• 정보처리학회논문지B
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• 제13B권1호
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• pp.63-70
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• 2006

말뭉치(corpus)는 많은 언어 정보를 포함하고 있으며, 언어처리 및 계산언어학 분야에서 다양한 용도로 사용되고 있다. 그러나 말뭉치에 언어 정보를 부착하는 데는 많은 시간과 인력이 소요된다. 이 문제를 완화시키기 위해서 말뭉치 구축 도구가 반드시 요구된다. 본 논문에서는 한국어 의존구조 부착을 위한 말뭉치 구축 도구의 설계 및 구현에 관해서 기술한다. 가장 이상적인 방법은 주석자가 전혀 개입하지 않고, 말뭉치를 구축하는 것이나 이것은 사실상 불가능하다. 따라서 대부분의 말뭉치 구축 도구는 반자동으로 구성되어 있으며, 본 논문에서 제안된 도구도 반자동이다. 제안된 도구는 언어 분석기의 분석 결과에 내포된 오류를 효과적으로 수정할 수 있고, 또한 가능한 한 반복적인 작업을 피할 수 있으며 쉽게 사용할 수 있도록 인터페이스를 설계하였다. 제안된 시스템을 이용해서 20어절 이상의 1만 문장에 의존구조를 부착해 보았다. 잘 훈련된 8명의 주석자들이 매일 4시간씩 2개월 동안 구축하였으며, 그 결과는 정확하고 일관성 있는 말뭉치를 구축할 수 있었으며, 작업 시간과 인력도 크게 줄일 수 있었다.

• Clinical and Experimental Pediatrics
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• 제52권1호
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• pp.111-118
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• 2009

목 적 : 어린시기에 genistein과 같은 식물성 에스트로겐의 섭취가 사회적 관심사로 대두되고 있다. 본 연구에서는 어린 쥐에서 genistein에 노출이 사춘기 개시 및 생식기관에 미치는 영향을 알아 보았다. 방 법 : 이유기(3주령) 암컷 흰쥐를 저용량 genistein (10 mg/kg/day), 고용량 genistein (100 mg/kg/day), 대조군의 세 그룹 (각 그룹 당 n=6)으로 나누고 첫 번째 질구 개방이 확인되는 날까지 농도별로 각각 경구 투여하였다. 질구 개방일을 확인하고 생식 기관의 무게를 측정하며 난소와 자궁에서 $ER{\alpha}$, $ER{\beta}$, PR 유전자들의 발현양상을 RT-PCR을 이용해 비교하였고, 난소와 자궁의 구조적 이상을 확인하기 위해 조직학적 분석을 실시하였다. 결 과 : 고용량 genistein 투여군은 저용량군 및 대조군에 비해 질구 개방일이 유의하게 촉진되었다. RT-PCR결과, $ER{\alpha}$, $ER{\beta}$, PR의 전사활성은 genistein에 노출된 쥐들의 난소와 자궁에서 유의하게 증가하였다. 그라프 난포와 황체는 genistein 투여군의 난소에서만 발견되었고, 대조군의 난소에서는 1차, 2차 난포들과 작은 미성숙 난포들만이 관찰되었다. Genistein 처리군의 자궁에서도 내막층 근막층 및 상피층이 과다성장상태였으나 대조군에서는 모든 세포층과 분비선이 미약하게 발달하였다. 결 론 : 결론적으로, 사춘기 이전 시기에 비교적 단기간의 genistein 노출이라도 미성숙 암컷 흰쥐에서 생식 내분비 활성을 일으켜 조기 사춘기와 성 스테로이드 호르몬 수용체의 발현 양상 변화를 초래할 수 있으며, genistein의 노출이 아동기 성성숙에 미치는 영향에 대한 더욱 많은 연구가 필요할 것으로 사료된다.

