• Journal of Preventive Medicine and Public Health
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• v.46 no.1
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• pp.10-18
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• 2013

Objectives: We investigated the association between particulate matter less than $10{\mu}m$ in aerodynamic diameter ($PM_{10}$) exposure and non-accidental mortality in Asian populations by meta-analysis, using both time-series and case-crossover analysis. Methods: Among the 819 published studies searched from PubMed and EMBASE using key words related to $PM_{10}$ exposure and non-accidental mortality in Asian countries, 8 time-series and 4 case-crossover studies were selected for meta-analysis after exclusion by selection criteria. We obtained the relative risk (RR) and 95% confidence intervals (CI) of non-accidental mortality per $10{\mu}g/m^3$ increase of daily $PM_{10}$ from each study. We used Q statistics to test the heterogeneity of the results among the different studies and evaluated for publication bias using Begg funnel plot and Egger test. Results: Testing for heterogeneity showed significance (p<0.001); thus, we applied a random-effects model. RR (95% CI) per $10{\mu}g/m^3$ increase of daily $PM_{10}$ for both the time-series and case-crossover studies combined, time-series studies relative risk only, and case-crossover studies only, were 1.0047 (1.0033 to 1.0062), 1.0057 (1.0029 to 1.0086), and 1.0027 (1.0010 to 1.0043), respectively. The non-significant Egger test suggested that this analysis was not likely to have a publication bias. Conclusions: We found a significant positive association between $PM_{10}$ exposure and non-accidental mortality among Asian populations. Continued investigations are encouraged to contribute to the health impact assessment and public health management of air pollution in Asian countries.

• International Journal of Fluid Machinery and Systems
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• v.3 no.1
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• pp.11-19
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• 2010

The performance of the crossover system of a centrifugal compressor stage consisting of static components of $180^{\circ}$ U-bend, return channel vanes and exit ducting with a $90^{\circ}$ bend is investigated. This study is confined to the assessment of performance of the crossover system by varying the shape of the return channel vanes. For this purpose two different types of Return Channel Vanes (RCV1 and RCV2) were experimentally investigated. The performance of the crossover system is discussed in terms of total pressure loss coefficient, static pressure recovery coefficient and vane surface pressure distribution. The experimentation was carried out on a test setup in which static swirl vanes were used to simulate the flow at the exit of an actual centrifugal compressor impeller with a design flow coefficient of 0.053. The swirl vanes are connected to a mechanism with which the flow angle at the inlet of U-bend could be altered. The measurements were taken at five different operating conditions varying from 70% to 120% of design flow rate. On an overall assessment RCV1 is found to give better performance in comparison to RCV2 for different U-bend inlet flow angles. The performance of RCV2 was verified using numerical studies with the help of a CFD Code. Three dimensional sector models were used for simulating the flow through the crossover system. The turbulence was predicted with standard k-$\varepsilon$, 2-equation model. The iso-Mach contour plots on different planes and development of secondary flows were visualized through this study.

• Korean Chemical Engineering Research
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• v.56 no.2
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• pp.151-155
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• 2018

Degree of membrane degradation in Proton Exchange Membrane Fuel Cells (PEMFC) is mainly evaluated by the hydrogen crossover current density. The hydrogen crossover current density is measured by linear sweep voltammetry (LSV), which differs from the DOE protocol and the NEDO protocol. In this study, two protocols were compared during PEMFC operation and accelerated stress test. In the LSV method by the DOE method, the scan rate change affects the hydrogen crossover current density, but the NEDO method does not affect the hydrogen crossover current density. In the course of 15,000 cycles of polymer membrane wet/dry cycle, the DOE method was sensitive to membrane degradation, but the NEDO method was less sensitive to membrane degradation than the DOE method.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1181-1193
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• 2014

Currently Ministry of food and drug safety allows add-on trial when the bioequivalence between two drugs fails to show since July 1, 2008. However, bioequivalence of highly variable drugs based on $2{\times}2$ crossover designs would require too many subjects, so the alternative designs like $2{\times}4$ or $2{\times}3$ crossover experiments are preferred. In this paper, we propose and discuss the statistical procedures for add-on trials in $2{\times}4$ and $2{\times}3$ crossover designs.

