• 제목/요약/키워드: cross-over studies

검색결과 359건 처리시간 0.023초

Fabulous Horses out of Water in B.Sīlā as Depicted in the Kūshnāma: A Cultural Encounter between East and West Asia

  • LIU, YINGJUN
    • Acta Via Serica
    • /
    • 제4권1호
    • /
    • pp.87-109
    • /
    • 2019
  • In the Iranian epic $K{\bar{u}}shn{\bar{a}}ma$, there is a rather interesting story that recounts how the inhabitants of $B.s{\bar{i}}l\bar{a}$ cross-breed their domesticated horses with a magical horse living in the sea in order to obtain fine-bred ones. What is even more interesting is that similar accounts are also seen in many of other classical Perso-Arabic works and Chinese sources. The regions that such events took place in mainly spread over Central Asia and western China while in $K{\bar{u}}shn{\bar{a}}ma$, the story happens in $B.s{\bar{i}}l\bar{a}$, a legendary kingdom with its historical prototype being Silla. By sorting out certain records of how ancient people sought fine horses by cross-breeding domesticated horses with wild horses that inhabited mountains and waters within Chinese sources and classical Muslim works, and comparing these accounts with similar plot lines as depicted in $K{\bar{u}}shn{\bar{a}}ma$, this paper attempts to elucidate that the story in $K{\bar{u}}shn{\bar{a}}ma$ is a result of flourishing land and maritime exchanges between East Asia and West Asia during ancient and medieval times, rather than a purely literary fiction. It was not only influenced by the horse culture that thrived over the Eurasian Steppe, but the story is also coincidentally in accordance with the fact that the nomadic zone which lies within the central Eurasian continent extends as far as the Korean Peninsula in northeast Asia.

해양 유류유출사고와 건강영향에 관한 해외 연구사례 분석 (A Literature Review on Health Effects of Exposure to Oil Spill)

  • 하미나;이원진;이승민;정해관
    • Journal of Preventive Medicine and Public Health
    • /
    • 제41권5호
    • /
    • pp.345-354
    • /
    • 2008
  • Objectives : Our objective is to review and summarize the previous studies on the health effects of exposure to oil spills in order to make suggestions for mid- and long-term study plans regarding the health effects of the Hebei Spirit oil spill occured in Korea. Methods : We searched PubMed to systemically retrieve reports on the human health effects related to oil spill accidents. The papers' reference lists and reviews on the topic were searched as well. Results : We found 24 articles that examined seven oil spill accidents worldwide over the period from 1989 to August 2008, including the Exxon Valdes, Braer, Sea Empress, Erika, Nakhodka, Prestige and Tasman Spirit oil spills. Most of the studies applied cross-sectional and short-term follow-up study designs. The exposure level was measured by assessing the place of residence, using a questionnaire and environmental and personal monitoring. Studies on the acute or immediate health effects mainly focused on the subjective physical symptoms related to clean-up work or residential exposure. Late or mid-term follow-up studies were performed to investigate a range of health effects such as pulmonary function and endocrine, immunologic and genetic toxicity. The economic and social impact of the accidents resulted in the socio-psychological exposure and the psychosocial health effects. Conclusions : Studies of the health effects of exposure to oil spills should consider a range of health outcomes, including the physical and psychological effects, and the studies should be extended for a considerable period of time to study the long-term chronic health effects.

형질전환 초파리를 이용한 Mdr49A 유전자의 살충제 교차저항성 기능 구명 (Molecular Mechanism of ABC Transporter Mdr49A Associated with a Positive Cross-Resistance in Transgenic Drosophila)

