• Title/Summary/Keyword: control parameters

Search Result 9,356, Processing Time 0.045 seconds

The Indian Magical Herb 'Sanjeevni' (Selaginella bryopteris L.) - A Promising Anti-inflammatory Phytomedicine for the Treatment of Patients with Inflammatory Skin Diseases

  • Paswan, Shravan Kumar;Gautam, Arti;Verma, Pritt;Rao, Chandana Venkateswara;Sidhu, Om Prakash;Singh, Ajeet Pratap;Srivastava, Sajal
    • Journal of Pharmacopuncture
    • /
    • v.20 no.2
    • /
    • pp.93-99
    • /
    • 2017
  • Objectives: Selaginella bryopteris L. (family: Selaginaceae), is often used in traditional Indian systems of medicine for the prevention and cure of several disorders and for the treatment of patient with spermatorrhoea, venereal disease, constipation, colitis, urinary tract infections, fever, epilepsy, leucorrhoea, beri-beri and cancer. It is also used as a strength tonic. This study aimed to evaluate the mechanisms underlying the anti-inflammatory effects of topically administered aqueous, polar and non-polar methanolic fractions ($10mg/20{\mu}L$) of Selaginella bryopteris. Methods: An acute oral toxicity study of Selaginella bryopteris at doses from 250 to 2,000 mg/kg body weight (bw) was performed. Aqueous, polar and non-polar methanolic extracts ($10mg/20{\mu}L$) applied topically for 5 days were evaluated for their anti-inflammatory effects against 12-tetra-O-decanoyl phorbol acetate (TPA)- induced inflammation by using the redness in the ear, the ear's weight (edema), oxidative stress parameters, such as lipid-peroxide (LPO) and nitric oxide (NO), and the pro-inflammatory cytokines involved in inflammation, such as tumour necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$ and IL-6. Indomethacine ($0.5mg/20{\mu}L$) was used for the positive control. Results: Selaginella bryopteris produced no mortalities when administered orally at doses from 250 to 2,000 mg/kg bw. Topical treatment with the non-polar methanolic fraction ($10mg/20{\mu}L$) significantly suppressed redness ($2.4{\pm}0.5$) and edema ($30.4{\pm}1$) and effectively reduced the LPO level ($32.3{\pm}3.3$). The NO level was ($8.07{\pm}0.55$), and the $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 levels were decreased to $69.6{\pm}15.5$, $7.7{\pm}4.8$ and $82.6{\pm}5.9$, respectively. Conclusion: This study demonstrated for the first time the mechanisms underlying the anti-inflammatory effect of medicinal plants like Selaginella bryopteris and quantified the pharmacological interactions between them. The present study showed this herbal product to be a promising anti-inflammatory phytomedicine for the treatment of patients with inflammatory skin diseases.

Efficiency of Various Nutritional Sources to Improve Physical Properties of Saline-Sodic Soil

  • Noor-Us-Sabah, Noor-Us-Sabah;Sarwar, Ghulam;Ibrahim, Muhammad;Tahir, Mukkram Ali;Iftikhar, Yasir;Haider, Muhammad Sajjad;Han, Kyung-Hwa;Ha, Sang-Keun;Zhang, Yong-Seon
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.45 no.1
    • /
    • pp.93-97
    • /
    • 2012
  • This study was conducted to evaluate the efficiency of various inorganic and organic materials to improve physical properties of soil. Saline sodic soil (saturation percentage = 40.36%, $EC_e=5.15dS\;m^{-1}$, $pH_s=8.70$, $SAR=18.84(m\;mol\;L^{-1})^{1/2}$, bulk density =$1.49Mg\;m^{-3}$) was collected, brought to wire house and filled in pots after laboratory analysis for various parameters. Different sources of organic nutrients like farm manure (FM), press mud, compost, poultry manure and sesbania green manure were analyzed for their chemical composition. The experiment comprised of 12 treatments replicated thrice; $T_1$: control (recommended NPK), $T_2:{\frac{1}{2}}$ recommended NPK, $T_3$: FM at 1.5% by soil weight, $T_4$: pressmud at 1.5% by soil weight, $T_5$: compost at 1.5% by soil weight, $T_6$: poultry manure at 1.5% by soil weight, $T_7$: sesbania green manure at 1.5% by soil weight, $T_8:T_2$ + FM at 0.75% by soil weight, $T_9:T_2$ + pressmud at 0.75% by soil weight, $T_{10}:T_2$ + compost at 0.75% by soil weight, $T_{11}:T_2$ + poultry manure at 0.75% by soil weight, $T_{12}:T_2$ + sesbania green manure at 0.75% by soil weight. These treatments were applied using completely randomized (CR) design and appropriate time was given to decompose these organic nutritional sources. Seeds of wheat cultivar Sahar-2006 were sown. After harvesting the wheat, soil samples were collected from each pot and analyzed for various physical properties like bulk density, porosity and saturation percentage. An improvement in physical properties (bulk density, porosity and saturation percentage) of soil was noticed with the application of various organic nutritional sources but role of compost alone ($T_5$) remained prominent.

