• Title/Summary/Keyword: cumulative exposure

Search Result 202, Processing Time 0.03 seconds

A study on radiation safety education, knowledge, and practice in using portable intraoral X-ray equipment of dental hygienist's (치과위생사의 이동형 구내방사선 촬영에 관한 방사선 방어 교육, 지식, 수행에 관한 연구)

  • Ryu, Jeong-Min;Kang, Bo-Sun;Kim, Seol-Hee
    • Journal of Korean society of Dental Hygiene
    • /
    • v.17 no.6
    • /
    • pp.1053-1065
    • /
    • 2017
  • Objectives: The purpose of this study is to evaluate radiation safety education, knowledge and practice of dental hygienists in using handheld portable intraoral X-ray equipment and to suggest the need for radiation safety education in using handheld portable intraoral X-ray equipment. Methods: We surveyed 223 dental hygienists from July, 2017 to August in the dental clinics of Daejeon, Seoul and Gyeonggi area. Results: Radiation safety educational experience was higher in a year's career (72.9%), than 3 years experience (32.5%) (p<0.05). 82.7% of dental clinic workers took university education for radiation safety education while 55.6% of dental hospital workers took company training (p<0.05). More than 70% of the subjects did not have experience of radiation safety education about using portable intraoral X-ray. Radiation safety knowledge was highest in a year's career (p<0.05). The cumulative dose, radiation sensitivity, and lead defense knowledge were high in all subjects, but knowledge related to scattering radiation and scattering radiation sources was low. Practice of portable intraoral X-ray safety was significantly lower than knowledge. Conclusions: Knowledge of portable intraoral radiography safety is available, but performance is poor. Even with the small amount of radiation exposure, the risk is perceivable. There is a need to actively utilize the provided radiation protection products. In order to do this, efforts should be made to improve knowledge and performance of radiation safety through not only college education but also postemployment training.

Effects of Jakyakgamchotang Extract on the Trachea Smooth Muscle (작약감초탕(芍藥甘草湯) 및 구성약물(構成藥物)이 기관지평골근(氣管支平滑筋)에 미치는 영향(影響))

  • Kook Yoon-Bum;Lee Jang-Chun;Kim Hee-Soo
    • Herbal Formula Science
    • /
    • v.10 no.2
    • /
    • pp.143-158
    • /
    • 2002
  • The purpose of the present study is to determine the effect of Jakyakgamchotang on histamine or acetylcholine induced tracheal smooth muscle contraction in rats and guinea pigs. Guinea pig(500g, male) and Sprague Dawley rats(250g, male) were killed by $CO_2$ exposure and a segment (4-5mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine(His) which evoked 50% of maximal response($ED_{50}$) was obtained from cumulative dose response curves for histamine($10^{-7}{\sim}10^{-4}M$). Contractions evoked by His($ED_{50}$) were inhibited significantly by Jakyakgamchotang. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 90.8% (p〈0.001) after $100{\mu}l/ml$ Jakyakgamchotang. In rat tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was 22.1% (p〈0.05) after $100{\mu}l/ml$ Jakyakgamchotang. Propranolol indomethacin and methylene blue($10^{-7}M$) slightly but significantly attenuated the inhibitory effects of Jakyakgamchotang. These results indicate that Jakyakgamchotang can relax histamine or acetylcholine induced contraction of guinea pig and rat tracheal smooth muscle.