  • 성건묵
    • 한국응용곤충학회지
    • /
    • 제59권4호
    • /
    • pp.341-348
    • /
    • 2020
  • ATP-binding cassette (ABC) transporter는 다양한 기질을 세포 밖과 세포 안으로 수송하는 대표적인 수송단백질이다. 곤충에서 ABC transporter는 살충제에 대한 저항성을 발달시키는 중요한 역할을 한다. 현재까지 모델곤충인 초파리를 대상으로 ABC transporter의 살충제 교차저항성에 관한 연구는 많이 수행되어오지 않았다. 본 연구에서는 ABC transporter에 속하는 Mdr49A 유전자가 여섯 종류의 살충제에 보이는 교차저항성 기작을 형질전환 초파리를 이용하여 구명하였다. 초파리 91-R과 91-C 계통은 공통된 조상으로부터 유래되었으며 91-R은 60년 이상 DDT에 노출되었지만 91-C는 어떠한 살충제에도 노출되지 않고 유지되어 왔다. 91-R 계통의 MDR49A 단백질에서 유래된 3개의 아미노산 돌연변이를 형질전환 초파리에 과발현 시켰을 때 carbofuran에 대해서 2.0~6.7배 그리고 permethrin에 대해서 2.5~10.5배의 교차저항성을 나타낸 반면 다른 약제, abamectin, imidacloprid, methoxychlor, prothiofos에 대해서는 어떠한 교차저항성도 나타내지 않았다. 이상의 결과는 Mdr49A 유전자의 과발현과 더불어 3개의 아미노산 돌연변이는 두 개 약제, carbofuran과 permethrin에 대해 교차저항성 기능을 한다고 제시하고 있다.

1인 1회 분량을 적용한 영양 섭취량 추정 타당도 평가 (Validation of Nutrient Intake Estimation based on One Serving Size)

  • 김이영;김미현;최미경
    • 한국식품영양학회지
    • /
    • 제28권5호
    • /
    • pp.871-879
    • /
    • 2015
  • 24-hour recall is the dietary assessment method most frequently used to evaluate dietary intake; however, accuracy is an issue when using this method, especially in large-scale studies. The purpose of this study was to assess the validity of dietary intake estimation using one serving size. Estimates of energy and nutrients taken in over a 24-hr period based on actual intake amount (24HRAI) and based on estimates of one serving size (24HRSS) were compared. Data were analyzed using a paired t-test, Pearson's correlation coefficients, and a cross-classification method. In male subjects, intake levels of energy, fat, vitamin C, vitamin $B_1$, Zn, and total food measured using 24HRAI were significantly higher than those measured using 24HRSS. In female subjects, intake of carbohydrates, fiber, fat, vitamin A, vitamin C, vitamin B complexes, various minerals, and total food measured using 24HRAI were significantly lower than those measured using 24HRSS. Energy-adjusted Pearson's correlation coefficients revealed that intake of all nutrients showed a significant positive relationship between the two measurement methods in both males and females. Cross-classification analysis revealed that 50.5~67.6% of women and 40.3~71% of men were classified in the same quartile of intake of each nutrient when comparing data from 24HRAI and 24HRSS. We conclude that using one serving size in 24-hr recall analysis was valid and therefore may be used in studies to assess food consumption in the general adult population. Also, this method can be used to classify energy and nutrient intake into quartile, which is useful in examining the association between diet and chronic diseases.

A longitudinal study of the relation of lead in blood to lead in air concentrations among battery workers

  • Hodgkins Douglas G.;Robins Thomas G.;Hinkamp David L.;Schork M. Anthony;Krebs William H.
    • 대한예방의학회:학술대회논문집
    • /
    • 대한예방의학회 1994년도 교수 연수회(환경)
    • /
    • pp.577-584
    • /
    • 1994
  • The relation between lead in air (PbA) and lead in blood (PbB), concentrations was investigated among 44 workers in five major operations in a United States high volume, lead acid battery plant. The study covered a 30 month period in which workers received frequent PbA and PbB determinations, workers remained in a single job, and PbA concentrations averaged below the US Occupational Safety and Health Administration (OSHA) permissible exposure limit of $50{\mu}g/m^{3}$. In both univariate and multivariable linear regressions, longitudinal analyses averaging PbA concentrations over the 30 month study period appeared superior to cross sectional analyses using only six month PbA averages .to model PbB concentrations. The covariate adjusted coefficient ($\alpha$ value) for PbA($\mu/m^{3}$) in models of PbB (${\mu}g/100\;g$) was 1-14. This figure is strikingly higher than that reported in previous studies in the lead acid battery industry in all of which PbA concentrations were substantially higher than in the current study. Plausible explanations for the differences in a: values include non-linearity of the PbA-PbB curve, a higher fraction of large size particulate associated with higher PbA concentrations, survivor bias among workers exposed to higher PbA concentrations, and the cross sectional designs of most previous studies. Despite previously reported problems with the model used by OSHA to predict PbA-PbB relations, the findings of this study are in good agreement with the predictions of that model.