• 대한수의학회지
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• 제34권4호
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• pp.873-880
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• 1994

Progesterone catabolizing enzyme, the enzyme $20{\alpha}$-hydroxysteroid deltydrgenase($20{\alpha}$-HSD) is pivotal in the regulation of ovarian function in rodents, which catabolizes progesterone into biologically inactive $20{\alpha}$ hydroxypregn-4-en-3-one($20{\alpha}$-OHP). In this study was carried out the influence of $20{\alpha}$-HSD activity to ovarian function and regulation such as ovulation, formation of corpus luteum, maintenance of estrous cycles and pregnancy, we investigated changes in activities of the splenic macrophages and ovarian histological findings in rat. During the estrous cycles, the ratious of phagocytotic macrophage in splenic adherent cells were highest on the proestrous, but they were lowest on metestrous. During the pregnancy, the ratious of phagocytotic macrophages in splenic adhrent cells were lowest by 1 day and then significantly increased toward the pregnancy, which were highest pregnancy on day 12. On histological findings in rat ovary, the mean number of growing, antral and mature follicles were 15.9(72.9%), 3.4(15.9%), and 2.4(11.2%), respectively. Growing follicles reached to lowest number at diestrus and mature follicle reached to lowest number at metestrus. The numbers of corpus luteums per tissue section of the ovary were 14.4 and the number of normal and atretic follicles were 11.0(76.4%) and 3.4(23.6%), respectively. The number of corpus luteum with vacolated cell were 1.7(11.8%). In this study suggests splenic macrophages are as a source of the substance which maintainer progesterone secretion from luteal cells, and are recognized pass the vessels and reside in the fresh corpora lutea soon after ovulation via inflammatory reactions, and these macrophages are felt to have a stimulatory effect on the formation of cropora lutea. In view of the results include previous report, ovarian $20{\alpha}$-hydroxysteroid dehydrogenase enzyme and splenic macrophages consider play central role in the control and maintenance of estrous cycles and pregnancy, and also applicable to both clinical and research in a wide variety such as control of reproductive system.

• 말소리와 음성과학
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• 제11권4호
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• pp.45-53
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• 2019

본 논문의 목적은 자연발화 음성 코퍼스를 대상으로 영어 무성 파열음 [p, t, k]과 한국어 격음 파열음 [p^h, t^h, k^h]의 조음위치 결정에 영향을 미치는 요인들을 살펴보는 것이다. 프랏 스크립트를 이용하여 요인들은 자동 추출하였고, 판별분석을 통해 요인의 수를 점차 증가시켜가면서 무성 파열음의 예측 정확도를 계산하였다. 분석에 사용된 요인들은 개방파열, 파열 후 기식음과 모음 시작 부분의 운동량과 스펙트럼 기울기, 폐쇄구간과 VOT, 단어와 발화 내 위치, 마지막으로 직후 모음의 종류 등이었다. 분석 결과에 따르면, 요인의 수가 다섯 개까지 증가하는 경우 예측정확도가 최대로 증가하여 영어는 74.6%, 한국어는 66.4%를 나타내었다. 그러나 사실상의 최대값에 도달하는 데는 네 개의 요인으로도 충분하였고, 이들은 개방파열과 직후 모음의 운동량과 스펙트럼 기울기, 폐쇄구간과 VOT였다. 이는 무성파열음의 조음위치가 자신의 내부 요인들과 직후 모음의 영향을 동시에 받는다는 것을 의미한다고 볼 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권2호
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• pp.188-196
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• 2010

