• 영재교육연구
• /
• 제22권2호
• /
• pp.371-386
• /
• 2012

본 연구는 공간능력이 영재학생들을 판별하는데 중요한 요소로 작용한다는 전제하에 한국의 중학교 영재학생들과 일반학생의 공간능력을 비교하는 것을 주 목적으로 하고 있다. 이를 위하여 한국의 중학생들에게 '퍼듀 공간 시각화 검사: 회전의 시각화(Revised PSVT:R)'를 실시하였다. Revised PSVT:R의 타당도 검증을 위하여 확인적 요인분석을 실시하였으며, 이를 바탕으로 영재 학생들과 일반 학생들의 공간 능력 차이를 비교하였다. 연구 결과, 영재학생들은 일반학생들보다 공간능력에 있어서 훨씬 우수하였다. 공간 능력에 대한 검사 결과를 확장하여 공간능력과 수학, 과학, 언어 분야와의 관계를 살펴보았다. 공간능력은 수학, 과학, 언어분야와 상관관계가 높은 것으로 나타났다. 이상의 연구 결과를 종합하여 볼 때, 공간능력이 우수한 학생과 영재교육에 참여하고 있는 영재학생은 같은 특성이 있는 것으로 판단된다. 따라서 공간능력은 영재학생을 판별하는 중요한 검사도구로 포함되어야 할 것이다.

• Molecules and Cells
• /
• 제39권6호
• /
• pp.508-513
• /
• 2016

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.

• Journal of the Korean Data and Information Science Society
• /
• 제25권6호
• /
• pp.1181-1193
• /
• 2014

현재 식품의약품안전처에서는 2008년 7월부터 $2{\times}2$ 교차설계법으로 수행된 제제간의 생물학적 동등성 입증이 실패했을 때 1회에 한하여 추가시험을 허용하고 있다. 하지만 최근 생체이용률의 변동계수가 30% 이상인 고변동성 제제가 많이 등장하면서 $2{\times}2$ 교차설계법에 의한 생물학적 동등성 시험수행에 지나치게 많은 피험자가 소요되면서 그 대안으로 $2{\times}4$ 혹은 $2{\times}3$ 교차설계법을 활용해야 하는 필요성이 증대되고 있다. 본 연구에서는 $2{\times}4$ 혹은 $2{\times}3$ 교차설계법에 기반한 제제의 생물학적 동등성 평가의 추가시험에 대한 통계적 절차를 제안하고 논의하고자 한다.

• 한국초등과학교육학회지:초등과학교육
• /
• 제24권2호
• /
• pp.145-159
• /
• 2005

Students' alternative concepts of evolution are similar to misconcepts and disputes which scientists had in science history. The aims of this study are to analyze the elementary children's concept in evolution based on science history. Lee (2004)'s two tests were applied to 6th grade to investigate the children's evolution concepts and genetic concepts related to the historical development of the evolution concepts. The test results were analyzed in accordance with 4 stages of science history based on Lee (2004)'s method. These stages are divided to stage 1 (Before Lamarck), stage 2 (Lamarck), stage 3 (Darwin), stage 4 (After Darwin). The major results are as follows. Most of elementary school children are fixed to the stage 2. They usually do not show the consistency of evolution concepts in the three dimensional aspects such as mechanism, time, and subjects. Many children do not have concrete meaning of gene, inheritance, sexual reproduction, mutation and could not connect these concetps and process of evolution. Also, they believe the inheritance of acquired traits and spontaneous generation. Therefore it is confirmed that they still have similar misconcepts and disputes which scientists had in transition time between stage 2 and 3 and most of children already have strong Lamarckian thought acquired from daily life experience before learning about natural selection and evolution.

