• 대한한의학원전학회지
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• 제27권3호
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• pp.155-166
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• 2014

Objectives : Many keyboarding staff are required for compositional herb data entry from ancient documents. It's the most difficult thing to build DB. So, we have studied to solve this problem. Methods : We have used Windows 7 and Access2013 for automatic extraction compositional herb in the Taipinghuiminhejijufang(太平惠民和劑局方). First of all, we have made synonyms list of herbs and list of herb volumes notation. And than we have analyzied order of arrangements between names of herb and notations of herb volume. Results : We have analyzied a part of prescriptions in the Taipinghuiminhejijufang(太平惠民和劑局方) (519 prescriptions). After 91 seconds, we can complete automatic extraction of compositional herb from 519 prescriptions. Conclusions : If we can analyzie order of arrangements between names of herb and notations of herb volume, we can automatically extract compositional herb of prescription from ancient documents.

• 대한한의학원전학회지
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• 제21권1호
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• pp.123-141
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• 2008

Objective Classification of herbal formulas through the analysis of compositional herb's is a suitable method in the aspects of the effective applications of herbal formulas. However, these classification methods have some problems in dealing with lots of herbal formulas because the estimations of herbal formula's effects are dependent upon one's memory. In this study, we aimed to establish the effective methodology to elicit the classified herbal formula's chart by introducing the DB systems without interfering with non-standard terms. Method : We entered the herbs informations of the composition of herbal formulas into database, made an alias tables of corresponding herbs, and achieved standardization of herb's informations. Using these databases, we made the classified herbal formula's chart according to the presence and the treatment informations of herbs. Results By analyzing the herbal formula into the set of compositional herbal elements, we could systemically express the parents and children herbal formula at once according to search terms. We provided the advanced searching tools entering the name of herbal formula and compositional herb together. Through these searching methods, it is facilitated to grasp the classified herbal formula's chart according to the addition and reduction of compositional herbs in Dong-uibogam(東醫寶鑑) and Bangjehak(方劑學)

• 사상체질의학회지
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• 제13권2호
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• pp.8-27
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• 2001

1. Purpose This paper was written in order to understand the concept of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ (東武遣稿 藥性歌) which was descending as the material of Sasang pharmacology. So we are planning to make use of the fundamental material of the study on the Sasang Medications and Prescriptions. 2. Methods Through comparing each clause of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ on all the sasang -records, we understood that concept. 3 Result 1) ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ of a literary work of DongMu(東武) which contain special elucidative-method of herb-nature has 18 type of YakSungGa which explain each 27 herbs for the Taeeumin, Soyangin and Soeumin. The period of authoship is supposed to the time just before ${\ulcorner}$DongyiSuseBowon Gabobon${\lrcorner}$ (東醫壽世保元 甲午本)(1894, DongMu 58 years old) or middle of fifties(53-57 years old). 2) YakSungGa of ${\ulcorner}$DongMuYooGo${\lrcorner}$ which is published by the BoGunsung(保健省) of North Korea is supposed to close to original type. The main meaning of that is the herb-nature which works on the weakst point of each Sasangin. And then the herbs were classfied by the diseases and symptoms possessing Bomyungjiju(保命之主), the herb's efficacy is explained at the each constitution. 3) The meaning of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ is exposure of the opinion of DongMu's early stage that proposed herb-nature which is applied to the principle of Jang(臟) of Sasangin, reason and purpose to enact newly created prescriptios by the constitutional diseases and symptoms, and the compositional principle of newly created prescription. 4) The selection of herbs or cogution of herb-nature of DongMu's pharmacological opinion of his early stage was changed by accumulating clinical experience. So all the newly created prescriptios of ${\ulcorner}$DongyiSuseBowon${\lrcorner}$ could not be explained by only the herb and the herd-nature on ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$. Therefore the purpose of DongMu's YaksungGa is not explaining the symptoms in charge of each herb or classifying the herb by constitution, but offering the principle of composition of prescription of Sasang, from the necessary herb which possess and expand Bomyungjiju to nature of herb which is applied to the constitution for treating all the diseases and sypmtoms by the heavy or light and slow or speedy.

• 대한본초학회지
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• 제35권3호
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• pp.33-45
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• 2020

Objective : The present study aimed to evaluate the change of the content of 7 active components in decoctions produced by various proportional pairs of Coptis chinensis Franch and Scutellaria baicalensis Georgi in 'Mixed decoction (MD)' and 'Single decoction mixture (SDM)'. Methods : The samples of MDs were prepared by decocting C. chinensis : S. baicalensis with the ratios of 10 g:10 g, 10 g:20 g, and 20 g:10 g. Those of SDMs were prepared by blending each single decoction from C. chinensis and S. Baicalensis with the ratios of 1:1, 1:2, and 2:1. The samples were evaluated by high-performance liquid chromatography with statistical analyses. Results : The analytical methods, which were optimized and validated, were reliably applied to present research. The content of all components in both MDs and SDMs at C. chinensis : S. baicalensis = 1:1 ratio were reduced compared with single herb decoction. The components from each compositional herb in MDs were proportionally increased with the ratio of original herb increased, but inversely proportional to paired herb. The contents of components in MDs were significantly lower than those in SDMs at all ratios, except for high content of baicalin at C. chinensis : S. baicalensis = 2:1. Conclusion : It was concluded that MDs and SDMs as well as the proportions of herbs could affect the contents of the components from original herbal medicines. These results provide the information for the quality control of herbal medicine combined C. chinensis with S. baicalensis.