• Journal of Electrochemical Science and Technology
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• v.14 no.2
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• pp.152-161
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• 2023

Vanadium redox flow batteries (VRFBs) have been considered one of promising power sources for large scale energy storage systems (ESS) because of their excellent cycle performance and good safety. However, VRFBs still have a few challenging issues, such as poor Coulombic efficiency due to vanadium crossover between catholyte and anolyte, although recent efforts have shown promise in electrochemical performance. Herein, the vanadium complexes with various glyme ligands have been examined as active materials to suppress vanadium crossover between catholyte and anolyte, thus improving the Coulombic efficiency of VRFBs. The conventional Nafion membrane has a channel size of ca. 10 Å, whereas vanadium cation species are small compared to the Nafion membrane channel. For this reason, vanadium cations can permeate through the Nafion membrane, resulting in significant vanadium crossover during cycling, although the Nafion membrane is a kind of ion-selective membrane. In this regard, various glyme additives, such as 1,2-dimethoxyethane (monoglyme), diethylene glycol dimethyl ether (diglyme), and tetraethylene glycol dimethyl ether (tetraglyme) have been examined as complexing agents for vanadium cations to increase the size of vanadium-ligand complexes in electrolytes. Since the size of vanadium-glyme complexes is proportional to the chain length of glymes, the vanadium permeability of the Nafion membrane decreases with increasing the chain length of glymes. As a result, the vanadium complexes with tetraglyme shows the excellent electrochemical performance of VRFBs, such as stable capacity retention (90.4% after 100 cycles) and high Coulombic efficiency (98.2% over 100 cycles).

• Asia Marketing Journal
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• v.11 no.3
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• pp.151-165
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• 2009

The objective of this case study is to analyze how effectively KIA SOUL, which is a leading Crossover Utility Vehicle (CUV) brand, has created a new market space through innovative product strategy. Up until now, most car manufacturers have focused only on the traditional product market segments missing out on the opportunity of the crossover segment market. KIA SOUL found a new market space by identifying the high crossover utility demand and filling the gap between the current product category values and the emerging crossover product category values. This case study illustrates that an innovative product strategy can be effectively employed to create a new market space in the saturated car manufacturing industry. The case summarizes that the innovative product strategy of KIA SOUL is comprised of four primary pillars: design innovation, market frontier in CUV, the first company to launch customizing service brand-TUON, and functional innovation. The KIA SOUL case study provides valuable insights and implications for many other companies that are planning to find "blue oceans" for their own business.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.965-969
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• 2003

In this paper, the implementation technique of digital crossover network using perfect linear phase IIR filters is presented. This system has various advantages which cannot be obtained from analog crossover network such as linear phase response, flat group delay and sharp cut-off at low-order over audio frequency band. The simulation results show that the group delay response is maximally flat and twice more attenuation in stop-band than the prototype elliptic IIR filter at all desired frequency.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2001.12a
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• pp.279-282
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• 2001

This paper presents an image contrast enhancement technique for improving the low contrast images using the improved IAFC(Integrated Adaptive Fuzzy Clustering) Model. The low pictorial information of a low contrast image is due to the vagueness or fuzziness of the multivalued levels of brightness rather than randomness. Fuzzy image processing has three main stages, namely, image fuzzification, modification of membership values, and image defuzzification. Using a new model of automatic crossover point selection, optimal crossover point is selected automatically. The problem of crossover point selection can be considered as the two-category classification problem. The improved MEC can classify the image into two classes with unsupervised teaming rule. The proposed method is applied to some experimental images with 256 gray levels and the results are compared with those of the histogram equalization technique. We utilized the index of fuzziness as a measure of image quality. The results show that the proposed method is better than the histogram equalization technique.

• Communications for Statistical Applications and Methods
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• v.7 no.2
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• pp.541-548
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• 2000

Various statistical methods for assessment of equivalence in average bioavailabilities have been developed under the assumption that the intra-subject variabilities for the test and reference formulations are the same. Without the assumption, assessing the equivalence in average bioavailabilites does not imply that the two formulations are therapeutically equivalent and exchangeable. The most commonly used test procedure for equality of variabilites in 2$\times$2 crossover experiment is the so called Pitman-Morgan's adjusted F test based on the model without carryover effects (Chow and Liu(1992)). In this paper, a Bayesian method based on the Intrinsic Bayes Factor is proposed, which can be applied to the model with carryover effects.

• Journal of Microbiology and Biotechnology
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• v.26 no.4
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• pp.725-729
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• 2016

A novel genome-engineering tool in Clostridium acetobutylicum was developed based on single-crossover homologous recombination. A small-sized non-replicable plasmid, pHKO1, was designed for efficient integration into the C. acetobutylicum genome. The integrated pHKO1 plasmid backbone, which included an antibiotic resistance gene, can be excised in vivo by Flp recombinase, leaving a single flippase recognition target sequence in the middle of the targeted gene. Since the pSHL-FLP plasmid, the carrier of the Flp recombinase gene, employed the segregationally unstable pAMβ1 replicon, the plasmid was rapidly cured from the mutant C. acetobutylicum. Consequently, our method makes it easier to engineer C. acetobutylicum.