• The korean journal of orthodontics
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• v.29 no.2 s.73
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• pp.209-217
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• 1999

This study was concerned with comparing the measured values of labial alveolar bone through the lateral cephalometric radiography and mandibular incisor cross-sectional tomogram between two groups, one group of mandibular prognathism patients who needed an orthognathic surgery as an experimental group and the other group who had normal molar relationships as a control group. The purpose of the study was to find out the predisposing factor of bone resorption and gingival recession before orthodontic treatment. The results were as follows: 1. The cross-sectional area of labial alveolar bony plate in mandibular prognathism was significantly smaller than that of control group. 2. In mandibular prognathism, the distance between cementoenamel junction and alveolar crest was significantly greater than control group. 3. There were negative correlations between area of labial alveolar bony plate and distance from cementoenamel junction to alveolar crest, and positive correlations between area of labial alveolar bony plate and distance from alveolar crest to root apex. 4. In mandibular prognathism, there were positive correlations between IMPA and thickness of symphysis, and negative correlations between IMPA and the alveolar bony height. The results of the present study suggest the mandibular prognathism patients are prone to the gingival recession due to the small amount of labial alveolar bone around lower incisors.

• Korean Journal of Cleft Lip And Palate
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• v.6 no.2
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• pp.69-89
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• 2003

The purpose of this study was to examine and analyze the basic conditions of dental health of cleft lip and palate patients at early mixed dentition (7-year-old, experimental group A) and early permanent dentition period (12,13-year old, experimental group B) and compare them with those of normal children. The sample was consisted of 25 patients at the age of 7 years, 15 at the age of 12 years and 5 at the age of 13 years. Two trained dentists examined orthopantomographs and clinical photos at the first visit of each patient and distinguished the states by teeth and dental surface and filled them on the prescribed forms. DMF rate, DMF index, FT rate, mean number of permanent teeth with fissure sealants, DMFS index and mean percentage of caries experienced maxillary anterior 6 teeth by tooth type are calculated and compared to those of other studies examined normal children. Oral hygiene of experimental groups is poorer than control groups'. Preventive and treatment rate of experimental groups' are lower than control groups'. More concem and effort are needed about prevention and treatment of dental caries of cleft lip and palate patients.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2008.10a
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• pp.422-425
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• 2008

Recently, electronic products and related parts are required to have thin thickness because of small form factor. To go with the trend, LGP(light guide plate) of LCD BLU(Liquid Crystal Display Back light unit: It is one of kernel parts of LCD) for cell phone has the thickness of 0.3 mm and the battery case of cell phone has 0.25 mm. Accordingly, high speed injection molding is required to make products which have thin thickness. High speed injection molding means that the resin is injected into the cavity at higher than normal speed avoiding short shot. In the case of hydro-mechanical high speed injection machine, it requires the design for hydraulic unit to make high injection speed and the design for control unit to control hydraulic unit. In the present paper, we concentrated on the molding stability of hydro-mechanical high speed injection machine to make an LGP of 0.3 mm thickness.

• Journal of Korea Foundry Society
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• v.11 no.4
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• pp.314-322
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• 1991

In this study, Na, Li, Sb, Sr were added as the modifiers to improve the mechanical proper ties of Al-Si alloys and their effects were compared one another Thermal analysis was carried out to measure the degree of undercooling, that is, the basic mechanism of modifying effect. The measurements of holding time and analyses of components of Al-Si alloys were carried out to compare the fading of the modifiers. Greater degree of undercooling was measured from the modified alloy than the normal alloys. In the modified alloy, the shape of Si was changed into a fine fiber phase or a lamellar phase from the coarse plate phase. There are not modifying effect of Sb below the $1.5^{\circ}C$ /sec of cooling rate. As the cooling rate increases, similar effects appears in the non-modified alloys like the modified alloys. Na and Li were faded in short time and were difficult to control on the melt, but Sb and Sr were scarcely faded for 6 hours of holding and were easy to control on the melt. Na and Sr are the good modifiers in terms of microstructure. Sb is the best modifier, but Na, Li are the inadequate modifiers in terms of fading.

