• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.66-83
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• 2002

Recently, we have provided evidence that ginsenosides, the active components of Panax ginseng, utilize pertussis toxin (PTX)-insensitive $G{\alpha}_{q/11}-phospholipase\;C-{\beta}3(PLC-{\beta}3)$ signal transduction pathway for the enhancement of $Ca^{2+}-activated\;Cl^{-}$ current in the Xenopus oocyte (British J. Pharmacol. 132, 641-647, 2001; JBC 276, 48797-48802, 2001). Other investigators have shown that stimulation of receptors linked to $G{\alpha}-PLC$ pathway inhibits the activity of G proteincoupled inwardly rectifying $K^+$ (GIRK) channel. In the present study, we sought to determine whether ginsenosides influenced the activity of GIRK 1 and GIRK 4 (GIRK 1/4) channels expressed in the Xenopus oocyte, and if so, the underlying signal transduction mechanism. In oocyte injected with GIRK 1/4 channel cRNAs, bath-applied ginsenosides inhibited high potassium (HK) solution-elicited GIRK current $(EC_{50}:4.9{\pm}4.3\;{\mu}g/ml).$ Pretreatment of the oocyte with PTX reduced the HK solution-elicited GIRK current by $49\%,$ but it did not alter the inhibitory ginsenoside effect on GIRK current. Prior intraoocyte injection of cRNA(s) coding $G{\alpha}_q,\;G{\alpha}_{11}\;or\;G{\alpha}_q/G{\alpha}_{11},\;but\;not\;G{\alpha}_{i2}\;or\;G{\alpha}_{oA}$ attenuated the inhibitory ginsenoside effect. Injection of cRNAs coding $G{\beta}_{1{\gamma}2}$ also attenuated the ginsenoside effect. Similarly, injection of the cRNAs coding regulators of G protein signaling 1, 2 and 4 (RGS1, RGS2 and RGS4), which interact with $G{\alpha}_i\;and/or\;G{\alpha}_{q/11}$ and stimulates the hydrolysis of GTP to GDP in active GTP-bound $G{\alpha}$ subunit, resulted in a significant reduction of ginsenoside effect on GIRK current. Preincubation of GIRK channel-expressing oocyte in PLC inhibitor (U73122) or protein kinase C (PKC) inhibitor (staurosporine or chelerythrine) blocked the inhibitory ginsenoside effect on GIRK current. On the other hand, intraoocyte injection of BAPTA, a free $Ca^{2+}$ chelator, had no significant effect on the ginsenoside action. Taken together, these results suggest that ginsenosides inhibit the activity of GIRK 1/4 channel expressed in the Xenopus oocyte through a PTX-insensitive and $G{\alpha}_{q/11}$-,PLC-and PKC-mediated signal transduction pathway.

• 대한전기학회논문지
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• 제35권7호
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• pp.261-271
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• 1986

This paper describes a method for the state estimation considering current measurement component and detection of the bad data. The state values are estimated by weighted least square method in which measurement vector included bus injection current and line current. The bad data are detected using standardized variable of normal distribution and identified using sensitivity coefficients. When the bad data were occured by the bad measurement values. The results of the application to the model power system reveal the effectiveness of the presented algorithms.

• Structural Engineering and Mechanics
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• 제14권5호
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• pp.543-563
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• 2002

The use of the epoxy pressure injection technique to rehabilitate reinforced concrete beam-column joints damaged by strong earthquakes is investigated experimentally and analytically. Two one-half-scale exterior beam-column joint specimens were exposed to reverse cyclic loading similar to that generated from strong earthquake ground motion, resulting in damage. Both specimens were typical of new structures and incorporated full seismic details in current building codes. Thus the first specimen was designed according to Eurocode 2 and Eurocode 8 and the second specimen was designed according to ACI-318 (1995) and ACI-ASCE Committee 352 (1985). The specimens were then repaired with an epoxy pressure injection technique. The repaired specimens were subjected to the same displacement history as that imposed on the original specimens. The results indicate that the epoxy pressure injection technique was effective in restoring the strength, stiffness and energy dissipation capacity of specimens representing a modem design.

• 한국환경과학회지
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• 제7권6호
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• pp.793-801
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• 1998

In this study, the Dilution Method is used to measure river discharge through the hydraulic model test. the dilution method is divided into Constant-Rate-Infection Method and Slug-Injection Method in the river discharge measurement techniques. When the dilution method is applied in the hydraulic model flume, it is analyzed that the estimated error of constant-rate-injection method is less than that of the slug-in-jection method, and the result shows that floodflow analysis is more efficient than lowflow analysis as compared observed discharge with calculated discharge. The result of statistical error analysis shows that the constant-rate-injection method is appropriate technique for the measurement of the river discharge. Therefore, the dilution method among the river discharge measurement techniques can be applied for the river basin which can't be measured with current meter or unsteady-flow regime in the urban-small drainage or hydraulic structure equipment area and can be obtained more exact results than any other discharge measurement techniques.

