• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4681-4688
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• 2016

Objective: Our aim was to estimate whether diabetes mellitus (DM) may be associated with an increased risk of colorectal cancer (CRC) mortality in Japan. Methods: The Japan Collaborative Cohort (JACC) Study is a nationwide prospective study, initiated in 1988, which involves 110,585 subjects (age range: from 40 to 79 years; 46,395 males and 64,190 females). Our present analysis population comprised 96,081 (40,510 men and 55,571 women) who provided details on DM history. The questionnaire also included age, sex, weight, height, family history of CRC, smoking, drinking and exercise habits, and education. Cox proportional-hazard regression was used to estimate the hazard ratio (HR). We used SPSS 21 software to analyze all data. Results: Among the participants with DM, we followed up for 71,174 person-years and 640. deaths from CRC were confirmed; and, among the non-diabetic participants, 785 CRC deaths were identified during 1,499,324 person-years. After adjusting for multivariate confounding factors, such as age, sex, body mass index (BMI), family history of colorectal cancer, smoking habit, drinking habit, physical activity (sports and walking) and education, DM was associated with an increased risk of CRC death (HR 1.4, 95% confidence interval [CI] 1.0-2.0). Diabetic women, but not diabetic men, experienced increased mortality from CRC (HR 1.7, 95% CI 1.0-3.0). Conclusion: The risk of CRC mortality is significantly increased in both sexes and women with diabetes, but no significant increase was seen for diabetic men among Japanese.

• 한국해안·해양공학회논문집
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• 제29권6호
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• pp.363-368
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• 2017

지진해일은 그 파랑이 연안 도시로 범람하여 육상 구조물에 피해를 주게 된다. 육상 구조물에 미치는 파압 및 파력에 대한 연구는 육상 구조물의 안정성 설계의 중요한 요인 중 하나이다. 본 연구에서는 단순화한 박스구조물에 미치는 지진 해일의 수평 파력 및 파압에 대한 2차원 단면 수리모형실험을 수행하였다. 시간에 따른 수평 파압의 수직 분포와 파력을 파압계와 파력계를 사용하여 계측하여 상호 비교하였다. 또한, 쇄파의 형태도 다양하게 고려하여 계측하였다. 쇄파된 파랑이 입사하는 경우 구조물에 미치는 수평 파력이 최대가 되는 순간에는 수평 파압이 수직적으로 균일하였고, 그 외의 경우에는 육상 저면에 가까울수록 수평 파압이 커지는 분포를 보였다. 최대 수평 파력을 다양한 입사파랑 조건에 대한 함수로 표현하기 위해 쇄파상사계수를 사용하여 수평 파력과의 관계식을 산출하였다. 그 결과 무차원화한 수평 파력은 쇄파상사계수가 증가함에 따라 지수적으로 감소하는 경향을 있음을 보였다.

• Journal of Preventive Medicine and Public Health
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• 제36권4호
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• pp.359-366
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• 2003

Objectives : This study was conducted to review the diffusion process and factors affecting the adoption of the Health Center Information System (HIS). Methods : Data were collected from POSDATA (private company), MOHW, other Ministries and local governments. To specify the date of adoption, supplementary information was collected from 40 health centers. The following three kinds of factors were analyzed. Internal factors included type, size, and innovativeness of health centers. Community factors were composed of population sire, economic status, and level of education. Organizational environmental factors consisted of information score of the municipalities, financial support of the from central government, and the neighborhoodness of innovator health centers. Results : All health centers in the metropolitan cities of Seoul, Gwangju and Jeju adopted the HIS. The laggards were those in the metropolitan cities of Busan (18.8%), Incheon (20.0%) and Daejun (20.0%), and cities with population more than 300,000 (54.8%) and counties with health center hospitals (47.1%). Financially supported rural health centers adopted the HIS more rapidly than those not supported. The factors identified as being statistically significant (p<0.05), from a univariate analysis by Kaplan-Meier method, were: (1) internal factors of the type, size and innovativeness of health centers; (2) community factors of population size and economic status; (3) organizational environmental factors of the central government financial support and the neighborhoodness of innovator health centers. A multivariate analysis, using a Cox proportional hazard method, proved the innovativeness of health centers, central government financial support and the neighborhoodness of innovator health centers, were statistically significant (p<0.05). Conclusions : The innovativeness of health centers, financial support from central government and the neighborhoodness of innovator health centers, rather than community factors related to regional socioeconomic status, affected ffe adoption of the HIS in health centers. Further in-depth studies, modifying the MOHW's strategy to propagate the HIS to the laggard health confers, are recommended.