• Korean Journal of Bronchoesophagology
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• v.2 no.1
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• pp.46-56
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• 1996

Perichondrium is generally used for reconstruction of airway and successful regeneration of cartilage framework using perichondrium are reported by several authors. It has many advantages for airway reconstruction. It can maintain the stable framework and it has higher flexibility so it's easy to design according to the shape of defects. It resist strongly against infection process. Its airtightness and rapid mucosalization enables to predict good postoperative recovery and results. To investigate the differences in cartilage regeneration between avascular and vascularized perichondrial flap, this study was designed with vascularized flaps composed of vascularized perichondrium and central auricular artery and vein. Morphologic study was performed to determine the fate of the grafted perichondrium at regular intervals using light microscopy with H & E stain. Chondrogenic potential and formation of cartilaginous plate of experimental group was superior than in the control group. Grafted perichondrium was fed by consistent feeding vessel. At 6 weeks, the regenerated cartilage could hardly be distinguished form the normal cartilage framework but in control group, regenerated cartilaginous tissue was generally immature in same period. In conclusion, this study indicated that consistent vasculature to grafed tissue is the essential factor for successful reconstruction of cartilaginous framework.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.774-781
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• 2002

This study was carried out to test the recuperative effect of 2 types of sample drugs for 3 degree burn. The burn injury was made by iron plate heated in the boiling water. The Sprague Dawley rats were shaven with a razor preliminarily and burned by direct contact method for 10 seconds. The experimental groups were classified with 5 each-normal, control, MEBO ointment, sample A, sample B. The effect of the sample drugs were decided by histological results after 3 week application. The results were as following. The 3 treatment groups recovered the burn injury faster than control group. The recuperative effect precedes about 4-5 days at the time of 15th day and 1 week at the time of 3rd week. The therapeutical procedure of 3 treatment groups was similar with naked eye and with microscopic histology in the 1 st, 2nd and 3rd specimens. So there weren't significant differences in curative effect in 3 treatment groups of this experiment. But a regeneration of hair follicle was noted in Sample B uniquely. These results suggested that 3 burn remedies have similar effect of therpy, but sample B containing yolk sac oil has slightly better effect in part of hair regeneration.

• Herbal Formula Science
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• v.20 no.1
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• pp.25-40
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• 2012

The purpose of this study explain the experimental effects of Guizhishaoyaozhimu-Tang (桂枝芍藥知母湯) that have clinical efficacy in rheumatoid Arthritis. Materials of present study were Guizhishaoyaozhimu-Tang freeze dried powder (GSZT), Sprague-dawley rats (300 g or so, male), various kinds of needing experimental studis. In order to study the therapeutic effects of GSZT, this Prescription (GSZT 500 mg/kg, 1,000 mg/kg) were administered per oral to the rats with the arthritis induced by Freund's complete adjuvant ($0.2m{\ell}/kg$), several experimental items were measured and compared each other ; that is body weight, rate of edema, analgesic effect by hot plate method, WBC, total protein, TNF-${\alpha}$, IL-10 and expression and localization of H&E, COX-2 staining in synovial tissues from rat with rheumatoid arthritis by immunohistochemical staining using polyclonal COX-2 antibodies. Rats were divided into four groups. Normal group was not treated with Freund's complete adjuvant and treated with DDW 1.0 $m{\ell}$, Control group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and DDW 1.0 $m{\ell}$, Sample A group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (500 $mg/m{\ell}$) $1.0m{\ell}$, Sample B group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (1,000 $mg/m{\ell}$) 1.0 $m{\ell}$. 0 was day that did not start experiment, 14 was day that confirmed rheumatism induced by Freund's complete adjuvant, 28 was day that completed experiment. The following results were obtained in this study ; Sample A group was increased in body weight, escape time and paw licking time statistical significance compared with Control group, and were decreased in edema, WBC, total protein, TNF-${\alpha}$ with statistical significance compared with Control group. Sample B group was increased in escape time with statistical significance compared with Control group, and were decreased in edema, WBC, total protein with statistical significance compared with Control group. Sample A and Sample B groups were increased in IL-10 compared with Control group, and Sample B group was decreased in TNF-${\alpha}$ compared with Control group. And, Control, Sample A and Sample B groups were showed considerable reduction of positive expression in comparison to Normal group. Especially, Sample B group was most significantly reduction of positive expression than the other groups. From above results, I suggest that GuizhiShaoyaoZhimu-Tang can be used for curing rheumatoid arthritis.

