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Clinical and Electrophysiological Features of HNPP Patients with 17p11.2 Deletion (염색체 17p11.2 유전자 결손을 동반한 유전성 압박마비 편향 신경병증의 임상적, 전기생리학적 특성)

  • Hong, Yoon-Ho;Kim, Manho;Sung, Jung-Joon;Kim, Sung Hun;Lee, Kwang-Woo
    • Annals of Clinical Neurophysiology
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    • v.4 no.2
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    • pp.125-132
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    • 2002
  • Objectives : Although the diagnosis of hereditary neuropathy with liability to pressure palsies (HNPP) is important for correct prognostic evaluation and genetic counseling, the diagnosis is frequently missed or delayed. Our main aim on undertaking this study was to characterize the electrodiagnostic features of HNPP. Material and Methods : Clinical, electrophysiologic and molecular studies were performed on Korean HNPP patients with 17p11.2 deletion. The results of electrophysiologic studies were compared with those of Charcot-Marie-Tooth disease type 1A (CMT1A) patients carrying 17p11.2 duplication. Results : Eight HNPP (50 motor, 39 sensory nerves) and six CMT1A (28 motor, 16 sensory nerves) patients were included. The slowing of sensory conduction in nearly all nerves and the distal accentuation of motor conduction abnormalities are the main features of background polyneuropathy in HNPP. In contrast to CMT1A, where severity of nerve conduction slowing was not different among nerve groups, HNPP sensory nerve conduction was more slowed in the median and ulnar nerves than in the sural nerve (p<0.01), and DML was more prolonged in the median nerve than in the other motor nerves (p<0.01). TLIs were significantly lower in HNPP than in the normal control and CMT1A patients for the median and ulnar nerves (p<0.01), and were also significantly reduced for the peroneal nerve (p<0.05) compared with those of the normal controls. Conclusion : The distribution and severity of the background electrophysiologic abnormalities are closely related to the topography of common entrapment or compression sites, which suggests the possible pathogenetic role of subclinical pressure injury at these sites in the development of the distinct background polyneuropathy in HNPP.

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The effect of implant system with reverse beveled platform design on marginal bone stress distribution (임플란트 경부의 역사면 디자인이 변연골 응력분포에 미치는 영향)

  • Cha, Ji-Young;Cho, Jin-Hyun;Jo, Kwang-Hun
    • The Journal of Korean Academy of Prosthodontics
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    • v.48 no.4
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    • pp.266-272
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    • 2010
  • Purpose: The purpose of this study was to investigate the effects of the surface morphology of the implant neck on marginal bone stress measured by using finite element analysis in six implant models. Materials and methods: The submerged type rescue implant system (Dentis co., Daegu, Korea) was selected as an experimental model. The implants were divided into six groups whose implant necks were differently designed in terms of height (h, 0.4 and 1.0 mm) and width (platform width, w = 3.34 + 2b [b, 0.2, 0.3 and 0.4 mm]). Finite element models of implant/bone complex were created using an axisymmetric scheme. A load of 100 N was applied to the central node on the top of crown in parallel with the implant axis. The maximum compression stress was calculated and compared. Results: Stress concentration commonly observed around dental implants did not occur in the marginal bone around all six test implant models. Marginal bone stress varied according to the implant neck bevel which had different width and height. The stress was affected more markedly by the difference in height than in width. Conclusion: This result indicates that the implant neck bevel may play an important role in improving stress distribution in the marginal bone area.

Results of Microvascular Decompression in Hemifacial Spasm (편측안면경련에서 미세혈관감압술의 성적)