• 정보처리학회논문지D
• /
• 제9D권4호
• /
• pp.561-570
• /
• 2002

본 논문에서는 실체화된 공간뷰의 일관성 유지를 위하여 뷰 유도관련성을 이용한 두 가지 방법인 값 복사 실체화 방법과 식별자 유지 실체화 방법에 대하여 실험 평가한다. 이 실험 결과, 뷰 유도관련성을 이용한 점진적 변경 방법을 값 복사 실체화 방법과 식별자 유지 실체화 방법과 비교할 때, 공간뷰 객체에 대한 변경 시간이 거의 차이가 나지 않는다. 그리고 공간뷰에 대한 질의 수행 실험 결과, 값 복사 실체화가 식별자 유지 실체화보다 질의 수행 시간이 훨씬 빠르다. 결론적으로 실체화와 점진적 변경에 따른 성능 평가를 고려해 볼 때, 전체적으로 식별자 유지 실체화보다 값 복사 실체화를 기반으로 뷰 유도관련성을 이용한 점진적 변경 방법이 가장 바람직하다.

• 한국농공학회지
• /
• 제35권2호
• /
• pp.43-56
• /
• 1993

The laboratory tests are performed on how the liquefaction potential of the sea dike structures on the saturated sand or silty sand seabed could be affected due to earthquake before and after construction results are given as follows ; 1. Earthquake damages to sea dike structures consist of lateral deformation, settlement, minor abnormality of the structures and differential settlement of embankments, etc. It is known that severe disasters due to this type of damages are not much documented. Because of its high relative cost of the preventive measures against this type of damages, the designing engineer has much freedom for the play of judgement and ingenuity in the selection of the construction methods, that is, by comparing the cost of the preventive design cost at a design stage to reconstruction cost after minor failure. 2. The factors controlling the liquefaction potential of the hydraulic fill structure are magnitude of earthquake(max. surface velocity), N-value(relative density), gradation, consistency(plastic limit), classification of soil(G & vs), ground water level, compaction method, volumetric shear stress and strain, effective confining stress, and primary consolidation. 3. The probability of liquefaction can be evaluated by the simple method based on SPT and CPT test results or the precise method based on laboratory test results. For sandy or silty sand seabed of the concerned area of this study, it is said that evaluation of liquefaction potential can be done by the one-dimensional analysis using some geotechnical parameters of soil such as Ip, Υt' gradation, N-value, OCR and classification of soils. 4. Based on above mentioned analysis, safety factor of liquefaction potential on the sea bed at the given site is Fs =0.84 when M = 5.23 or amax= 0.12g. With sea dike structures H = 42.5m and 35.5m on the same site Fs= 3.M~2.08 and Fs = 1.74~1.31 are obtained, respectively. local liquefaction can be expected at the toe of the sea dike constructed with hydraulic fill because of lack of constrained effective stress of the area.

• 정보과학회 컴퓨팅의 실제 논문지
• /
• 제21권4호
• /
• pp.308-314
• /
• 2015

사용성에 대한 사람들의 관심이 증가하고 있는 반면, 사용성 평가 계획의 수립과 진행, 평가결과의 수집과 분석을 지원하는 시스템은 미비한 실정이다. 사용성 평가는 크게, 사용성 평가 계획 수립, 실제 평가 진행, 평가 후 결과 수집 및 분석의 절차를 가지고 있으며, 본 논문에서는 사용성 평가의 전 과정에서 활용할 수 있는 웹 기반 사용성 평가 시스템을 설계 및 구현하였다. 따라서, 사용성 평가에 참가하는 참가자들은 언제 어디서나 기기에 상관없이 효과적으로 사용성 평가에 참여하고, 사용성 평가 책임자는 평가 관련 문서와 결과 데이터를 보다 효율적으로 관리하고 평가의 전 과정의 진행에서 신뢰도를 높일 수 있는 시스템을 구현하는 데 목표를 두었다. 웹 기반 사용성 평가 시스템은 제품의 사용성 평가를 실제 사용하는 장소에서 바로 수행할 수 있다는 장점과 이동이 불편한 장애인 대상 제품의 사용성 평가에 유용할 것으로 기대한다.