  • PDF

IDENTIFICATION OF GENES EXPRESSED IN LOW-DOSE-RATE γ-IRRADIATED MOUSE WHOLE BRAIN

  • Bong, Jin Jong;Kang, Yu Mi;Choi, Seung Jin;Kim, Dong-Kwon;Lee, Kyung Mi;Kim, Hee Sun
    • Journal of Radiation Protection and Research
    • /
    • v.38 no.4
    • /
    • pp.166-171
    • /
    • 2013
  • While high-dose ionizing radiation results in long term cellular cytotoxicity, chronic low-dose (<0.2 Gy) of X- or ${\gamma}$-ray irradiation can be beneficial to living organisms by inducing radiation hormesis, stimulating immune function, and adaptive responses. During chronic low-dose-rate radiation (LDR) exposure, whole body of mice is exposed to radiation, however, it remains unclear if LDR causes changes in gene expression of the whole brain. Therefore, we aim to investigate expressed genes (EGs) and signaling pathways specifically regulated by LDR-irradiation ($^{137}Cs$, a cumulative dose of 1.7 Gy for total 100 days) in the whole brain. Using microarray analysis of whole brain RNA extracts harvested from ICR and AKR/J mice after LDR-irradiation, we discovered that two mice strains displayed distinct gene regulation patterns upon LDR-irradiation. In ICR mice, genes involved in ion transport, transition metal ion transport, and developmental cell growth were turned on while, in AKR/J mice, genes involved in sensory perception, cognition, olfactory transduction, G-protein coupled receptor pathways, inflammatory response, proteolysis, and base excision repair were found to be affected by LDR. We validated LDR-sensitive EGs by qPCR and confirmed specific upregulation of S100a7a, Olfr624, and Gm4868 genes in AKR/J mice whole brain. Therefore, our data provide the first report of genetic changes regulated by LDR in the mouse whole brain, which may affect several aspects of brain function.

Effects of Several Herbs on the Blood Vessel (수종 한약재가 혈관에 미치는 영향)

  • Han Jong-Hyun;Choi Min-Ho;Nam Tae-Sun;Ryu Do-Gon
    • Herbal Formula Science
    • /
    • v.7 no.1
    • /
    • pp.167-181
    • /
    • 1999
  • Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae, Radixi, Radix Ledeboutriellae, Rhizoma Atractylodis, Herba Ephedrae, Radix Puerariae and Radi Aconitx Bupleuri have been used in Korea for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of several herbs on norepinephrine(NE) induced blood vessel contraction in rabbits and pigs. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response $(ED_{50})$ was obtained from cumulative dose response curves for NE $(10^{-6}{\sim}10^{-3}M)$. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae and Herba Ephedrae in abdominal aorta. Contractions evoked by NE $(ED_{50})$ were inhibited significantly be Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Herba Ephedrae, Radix Puerariae and Radix Bupleuri in femoral artery. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Radix Sophorae Subprostratae, Radix Aconiti and Herba Ephedrae in renal artery. These results indicate that each herb can relax NE induced contraction of rabbit and pig blood vessel selectively, and that this relaxation relates to Gui-Gyung(歸經).

  • PDF

Complication incidence of two implant systems up to six years: a comparison between internal and external connection implants

  • Chae, Sung-Wook;Kim, Young-Sung;Lee, Yong-Moo;Kim, Won-Kyung;Lee, Young-Kyoo;Kim, Su-Hwan
    • Journal of Periodontal and Implant Science
    • /
    • v.45 no.1
    • /
    • pp.23-29
    • /
    • 2015
  • Purpose: This study was conducted to compare the cumulative survival rates (CSRs) and the incidence of postloading complications (PLCs) between a bone-level internal connection system (ICS-BL) and an external connection system (ECS). Methods: The medical records of patients treated with either a ICS-BL or ECS between 2007 and 2010 at Asan Medical Center were reviewed. PLCs were divided into two categories: biological and technical. Biological complications included >4 mm of probing pocket depth, thread exposure in radiographs, and soft tissue complications, whereas technical complications included chipping of the veneering material, fracture of the implant, fracture of the crown, loosening or fracture of the abutment or screw, loss of retention, and loss of access hole filling material. CSRs were determined by a life-table analysis and compared using the log-rank chi-square test. The incidence of PLC was compared with the Pearson chi-squared test. Results: A total of 2,651 implants in 1,074 patients (1,167 ICS-BLs in 551 patients and 1,484 ECSs in 523 patients) were analyzed. The average observation periods were 3.4 years for the ICS-BLs and 3.1 years for the ECSs. The six-year CSR of all implants was 96.1% (94.9% for the ICS-BLs and 97.1% for the ECSs, P=0.619). Soft tissue complications were more frequent with the ECSs (P=0.005) and loosening or fracture of the abutment or screw occurred more frequently with the ICS-BLs (P<0.001). Conclusions: Within the limitations of this study, the ICS-BL was more prone to technical complications while the ECS was more vulnerable to biological complications.