  • Kwak, Hyoung Jun;Kim, Jae Hyoo;Lee, Jung Kil;Kim, Tae Sun;Jung, Shin;Kim, Soo Han;Kang, Sam Suk;Lee, Je Hyuk
    • Journal of Korean Neurosurgical Society
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    • v.30 no.4
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    • pp.501-508
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    • 2001
  • Objectives : Hemifacial spasm is painless uncommon disorder characterized by involuntary paroxysmal movement on one side of face. It is known that hemifacial spasm is mainly due to pulsatile compression by vessels at the root exit zone(REZ) of the facial nerve. Microvascular decompression at REZ of the facial nerve has become the standard treatment modality for hemifacial spasm. The authors have analized patients with hemifacial spasm treated with microvascular decompression to evaluate operation result and clinical course after operation. Patients and Methods : From 1992 to 1999, 41 patients with hemifacial spasm underwent this operation. Retrospective analysis of operation results and clinical recovery patterns was done. The length of observation had been more than 6 months in all cases. Results : The ratio of male to female was 1:1.4, and age at operation ranged from 24 to 66 years. Their mean age was 47.6 years and the mean preoperative duration of symptoms was 7.2 years. Most common offending vessels were AICA in 18 cases(48%) and second most common were PICA in 13 cases(31.7%). The rest of them were 3 case in vertebral artery, and 7 cases(13%) in multiple offending vessels. Patterns of improvement after surgery could be divided into 4 clinical types. There was complete recovery in 3 days after operation in 24 cases(58.6%, Immediate complete recovery). There was complete recovery in 3 days after operation, and symptom was recurred partially, which was gradually subsided in 2 weeks after operation in 4 cases(9.8%, Delayed complete recovery type I). There was partial recovery after operation and symptom was compretely disappeared gradually in 6 months after operation in 7 cases(17.1%, Delayed complete recovery type II). Finally, there was partial recovery after operation, and symptom was somewhat remained after 6 months later(14.5%, Delayed partial recovery). Conclusion : In conclusion, microvascular decompression for hemifacial spasm is a safe and reliable treatment modality with good results of improvement and there are 4 recovery patterns in clinical course after operation in our series. Therefore, follow-up observation after microvascular decompression is necessary to evaluate the operative results and complication, especially in the delayed resolved cases.

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Pressure Regulation System for Optimal Operation of the Pneumatic VAD with Bellows-Type Closed Pneumatic Circuit (벨로우즈 방식의 폐회로를 가진 공압식 심실 보조장치의 최적 작동을 위한 압력 조절 시스템)

  • Kim, Bum-Soo;Lee, Jung-Joo;Nam, Kyung-Won;Jeong, Gi-Seok;Ahn, Chi-Bum;Sun, Kyung
    • Journal of Biomedical Engineering Research
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    • v.28 no.4
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    • pp.569-576
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    • 2007
  • Ventricular Assist Device(VAD) has switched its goal from a short-tenn use for bridge-to-transplantation to a long-tenn use for destination therapy, With this goal, the importance of long-tenn reliability gets more interests and importances, H-VAD is an portable extracorporeal biventricular assist device, and adopts an electro-pneumatic driving mechanism. The pneumatic pressure to pump out blood is generated with compression of bellows, and is transmitted in a closed pneumatic circuit through a pneumatic line. The existing pneumatic VAD adopts a air compressor which can generate stable pressures but has defects such as a noise and a size problem. Thus, it is not suitable for being used as a portable device, These problems are covered with adopting a closed pneumatic circuit mechanism with a bellows which has a small size and small noise generation, but it has defects that improper pneumatic setting causes a failure of adequate flow generation. In this study, the pneumatic pressure regulation system is developed to cover these defects of a bellows-type pneumatic VAD. The optimal pneumatic pressure conditions according to various afterload conditions for an optimal flow rate were investigated and the afterload estimation algorithm was developed, The final pneumatic regulation system estimates a current afterload and regulate the pneumatic pressure to the optimal point at a given afterload condition. The afterload estimation algorithm showed a sufficient performance that the standard deviation of error is 8.8 mmHg, The pneumatic pressure regulation system showed a sufficient performance that the flow rate was stably governed to various afterload conditions. In a further study, if a additional sensor such as ultrasonic sensor is developed to monitor the direct movement of diaphragm in a blood pump part, the reliability would be greatly increased. Moreover, if the afterload estimation algorithm gets more accuracy, it would be also helpful to monitor the hemodynamic condition of patients.

Evaluation of Hot Mix Asphalt Properties using Complex Modifiers (복합개질제를 이용한 아스팔트 혼합물의 물성 평가)

