• Archives of Pharmacal Research
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• 제28권5호
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• pp.587-591
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• 2005

The effect of extremely low frequency (ELF,60Hz) magnetic fields (MFs) on convulsions was investigated in rats. We determined the onset arid duration of convulsions induced by bicuculline alone or by co-exposure to MFs and bicuculline. In addition, we measured the GABA concentrations in the rat brains using HPLC-ECD. MFs strengthened the convulsion induced by bicuculline (0.3, 1, and 3${\mu}g$, I.c.v.), with a shortening of the onset time, but lengthening of the duration time. Co-exposure to MFs and bicuculline decreased the GABA levels in the cortex, hippocampus and hypothalamus, whereas MFs alone reduced the level of GABA only in the hippocampus. These results suggest that the exposure to MFs may modulate bicuculline-induced convulsions due to GABA neurotransmissions in rat brains.

• 대한약침학회지
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• 제5권1호
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• pp.181-188
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• 2002

Objective: Through the literatures on the effects of Buthus martensii Karsch, we are finding out the clinical possibility and revealing the more effctive to intractable diseases. Method: We investigated the literatures of Oriental Medicine and experimental reports about Buthus martensii Karsch. Results: 1. The taste of Buthus martensii Karsch is salty, hot and toxic, and the effect of this is tetanus, headache, facial palsy and convulsion. 2. The venom of Buthus martensii Karsch is anaesthetic and toxic protein, composed of buthotoxin, lecithin, trimethylamine, betaine, taurine, cholesterol, stearic acid and palmitic acid and similar to the snake venom. 3. The pharmacological effects ofButhus martensii Karsch are anti-convulsion, depressor, anesthesia, anti-thrombosis and anti-cancer. 4. Symptoms of Buthotoxin poisoning are local pain, vomiting, fever, hypertension and palpitaion, and critical condition to Dyspnea, coma and death.

• 생약학회지
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• 제19권3호
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• pp.208-215
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• 1988

To investigate the experimental effects of Chunwangboshimdan which have been widely used for aterial or auricular flutter, neurosis, insomnia and disease caused by cardiac malfunction, we have done the effects on the central nervous and cardiovascular system. The result as follow; It inhibited the convulsion induced by caffeine, the writhing syndrome induced by acetic acid and the spontaneous movement. Furthermore it prolonged the sleeping time induced by thiopental-Na in mice. It also showed the negative inotropic action on the isolated heart of frog, the vasodilative action as to peripheral bloods of rabbit ear and the hypotensive action in the anesthetized rabbit.

• 생약학회지
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• 제16권1호
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• pp.26-30
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• 1985

These studies were conducted to investigate the effect of Yijin-tang on the anticonvulsion, analgesic, sedative actions, effect on blood vessels and blood pressure. The result of these studies was summarized as follows; Suppressive action was shown on convulsion due to cerebrocortical causes, but no such actions were noted either myelic or diencephaltic causes in mice. Analgesic and sedative actions were significantly recognized in mice. Increasing of blood pressure and vasocontractive actions were noted.

• 대한한의학방제학회지
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• 제11권1호
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• pp.205-216
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• 2003

A general review is made on Insamyangwitang(人蔘養胃湯). Following conclusions are drawn from the clinical cases of Insamyangwitang in Hyungsang medicine. 1. Insamyangwitang is composed of four different prescriptions of Huisaentang, Sakoonjatang, Eajintang and Pyungwisan. Huisaentang is usually prescribed for the intestinal convulsion. Sakoonjatang for the deficiency of Ki. Eajintang for retention of phlegm. 2. Insamyangwitang is effective in strengthening the spleen, drying the dampness, warning the middle-warmer to stop vomiting, regulating the flow of Ki, and eliminating phlegm. 3. Insamyangwitang is applicable to malaria caused by cold, intestinal convulsion, abdominal mass, edema, tympanites, Yin syndrome of exogenous febrile disease, distension, lack of appetite, stomachache, and diarrhea. 4. Persons with the following characteristic in Hyungsang are more susceptible to Insamyangwitang : Jung type, Hyul type, fish type, Taium meridian type, white fat damp constitution, person with big mouth, and woman rather than man.