The objective of this study was to characterize the litter sizes in Huanghuai goats with high prolificacy (HP, five or more kids born per litter on at least one occasion), and to compare their peripheral blood concentrations of progesterone and estradiol with those of goats with poor prolificacy (PP, up to three kids born per litter on any occasion). The circulating concentrations of progesterone and estradiol were measured by radioimmunoassay from daily blood samples taken during natural estrus cycles and at 1-5 days after ovariectomy. Estrus was synchronized using two doses of a prostaglandin analog. Litter size for the HP goats increased up to a parity of five and decreased thereafter. The percentage of goats with litter sizes of $\geq$4 from parities 3 to 6 ranged from 44.5% to 58.3%. Although small differences in litter size were obtained for goats of parities three, four and six relative to five, parity five does had the highest mean litter size. Progesterone concentrations began to rise earlier and were higher in the HP than in the PP goats on most days of the luteal phase, but not during the follicular phase of the cycle or after ovariectomy. There was a significant difference between the two groups (p<0.05) in the magnitude of the progesterone plateau. Mean estradiol concentrations in the HP group remained significantly higher than in the PP group (p<0.05) during the estrus cycle. There were two estradiol peaks in the HP goats during the early luteal phase, but only one in the PP group. Measurements of individual corpora lutea (CL) in vitro showed that there was a greater prevalence of small CL (<6 mm in diameter) in the HP group than in the PP group (p<0.05). After ovariectomy, the estradiol level on day 1 was significantly higher than at the nadir during the estrus cycle in both the HP (p<0.01) and PP (p<0.05) goats, while levels decreased by 12.3% and 26.2% respectively compared with the mid-luteal period in HP and PP goats (p<0.05). The overall mean estradiol concentrations in HP goats were lower than in the PP group, but no significant differences were found between groups at 1-5 days after ovariectomy.

• 인지과학
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• 제4권1호
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• pp.153-176
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• 1993

구조적 모호성은 자연 언어 문장을 분석할 때 흔히 나타내는 문제점 중의 하나로,지금까지 이문제의 해결은 대단히 어려운 것으로 인식되어 왔다.그러나,구조적 모호성을 해소하지 않고 올바른 언어 처리를 한다는 것은 사실상 불가능하다.본 논문에서는 이 문제에 대하여 정보 이론적(information-theoretic)개념인 상호 정보(mutual information)를 이용한 통계적 접근방법을 제안한다.상호정보는 말 뭉치로 부터 자동 습득이 가능하므로 지식습득속도가 대단히 빠를뿐만 아니라 지속적인 지식습득이 가능하다. 구조적 모호성 해소는 물론 모호성 해소 결과의 옳고 그름을 스스로 판단할수 있는 능력을 부여할수 있다면 보다 지능적인 시스템을 개발하는데 도움이 될것이다.본 논문에서는 그와 같은 지적 능력을 부여한느데 필요한 확신도(congidence measure) 개념도 또한 제시한다.확신도는 구조적 모호성을 해소하고 난 후에 계산되는 수치로서,구조적 모호성이 올바르게 해소되었을 가능성이 높으면 높을수록 그 값이 커지는 성질을 가지고 있다. 본 논문에서 제시한 구조적 모호성 해소 알고리즘의 타당성을 검증하기 위하여 이공계 논문 초록으로부터 발췌된 약 160만 단어의 말뭉치로부터 상호 정보를 자동 습득하고 이를 이용하요,1,639개의 문장에 대하여 구조적 모호성을 해소하는 실험을 하였다. 실험결과 구조적 모호성 해소 정화도는 약 80%로 나타났다.확신도 개념을 이용할 경우 구조적 모호성 해소가 잘못된 문장을 찾아 정정하는 작업을 매우 효과적으로 진행할 수 있었다.

• 대한수의학회지
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• 제35권1호
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• pp.159-167
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• 1995

