• Journal of Advanced Marine Engineering and Technology
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• 제40권8호
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• pp.726-732
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• 2016

Clustering analysis is widely used in data mining to classify data into categories on the basis of their similarity. Through the decades, many clustering techniques have been developed, including hierarchical and non-hierarchical algorithms. In gene profiling problems, because of the large number of genes and the complexity of biological networks, dimensionality reduction techniques are critical exploratory tools for clustering analysis of gene expression data. Recently, clustering analysis of applying dimensionality reduction techniques was also proposed. PCA (principal component analysis) is a popular methd of dimensionality reduction techniques for clustering problems. However, previous studies analyzed the performance of PCA for only full data sets. In this paper, to specifically and robustly evaluate the performance of PCA for clustering analysis, we exploit an improved FCBF (fast correlation-based filter) of feature selection methods for supervised clustering data sets, and employ two well-known clustering algorithms: k-means and k-medoids. Computational results from supervised data sets show that the performance of PCA is very poor for large-scale features.

• Parasites, Hosts and Diseases
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• 제46권1호
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• pp.1-15
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• 2008

Introduction of double-stranded RNA (dsRNA) into some cells or organisms results in degradation of its homologous mRNA, a process called RNA interference (RNAi). The dsRNAs are processed into short interfering RNAs (siRNAs) that subsequently bind to the RNA-induced silencing complex (RISC), causing degradation of target mRNAs. Because of this sequence-specific ability to silence target genes, RNAi has been extensively used to study gene functions and has the potential to control disease pathogens or vectors. With this promise of RNAi to control pathogens and vectors, this paper reviews the current status of RNAi in protozoans, animal parasitic helminths and disease-transmitting vectors, such as insects. Many pathogens and vectors cause severe parasitic diseases in tropical regions and it is difficult to control once the host has been invaded. Intracellularly, RNAi can be highly effective in impeding parasitic development and proliferation within the host. To fully realize its potential as a means to control tropical diseases, appropriate delivery methods for RNAi should be developed, and possible off-target effects should be minimized for specific gene suppression. RNAi can also be utilized to reduce vector competence to interfere with disease transmission, as genes critical for pathogenesis of tropical diseases are knockdowned via RNAi.

• 식물병과 농업
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• 제5권1호
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• pp.1-7
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• 1999

The grain rot of caused by Bukholderia glumae was fist reported in japan in 1955 and then reported in other countries as well as in Korea in 1986. The pathogen causes both seedling and grain rot of rice but it cannot attack any other parts of adult rice plant. Bacterial colonies grow slowly, and are circular and greyish white. The causal bacterium is Gram-negative and rod shape with 1-3 polar flagella, and produce a diffusible yellow-greenish nonfluorescent pigment on King's medium B. Biochemical characteristics such as negative in arginine dehydrolase, oxidase reaction and nitrate reduction and positive in lecithinase, and the utilization of L-arginine and inositol are useful in differentiation of this from other nonfluorescent bacteria pathogenic to rice. This pathogenic bacterium had belonged to the genus of Pseudomonas but recently was transferred to the new genus Burkholderia on the basis of physiological characteristics and DNA-DNA hybridization data. However, other characteristics such as colony heterogenicity or colonial variation after subcultures, phytotoxin, secreting antibiotics, and relationship between yellow greenish pigment production and pathogenicity need to be clarified more. To develop an effective control strategy for this disease, understanding of detailed life cycle of the disease and critical environmental factors affecting disease development is prerequisite. Although 5,435 ha of rice paddy in Korea was infested during 1998, there is no exact estimation of yield losses and distribution of the pathogen. The review will focus on recent progress on the understanding of the bacteriological and ecological characteristics of the causal bacterium and control means of the disease.

• 한국화재소방학회논문지
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• 제22권4호
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• pp.76-84
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• 2008

건축물의 지상층 주요구조부인 기둥, 보 및 바닥에 대한 내화성능의 연구는 활발하게 진행되고 있으나, 모든 구조적 하중을 지반으로 전달하는 지하층의 기둥을 비롯한 주요 구조부의 내화성능에 관한 자료 및 연구는 거의 없는 실정이다. 개구부율이 낮은 지하층에서의 화재크기는 지상층 화재보다 열에너지량이 크므로 구조적 붕괴의 위험성은 높다. 따라서 본 논문에서는 지하에 위치된 구조부재에 대한 내화성능의 적정성 평가를 위한 기본 자료 제공을 목적으로 국내외 지하 구조물의 내화법규정을 조사하고, 국내의 기시공된 건축물의 지하층의 구조형식, 구조재료 및 내화피복 현황을 분석하였다.

• Steel and Composite Structures
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• 제4권4호
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• pp.281-301
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• 2004

The paper begins by presenting a unified variational approach to the lateral-torsional buckling (LTB) analysis of doubly symmetric prismatic and tapered thin-walled beams with open cross-sections, which accounts for the influence of the pre-buckling deflections. This approach (i) extends the kinematical assumptions usually adopted for prismatic beams, (ii) consistently uses shell membrane theory in general coordinates and (iii) adopts Trefftz's criterion to perform the bifurcation analysis. The proposed formulation is then applied to investigate the influence of the pre-buckling deflections on the LTB behaviour of prismatic and web-tapered I-section simply supported beams and cantilevers. After establishing an interesting analytical result, valid for prismatic members with shear centre loading, several elastic critical moments/loads are presented, discussed and, when possible, also compared with values reported in the literature. These numerical results, which are obtained by means of the Rayleigh-Ritz method, (i) highlight the qualitative differences existing between the LTB behaviours of simply supported beams and cantilevers and (ii) illustrate how the influence of the pre-buckling deflections on LTB is affected by a number of factors, namely ($ii_1$) the minor-to-major inertia ratio, ($ii_2$) the beam length, ($ii_3$) the location of the load point of application and ($ii_4$) the bending moment diagram shape.

