• 보건행정학회지
• /
• 제14권2호
• /
• pp.78-98
• /
• 2004

The purpose of this study was to categorize the contribution evasion and develop the expected models for contribution arrears in National Health Care System. The modified logistic regression model in non-payments was used as logistic regression model based on the statistical method. By using this model, we arranged non-payment types and typical branches those are appeared by statistical technique. First fact, sex and age branches those are able to take a part in economy had effect mostly. Also they had difference in non-payment probability by existence of their incomes and property. Especially people who didn't have their own house and car were appeared in high non-payment probability, disease and reduction characteristic(rare diseases, reduction of seniors, handicaps, numbers of medical treatments) didn't effect much in probability. The reason for some characteristic of non-payment which is higher than the correct threshold value of Logistic Regression Model (a suggested model for predicting non-payment)'s distribution of probability was mostly moral hazard. Living difficulty was the bigger reason for non-payment, but moral slackening was the bigger reason for non-payment. But it is careless to decide that moral hazard is just the reason, there is a necessity to examine on the side of sociology based in family. By the reason, the member's non-payment reason can be classified by economy, population, and psychology, but there was a comprehension that losing of work desire could be one reason. So we analyzed informations for composition of family of members. In conclusion, we grasped that family conflict makes non-payment and conversion of member in the National Basic Livelihood Protection System difficult.

• IMMUNE NETWORK
• /
• 제22권1호
• /
• pp.2.1-2.22
• /
• 2022

Targeting immune evasion via immune checkpoint pathways has changed the treatment paradigm in cancer. Since CTLA-4 antibody was first approved in 2011 for treatment of metastatic melanoma, eight immune checkpoint inhibitors (ICIs) centered on PD-1 pathway blockade are approved and currently administered to treat 18 different types of cancers. The first part of the review focuses on the history of CTLA-4 and PD-1 discovery and the preclinical experiments that demonstrated the possibility of anti-CTLA-4 and anti-PD-1 as anti-cancer therapeutics. The approval process of clinical trials and clinical utility of ICIs are described, specifically focusing on non-small cell lung cancer (NSCLC), in which immunotherapies are most actively applied. Additionally, this review covers the combination therapy and novel ICIs currently under investigation in NSCLC. Although ICIs are now key pivotal cancer therapy option in clinical settings, they show inconsistent therapeutic efficacy and limited responsiveness. Thus, newly proposed action mechanism to overcome the limitations of ICIs in a near future are also discussed.

• 사회복지연구
• /
• 제39호
• /
• pp.365-393
• /
• 2008

이 연구는 연금개혁 정치에서 노동조합의 영향력, 전략, 그리고 이것이 연금개혁에 가져온 결과에 관한 것이다. 분석 사례는 1994년부터 2004년 사이의 이탈리아 연금개혁이다. 노조의 영향력 면에서 1990년대에 이탈리아 노조는 연금개혁의 중요한 행위자였으나 2004년 개혁에서는 노조의 영향력이 약화되었다. 이는 좌파분열이라는 권력자원의 변화뿐만 아니라 1990년대 노조주도의 연금 삭감을 경험하고 노조가 연금정책에서 노조원의 이익 보호를 강조한데 따라 연금이슈의 성격이 달라졌기 때문이다. 전략 면에서 이탈리아 사례는 노조가 코포라티즘적 협의를 추구하느냐 대중적 저항을 선택하느냐는 기본적으로 정부 태도에 달려있음을 보여준다. 1994년 연금개혁 실패로 촉발된 정권교체를 경험한 후 이탈리아 정부는 사회적 합의를 추구하였다. 협의절차가 강조된 1995년 디니개혁에서 이탈리아 노조는 협의에서 주도권을 가졌을 뿐만 아니라 노조내 민주주의를 적극적으로 추구하였다. 노조는 토론과 전체 투표 등을 활용하여 전투적 노조부문의 반대를 누르고 정부와의 협의 결과에 대한 승인을 얻었다. 한편 연금개혁 정치에 노조가 참여한 결과 면에서, 노조는 장기가입자의 기득권 보호에 집중된 성과를 얻었다. 소기업 노동자들의 연금 미가입 문제와 젊은 세대의 급여적절성 등은 연금개혁에서 도외시되었다. 노동조합이 주도하는 타협이라는 호조건과 노조민주주의를 실현하는 가운데에서도 노조의 제도개혁에 대한 영향력은 제한되었다.