  • Lee, Kwan-Ho;Kim, Seong-Kyum
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.5
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    • pp.146-152
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    • 2018
  • In this study, to improve the performance of asphalt mixtures for plastic deformation occurring mainly in Korea, complex modifiers were prepared by mixing powders and liquid type modifiers. The main constituents were powdery diatomaceous earth, mica and carbon black, and liquid type solid 70% SBR latex. The tensile strength ratios for the two asphalt mixtures used in the test were above 0.80 for the Ministry of Land Transportation (2017) asphalt mixture production and construction guidelines. The effects of increasing the tensile strength in the dry state was more than 14% when the composite modifier was added. The deformation rate per minute by the wheel tracking test load was an average of 0.07 to 0.147 for each mixture. The strain rate per minute was improved by the modifier, and the dynamic stability was improved by almost 100% from 295 to 590. In addition, the final settling was reduced from 11.38 mm to 9.57 mm. A plastic deformation test using the triaxial compression test showed that the amount of deformation entering the plastic deformation failure zone at the end of the second stage section and in the third stage plastic deformation section was 1.76 mm for the conventional mixture and 1.50 mm for the complex modifier mixture. The average slope of the complex modifier asphalt mixture mixed with the multi-functional modifier was 0.005 mm/sec. The plastic deformation rate is relatively small in the section where the road pavement exhibits stable common performance, i.e. the traffic load.

Image Quality Evaluation of Medical Image Enhancement Parameters in the Digital Radiography System (디지털 방사선시스템에서 영상증강 파라미터의 영상특성 평가)

  • Kim, Chang-Soo;Kang, Se-Sik;Ko, Seong-Jin
    • The Journal of the Korea Contents Association
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    • v.10 no.6
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    • pp.329-335
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    • 2010
  • Digital imaging detectors can use a variety of detection materials to convert X-ray radiation either to light or directly to electron charge. Many detectors such as amorphous silicon flat panels, CCDs, and CMOS photodiode arrays incorporate a scintillator screen to convert x-ray to light. The digital radiography systems based on semiconductor detectors, commonly referred to as flat panel detectors, are gaining popularity in the clinical & hospital. The X-ray detectors are described between a-Silicon based indirect type and a-Selenium based direct type. The DRS of detectors is used to convert the x-ray to electron hole pairs. Image processing is described by specific image features: Latitude compression, Contrast enhancement, Edge enhancement, Look up table, Noise suppression. The image features are tuned independently. The final enhancement result is a combination of all image features. The parameters are altered by using specific image features in the different several hospitals. The image in a radiological report consists of two image evaluation processes: Clinical image parameters and MTF is a descriptor of the spatial resolution of a digital imaging system. We used the edge test phantom and exposure procedure described in the IEC 61267 to obtain an edge spread function from which the MTF is calculated. We can compare image in the processing parameters to change between original and processed image data. The angle of the edge with respect to the axes of detector was varied in order to determine the MTF as a function of direction. Each MTF is integrated within the spatial resolution interval of 1.35-11.70 cycles/mm at the 50% MTF point. Each image enhancement parameters consists of edge, frequency, contrast, LUT, noise, sensitometry curve, threshold level, windows. The digital device is also shown to have good uniformity of MTF and image parameters across its modality. The measurements reported here represent a comprehensive evaluation of digital radiography system designed for use in the DRS. The results indicate that the parameter enables very good image quality in the digital radiography. Of course, the quality of image from a parameter is determined by other digital devices in addition to the proper clinical image.

A Study on the Development of Plastic Floater for Solar Power Plant on a Body of Water (수상 태양광 발전을 위한 플라스틱 부유체 개발에 관한 연구)

  • Jeong, Kwang-Soo;Jung, In Jun;Shin, Dong-Kil
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.10
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    • pp.283-290
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    • 2020
  • In this study, a floater was developed for a frame-type solar power plant. The floater supports the frame and the solar panels. A finite element analysis was performed to design its shape and thickness, and the floater was manufactured by a rotational molding method using linear low-density polyethylene. It was found that the floater did not cause collapse and it maintained its stiffness even at 4 times the maximum load of 322.7 kgf. To perform a long-term compression test, a weight-type load application device that uses gravity was designed and manufactured. The amount of compressive deformation was measured for 7 days, and a long-term deformation equation was obtained. Even under small loads, continuous deformation was observed. However, the 10-year deformation amount for a constant load of 100 kgf was predicted to be small at about 4.64 mm. As a result, it was found that the developed floater could be used in a solar power plant on a body of water.