The relationship between palpable ovarian structure and milk progesterone levels were determined in 144 dairy cows. Depending on the ovarian structure and diseases were divided into two groups, Group I (absence of functional luteal tissue in ovary and <2ng/ml in milk progesterone levels) and Group II(presence of functional luteal tissue in ovary and ${\geq}2ng/ml$ in milk progesterone levels) 1. Among 69 cows of group I, dysfunction of ovary, atropy of ovary, follicle is ovary, follicular cyst and corpus luteum albicans were 17(11.8%), 19(13.2%), 14(9.7%), 3(2.1%) and 16 cows(11.1%), and among 75 cows of group II, corpus luteum A, B and C were 16(11.1%), 17(11.8%) and 42 cows(29.2%), respectively. 2. In Group I, milk progesterone concentrations were <1ng/ml in 55 cows(79.9%). Conversely in Ggroup II, milk progesterone concentrations were ${\geq}4ng/ml$ in 55 cows(73.3%). 3. The mean(${\pm}SE$) concentrations of milk progestsrone in the Group I and II were $1.62{\pm}0.45$ and $7.64{\pm}0.68ng/ml$, respectively, and CR test showed the difference in milk progesterone concentrations between the two groups to be statistically significant(p<0.01). 4. The mean(${\pm}SE$) concentration of milk progesterone in cows with corpus luteum A, B and C were $8.11{\pm}1.83$, $8.48{\pm}1.30$ and $7.12{\pm}0.82ng/ml$, respectively, there was no significant relationship between palpable corpora luteum structure and milk progesterone concentration. 5. The accuracy of ovarian diagnosis was 82.6 and 20.2% in the Group I and II, respectively, and Chi-square test showed the difference in accuracy between the two groups to be statistically significant (p<0.001). 6. The agreement between the rectal palpation and milk progesterone concentrations in ovarian disease was 50%.

• 한국발생생물학회지:발생과생식
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• 제13권3호
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• pp.183-190
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• 2009

In mammals, puberty is a dynamic transition process from infertile immature state to fertile adult state. The neuroendocrine aspect of puberty is started with functional activation of hypothalamus-pituitary-gonadal hormone axis. The timing of puberty can be altered by many factors including hormones and/or hormone-like materials, social cues and metabolic signals. For a long time, attainment of a particular body weight or percentage of body fat has been thought as crucial determinant of puberty onset. However, the precise effect of high-fat (HF) diet on the regulation of hypothalamic GnRH neuron during prepubertal period has not been fully elucidated yet. The present study was undertaken to test the effect of a HF diet on the puberty onset and hypothalamic gene expressions in immature female rats. The HF diet (45% energy from fat, HF group) was applied to female rats from weaning to around puberty onset (postnatal days, PND 22-40). Body weight and vaginal opening (VO) were checked daily during the entire feeding period. In the second experiment, all animals were sacrificed on PND 36 to measure the weights of reproductive tissues. Histological studies were performed to assess the effect of HF diet feeding on the structural alterations in the reproductive tissues. To determine the transcriptional changes of reproductive hormone-related genes in hypothalamus, total RNAs were extracted and applied to the semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). Body weights of HF group animals tend to be higher than those of control animals between PND 22 and PND 31, and significant differences were observed PND 32, PND 34, PND 35 and PND 36 (p<0.05). Advanced VO was shown in the HF group (PND $32.8{\pm}0.37$ p<0.001) compared to the control (PND $38.25{\pm}0.25$). The weight of ovaries (p<0.01) and uteri (p<0.05) from HF group animals significantly increased when compared to those from control animals. Corpora lutea were observed in the ovaries from the HF group animals but not in control ovaries. Similarly, hypertrophy of luminal and glandular uterine epithelia was found only in the HF group animals. In the semi-quantitative RT-PCR studies, the transcriptional activities of KiSS-1 in HF group animals were significantly higher than those from the control animals (p<0.001). Likewise, the mRNA levels of GnRH (p<0.05) were significantly elevated in HF group animals. The present study indicated that the feeding HF diet during the post-weaning period activates the upstream modulators of gonadotropin such as GnRH and KiSS-1 in hypothalamus, resulting early onset of puberty in immature female rats.