• Smart Structures and Systems
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• 제10권2호
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• pp.89-110
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• 2012

This study was intended to efficiently perform the probabilistic optimal safety assessment of steel cable-stayed bridges (SCS bridges) using stochastic finite element analysis (SFEA) and expected life-cycle cost (LCC) concept. To that end, advanced probabilistic finite element algorithm (APFEA) which enables to execute the static and dynamic SFEA considering aleatory uncertainties contained in random variable was developed. APFEA is the useful analytical means enabling to conduct the reliability assessment (RA) in a systematic way by considering the result of SFEA based on linearity and nonlinearity of before or after introducing initial tensile force. The appropriateness of APFEA was verified in such a way of comparing the result of SFEA and that of Monte Carlo Simulation (MCS). The probabilistic method was set taking into account of analytical parameters. The dynamic response characteristic by probabilistic method was evaluated using ASFEA, and RA was carried out using analysis results, thereby quantitatively calculating the probabilistic safety. The optimal design was determined based on the expected LCC according to the results of SFEA and RA of alternative designs. Moreover, given the potential epistemic uncertainty contained in safety index, failure probability and minimum LCC, the sensitivity analysis was conducted and as a result, a critical distribution phase was illustrated using a cumulative-percentile.

• 건축역사연구
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• 제25권2호
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• pp.21-30
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• 2016

Autonomia movement that emerged in Italy in the 1960s from workerist (operaismo) communism gives historical and discursive context to Manfredo Tafuri's famous criticism of ideology. His thesis on the death of architecture was a radical criticism of Keynesian intervention which was a strategy to cope with the Great Depression. For him, this capitalist development had taken away ideological prefiguration from architecture. At least Tafuri's this early intellectual phase was formed in the wake of magazine Contrapiano and Antonio Negri's influence. Tafuri almost entirely adapted Negri's thought on the importance of capitalist innovation that was uncovered by Keynes, Schumpeter, and Manheim and the periodization in modern history. When we read Tafuri's text with this concrete context, we can avoid being plunged into his abstruseness. On the other hand, 1980's Korea cannot understand Tafuri comprehensibly. 1980's situation to struggle to acquire democracy prescribed only one mode of reception of Tafuri's historiography in Korea. Tafuri's so-called pessimist view point could not satisfy student activists. They want to take intellectual means to sustain student movement and to secure political dynamics of protest. But at the same time they have anxiety to understand tafuri's thesis that they consider ad a critical theory for Korean Architecture. Double contexts of Tafuri's criticism of ideology bring to light to historicize both Tafuri's historiography itself and reception of his text in Korea.

• 반도체디스플레이기술학회지
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• 제12권4호
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• pp.45-48
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• 2013

The electronic device, such as flat panel display (FPD), is very important in our life as a means of communication between humans. Liquid crystal display (LCD), which is categorized as a flat panel display, has been used in many display products, especially in TV industry. An LED TV is composed of several electrical components, such as liquid critical module (LCM), analog to digital convertor (AD), power supplier, and inverter board. These modules are very vulnerable to particulate contamination, and causing malfunction or visibility degradation. In this study, we developed a test method for prediction of LCM's lifetime. The test system consists of carbon particle generation flame, dilution system, test chamber, and particle concentration monitoring instrument. Since the carbon particles are the most abundant in the atmosphere and easily absorb light, soot particles are used as a challenging material for this test. The concentration of generated soot particles is set around 4,000,000 #/cc, which is 400 times higher than that of usual atmospheric particles. Through this experiment, we deduced the relationship between the dust concentration and life time of the test specimen.

• 한국시뮬레이션학회논문지
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• 제10권1호
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• pp.63-65
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• 2001

To investigate the natural frequencies of curved piping systems with various elbow angles conveying flow fluid, a simulation is performed considering Initial tension due to the inside fluid. The system is analyzed by finite element method utilizing straight beam element. Elbow part is meshed using 4 elements, and the initial tension is considered by inserting equivalent terms into the stiffness matrix. Without considering the initial tension, the system becomes unstable, that is, the fundamental natural frequency approaches to zero value fast, as the flow velocity reaches critical value. With the initial tension terms, the system becomes stable where there is no abrupt decrease of the fundamental natural frequency. The change rate of the natural frequency with respect to the flow velocity reduces. As elbow angle increases, the system becomes stiffer, then around 150 degrees of the elbow angle the natural frequency has the largest value, the value decreases after the angle of the largest natural frequency. When angle is between 170 degrees and 179 degrees, the natural frequency is very sensitive. This means that small change of angle results in great change of natural frequency, which is expected to be utilized in the control of the natural frequency of the piping system conveying flow fluid.

• Nuclear Engineering and Technology
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• 제50권4호
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• pp.532-541
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• 2018

Decision support systems are a key focus of research on developing control rooms to aid operators in making reliable decisions and reducing incidents caused by human errors. For this purpose, models of complex systems can be developed to diagnose causes or consequences for specific alarms. Models applied in safety systems of complex and safety-critical systems require rigorous and reliable model building and testing. Multilevel flow modeling is a qualitative and discrete method for diagnosing faults and has previously only been validated by subjective and qualitative means. To ensure reliability during operation, this work aims to synthesize a procedure to measure model performance according to diagnostic requirements. A simple procedure is proposed for validating and evaluating the concept of multilevel flow modeling. For this purpose, expert statements, dynamic process simulations, and pilot plant experiments are used for validation of simple multilevel flow modeling models of a hydrocyclone unit for oil removal from produced water.