• 한국산학기술학회논문지
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• 제2권2호
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• pp.33-37
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• 2001

본 논문은 사출성형제품의 게이트 설계를 합리적으로 수행하기 위해 사출금형설계전문가의 축적된 지식과 경험을 발췌·정리하여 지식베이스를 작성하였으며, 설계에 필요한 제품의 형상정보를 제공하기 위해 총칭형상과 특징형상 개념을 이용하여 특징형상을 정의하였다. 또한 지식베이스를 통해 산출된 설계결과를 기하학적 모델러와의 인터페이스를 통해 3차원 형상으로 보여지도록 하였으며 최종 생성된 3차원 기하학적 형상정보는 CAE 모듈이나 CAPP 모듈에서의 후속작업을 위해 제공될 수 있도록 구축되었다.

• Design & Manufacturing
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• 제8권2호
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• pp.41-45
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• 2014

Automated polishing apparatus based on the research have been developed. The research is improvement of polishing process for surface quality and uniformity improvement of preform injection mold core. Surface quality of preform core have influence on ejecting and product quality after injection molding. Thus, the current being made by hand to automate the polishing process, the surface of the preform to improve the quality and uniformity improvement. First made a division by analyzing manual process a step-by-step. And draw a mechanism for converting mechanical movement. Automated polishing apparatus for preform core was developed, through which shortens production time and were able to secure the safety of the worker.

• 한국기계가공학회지
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• 제15권6호
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• pp.50-57
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• 2016

Refrigerator glass shelves are manufactured by Insert Injection Molding. The current process of injection of glass into the mold induces movement of the core, on urethane springs. Defects in the product can result from too low a force being transmitted from the springs. To solve this problem, the force on the moving core and the injection molding pressure were subjected to numerical analysis. Based on this, the number of urethane springs as well as their hardness was changed to improve the situation. The number of springs was changed from 6 to 4. The diameter of the springs was increased from ${\emptyset}75$ to ${\emptyset}100$, and the hardness was increased from 70 (shore A) to 90 (shore A). These improvements caused the force on the molding core to increase by approximately 65,442 N. The proportion of defects decreased by 66%.

• Journal of Power Electronics
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• 제7권1호
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• pp.72-80
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• 2007

Voltage sags are one of the most frequently occurring power quality problems challenging power systems today. The Unified Power Quality Conditioner (UPQC) is one of the major custom power solutions that are capable of mitigating the effect of supply voltage sags at the load or Point of Common Coupling (PCC). A UPQC-Q employs a control method in which the series compensator injects a voltage that leads the supply current by $90^{\circ}C$ so that the series compensator at steady state consumes no active power. However, the UPQC-Q has the disadvantage that its series compensator needs to be overrated. Thus it cannot offer effective compensation. This paper proposes a new control scheme for the UPQC-Q that offers minimum power injection. The proposed minimum power injection method takes into consideration the limits on the rated voltage capacity of the series compensator and its control scheme. The validity of the proposed control scheme is investigated through simulation and experimental results.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.766-769
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• 2002

We have seen the effects of hole-injection buffer layer in organic light-emitting diodes using copper phthalocyanine(CuPc), poly(vinylcarbazole)(PVK), and Poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate)(PEDOT:PSS) in a device structure of ITO/buffer/TPD/$Alq_3$/Al. Polymer PVK and PEDOT:PSS buffer layer was made using spin casting method and the CuPc layer was made using thermal evaporation. Current-voltage characteristics, luminance-voltage characteristics and efficiency of device were measured at room temperature with a thickness variation of buffer layer. We have obtained an improvement of the external quantum efficiency by a factor of two, four, and two and half when the CuPc, PVK, and PEDOT:PSS buffer layer are used, respectively. The enhancement of the efficiency is attributed to the improved balance of holes and elelctrons due to the use of hole-injection buffer layer. The CuPc and PEDOT:PSS layer functions as a hole-injection supporter and the PVK layer as a hole-blocking one.

• 한국자동차공학회논문집
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• 제9권6호
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• pp.76-84
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• 2001

Generally fuel injection system using solenoid have some problems between control signal and mechanical movement like as time lag. Main purpose of the present study is to help the design optimization of GDSI for real engine application. We have adopted two different solenoid driving circuit, namely saturation and pick-hold type and have investigated experimentally the current, needle force, needle opening duration and injection quantity. The pick-hold type driving circuit surpassed a saturation type in the response time and pression control of injection quantity. Accordingly, Using characterization data of operating factors such as time constant, driving force and so on, can be evaluated and adjusted to obtain an optimum injector performance.