• 대한한방부인과학회지
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• 제20권1호
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• pp.99-113
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• 2007

Purpose : This study was designed to investigate the effects of Jeongkyeong-Tang(JKT) on the polycystic ovary(PCO) induced by estradiol valerate(EV) in rats. Methods : PCO was induced by single intramuscular injection with EV(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for sixty days. PCO control group(n=8) were injected with EV and orally administrated distilled water for sixty days. JKT treated group(n=8) were injected with EV and orally administrated JKT for sixty days. Then we measured weights of body, ovaries and adrenal glands, and measured content of serum estrogen. The histomorphometrical changes of ovaries were also evaluated. The expressions of nerve growth factor(NGF) were analyzed in the central nervous system, adrenal glands and ovaries by immunohistochemistry. Results : - The weights(mg) of ovaries in JKT treated group (69.7${\pm}$6.7) were significantly increased( p<0.001) compared with PCO control group(46.7${\pm}$12.2). - The numbers of secondary follicles in JKT treated group(4.00${\pm}$l.31) were significantly increased(p <0.05) compared with PCO control group(2.25${\pm}$1.39). - The numbers of mature follicles in JKT treated group(5.50${\pm}$1.51) were significantly increased(p<0.01) compared with PCO control group(2.88${\pm}$1.13). - The numbers of atretic follicles in JKT treated group(2.75${\pm}$l.16) were significantly decreased(p<0.001) compared with PCO control group(6.88${\pm}$2.03). - The numbers of corpora lutea in JKT treated group(4.13${\pm}$1.46) were significantly increased(p<0.01) compared with PCO control group(2.13${\pm}$1.46). - The contents(pg/ml) of serum estrogen in JKT treated group(115.18${\pm}$18.29) were significantly decreased(P<0.01) compared with PCO control group(153.06${\pm}$29.47). - The expressions of NGF-immunoreactive cells in the ovarian granulosa cells in JKT treated group were lesser observed than PCO control group. Conclusion : From the above results, we concluded that Jeongkyeong-Tang has inhibitory effect on the development of EV-induced polycystic ovary. And it's effect may be related with decreased NGF activities in the ovary.

• 대한한방부인과학회지
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• 제21권3호
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• pp.60-74
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• 2008

Purpose: This study was designed to investigate the effects of Gwibi-Tang(GBT) on the polycystic ovary(PCO) induced by estradiol valerate(EV) in rats. Methods: PCO was induced by single intramuscular injection with EV(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for eight weeks. PCO control group(n=8) were injected with EV and orally administrated distilled water for eight weeks. GBT treated group(n=8) were injected with EV and orally administrated GBT for eight weeks. Then we measured weight of body, ovaries, adrenal glands, and uterus of rats. The histopathology changes of ovaries were also evaluated. The expression of nerve growth factor(NGF) was analyzed in the central nervous system, adrenal glands and ovaries by immunohistochemistry. And also CRF expression in median eminance of Rats were analyzed. Results: 1. The weight(g) of rats in GBT treated group($275{\pm}14$) was significantly increased(p<0.01) compared with control group($253{\pm}8$), 2. The weight(mg) of ovaries in GBT treated group($75.8{\pm}16.7$) was significantly increased(p<0.001) compared with control group($37.4{\pm}6.7$). 3. The number of mature follicles in GBT treated group($3.6{\pm}1.2$) was significantly increased(p<0.01) compared with control group($1.5{\pm}1.5$. 4. The number of atretic follicles in GBT treated group($8.0{\pm}3.1$) was significantly decreased(p<0.01) compared with control group($18.6{\pm}6.0$). 5. The number of cystic follicles in GBT treated group($0.5{\pm}0.5$) was significantly increased(p<0.01) compared with control group($2.3{\pm}1.3$). 6. The number of corpora lutea in GBT treated group($6.1{\pm}3.9$) was significantly increased(p<0.01) compared with control group($1.6{\pm}2.3$). 7. The expression of NGF-immunoreactive cells in the ovarian granulosa cells in GBT treated group was lesser observed than control group. Conclusion: From the above results, we concluded that Gwibi-Tang has inhibitory effect on the development of EV-induced polycystic ovary. And it's effect may be related with decreased NGF activities in the ovary.