• Tuberculosis and Respiratory Diseases
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• 제81권4호
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• pp.330-338
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• 2018

Background: We developed an additional laser guidance system to improve the efficacy and safety of conventional computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB), and we conducted this study to evaluate the efficacy and safety of our system. Methods: We retrospectively analyzed the medical records of 244 patients who underwent CT-guided PTNB using our additional laser guidance system from July 1, 2015, to January 20, 2016. Results: There were nine false-negative results among the 238 total cases. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of our system for diagnosing malignancy were 94.4% (152/161), 100% (77/77), 100% (152/152), 89.5% (77/86), and 96.2% (229/238), respectively. The results of univariate analysis showed that the risk factors for a false-negative result were male sex (p=0.029), a final diagnosis of malignancy (p=0.033), a lesion in the lower lobe (p=0.035), shorter distance from the skin to the target lesion (p=0.003), and shorter distance from the pleura to the target lesion (p=0.006). The overall complication rate was 30.5% (74/243). Pneumothorax, hemoptysis, and hemothorax occurred in 21.8% (53/243), 9.1% (22/243), and 1.6% (4/243) of cases, respectively. Conclusion: The additional laser guidance system might be a highly economical and efficient method to improve the diagnostic efficacy and safety of conventional CT-guided PTNB even if performed by inexperienced pulmonologists.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2004년도 춘계 학술대회논문집
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• pp.208-213
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• 2004

The HANARO, multi-purpose research reactor, 30 MWth open-tank-in- pool type, is under normal operation since it reached the initial critical in February 1995. The HANARO is planning to produce a fission moly-99 of radio isotopes, a mother nuclide of Tc-99m, a medical isotope and is under developing a target handling tool for loading and unloading it in a circular flow tube (OR-5). A guide tube is extended from the reactor core to the top of the reactor chimney for easily un/loading a target under the reactor normal operation. But active coolant through the core can be quickly raised up to the top of the chimney through the guide tube by jet flow. This paper is described an analytical analysis to calculate the hole size of a orifice inserted in the circular irradiation hole and to study the flow characteristics through the guide tube under reactor normal operation and loading the target. As results, the results show that the hole size of orifice was 31 mm of the inner diameter to suppress the guide tube jet flow and the coolant safely cooled the target of fission moly after inserting the orifice to the flow tube.

• 한국군사과학기술학회지
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• 제15권1호
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• pp.66-74
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• 2012

The virtual target signal generator was developed to verify the shipborne tracking radar performance. It was used to DRFM(Digital RF Memory) method to generate the virtual moving targets. The target signal includes Doppler shift and RCS according to the target motion. And the signal generator can make jamming signal and clutter to test shipborne radar performance at real environmental condition. This paper described the functional diagram and the hardware configuration items to meet the test requirements for the tracking radar. And it showed the critical design points for the sub-systems. The signal generator which was developed in this paper shared the operational information of the radar with the radar command and control part. To test the frequency agility of the radar, it had the local oscillator which could do high speed frequency switching according to radar information. By communicating between the signal generator and the radar command and control part, the local oscillator of signal generator could be controlled every pulse. It reduced the instantaneous bandwidth of signal generator and minimized the spurious. So it lowered the probability of generating wrong targets.

• 한국음향학회지
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• 제38권3호
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• pp.302-307
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• 2019

현대 대잠전에 있어 잠수함에 대한 2차원 위치추정에 다양한 방법들이 있다. 잠수함에 대한 보다 효과적인 추적 및 공격을 위해 표적 심도는 매우 중요한 요소이다. 하지만 현재까지도 잠수함의 심도를 찾아낸다는 것은 어려운 일이다. 본 논문에서는 최단접근점(Closest Point of Approach, CPA) 전후의 표적 접촉방위와 표적 도플러 신호 등 다이파 소노부이 접촉정보를 이용한 잠수함 심도 추정 기법을 제안하고자 한다. 표적의 상대심도는 표적과 다이파 소노부이의 청음기 간 사선거리 및 수평거리에 피타고라스 정리를 적용하여 결정된다. 이때 사선거리는 도플러변이와 표적 속도에 의해서 계산되며, 수평거리는 표적에 대한 연속된 접촉방위와 표적의 이동거리에 삼각함수를 적용하여 얻을 수 있다. 본 논문에서 제시된 알고리즘의 성능은 소노부이-표적 간 수평거리 및 상대심도에 의해 결정되는 고각과 도플러 변이 값의 측정 정확성에 의해 좌우됨을 시뮬레이션을 통해 알 수 있다.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.419-427
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• 2020