  • PDF

Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries

  • Vorn, Rany;Yoo, Hae Young
    • The Korean Journal of Physiology and Pharmacology
    • /
    • 제21권1호
    • /
    • pp.91-97
    • /
    • 2017
  • Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or without other metabolic substrates including FFAs termed "nutrition full" (NF) solution, on mesenteric (MA) and deep femoral arteries (DFA) of rats. Arterial ring segments were mounted in a double-wire myograph. Contraction in response to phenylephrine (PhE) was determined in control (5 mM) and high glucose (23 mM, HG) environments over a 30 min period. In both arteries, PhE-inducedvasocontraction was enhanced by pre-incubation of HG solution. A combined incubation with HG and palmitic acid ($100{\mu}M$) induced similar sensitization of PhE-contractions in both arteries. In contrast, high $K^+$-induced contractions were not affected by HG. Interestingly, pre-incubation with NF solution decreased PhE-induced contraction in MA but increased the contraction in DFA. In NF solution, the HG-induced facilitation of PhE-contraction was not observed in MA. Furthermore, the PhE-induced contraction of DFA was attenuated by HG in NF solution. Our results demonstrate that the sensitization of PhE-induced arterial contraction by HG is differentially affected by other metabolic substrates. The conversation of skeletal arterial contractility by HG in NF solution requires careful interpretation of the previous in vitro studies where only glucose is included in physiological salt solutions. Further studies are required to elucidate the mechanism underlying the inconsistent effect of NF solution on MA and DFA.

한국의 '정(情)'과 일본의 '아마에(甘え)'에 대한 인지적 고찰 (A Cognitive Study on Jeong in Korean and Amae in Japanese)

  • 김명희
    • 비교문화연구
    • /
    • 제27권
    • /
    • pp.471-496
    • /
    • 2012
  • Since Takeo Toi's discussion in The Anatomy of Dependence (1973), the concept of amae has generated considerable interest in the fields of psychology, anthropology, communication and other fields. However, there have been few agreements on the definition and functions of amae (Behrens, 2004). Furthermore, it has rarely drawn interest from linguists in general and has rarely been discussed in the context of social interaction. This study aims to examine the concept of amae in Japanese and the corresponding phenomena in Korean, and attempts to explore the similarities and differences between them. The prototype of the amae relationship is the mother-infant relationship (Doi,1973). Even an adult can assume the role of a baby, showing his or her need for dependence on others and expecting to be accepted. It turns out that amae-like phenomena frequently occur in everyday life in Korea as well (Lee, 1982). There is no single term for the concept, but it can be translated in many different ways in Korean, for example, aykyo, ayang, ungsek, erikwang, etc. It can have either positive or negative connotations depending on the situation. It seems that the psychological system that causes dependent behaviors such as ungsek in Korea is cheong, one of the key terms characterizing the Korean culture. Cheong, like amae, starts in the mother-infant relationship extending to familial and to other relationships. A corpus-based analysis shows that cheong is conceptualized as gluing people together, growing over time, and also potentially fatal because it assumes illogical, uncalculated, and personal relationships. In conclusion, unlike some Japanese scholars' claim that amae is the Japanese concept that exists only in Japan, it seems that similar phenomena do exist in Korea as well, but that Korean has no single term corresponding to amae in Japanese. It seems that cheong can be posited in Korean as the inner emotional system that makes amae-like behaviors possible, and that there is not single term, but many, designating the behaviors, possibly because the behaviors have a negative connotation and are not encouraged in Korean society.

『중국경극복장도보(中國京劇服裝圖譜)』의 의(衣) - 한중 연극의 비교학적 관점에서 접근한 해제와 역주 (CHINA COSTUME ART OF PEKING OPERA: Analytical&its translation)

