• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.70.2-70.2
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• 2000

• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.74-74
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• 2000

• Journal of Radiation Protection and Research
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• v.26 no.3
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• pp.231-236
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• 2001

A brief introduction is presented on the radiation safety studies at Tohoku University Cyclotron & Radioisotope Center. Studies on two subject are described; (1) measurement of the thick target neutron yield and radioisotope production / activation cross section for ten's of MeV neutrons and ions using K=110 Tohoku University cyclotron to provide basicdata for accelerator shielding, and (2) development of techniques for high sensitive radiation detection and profile measurement using an Imaging Plate which is a high sensitive two-dimensional radiation sensor. Application of the Imaging Plate techniques to localization of very weak radioactivity and to neutron profile measurement is described.

• Bulletin of the Korean Chemical Society
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• v.25 no.8
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• pp.1147-1150
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• 2004

Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.1 no.1
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• pp.9-14
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• 2015

Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about physiological and biological events such as diseases. In order to use the PET technique for healthcare, promising molecular probes such as PET tracers required. [$^{18}F$]Fluoromisonidazole ([$^{18}F$]FMISO) is the most widely used in PET tracers for hypoxia. In this review, major developments of the synthetic method of [$^{18}F$]FMISO are discussed.

• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.105-109
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• 1995

L-3-[$^{123}I$]iodo-${\alpha}$-methyltyrosine([$^{123}I$] IMT) was synthesized by electrophilic radio-iodination using chloramine-T and Iodobead in phosphate buffered solution. And the biodistribution was examined in 9L glioma bearing rats. The radiosynthesis of [$^{123}I$]IMT with iodobead was simpler and higher in radiochemical yield(88%) than the method using chloramine-T(83%) as radioiodinating reagent. The highest yield was obtained from the reaction using 1 piece of Iodobead, $200{\mu}g$ ${\alpha}$-methyltyrosine in $100{\mu}l$ phosphate-buffered solution(pH 5.5) and the reaction was completed in 7min. 24 hours after the injection, the biodistribution in 9L glioma transplanted rats revealed the in vivo deiodination, the excretion via kidney, and 3 times higher uptake in the tumor than normal brain. These results suggest the promising clinical use of [$^{123}I$] IMT in the various malignancies.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2203-2205
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• 2003

KIRAMS-13, the first medical cyclotron developed by domestic technique, is used to produce radio-isotope such as $^{18}F$ whose life time is relatively short through test operation. For high-power operation of charged particle accelerators, the power coupler must withstand enormous stresses due to charging induced by high RF power passing through. High-power RF testing with peak power in excess of 30kW has been performed on prototype power coupler for KIRAMS-13 normal conducting cavities. CST MICROWAVE STUDIO(CST MWS) is used for fundamental RF Design, and power coupler is manufactured according to fundamental power coupler design requisite. The qualification of the couplers has occurred for the time being only in a limited set of conditions as the available RF system and control instrumentation are under improvement.

• Journal of Radiation Protection and Research
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• v.26 no.3
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• pp.265-270
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• 2001

Experimental data have been obtained on the neutron elastic scattering cross sections for 55, 65 and 75 MeV neutrons, and non-elastic scattering cross sections for 40 to 80 MeV neutrons using the $^7Li(p,n)$ neutron source at TIARA of Japan Atomic Energy Research Institute and the TOF method. Data were obtained for C, Si, Fe, Zr, and Pb of natural elements. Elastic scattering data were obtained for 25 laboratory angles between 2.6 and 53.0 that clarified the angular distributions and angle integrated values. The data obtained were compared favorably with recent LA150 data library.

• 대한핵의학회:학술대회논문집
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• 1999.05a
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• pp.189-192
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• 1999

$^{188}Re$ (${\beta}^-=2.2$ MeV; ${\gamma}^-$=155 keV; $T_{1/2}$=16.9 hours) is an attractive therapeutic radioisotope which is produced from decay of reactor-produced tungsten-188 parent ($T_{1/2}$=69 days). $^{188}W$ has been produced from the double neutron capture reaction of $^{186}W.\;^{188}Re$ can be easily obtained by elution of saline on alumina based $^{188}W/^{188}Re$ generator, which is commercially available. Complexes labelled with $^{188}Re$ have been developed for the radiotherapy treatment of diseases because of the desirable nuclear properties of the radioisotope and it's chemical properties similar to those of technetium, a well established diagnostic agent.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.2
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• pp.154-155
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• 2009

A 45-year-old man presented with fatigue and weight loss underwent a Tc-99m MDP bone scan because of increased serum alkaline phosphatase. Delayed images at 4 hours demonstrated diffuse increased activity throughout both lobes of the thyroid in the absence of activity of the stomach and salivary glands. Thyroid laboratory indices and a Tc-99m pertechnetate thyroid scan suggested Graves' hyperthyroidism.