잠수함과 같은 대형 복합무기체계는 일반적인 무기체계의 램(RAM: Reliability, Availability, Maintainability) 목표 값 설정 방법을 적용 및 검증하는 것은 제한적이다. 잠수함은 소나체계, 무장체계 등 다수의 무기체계로 구성되어 있어 운용형태종합 및 임무(OMS: Operational Mode Summary/MP: Mission Profile)의 다양성, 장비의 복잡성 등의 특성을 갖는 복합무기체계이기 때문이다. 따라서 기존 무기체계의 개발사례 즉, 램 목표 값 설정 사례를 분석하고, 사례에 대한 문제점 및 제한사항을 도출하여 잠수함의 램 목표 값 설정 및 검증을 위한 개선방안을 제시하였다. 또한 잠수함은 다른 무기체계와는 달리 전 세계지역을 운용환경으로 하며, 서로 다른 운용조건 및 정비조건을 가진다. 이런 이유로, 잠수함의 램 목표 값은 구성하는 모든 구성품이 아닌, 임무 필수장비와 임무 중요장비를 중심으로 설정하고 검증해야 한다. 이에 본 연구는 잠수함건조 국방획득사업 추진시 잠수함의 체계 및 장비의 물리적인 성능요구와 더불어, 요구되는 성능 램 목표 값 설정에 대하여 검증하는 방법을 잠수함의 특성을 고려한 현실성 있는 방안을 제시하였다.

• 제어로봇시스템학회논문지
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• 제19권8호
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• pp.694-701
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• 2013

This paper deals with the problem of accurately tracking a single target moving through UWSNs (Underwater Wireless Sensor Networks) by employing underwater acoustic sensors. This paper addresses the issues of estimating the states of the target, and improving energy efficiency by applying a Kalman filter in a distributed architecture. Each underwater wireless sensor nodes composing the UWSNs is battery-powered, so the energy conservation problem is a critical issue. This paper provides an algorithm which increases the energy efficiency of each sensor node through WuS (Waked-up/Sleeping) and VM (Valid Measurement) selecting schemes. Simulation results illustrate the performance of the distributed tracking filter.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVI)
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• pp.82-85
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• 2005

Doxorubicin is a highly-valuable anthracycline-family polyketide drug with a very potent anticancer activity, typically produced by a Gram-positive soil bacterium called Streptomyces peucetius. Thanks to the recent development of Streptomyces genomics-based technologies, the random mutagenesis approach for Streptomyces strain improvement has been switched toward the genomics-based technologies including the application of DNA microarray systems. In order to identify and characterize the genomics-driven potential target genes critical for doxorubincin overproduction, three different types of doxorubicin overproducing strains, a dnrI(doxorubicin-specific positive regulatory gene)-overexpressor, a doxA (gene involved in the conversion from daunorubicin to doxorubicin)-overexpressor, and a recursively-mutated industrial strain, were generated and examined their genomic transcription profiles using Streptomyces DNA microarray systems. The DNA microarray results revealed several potential target genes in S. peucetius genome, whose expressions were significantly either up- or down-regulated comparing with the wild-type strain. A systematic understanding of doxorubicin overproduction at the genomic level presented in this research should lead us a rational design of molecular genetic strain improvement strategy.

• Ocean Systems Engineering
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• 제1권3호
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• pp.195-205
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• 2011

A method for calibrating a laser profiling system for seafloor micro-topography measurements is described. The system consists of a digital camera and an arrangement of six red lasers that are mounted as a unit on a remotely operated vehicle (ROV). The lasers project as parallel planes onto the seafloor, creating profiles of the local topography that are interpreted from the digital camera image. The goal of the calibration was to determine the plane equations for the six lasers relative to the camera. This was accomplished in two stages. First, distortions in the digital image were corrected using an interpolation method based on a virtual pinhole camera model. Then, the laser planes were determined according to their intersections with a calibration target. The position and orientation of the target were obtained by a registration process. The selection of the target shape and size was found to be critical to a successful calibration at sea, due to the limitations in the manoeuvrability of the ROV.

• International Journal of Aeronautical and Space Sciences
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• 제9권2호
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• pp.87-97
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• 2008

Modem anti-ship missiles employ complex and sophisticated guidance laws to hit the target and enhance their survivability by executing additional maneuvers. However, such maneuvers may cause the target to move out of the missile seeker's Field-Of-View (FOV). Maintaining seeker lock-on during an engagement is a critical factor for missile guidance. In this paper, a guidance law switching logic that maintains seeker lock-on and a simple guidance law that keeps the target look angle of the seeker constant is proposed. The proposed method can be used for the terminal homing phase, and can be switched from any kind of guidance laws if a proper switching condition is satisfied. The minimum and maximum flight time calculation method in consideration of the missile maneuver limit and the FOV of the seeker is also provided.

• The Korean Journal of Physiology and Pharmacology
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• 제17권2호
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• pp.111-120
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• 2013

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the pathophysiology of number of diseases including myocardial infarction, congestive heart failure, stroke, neurodegeneration, inflammatory disease, respiratory diseases, retinopathy and others. The present review discusses the different aspects of these enzymes including their pathophysiological role in disease development.