• 대한한의학원전학회지
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• 제21권1호
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• pp.79-92
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• 2008

Objective The analysis method based on the herbal formula's effects is a general tool, in traditional medicine. In effective applications of herbal formula, Korean herbal medicines traditionally used the classification methods based on the curative effects through the various compositions of herbal formulas. However' the effects of herbal formulas were not filed systemically in ancient literatures, and the standards to confirm their effects are not clear. Thus, it is not easy to classify herbal formulas according to the curative effects. Furthermore, there are no standards to estimate the effects of prescriptions frequently directed in clinic. In this study, we aimed to provide the methodology of classifying the curative effects of herbal formulas by calculating the combination of the effect of each compositional herb through the DB systems. Results : By comparing effects of herbal formula with those of compositional herbs, we found that about 25-50% of the herbal effects were included in herbal formula's effects. These results showed that the prospective estimation of herbal formula's effects may be possible through the DB systems filing herbal effects. To enhance the accuracy in explaining the herbal formula's effect, more studies are needed by giving prominence to major effects and by subtracting minor effects.

• 대한한의학회지
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• 제30권2호
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• pp.127-132
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• 2009

Objectives: This study aimed to investigate the stability of a decoction using three herbal plants and their major components according to the storage conditions and periods. Materials and Methods: A three-herb mixture (1:1:1) of Glycyrrhiza uralensis Fischer, Artemisia capillaris Thunberg, and Poncirus trifoliata Rafinesqui was decocted and kept at room temperature ($25{\pm}2^{\circ}C$) or cold temperature ($4^{\circ}C$) for 0, 2, 4 or 8 weeks in liquid form in a plastic pack under dark conditions. At time points given, they were lyophilized. 200 mg of powdered samples were dissolved in 1 mL of 90% methanol and then applied to a high performance thin layer chromatography (HPTLC) with glycyrrhizin, 6,7-dimethoxycoumarin or poncirin for quantitative or qualitative analysis. Results: There were no gross changes in HPTLC-based compositional band-patterns of the three herbal mixture according to the storage conditions and period. The major components of each herb, glycyrrhizin, 6,7-dimethoxycoumarin and poncirin, showed slight time-dependent reduction in their contents both at room and cold temperature for 8 weeks. Conclusion: We could conclude that the current herbal decoction is generally safe for the stability at both RT or CT for at least 8 weeks. Nevertheless, we proposed that further advanced studies are required for more multiple herbal mixtures and longer storage periods.

• 대한한의학원전학회지
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• 제21권1호
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• pp.143-151
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• 2008

Objective : Classification of herbal formulas through the analysis of compositional herb's is a suitable method in the aspects of the effective applications of herbal formulas. However, these classification methods have some problems in dealing with lots of herbal formulas because the estimations of herbal formula's effects are dependent upon one's memory. In this study, we aimed to establish the effective methodology to elicit the classified herbal formula's chart by introducing the DB systems without interfering with non-standard terms. Results : We have known that this plan is realized by follow methods. We entered the herbs informations of the composition of herbal formulas into database, made an alias tables of corresponding herbs, and achieved standardization of herb's informations. Using these databases, we made the classified herbal formula's chart according to the presence and the treatment informations of herbs.

• Food Science and Biotechnology
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• 제18권1호
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• pp.113-117
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• 2009

A method was developed using enhanced liquid chromatography coupled with electrospray ionization mass spectrometry for the analysis and quantitation of 2 main potato glycoalkaloids, $\alpha$-chaconine, and $\alpha$-solanine, without any pre-concentration or derivatisation steps. Calibration curves generated by this technique exhibited a linear dynamic range from 0.025 to $50{\mu}g/mL$ and from 0.05 to $50{\mu}g/mL$ for $\alpha$-chaconine and $\alpha$-solanine, respectively. Matrix effects were evaluated by comparing calibration curves measured in matrix-matched and solvent-based systems. Ion suppression due to matrix effects was weak and extraction recoveries of 88 to 114% were obtained in different sample matrices spiked with analyte concentrations ranging from 15 to $35{\mu}g/mL$. Potatoes that had been genetically modified to tolerate glufosinate contained the same glycoalkaloid levels as their non-transgenic counterpart. We suggest complementing compositional comparison assessment strategy by validating quantitative analytical methods for the toxic glycoalkaloids in potato plants.