Geochemical Characteristics in the costal wetland and intertidal zone of Suncheon Bay (순천만 습지 및 조간대의 지화학적 특성)

  • Kim, Sook Yang;Jung, Kyu Kui;Kim, Byoung Man;Lee, Yeon Gyu;Choi, Yoon Seok;Kim, Sin
    • Journal of Wetlands Research
    • /
    • v.10 no.2
    • /
    • pp.81-96
    • /
    • 2008
  • This study was performed to know about the characteristics of geochemicals of sampling sites in Suncheon bay. Salinity and parameters of water pollution as COD, DIN and DIP showed typical character of an estuary with its values higher at the end of estuary and gradually lowering at the up stream. The value of Excess DIN showed positive so the phosphorus appeared in a role as limiting nutrient. As quoted results of correlation analysis of SPSS and PCA, salinity was revealed as a main factor of control for water qualities at sampling sites in Suncheon bay. The Mz of wet lands and intertidal zone in Sun-cheon bay showed a variation of 6.74 to $8.52{\phi}$ and the sorting also to appeared poorly sorted to very poorly sorted. The fractional composition of phosphorus in phosphorus of sediments were high and appeared orderly as redisual-P> NAI-P> apatite-P> absorbed-P. The labile-Phosphorus showed high concentration then the other station. It means that phosphorus of these stations can easily move from the deposit to the water column than another station.

  • PDF

Estimation of Mega Flood Using Mega Rainfall Scenario (거대강우 시나리오를 이용한 거대홍수량 산정)

  • Han, Daegun;Kim, Deokhwan;Kim, Jungwook;Jung, Jeawon;Lee, Jongso;Kim, Hung Soo
    • Journal of Wetlands Research
    • /
    • v.21 no.spc
    • /
    • pp.90-97
    • /
    • 2019
  • In recent years, flood due to the consecutive storm events have been occurred and property damage and casualties are in increasing trend. This study calls the consecutively occurred storm events as a mega rainfall scenario and the discharge by the scenario is defined as a mega flood discharge. A mega rainfall scenario was created on the assumption that 100-year frequency rainfall events were consecutively occurred in the Gyeongancheon stream basin. The SSARR (Streamflow Synthesis and Reservoir Regulation) model was used to estimate the mega flood discharge using the scenario in the basin. In addition, in order to perform more reasonable runoff analysis, the parameters were estimated using the SCE_UA algorithm. Also, the calibration and verification were performed using the objective functions of the weighted sum of squared of residual(WSSR), which is advantageous for the peak discharge simulation and sum of squared of residual(SSR). As a result, the mega flood discharge due to the continuous occurrence of 100-year frequency rainfall events in the Gyeongan Stream Basin was estimated to be 4,802㎥/s, and the flood discharge due to the 100-year frequency single rainfall event estimated by "the Master Plan for the Gyeongancheon Stream Improvement" (2011) was 3,810㎥/s. Therefore, the mega flood discharge was found to increase about 992㎥/s more than the single flood event. The results of this study can be used as a basic data for Comprehensive Flood Control Plan of the Gyeongan Stream basin.

Geocoding of the Free Stereo Mosaic Image Generated from Video Sequences (비디오 프레임 영상으로부터 제작된 자유 입체 모자이크 영상의 실좌표 등록)

  • Noh, Myoung-Jong;Cho, Woo-Sug;Park, Jun-Ku;Kim, Jung-Sub;Koh, Jin-Woo
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
    • /
    • v.29 no.3
    • /
    • pp.249-255
    • /
    • 2011
  • The free-stereo mosaics image without GPS/INS and ground control data can be generated by using relative orientation parameters on the 3D model coordinate system. Its origin is located in one reference frame image. A 3D coordinate calculated by conjugate points on the free-stereo mosaic images is represented on the 3D model coordinate system. For determining 3D coordinate on the 3D absolute coordinate system utilizing conjugate points on the free-stereo mosaic images, transformation methodology is required for transforming 3D model coordinate into 3D absolute coordinate. Generally, the 3D similarity transformation is used for transforming each other 3D coordinates. Error of 3D model coordinates used in the free-stereo mosaic images is non-linearly increased according to distance from 3D model coordinate and origin point. For this reason, 3D model coordinates used in the free-stereo mosaic images are difficult to transform into 3D absolute coordinates by using linear transformation. Therefore, methodology for transforming nonlinear 3D model coordinate into 3D absolute coordinate is needed. Also methodology for resampling the free-stereo mosaic image to the geo-stereo mosaic image is needed for overlapping digital map on absolute coordinate and stereo mosaic images. In this paper, we propose a 3D non-linear transformation for converting 3D model coordinate in the free-stereo mosaic image to 3D absolute coordinate, and a 2D non-linear transformation based on 3D non-linear transformation converting the free-stereo mosaic image to the geo-stereo mosaic image.