• The Journal of the Korean dental association
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• v.46 no.9
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• pp.563-573
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• 2008

Purpose : The purpose of this study is to investigate the effects of Simvastain, which is HMG-CoA reductase inhibitor, on proliferation and differentiation of osteoblast. Materials & Methods : Twenty-four cell culture plates containing essential medium were seeded with UMR-106 cell lines, at density of 5 x $10^4$ cells per plate. Each plates were incubated with 5% $CO^2$incubator $37^{\circ}C$. Starting from 2 days after incubation, cell culture medias were replaced with Osteogenesis induction media every 2 days, for 12 days. In some plates, 0.01, 0.1, 1, 10, $100\muM$ of Simvastatin were added with Osteogenesis induction media, and classified as "test group". Those not added with Simvastatin were classified as "control group". Results : 1. When Alrizarin Red staining was observed with naked eye, control group showed normal deep red color, but test group show rapid decrease of red color as Simvastatin concentration increased more than $0.1\muM$. 2, When observed with microscope, compared to control group, amount of osteo matrix stained with Alrizarin Red decreased rapidly in Simvastatin concentration more than $0.1\muM$. 3. In optical density analysis, regarding control group as a basis, mineral deposition decreased rapidly when Simvastatin concentration increased more than $0.1\muM$. 4. In flow cytometry analysis, survival rate of UMR-106 cell showed no changes in both control group and test group. Conclusion : From the above results, we were able to identify that Simvastatin inhibited osteogenesis without effecting survival or cell number of osteoblasts.

• Journal of Life Science
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• v.28 no.6
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• pp.726-732
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• 2018

The purpose of this study was to investigate the effects of Bacillus polyfermenticus KJS-2 (B. polyfermenticus KJS-2) and Angelica gigas Nakai extracts (AGNE) on hyperlipidermia. The purity of the major decursin and decursinol angelate (D/DA) in the AGNE were analyzed at 78%. Increased concentrations of AGNE (0.1-20 mg/ml) showed a higher 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibition activity. Endospore-forming B. polyfermenticus KJS-2 ($1{\times}10^9CFU/ml$) exhibited good bile tolerance (0.3 mm) on an agar plate. An animal study was carried out using different groups, including a normal control, positive control (atorvastatin), negative control (triton WR-1339), AGNE group, B. polyfermenticus KJS-2 group, AGNE + B. polyfermenticus KJS-2 group, and Atorvastatin + AGNE + B. polyfermenticus KJS-2 group to determine the effect of hyperlipidemia. There were no significant changes in body weight, kidney weight, or liver weight except for the liver weight of the triton WR-1339-treated group. Groups with AGNE and B. polyfermenticus KJS-2 had increased HDL-cholesterol and decreased total cholesterol and triglycerides. The liver histopathological results also showed that all AGNE and B. polyfermenticus KJS-2-treated groups contained lower fat accumulation in the liver tissues. The findings of this study verified that AGNE and Endospore-forming B. polyfermenticus KJS-2 combination materials have a hyperlipidemic effect.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.2
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• pp.45-49
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• 2010

Purpose: Several radiopharmaceuticals were used for cisternography. But recently, due to more short acquisition time, high resolution than other radiopharmaceuticals like In-111 DTPA, we were using Tc-99m DTPA in cisternography. Using of Tc-99m DTPA for intrathecal, was not officially recognised by the FDA. And there are matters of aseptic meningitis, muscular tetany, seizures by inappropriate radiopharmaceuticals handling. So, it is necessary to prevent adverse reactions while handling the radiopharmaceuticals using in cisternography. Therefore, this study aims to evaluation of usefulness and procedures for safety of radiopharmaceuticals in cisternography. Materials and Methods: Subjects were 12radioactive tracer vials using in cisternography in 2008 Dec. 16 - 2009 Dec. 30. (1) Radioactive tracer Vial test - We were measured NaPertechnetate radiation dose and volume, normal saline volume for dilution, source volume and dose activity for patient injection. And then, calculated mass of pure DTPA. (2) Bacterial endotoxin test - We performed pyrogen test using by negative/positive control vials which was added normal saline 0.2 mL and added normal saline 0.1 mL, Tc-99m DTPA 0.1 mL in test control vial. And then, reacted by digital hot plate in $37.5^{\circ}C$ for 1 hour and compared of gel-clot in each control vials. (3) Compliance safety procedure - We were checked safety issues and wrote out a safety procedure exam sheet. Results: (1) Radioactive tracer Vial test - Mass of DTPA per dose for patient injection (mg) was 0.88 (mg) on average, and Mass of DTPA per volume for patient injection (mg) was 0.74 (mg) on average. (2) Bacterial endotoxin test - All control test vials showed negative reactions. (3) Compliance safety procedure - We were checked safety issues and wrote out a safety exam sheet in all the exams. So, there were no adverse reactions. Conclusion: We could examine easier to safety tests using by Techscan - DTPA (Mallinckrodt): CaNa3. Each test results were passed the safety tests and there are no adverse reactions. The use of Tc-99m DTPA for cisternography, always has been become an issue. Since it has occur adverse reaction while examine the cisternography using by Tc-99m DTPA, it needs to set up the 'Standard Operating procedures'.