  • 조만호;정유선
    • 비교문화연구
    • /
    • 제22권
    • /
    • pp.223-277
    • /
    • 2011
  • Tan Yuanjie(譚元杰) of CHINA COSTUME ART OF PEKING OPERA("中國京劇服裝圖譜") is 'Foreword' attention from the bar 'Formalism'. A note is makeup system from ever performances here, 'what kind of adaptation must be a corresponding type of costume should be worn.' This stance to 'type of person's identity and faced the scene correlated' with the actual performance tradition plays out is going and, while here the rules to capture the opera's on the character of 'identity and the circumstances under clothing' is defined. This position discussed previously 'Formalism' in line with the will he perform, and looks to meet the elements of production. This basic stance is clean up, while 'Old Beijing Opera costumes costumes taxonomy largely' literary costume' and 'militant outfit' into two groups divided over throughout steamroll surgery, because surely need to have a more systematic classification. The classification system was established as 'Part 1. Mang, Part 2. Pi, Part 3. Xi, Part 4. Kao, Part 5. YI'. In addition to these classification systems, as well as the aforementioned 'object theory' Given the symbolic significance of the capacity to keep in mind is necessary. Costumes conduct, character, situation, atmosphere and so the transport of charged symbols here, a target symbol of the system is the projection of water. This costume is detrimental to the mall for the positionsay, but I kept in mind damwongeolyi internationalization of Chinese culture. when you see the view from the perspective of semiotic systems for the sign, that the theater is necessary to complement. In this paper, 'Yi(衣)' costume on the corresponding point of the target compared to the China Culture Department of Theatre and Folklore methodology ran off and sprinting was to lay the groundwork for research.

생명 문화 정립을 위한 시론적 모색 (Contemporary Explorations to Establish Life Culture)

  • 이재복
    • 비교문화연구
    • /
    • 제21권
    • /
    • pp.165-188
    • /
    • 2010
  • One of the things that should be done first in establishing the cosmic life culture is to reflect on the old human-oriented culture. If the cosmic life culture absolutizes everything except for humans according to the logic of reason, its foundation will weaken or eventually get lost. Separating humans from the universe is just like separating life from it. Given that all life, whether it is humans or the earth, originated from the universe, such an effort for separation merely values an individual life by excluding all life or whole life. When the human body and the cosmic chi' blood are not in an active flow, it means there is a problem with life. What is in the greatest need in such a case is the sincere human mind that follows the principle of cosmic life. It is like the sincerity found in the pasonri singer, who mellows all the hardships and difficulties in the world out and create songs out of them like the shadow. It is the pansori singer's shadow that changes the universe. It is only when the extreme force of human mind communicates with that of the universe that the cosmic life or cosmic life culture can be created. In that sense, it is urgent to create life out of the universe inside me and create a universe out of all life in and outside me. It is such a grave plan in human history in that it involves finding the "Sanal" which is the core of life living hidden inside the body whose life force gradually goes away or inside the universe, and creating the culture of Bokseung in which it bursts out. The most important thing in life is the flow, and the mankind is currently standing in the life flow of the massive universe's chaosmos. The greatest task the mankind is currently faced with is to think over how to deal with the period of Big Chaos in the massive universe's chaosmos reversely and establish the cosmic life culture anew.

탈발전(Posdesarrollo)의 정치생태학 연구소고 - 아르뚜로 에스꼬바르의 비판이론을 중심으로 (A study of political ecology of Post-development - on critical discourses of Arturo Escobar)

  • 안태환
    • 비교문화연구
    • /
    • 제22권
    • /
    • pp.73-98
    • /
    • 2011
  • This study has as a object to investigate some various meanings of the discourses of postdevelopment of Arturo Escobar with the respect of the social movements of the indigenous and the afro-colombians in the area of the Pacific Coast of Colombia. The ideological lines of Escobar go around the group of critical discourse Modernity/(De)coloniality whose thesis lies on revealing the coloniality as principal elements of the modernity from the XVI century until now culminating in the neoliberal globalization. In another words, they try to seek for the alternative globalization based on the autonomy of the people who has been alienated for long time as 'others' by the eurocentrism of the power and the knowledge and on the equality of the cultural differences o the cosmovisions in Latin America. Escobar concentrates on the fact that the neoliberal regime would turn the nature into the environment considered as the resources for example the traditional knowledges of biodiversity of the indigenous as the capital of the pharmaceutical companies through the patents. However, the indigenous and the afro-colombians have fought fiercely to have them be maintained as a colective right of the possession not only to guard the economic interests but also their proper cultural traditions and the way of life based on the social solidarity of reciprocal care instead of the occidental individualism. This corresponds not only to the social relations but between the nature and the human society. And so, Arturo Escobar interprets these movements not only to defend the places but to express the cosmovisions of Postdevelopment further more the modern paradigm of nation-state.