New Dwarf Galaxies in the Nearby NGC 2784 Galaxy Group Discovered in the KMTNet Supernova Program

  • Park, Hong Soo;Moon, Dae-Sik;Lee, Jae-Joon;Pak, Mina;Kim, Sang Chul
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.41 no.1
    • /
    • pp.53.2-53.2
    • /
    • 2016
  • We present surface photometry results of the dwarf galaxies in the nearby NGC 2784 galaxy group. We newly detected about 30 dwarf galaxy candidates at about 30 square degree area around the nearby NGC 2784 galaxy (D~10 Mpc and MV=-20.5) applying a visual inspection technique on the wide-field optical images taken by the KMTNet Supernova Program (KSP). Surface brightnesses of the objects estimated from the stacked-images with total exposure time of about 6 hours reach approximately ${\mu}V$ ~28.5 mag/arcsec2 around $3{\sigma}$ above sky background. The central surface brightness and the total absolute magnitude for the faintest candidate dwarf galaxy among about 40 galaxies including the previously known ones is ${\mu}0$, V~26.1 mag/arcsec2 and MV~-9.5 mag, respectively. The effective radii of the candidates are larger than ~200 pc. The radial number density of the dwarf galaxy candidates from the center of NGC 2784 is decreasing. The mean color (<(B-V)0>~0.7) and $S{\acute{e}}rsic$ structure parameters of the dwarfs, assuming them to be located in the NGC 2784 group, are well consistent with those of the dwarf galaxies in other groups (e.g. M83 group and the Local Group (LG)). The faint-end slope of the cumulative luminosity function (CLF) of the galaxies in NGC 2784 group is about ${\alpha}=-1.2$, which is steeper than that of the LG galaxies, but is much flatter than that of the CLF expected by a ${\Lambda}CDM$ model.

  • PDF

Effects of Radix Stemonae on the Airway Smooth Muscle (기관지(氣管支) 평활근(平滑筋)에 미치는 백부근(百部根)의 효과(效果))

  • Kim Sung-Kyu;Woo Won-Hong;Ryu Do-Gon;Han Jong-Hyun
    • Korean Journal of Acupuncture
    • /
    • v.17 no.1
    • /
    • pp.67-73
    • /
    • 2000
  • The purpose of the present study is to determine the effect of Radix Stemonae on histamine induced tracheal smooth muscle contraction in guinea pigs. Guinea pig(500g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine (His) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine ($10^{-7}∼10^{-4}M$). Contractions evoked by His ($ED_{50}$) were inhibited significantly by Radix Stemonae. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 87.4% (p<0.01) after $100{\mu}l/ml$ Radix Stemonae. Following treatment with propranolol, the mean percent inhibition caused by $100{\mu}l/ml$ Radix Stemonae fell to 16.2% in guinea pig induced by histamine contraction. Indomethacin and methylene blue($10^{-7}M$) did not significantly alter the inhibitory effect of Radix Stemonae. These results indicate that Radix Stemonae can relax histamine induced contraction of guinea pig tracheal smooth muscle, and that this inhibition involves sympathetic effects.