• 생약학회지
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• 제29권3호
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• pp.179-186
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• 1998

The fractions of Uncariae Ramulus et Uncus seemed to be closely related with the levels of amino acids and other components which concerns with formation and metabolism of neurotransmitters in brain. The pretreatments of methanolic extract and its fractions prohibited the pentylenetetrazole (PTZ) induced convulsion. In such cases, lowered levels of ${\gamma}-aminobutyric$ acid and glutathione in brain were significantly recovered. And also the increased levels or activities of lipid peroxide, ${\gamma}-aminobutyric$ acid aminotransferase, xanthine oxidase, aldehyde oxidase, superoxide dismutase, catalase and glutathione peroxidase by PTZ-convulsion were lowered to normal state.

• 사상체질의학회지
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• 제1권1호
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• pp.171-181
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• 1989

We have studied some effects of the SOYANGIN-HYEONGBANGPAEDOK-SAN (S.H.P.). Several empirical remarks, depending on the different treatments, are investigated through this study as follow; 1. The Analgesic effects of S.H.P. are remarked by Acetic acid method in mice, 100 and 300mg/kg (Sample II, III), 2. The Antipyretic effect of S.H.P. are remarked by yeast method in rats, 100 and 300mg/kg (Sample II, III). 3. The inhibitory effects of S.H.P. on strychnine induced convulsion in mice is remarked. However the inhibitory effects of S.H.P. on picrotoxin induced convulsion in mice is not observed. 4. The effects of S.H.P. on muscle relaxation in mice, using the Rota-Rod test, is remarked on 1,2,3 hours by 300mg/kg (Sample III).

• 사상체질의학회지
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• 제1권1호
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• pp.153-170
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• 1989

We have studied some effects of the SOEUMIN-HYANGSAYANGYUI-TANG (S.H.Y.) on the C.N.S. and on the intestines. Several empirical remarks, depending on the different treatments, are investigated throughout this study as follows; 1) The treatment, using atropine bromide, represses the effect of the S.H.Y. on the contractive force of intestines. 2) The treatment, using pheniramine maleate, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 3) The treatment, using cyproheptadine, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 4) The analgesic effect as well as the antipyretic effect are remarked while the acetic acid is applied. 5) The suppressive action on the convulsion, induced by strychine, is not observed. However the significant effect on the convulsion induced by picrotoxin is remarked. 6) The sedactive effect of the S.H.Y., using the Rotor rod test, is not obviously observed.

• 대한한방소아과학회지
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• 제13권1호
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• pp.181-190
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• 1999

Cerebral palsy is a nonprogressive brain disorder occurring during gestation, parturition or neonatal period with resultant abnormality of posture or other deficits. Recently the early diagnosis and early treatment has been emphasized in management of cerebral palsy. We studied 1 cerebral palsied child that having been treated anticonvulsive therapy in Sangge-Baek Hospital(상계 백병원) for 1 year. We improved the patient's general condition through dispensing Herb-Med(養胃湯 加味), thus we could reduce the antiepileptic & Sedative drug dose simultaneously controlling convulsion. In this point, we could find the possibility of east-west integrated medicine's cooperation and the fact that Herb-Med could be helpful to controlling convulsion.

• Clinical and Experimental Pediatrics
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• 제53권9호
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• pp.859-862
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• 2010

Transient magnetic resonance (MR) signal changes in the splenium of the corpus callosum (SCC) arise from many different conditions, including encephalopathy or encephalitis caused by infection, seizures, metabolic derangements, and asphyxia. Few case reports exist on reversible SCC lesions associated with rotavirus infection. A benign convulsion with mild gastroenteritis (CwG) is frequently associated with rotaviral infections. This entity is characterized by normal laboratory findings, electroencephalogram, neuroimaging, and good prognosis. We report a case of a 2.5-year-old Korean girl with rotavirus-associated CwG demonstrating a reversible SCC lesion on diffusion-weighted MR images. She developed 2 episodes of brief generalized tonic-clonic seizure with mild acute gastroenteritis without any other neurologic abnormality. Stool test for rotavirus antigen was positive. Brain MRI done on the day of admission showed a linear high signal intensity and decreased apparent diffusion coefficient values on the SCC. The lesion completely disappeared on follow-up MRI 6 days later. The patient fully recovered without any sequelae.