상온에서 7분간 반응시키는 것이 최적 반응조건이었다. 9L glioma 이식 백서 체내동태는 [$^{123}I$]IMT가 신장으로 배설됨과 체내에서 탈요오드 반응이 일어남이 추측되었고, 정상조직의 3배 방사능 섭취가 관찰되어, 각종 뇌종양의 진단 및 치료 후 경과 관찰에 이용 가능성이 보여 임상연구의 진행이 기대된다.

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Design of RF coupler for KIRAMS-13;Korea Institute of Radiological & Medical Sciences-13

  • Jung, In-Su;An, Dong-Hyun;Kim, Yu-Seok;Yang, Tae-Gun;Kim, Jea-Hong;Jang, Hong-Seok;Hong, Bong-Hwan;Lee, Min-Yong;Hong, Sung-Seok;Chai, Jong-Seo;Oh, Bong-Hun
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2003년도 ICCAS
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    • pp.2203-2205
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    • 2003
  • KIRAMS-13, the first medical cyclotron developed by domestic technique, is used to produce radio-isotope such as $^{18}F$ whose life time is relatively short through test operation. For high-power operation of charged particle accelerators, the power coupler must withstand enormous stresses due to charging induced by high RF power passing through. High-power RF testing with peak power in excess of 30kW has been performed on prototype power coupler for KIRAMS-13 normal conducting cavities. CST MICROWAVE STUDIO(CST MWS) is used for fundamental RF Design, and power coupler is manufactured according to fundamental power coupler design requisite. The qualification of the couplers has occurred for the time being only in a limited set of conditions as the available RF system and control instrumentation are under improvement.

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NEUTRON ELASTIC AND NON-ELASTIC SCATTERING STUDIES IN TENS OF MeV REGION

  • Baba Mamoru;Ibaraki Masanobu;Miura Takako;Aoki Takao;Nakashima Hiroshi;Tanaka Shin-ichiro Meigo Susumu
    • Journal of Radiation Protection and Research
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    • 제26권3호
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    • pp.265-270
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    • 2001
  • Experimental data have been obtained on the neutron elastic scattering cross sections for 55, 65 and 75 MeV neutrons, and non-elastic scattering cross sections for 40 to 80 MeV neutrons using the $^7Li(p,n)$ neutron source at TIARA of Japan Atomic Energy Research Institute and the TOF method. Data were obtained for C, Si, Fe, Zr, and Pb of natural elements. Elastic scattering data were obtained for 25 laboratory angles between 2.6 and 53.0 that clarified the angular distributions and angle integrated values. The data obtained were compared favorably with recent LA150 data library.

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Rhenium-188 생산 (Production of Re-188)

  • 양승대;서용섭;김상욱;임상무
    • 대한핵의학회:학술대회논문집
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    • 대한핵의학회 1999년도 제38차 춘계학술대회
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    • pp.189-192
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    • 1999
  • $^{188}Re$ (${\beta}^-=2.2$ MeV; ${\gamma}^-$=155 keV; $T_{1/2}$=16.9 hours) is an attractive therapeutic radioisotope which is produced from decay of reactor-produced tungsten-188 parent ($T_{1/2}$=69 days). $^{188}W$ has been produced from the double neutron capture reaction of $^{186}W.\;^{188}Re$ can be easily obtained by elution of saline on alumina based $^{188}W/^{188}Re$ generator, which is commercially available. Complexes labelled with $^{188}Re$ have been developed for the radiotherapy treatment of diseases because of the desirable nuclear properties of the radioisotope and it's chemical properties similar to those of technetium, a well established diagnostic agent.

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뼈 스캔상 우연히 발견된 그레이브스 갑상선기능항진증에서 갑상선의 섭취증가 (Incidental Visualization of Thyroid Gland on Bone Scan Caused by Graves' Hyperthyroidism)

  • 손명희;정환정;김동욱;임석태
    • Nuclear Medicine and Molecular Imaging
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    • 제43권2호
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    • pp.154-155
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    • 2009
  • A 45-year-old man presented with fatigue and weight loss underwent a Tc-99m MDP bone scan because of increased serum alkaline phosphatase. Delayed images at 4 hours demonstrated diffuse increased activity throughout both lobes of the thyroid in the absence of activity of the stomach and salivary glands. Thyroid laboratory indices and a Tc-99m pertechnetate thyroid scan suggested Graves' hyperthyroidism.