• Journal of Preventive Medicine and Public Health
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• 제49권5호
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• pp.275-287
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• 2016

Objectives: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea. Methods: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level ${\geq}10mg/L$) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors. Results: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality. Conclusions: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.

• 대한한의학방제학회지
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• 제25권4호
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• pp.483-497
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• 2017

Background : Behavioral stress has been suggested as one of the significant factors that is able to disrupt physiological systems and cause depression as well as changes in various body systems. The stressful events can alter cognition, learning, memory and emotional responses, resulting in mental disorders such as depression and anxiety. Results : We used a restraint stress model to evaluate the alteration of behavior and stress-related blood parameter. The animals were randomly divided into two groups of five animals each group. Furthermore, we assessed the change of body weight to evaluate the locomotor activity as well as status of emotional and anxiety in mice. After 7 days of restraint stress, the body weight had significantly decreased in the restraint stress group compared with the control group. We also observed stress-associated behavioral alterations, as there was a significant decrease in open field and forced swim test, whereas the immobilization time was significantly increased in the stress group compared to the control group. We observed the morphological changes of neuronal death and microglia by immunohistochemistry and western blot. In our study restraint stress did not cause change in neuronal cell density in the frontal cortex and CA1 hippocampus region, but there was a trend for an increased COX-2 and iNOS protein expression and microglia (CD11b) in brain, which is restraint stress. Conclusion : Our study, there were significant alterations observed in the behavioral studies. We found that mice undergoing restraint stress changed behavior, confirming the increased expression of inflammatory factors in the brain.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2527-2530
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• 2015

Background: The cancer of the prostate risk assessment (CAPRA) score has been defined to predict prostate cancer recurrence based on the pre-clinical data, then pathological data have also been incorporated. Thus, CAPRA post-surgical (CAPRA-S) score has been developed based on six criteria (prostate specific antigen (PSA) at diagnosis, pathological Gleason score, and information on surgical margin, seminal vesicle invasion, extracapsular extension and lymph node involvement) for the prediction of post-surgical recurrences. In the present study, biochemical recurrence (BCR)-free probabilities after open retropubic radical prostatectomy (RP) were evaluated by the CAPRA-S scoring system and its three-risk level model. Materials and Methods: CAPRA-S scores (0-12) of our 240 radical prostatectomies performed between January 2000-May 2011 were calculated. Patients were distributed into CAPRA-S score groups and also into three-risk groups as low, intermediate and high. BCR-free probabilities were assessed and compared using Kaplan-Meier analysis and Cox proportional hazards regression. Ability of CAPRA-S in BCR detection was evaluated by concordance index (c-index). Results: BCR was present in 41 of total 240 patients (17.1%) and the mean follow-up time was $51.7{\pm}33.0$ months. Mean BCR-free survival time was 98.3 months (95% CI: 92.3-104.2). Of the patients in low, intermediate and high risk groups, 5.4%, 22.0% and 58.8% had BCR, respectively and the difference among the three groups was significant (P = 0.0001). C-indices of CAPRA-S score and three-risk groups for detecting BCR-free probabilities in 5-yr were 0.87 and 0.81, respectively. Conclusions: Both CAPRA-S score and its three-risk level model well predicted BCR after RP with high c-index levels in our center. Therefore, it is a clinically reliable post-operative risk stratifier and disease recurrence predictor for prostate cancer.

