• 한국소음진동공학회논문집
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• 제12권5호
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• pp.355-364
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• 2002

The goal of this research is to reduce noise level of an outdoor unit of air conditioner by changing its dynamic characteristics using SDM (structural dynamics modification) technique. At first, the emitting noise was measured and analyzed. The measurement records show the most critical frequency components which influences on the noise level. Then it was tried to move the natural frequencies outside the critical frequency region by SDM. Since it is very difficult to get a reliable FE model of air conditioner, experimentally measured frequency response functions were used to derive sensitivities that are very important to obtain design changes. The positions of modification and the thickness of modifying structures were determined to improve the dynamic characteristics of air conditioner. The recommended design guideline to move its natural frequencies outside the targeting frequency range was obtained. Then in order to prove its effectiveness, the changed design was experimentally tested and found that the SDM result is very effective to reduce not only its vibration but also its emitting noise.

• Animal cells and systems
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• 제13권4호
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• pp.405-409
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• 2009

When DNA double-strand breaks (DSBs) were induced in mammalian cells, many DNA damage response proteins are accumulated at damage sites to form nuclear foci called IR-induced foci. Although the formation of foci has been shown to promote repair efficiency, the structural organization of chromatin in foci remains obscure. BAF53 is an actin-related protein which is required for maintenance of chromosome territory. In this study, we show that the formation of IR-induced foci by $\gamma$-H2AX and 53BP1 were reduced when BAF53 is depleted, while DSB- activated ATM pathway and the phosphorylation of H2AX remains intact after DNA damage in BAF53 knockdown cells. We also found that DSB repair efficiency was largely compromised in BAF53 knockdown cells. These results indicate that BAF53 is critical for formation of foci by $\gamma$-H2AX decorated chromatin at damage sites and the structural organization of chromatin in foci is an important factor to achieve the maximum efficiency of DNA repair.

• Wind and Structures
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• 제4권6호
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• pp.505-518
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• 2001

Shantou Bay Bridge is the first long-span suspension bridge in China. Because of its location near the Shantou Seaport and its exposure to high typhoon winds, wind-resistant studies are necessary to be made. In this paper, critical flutter wind speeds and buffeting responses of this bridge at its operation and main construction stages are investigated. The Buffeting Response Spectrum method is first briefly presented. Then the sectional model test is carried out to directly obtain the critical flutter wind speed and to identify the flutter derivatives, which are adopted for the later analysis of the buffeting responses using the Buffeting Response Spectrum method. Finally the aeroelastic full bridge model is tested to further investigate the dynamic effects of the bridge. The results from the tests and the computations indicate that the flutter and buffeting behaviors of the Shantou Bay Bridge are satisfied.

• BMB Reports
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• 제52권2호
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• pp.127-132
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• 2019

Cells must fine-tune their gene expression programs for optimal cellular activities in their natural growth conditions. Transcriptional memory, a unique transcriptional response, plays a pivotal role in faster reactivation of genes upon environmental changes, and is facilitated if genes were previously in an active state. Hyper-activation of gene expression by transcriptional memory is critical for cellular differentiation, development, and adaptation. TREM (Transcriptional REpression Memory), a distinct type of transcriptional memory, promoting hyper-repression of unnecessary genes, upon environmental changes has been recently reported. These two transcriptional responses may optimize specific gene expression patterns, in rapidly changing environments. Emerging evidence suggests that they are also critical for immune responses. In addition to memory B and T cells, innate immune cells are transcriptionally hyperactivated by restimulation, with the same or different pathogens known as trained immunity. In this review, we briefly summarize recent progress in chromatin-based regulation of transcriptional memory, and its potential role in immune responses.

• 한국의학물리학회지:의학물리
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• 제35권1호
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• pp.1-9
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• 2024