• 임상간호연구
• /
• 제17권3호
• /
• pp.307-318
• /
• 2011

Purpose: This study was to identify topics for evidence-based clinical nursing practice guidelines in Korea. Methods: Data were collected from 330 staff nurses from 10 general hospitals and 53 nurses in charge of nursing education in 110 hospitals with over 500 beds. Using open questions, the nurses identified activities which could not be verified, which lacked consistency among nurses, clinical units and/or hospitals, which were not based on the up-to-date knowledge and which needed reform. The data were analysed by content analysis using a qualitative methodology. Results: Collected data consisted of 1882 clinical topics, which were classified into 50 topics, 207 mid-categories, and 456 sub-categories. The most frequent topics in order of frequency were medications, central line management, intravenous injections, urinary catheterization, perioperative nursing care, skin tests, pressure ulcer care, blood transfusions, laboratory examination-culture, respiratory care which were performed routinely in clinical setting by staff nurses. Conclusion: The research findings indicate the urgent need to develop evidence-based clinical nursing practice guidelines related to these research findings. Further research is needed to identify topics related to health promotion, and symptom/management of health problem.

• 한국지진공학회논문집
• /
• 제25권3호
• /
• pp.145-152
• /
• 2021

KAERI has planned to carry out a series of dynamic tests using a shaking table and time-history analyses for a channel-type concrete shear wall to investigate its seismic performance because of the recently frequent occurrence of earthquakes in the south-eastern parts of Korea. The overall size of a test specimen is b×l×h =2500 mm×3500 mm×4500 mm, and it consists of three stories having slabs and walls with thicknesses of 140 mm and 150 mm, respectively. The system identification, FE model updating, and time-history analysis results for a test shear wall are presented herein. By applying the advanced system identification, so-called pLSCF, the improved modal parameters are extracted in the lower modes. Using three FE in-house packages, such as FEMtools, Ruaumoko, and VecTor4, the eigenanalyses are made for an initial FE model, resulting in consistency in eigenvalues. However, they exhibit relatively stiffer behavior, as much as 30 to 50% compared with those extracted from the test in the 1st and 2nd modes. The FE model updating is carried out to consider the 6-dofs spring stiffnesses at the wall base as major parameters by adopting a Bayesian type automatic updating algorithm to minimize the residuals in modal parameters. The updating results indicate that the highest sensitivity is apparent in the vertical translational springs at few locations ranging from 300 to 500% in variation. However, their changes seem to have no physical meaning because of the numerical values. Finally, using the updated FE model, the time-history responses are predicted by Ruaumoko at each floor where accelerometers are located. The accelerograms between test and analysis show an acceptable match in terms of maximum and minimum values. However, the magnitudes and patterns of floor response spectra seem somewhat different because of the slightly different input accelerograms and damping ratios involved.

• 중환자간호학회지
• /
• 제12권2호
• /
• pp.1-12
• /
• 2019

Purpose : The purpose of this study was to validate the Korean version of Partners In Health scale (PIH-K) which is used to measure the self-management of patients with chronic illnesses in Korea. Methods : Translation of the 12-item PIH-K was conducted according to the World Health Organization guidelines. Data from 306 participants who took medicines over 3 months by doctor's prescription were collected from October to November 2017. Validity such as content validity, construct validity, and concurrent validity were conducted using content validity index (CVI), exploratory and confirmatory factor analyses (CFA). To evaluate concurrent validity, the correlation coefficients between the PIH-K and concurrent scales (Self-As-Carer Inventory) were calculated. The reliability of the PIH-K was examined using the internal consistency and test-retest reliability tests. Results : The CVI of the PIH-K was 0.91. According to the CFA, factor loadings for four factors ranged from .64 to .97, which explained 67.5% of the total variance. The PIH-K was significantly correlated with concurrent variables such as those on the Self-As-Carer Inventory. The Cronbach's ${\alpha}$ was .86 and the intraclass correlation coefficient for the two-week test-retest reliability was .88. Conclusion : Findings show that the PIH-K is reliable and valid in measuring self-management of patients with chronic illnesses.