• Title/Summary/Keyword: cyclic phosphate of 2',3'-seconuclcoside

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A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (II):Synthesis of 3',5'-Cyclic Phosphates of 6-aza-2'-azido-secouridine

  • Shin, Dae-Hong;Yang, Jae-Wook;Kim, Joong-Hyup;Lee, Chong-Kyo;Chung, Won-Keun;Chun, Moon-Woo
    • Archives of Pharmacal Research
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    • v.15 no.4
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    • pp.343-346
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    • 1992

  • The synthesis of 6-aza-3', 5'-p-nitrophenylphosphoryltrioxy-2'-azido-2'-deoxy-2', 3' secouridine and 6-aza-3', 5'-phosphoryltrioxy-2'-azido-2'-deoxy-2', 3'-secouridine ammonium salt are described and they were evaluated for antiviral activity primarily against DNA and RNA viruses and found to be inactive, but no significant cytocidal effect was observed against Vero and Hela cell.

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