Margin inclusion or exclusion remains the most critical and controversial aspect of stereotactic radiosurgery (SRS) for metastatic brain tumors. This review aimed to examine the available literature on the impact of margins in SRS of brain metastasis and to assess the response of some medical physicists on the use of these margins. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method was used to review articles published in PubMed, Embase, and Science Direct databases from January 2012 to December 2022 using the following keywords: planning target volume, brain metastasis, margin, and stereotactic radiosurgery. A simple survey consisting of five questions was completed by ten medical physicists with experience in SRS treatment planning. The results were analyzed using IBM SPSS Statistics version 26.0. Of the 1,445 articles identified, only 38 articles were chosen. Of these, eight papers were deemed relevant to the focus of this review. These papers showed an increase in the risk of radionecrosis, whereas differences in local control were variable as the margin increased. In the survey, the response rate to whether or not to use margins in SRS, a critical question, was 50%. Margin addition increases the risk of radio necrosis. The local control rate varies among treatment modalities and cannot be generalized. From the survey, no consensus was reached regarding the use of these margins. This calls for further deliberations among professionals directly involved in SRS.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2009년도 추계학술대회 논문집
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• pp.185-189
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• 2009

It is very important to control the vibration transmitted from external utilities and the transient response due to the internal sources for the precision equipment, which is very sensitive to the vibration environment. The anti-vibration tables that use air springs have been widely used due to their excellent isolation performance, but the systems with high flexibility have the critical problem of large transient response by the impulsive force of the moving mass in operation of the equipment. In this paper, the hybrid vibration control system is proposed, which is combined the air springs with the semi-active MR dampers in order to satisfy the performances of isolation and vibration reduction simutaneously.

• Journal of Biosystems Engineering
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• 제24권5호
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• pp.383-390
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• 1999

When a tractor travels slope lands, problems of operator safety and the reduction of job efficiency usually occur. Therefore, maintaining the tractor body being horizontal is critical to improve the security of traveling and the job performance. An experiment was made in a soil bin using the experimental model system built and equipped with a leveling control system. Adaptability of the control system was tested and investigated by analyzing system response in time and frequency domains. Control response time of hydraulic cylinder with 10lpm flow rate on a step input of 10$^{\circ}$slope was about 0.42sec. And it showed a linearly increasing trend without any hunching state. A steady state error of 0.6$^{\circ}$occurred but it was negligible. The hydraulic control system showed a little phase differences within the range of 0.4Hz input frequency. The experimental model showed that implementation of the proposed tractor control system to on slope lands tractor was feasible.

• 한국안전학회지
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• 제27권1호
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• pp.44-48
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• 2012

The seismic safety of long-period cable-stayed bridges is assessed by probabilistic finite element analysis and reliability analysis under NFE. The structural response of critical members of cable-stayed bridges is evaluated using the developed probabilistic analysis algorithm. In this study, the real earthquake recording(Chi-Chi Earthquake; 1997) was selected as the input NFE earthquake for investigating response characteristics. The probabilistic response and reliability index shows the different aspect comparing the result from FFE earthquake. Therefore, the probabilistic seismic safety assessment on NFE earthquakes should be performed for the exact evaluation of long-period cable-stayed bridges and the earthquake resistant design criteria should be complemented.

• Structural Engineering and Mechanics
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• 제34권4호
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• pp.417-447
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• 2010

The uncertainty often observed in experimental strengths of masonry constituents makes critical the selection of the appropriate inputs in finite element analysis of complex masonry buildings, as well as requires modelling the building ultimate load as a random variable. On the other hand, the utilization of expensive Monte Carlo simulations to estimate collapse load probability distributions may become computationally impractical when a single analysis of a complex building requires hours of computer calculations. To reduce the computational cost of Monte Carlo simulations, direct computer calculations can be replaced with inexpensive Response Surface (RS) models. This work investigates the use of RS models in Monte Carlo analysis of complex masonry buildings with random input parameters. The accuracy of the estimated RS models, as well as the good estimations of the collapse load cumulative distributions obtained via polynomial RS models, show how the proposed approach could be a useful tool in problems of technical interest.

• 조명전기설비학회논문지
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• 제24권3호
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• pp.20-26
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• 2010

In ultrashort-pulse reflectometry (USPR), a chirped waveform transformed from the USPR source impulse signal via waveguide makes it possible to employ millimeter-wave mixers for the frequency up-conversion process. Consequently, the frequency bandwidth of the USPR system is sufficiently wide to cover a large portion of the electron density profile of the plasma. Some physical aspects of the chirped waveform, such as maximum amplitude and length, are critical factors to determine the performance of the system. In this paper, the propagation of the USPR impulse signal through a rectangular waveguide is numerically studied to derive the chirped waveform using the impulse response of the waveguide. The results of numerical computation show that the chirped waveform significantly depends on the waveguide cutoff frequency as well as the waveguide length.