Animation Generation for Chinese Character Learning on Mobile Devices (모바일 한자 학습 애니메이션 생성)

  • Koo, Sang-Ok;Jang, Hyun-Gyu;Jung, Soon-Ki
    • Journal of KIISE:Computer Systems and Theory
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    • v.33 no.12
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    • pp.894-906
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    • 2006
  • There are many difficulties to develop a mobile contents due to many constraints on mobile environments. It is difficult to make a good mobile contents with only visual reduction of existing contents on wire Internet. Therefore, it is essential to devise the data representation and to develop the authoring tool to meet the needs of the mobile contents market. We suggest the compact mobile contents to learn Chinese characters and developed its authoring tool. The animation which our system produces is realistic as if someone writes letters with pen or brush. Moreover, our authoring tool makes a user generate a Chinese character animation easily and rapidly although she or he has not many knowledge in computer graphics, mobile programming or Chinese characters. The method to generate the stroke animation is following: We take basic character shape information represented with several contours from TTF(TrueType Font) and get the information for the stroke segmentation and stroke ordering from simple user input. And then, we decompose whole character shape into some strokes by using polygonal approximation technique. Next, the stroke animation for each stroke is automatically generated by the scan line algorithm ordered by the stroke direction. Finally, the ordered scan lines are compressed into some integers by reducing coordinate redundancy As a result, the stroke animation of our system is even smaller than GIF animation. Our method can be extended to rendering and animation of Hangul or general 2D shape based on vector graphics. We have the plan to find the method to automate the stroke segmentation and ordering without user input.

The Fundamental Study on th e Soil Remediation for Copper Contaminated Soil using Nanobubble Water (나노버블수에 의한 구리 오염 토양의 정화에 관한 기초 연구)

  • Jeong, So-Hee;Kim, Dong-Chan;Han, Jung-Geun
    • Journal of the Korean Geosynthetics Society
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    • v.16 no.1
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    • pp.31-39
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    • 2017
  • The fundamental study for an application of nanobubble as a soil remediation enhancer on heavy metal contaminated soil was carried out. The existence and long-term stability of hydrogen nanobubbles were investigated by particle analysis and zeta-potential analysis. And the removal efficiency of copper using nanobubble water(NBW) and distilled water(DW) were compared and analyzed through a batch desorption test. As a result, it is confirmed that nanobubble which was fabricated by compression-dissolution type generator can exist for more than 14 days. The results of batch test show that copper removal of NBW was higher than that of DW irrespectively to soil type and increased as solid-liquid ratio and contact time increased, respectively. According to the pH change, the removal of copper on sand was higher on the acid side but the removal difference was slightly lower on the clay. It is considered that a high efficiency of NBW in copper removal is due to the large surface area and high zeta-potential of nanobubbles. Therefore, the nanobubble can be applied to soil remediation for heavy-metal contaminated soil as an eco-friendly enhancer.

A Design and Implementation of WML Compiler for WAP Gateway for Wireless Internet Services (무선 인터넷 서비스를 위한 WAP 게이트웨이용 WML 컴파일러의 설계 및 구현)

  • Choi, Eun-Jeong;Han, Dong-Won;Lim, Kyung-Shik
    • Journal of KIISE:Computing Practices and Letters
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    • v.7 no.2
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    • pp.165-182
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    • 2001
  • In this paper, we describe a design and implementation of the Wireless Markup Language(WML) compiler to deploy wireless Internet services effectively. The WML compiler translates textual WML decks into binary ones in order to reduce the traffic on wireless links that have relatively low bandwidth to wireline links and mitigate the processing overhead of WML decks on, wireless terminals that have relatively low processing power to fixed workstations. In addition, it takes over the overhead of eXtensible Markup Language(XML) well-formedness and validation processes. The WML compiler consists of the lexical analyzer and parser modules. The granunar for the WML parser module is LALR(1) context-free grammar that is designed based on XML 1.0 and WML 1.2 DTD(Document Type Definition) with the consideration of the Wireless Application Protocol Binary XML grammar. The grammar description is converted into a C program to parse that grammar by using parser generator. Even though the tags in WML will be extended or WML DTD will be upgraded, this approach has the advantage of flexibility because the program is generated by modifying just the changed parts. We have verified the functionality of the WML compiler by using a WML decompiler in the public domain and by using the Nokia WAP Toolkit as a WAP client. To measurethe compressibility gain of the WML compiler, we have tested a large number of textual WML decks and obtained a maximum 85 %. As the effect of compression is reduced when the portion of general textual strings increases relative to one of the tags and attributes in a WML deck, an extended encoding method might be needed for specific applications such as compiling of the WML decks to which the Hyper Text Markup Language document is translated dynamically.

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