• Journal of Chest Surgery
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• 제41권6호
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• pp.724-728
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• 2008

배경: 본원에서 자발성 기흉으로 흉강경을 이용 폐 쐐기절제술 후 퇴원한 환자가운데 재발로 수술을 다시 받은 환자에서 기흉의 재발에 관한 위험 인자에 대해 연구하였다. 대상 및 방법: 2002년 1월부터 2005년 12월까지 본원 흉부외과에서 흉강경을 이용하여 흉막 유착술 없이 폐 쐐기절제술만을 시행한 235명을 대상으로 하였다. 퇴원 후 외래 추적관찰 중에 재발이 없었던 A군(225명: 96%), 재발이 있었던 B군(10명: 4%)으로 나누어서 후향적 조사를 통하여 재발 위험인자에 대하여 알고자 하였다. 결과: 각 군의 평균나이는 재발되는 군에서 $19.6{\pm}7.17$세로 더 어렸으며(p<0.05), 각군 남녀 비는 남자가 많았으나, 통계학적 의의는 없었다 흡연력, 병변 부위 및 폐허탈 정도는 양군사이에 유의한 차이는 없었다. 수술적 요인에 대한 것으로 술 후 공기 누출기간이 길수록, 흉관 거치 기간이 짧을수록 재발 가능성이 더 높았으며(p<0.05), 평균 재발기간은 $10.2{\pm}8.5$개월($0.6{\sim}22$개월)이었다. 재발된 군 중 4명은 술 후 한달 동안 충분한 준비 운동 없는 과격한 운동(농구 등)을 했던 경험이었다. 술 후 재발에 영향을 주는 단일 변수는 수술 시 나이,공기 누출기간, 키/몸무게 비 및 흉관 유지 기간이었으며, 다중 변수에 의한 위험 인자는 수술 시 나이, 신장/몸무게 비, 공기 누출 및 흉관 유지 기간 순이었다 결론: 자발성 기흉에서 흉강경을 이용한 폐기포 절제술은 재발율이 개흉술에 비하여 높지 않아서 시행할 수 있지만, 재발 위험인자로 나이가 젊거나, 큰 신장/몸무게비, 지속적인 공기 누출 있거나 짧은 흉관 유지 기간이었으며, 퇴원 후 너무나 빠른 심한 운동은 폐기포절제술 후 기흉 재발의 원인이 될 수 있다.

• 한국인구학
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• 제19권1호
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• pp.5-44
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• 1996