Development and Quality Characteristics of Lotus Root Jeonggwa Admixed with Omija (the Medicinal Herb Schizandra chinensis Baillon) Extract during Storage (오미자첨가 연근정과의 제조와 저장중 품질 변화)

  • Kwon, Hoo-Ja;Choi, Mi-Ae;Park, Chan-Sung
    • Food Science and Preservation
    • /
    • v.17 no.4
    • /
    • pp.457-465
    • /
    • 2010
  • We sought to develop lotus (Nelumbo nucifera) root Jeonggwa as a health food. Jeonggwa was mixed with 0-8% (w/w) Omija water extract and stored at $25^{\circ}C$ for 12 weeks. Quality characteristics during storage were investigated. The pH of Jeonggwa fell, and the acidity level rose, as increasing amounts of Omija water extract were added. The moisture content of Jeonggwa rose from 7-8% to 14-17% within 2 weeks of storage at $25^{\circ}C$, and was maintained at that level to the end of storage. Total viable bacterial cells in Jeonggwa were initially 2.4~3.2 log CFU/g, and increased in number during storage, but never exceeded 4 log CFU/g. The shelf life of Jeonggwa was extended when Omija extract was added. The lightness (L), redness (a). and yellowness (b) of Jeonggwa during storage at $25^{\circ}C$ were highest in control samples and the values fell with increasing Omija extract concentration (p<0.001). Mechanical evaluation Jeonggwa showed that various tested parameters fell during storage at $25^{\circ}C$. The hardness and strength of Jeonggwa were significantly reduced as the Omija extract concentration rose (p<0.05). In sensory evaluation tests, the acceptability of Jeonggwa was optimal when 2~4% (w/w) Omija extract was added.

Electrochemical and Sludge Dissolution Behavior During a Copper Removal Process for Chemical Cleaning on the Secondary Side of Nuclear Steam Generators (원전 증기발생기 2차측 화학세정을 위한 제동공정중의 전기화학적 거동 및 슬러지용해 거동)

  • Hur, Do-Haeng;Chung, Han-Sub;Kim, Uh-Chul;Chae, Sung-Ki;Park, Kwang-Kyoo;Kim, Jae-Pyong
    • Nuclear Engineering and Technology
    • /
    • v.24 no.2
    • /
    • pp.154-162
    • /
    • 1992
  • Two major goals for chemical cleaning on the secondary side of nuclear steam generators are to remove sludge effectively and to minimize corrosion of base metals. In this work, electrochemical and sludge dissolution behaviors have been investigated in order to find out which parameters are critical and important during a copper removal process for chemical cleaning and to evaluate safety aspects and effectiveness of two major copper removal processes developed commercially in foreign countries. Hydrogen peroxide is vert effective for the process to use EDTA, NH$_4$OH and EDA at 38$^{\circ}C$ to control the potential of copper in a potential range sood for copper sludge removal. Corrosion rates for carbon steel SA 285 Gr.C and Alloy 600 are very small during this process if it is controlled properly. However, the corrosion rate of SA 285 Gr.C will be increased greatly if its corrosion potential is maintained below -450mV. The process to use EDA and ammonium carbonate is effective at 6$0^{\circ}C$ to dissolve copper sludge if the corrosion potential of copper can be controlled above -200mV. However, it is very difficult to raise the corrosion potential of copper to this range by air blowing and stirring.

