• Title/Summary/Keyword: conformationally rigid sulfonylurea derivatives

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Hyperglycemic Effect of Conformationally Rigid Sulfonylurea Derivatives (Conformation이 고정된 Sulfonylurea 유도체의 혈당상승작용)

  • 박혜영;김연경;권진숙;김화정
    • Biomolecules & Therapeutics
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    • v.4 no.4
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    • pp.408-410
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    • 1996

  • 3, 4-Dihydro-3-oxo-2H-1, 2, 4-benzothiadiazine-1, 1-dioxides were synthesized as conformationally rigid analogues of sulfonylurea hypoglycemic agents. All the compounds prepared showed hyperglycemic activity. The hyperglycemic activity was enhanced for the diabetic rats in which the blood glucose level was increased by 30-70%.

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