여성, 특히 기혼여성의 사회적 참여는 해마다 증가하는 추세를 보이고 있으며, 이들을 좀 더 적극적으로 활용하려는 정책적 관심도 증대되고 있다. 그러나 기혼여성 노동력의 노동시장 참여를 걸정짓는 요인에 대한 분석은 매우 부진했으며, 특히 가사분담과 생애주기에 따른 가족내 재생산노동의 수요변화 등에 동태적인 변화에 대한 경험적 분석은 매우 미미하였다. 이 연구는 여성의 노동시장 참여에 관한 개인사적 자료를 활용하여 여성의 재생산노동과 생산노동간의 연관성, 그리고 생애주기에 따른 가족내 여성의 변화 등이 여성의 노동시장 참여에 미치는 영향에 관하여 사건사분석의 방법론을 활용하여 경험적인 분석을 행하였다. 한국여성개발원이 1991년도에 수집한 '제2차 여성취업실태 조사' 자료를 토대로 도시지역에 거주하는 여성들만을 대상으로 분석하였고, 분석방법으로는 횡단면자료를 중심으로는 로짓분석을, 취업과 비취업간의 전환에 대해서는 전환율을 종속변수로 하는 콕스회귀 분석을 시행하였다. 그 결과 여성의 노동시장 참여가 전반적인 증대에도 불구하고 나이, 코호트, 가족형성의 주기 등에 따라 상당한 편차를 나타내고 있다. 특히 결혼과 출산은 고용의 지속성에 강한 부정적 영향을 미치며, 가사노동과 육아 책임의 대부분을 여성이 부담하는 상황에서 가족내 재생산과 노동시장내 생산노동간의 상호교환관계(trade-off)가 존재함을 보여준다. 여성의 취업주기는 개인의 인적 특성과 가족형성기의 특징 이외에 전반적인 노동시장구조의 영향을 받고 있는 것으로 나타내는데, 특히 하층 저학력 여성의 전환과정은 신경제학적 개념이, 고학력 여성의 비취업으로의 강한 회귀현상은 신구조주의적 관점에서 이해되어야 할 사항이다. 이 연구의 결과는 여성의 노동시장 참여를 제고하고 취업의 질을 높이기 위해서는 가족형성주기와 연관된 여성들의 기회비용를 낮추는 방법, 예를 들면 다양한 탁아 및 보육시설의 설치, 차별적 고용관행의 폐지, 유연한 시간근무를 가능케 하는 다양한 파트타임제의 확대 등과 같은 정책이 필요함을 시사하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2953-2958
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• 2015

Although associations between thioredoxin interacting protein (TXNIP) and cancers have been recognized, the effects of TXNIP on non-small cell lung cancer (NSCLC) prognosis remained to be determined in detail. In addition, while hypoxia is a key characteristic of tumor cell growth microenvironment, the effect of hypoxia on TXNIP expression is controversial. In this study, formaldehyde fixed and paraffin embedded (FFPE) samples of 70 NSCLC patients who underwent resection between January 2010 and December 2011 were obtained. Evaluation of TXNIP and hypoxia inducible factor-$1{\alpha}$ ($HIF-1{\alpha}$) protein expression in FFPE samples was made by immunohistochemistry. By Kaplan-Meier method, patients with high TXNIP expression demonstrated a significantly shorter progression free survival (PFS) compared with those with low TXNIP expression (18.0 months, 95%CI: 11.7, 24.3 versus 23.0 months, 95%CI: 17.6, 28.4, P=0.02). High TXNIP expression level was also identified as an independent prognostic factor by Cox regression analysis (adjusted hazard ratio: 2.46; 95%CI: 1.08, 5.56; P=0.03). Furthermore, TXNIP expression was found to be significantly correlated with $HIF-1{\alpha}$ expression (Spearman correlation=0.67, P=0.000). To further confirm correlations, we established a tumor cell hypoxic culture model. Expression of TXNIP was up-regulated in all three NSCLC cell lines (A549, SPC-A1, and H1299) under hypoxic conditions. This study suggests that hypoxia induces increased TXNIP expression in NSCLC and high TXNIP expression could be a poor prognostic marker.

• BMB Reports
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• 제48권11호
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• pp.618-623
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• 2015

FK506 binding protein 12 (FK506BP) is a small peptide with a single FK506BP domain that is involved in suppression of immune response and reactive oxygen species. FK506BP has emerged as a potential drug target for several inflammatory diseases. Here, we examined the protective effects of directly applied cell permeable FK506BP (PEP-1-FK506BP) on corneal alkali burn injury (CAI). In the cornea, there was a significant decrease in the number of cells expressing pro-inflammation, apoptotic, and angiogenic factors such as TNF-α, COX-2, and VEGF. Both corneal opacity and corneal neovascularization (CNV) were significantly decreased in the PEP-1-FK506BP treated group. Our results showed that PEP-1-FK506BP can significantly inhibit alkali burn-induced corneal inflammation in rats, possibly by accelerating corneal wound healing and by reducing the production of angiogenic factors and inflammatory cytokines. These results suggest that PEP-1-FK506BP may be a potential therapeutic agent for CAI.