  • PDF

Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice

  • Huang, Bo;Wang, Zhiqiang;Park, Jong Hyuk;Ryu, Ok Hyun;Choi, Moon Ki;Lee, Jae-Yong;Kang, Young-Hee;Lim, Soon Sung
    • Nutrition Research and Practice
    • /
    • v.9 no.1
    • /
    • pp.22-29
    • /
    • 2015
  • BACKGROUND/OBJECTIVES: Recently, anthocyanins have been reported to have various biological activities. Furthermore, anthocyanin-rich purple corn extract (PCE) ameliorated insulin resistance and reduced diabetes-associated mesanginal fibrosis and inflammation, suggesting that it may have benefits for the prevention of diabetes and diabetes complications. In this study, we determined the anthocyanins and non-anthocyanin component of PCE by HPLC-ESI-MS and investigated its anti-diabetic activity and mechanisms using C57BL/KsJ db/db mice. MATERIALS/METHODS: The db/db mice were divided into four groups: diabetic control group (DC), 10 or 50 mg/kg PCE (PCE 10 or PCE 50), or 10 mg/kg pinitol (pinitol 10) and treated with drugs once per day for 8 weeks. During the experiment, body weight and blood glucose levels were measured every week. At the end of treatment, we measured several diabetic parameters. RESULTS: Compared to the DC group, Fasting blood glucose levels were 68% lower in PCE 50 group and 51% lower in the pinitol 10 group. Furthermore, the PCE 50 group showed 2-fold increased C-peptide and adiponectin levels and 20% decreased HbA1c levels, than in the DC group. In pancreatic islets morphology, the PCE- or pinitol-treated mice showed significant prevention of pancreatic ${\beta}$-cell damage and higher insulin content. Microarray analyses results indicating that gene and protein expressions associated with glycolysis and fatty acid metabolism in liver and fat tissues. In addition, purple corn extract increased the phosphorylation of AMP-activated protein kinase (AMPK) and decreased phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6pase) genes in liver, and also increased glucose transporter 4 (GLUT4) expressions in skeletal muscle. CONCLUSIONS: Our results suggested that PCE exerted anti-diabetic effects through protection of pancreatic ${\beta}$-cells, increase of insulin secretion and AMPK activation in the liver of C57BL/KsJ db/db mice.

Effects of Salt, Glucono-$\delta$-Lactone and High Pressure Treatment on Physico-Chemical Properties of Restructured Pork (소금과 Glucono-$\delta$-Lactone의 첨가 및 초고압 처리가 재구성 돈육의 이화학적 특성에 미치는 영향)

  • Hong, Geun-Pyo;Park, Seong-Hui;Kim, Ji-Yeon;Go, Se-Hui;Min, Sang-Gi
    • the MEAT Journal
    • /
    • s.34 winter
    • /
    • pp.26-39
    • /
    • 2007
  • This study investigated the effect of salt and glucono-$\delta$-lactone (GdL) on the cold-set binding of restructured pork washed and pressurized at 200 MPa. Binding strength, pH, water holding capacity (WHC) and color were determined. NaCl improved pH, WHC and binding strength. GdL also increased binding strength while decreased WHC and pH significantly (p<0.05). However, low GdL level combined with NaCl showed high pH and WHC, compared to control. In color, NaCl decreased L*-value with increasing a*-value significantly (p<0.05). In contrast to NaCl, GdL increased L*-value and decreased a*-value. GdL tended to decrease b*-value and significant differences were found when GdL was added above 1%. Pearson’s correlation coefficients presented that NaCl had a significant effect on binding strength (0.6632) and lightness (?0.7330) while GdL had a significant correlation with all parameters barring binding strength. The results indicated that under washing and pressure treatments, GdL had a potential effect on cold-set binding with reducing NaCl concentration, especially when low GdL concentration combined with NaCl was added.

  • PDF

BER Performance of DS/CDMA-BPSK Systemin 3-State Land Mobile Satellite fading Channel (3-상태 육상이동위성 페이딩 채널에서 DS/CDMA-BPSK 시스템의 오율 성능)

  • Cho, Sung-Eon;Cho, Kyung-Ryong;Yeo, Hyun
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.3 no.4
    • /
    • pp.795-804
    • /
    • 1999
  • The increasing number of users of mobile communication systems and the corresponding need for increased system capacity require the use of a modulation scheme which is both power and spectrally efficient. In this paper, we numerically calculate the BER performance of DS/CDMA-BPSK system in different fading channel (Rayleigh, Rician, Shadow Rician). Also, we calculate BER performance and the channel capacity of DS/CDMA-BPSK system which is constant or nearly constant envelopes in 3-state fading channel model. The Shadow Rician fading model described in this paper apply the parameters of the Canadian Mobile Satellite (MSAT). And we assume that the 3-state fading channel model is consist of Rayleigh fading state, Rician fading state, and shadow Rician fading state. This model can be used as a basis for the simulation of the land mobile satellite channel. The dynamic 3-state fading channel model is considered corresponding to different environments and the transitions between these environments. From the numerically calculate results, the DS/CDMA-BPSK system with MUI-20, PG-511 can not achieve the BER performance ($P_b\leq10^{-5}$). And the channel capacity did not meet the system requirement. Also, we know that the BER performance is depend m the occupancy probability of radio channel and the degree of shadow. From the results, we how that during shadowed time intervals it is necessary to use some form of error control coding and receiver diversity in order to support reliable data communication.

  • PDF