  • PDF

A Study on the Monitoring Technique for Musculoskeletal Safety Management and Implementation of the System (근골격계 안전관리를 위한 모니터링 기법에 관한 연구 및 시스템 구현)

  • Shin, Yeong-Ju;Joo, Ha-Young;Yang, Jin-Hong
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
    • /
    • v.13 no.3
    • /
    • pp.267-276
    • /
    • 2020
  • Manufacturing workers are easily exposed to the risk of musculoskeletal disorders caused by repetitive tasks in their working environment. This is due to problems with occupational characteristics that repeatedly use the body. However, the current lack of monitoring systems for monitoring and prevention has led to an increase in workers' exposure to risks each year. This paper presents how to solve these problems in real working environment by producing wearable devices using IMU sensors. After wearing a wearable type device, the user's movement is judged through data analysis by receiving the rotation value according to musculoskeletal movement. At this time, the risk is determined by measuring the number of rotations of the user by eliminating bias and eliminating cumulative error, acquiring sophisticated data, and analyzing it in the form of dynamic threshold values. Using the wearable device proposed in this paper, the effect of this method could be checked through a web page measuring the number of rotations for elbow musculoskeletal disorders.

Rhizoma Coptidis INHIBITS HISTAMINE-INDUCED CONTRACTILE RESPONSES OF AIRWAY SMOOTH MUSCLE (기관지(氣管支) 평골절(平滑筋)에 미치는 황연(黃連)의 효과(效果))

  • O, Kwang-Soo;Han, Jong-Hyun
    • The Journal of Internal Korean Medicine
    • /
    • v.18 no.2
    • /
    • pp.83-93
    • /
    • 1997
  • Rhizoma Coptidis, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for many disease. The purpose of the present study was to determine the effect of Rhizoma Coptidis on histamine-induced tracheal smooth muscle contraction in guinea pigs and rats. Guinea pigs(500g, male) and rats(250g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine ($10^{-7}-10^{-3}M$). Contractions evoked by histamine($ED_{50}$) were inhibited significantly by Rhizoma Coptidis. The mean percent inhibition was 33.2% after 1.5mg/ml Rhizoma Coptidis, and 69.5% after 5.0mg/ml Rhizoma Coptidis in guinea pigs, and the mean percent inhibition was 25.3% after 1.5mg/ml Rhizoma Coptidis, and 65.8% after 5.0mg/ml Rhizoma Coptidis in rats. Indomethacin ($10^{-7}M$) slightly but significantly attenuated the inhibitory effects of Rhizoma Coptidis. But propranolol and methylene blue ($10^{-7}M$) did not significantly alter the inhibitory effect of Rhizoma Coptidis. These results indicate that Rhizoma Coptidis can relax histamine-induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves, in part, cyclooxygenese inhibitor.

  • PDF

Studies on Digitalis Receptor Desensitization in Rat Ventricle (쥐 심실에서 Digitalis Receptor Desensitization에 관한 연구)

  • 이신웅;이정수;장태수
    • Biomolecules & Therapeutics
    • /
    • v.2 no.2
    • /
    • pp.114-119
    • /
    • 1994
  • [$^3$H]Ouabain binding parameters ( $K_{D}$ and $B_{max}$) to control rat ventricular strips and Langendorff preparations which were not previously exposed to ouabain were compared with those to both preparations that had been first exposed to a complete ouabain dose range of dose-response curve (10$^{-8}$ to 10$^{4}$M). In rat ventricular strips and Langendorff perfused heart preparations, cumulative dose-response curves of ouabain revealed biphasic positive inotropic effects, a "low-dose" effect and a "high-dose" effect with E $d_{50}$ values of 0.5 $\mu$M and 35 $\mu$M ouabain, respectively. The "low-dose" effect in ventricular strip disappeared or was diminished significantly when the ouabain dose-response curve was repeated after the washout of the effects of the first dose-response curve, whereas there were no significant differences in the maximal "high-dose"effect in both exposures to oubain. However, both of the control and ouabain-preexposed Langendorff perfused hearts revealed the same low-dose effects. The $K_{D}$ value for [$^3$H] ouabain binding and the ouabain binding site concentration ( $B_{max}$) estimated by [$^3$H]ouabain displacement assay in control preparations were 230 nM and 2 pmol/mg protein, respectively. [$^3$H]Ouabain binding parameters were not changed by repeated exposure to high concentrations of ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site ($\alpha$$_2$isoform).).).).).

  • PDF