• 소성∙가공
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• 제12권5호
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• pp.465-472
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• 2003

Engineering design can be viewed as a decision making process, which involves the nonlinear tradeoffs task among the multiple conflicting attributes and considers the robustness of design. In order to obtain best engineering design, methodology for accurate assessment of his/her preference about the multiple attributes is required. Conventionally, intuitive procedures based on lottery questions are used to elicit the designer's preference structure: however, they can lead to inconsistent and inexact preference results due to the rank reversal problems derived from the designer's big cognitive burden. In this paper, alternatively, a design methodology based on multiattribute utility function through the pairwise comparison among alternatives is presented. The proposed procedure is applied to an actual injection mold design with the aid of the CAE simulation and the result is discussed.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1464-1478
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• 2021

Selective Production of Exotic Species is an innovative plant for advanced nuclear physic studies. A radioactive beam, generated by using an UCx target-ion source system, is ionized, selected and accelerated for experimental objects. Very high vacuum conditions and appropriate safety systems to storage exhaust gases are required to avoid radiological risk for operators and people. In this paper, Failure Mode, Effects, and Criticality Analysis of a preliminary design of high activity gas recovery system is performed by using a modified Fuzzy Risk Priority Number to rank the most critical components in terms of failures and human errors. Comparisons between fuzzy approach and classic application allow to show that Fuzzy Risk Priority Number is able to enhance the focus of risk assessments and to improve the safety of complex and innovative systems such as those under consideration.

• 대한간호학회지
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• 제42권6호
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• pp.843-852
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• 2012

Purpose: In this study a recreational combination gymnastics program was provided for women 75 years of age or older and the effects on physical fitness (grip strength, static balance, ability to do complex movement), depression, cognitive function and quality of life were examined. Methods: A quasi-experimental study employing a nonequivalent control group, pre-post design was conducted. Participants included 53 women elders whose cognitive function was within the normal range. The women were assigned to an experimental group (27) or a control group (26). The intervention was conducted twice a week for a period of 12 weeks. Chi-square test, t-test, paired t-test, Wilcoxon rank sum test and Wilcoxon signed rank test were used for data analysis. Results: Following completion of the program, left grip strength (t=2.17, p=.035), right grip strength (t=2.04, p=.046), static balance (t=-2.18, p=.030), depression (z=-2.88, p=.004), cognitive function (t=3.96, p<.001), and quality of life (t=-3.19, p=.002) were significantly better in the experimental group. Conclusion: Findings from this study indicate that recreational combination gymnastics programs are effective in enhancing physical fitness, cognitive function, and quality of life and in decreasing depression for female elders and could therefore be regarded as positive programs for promotion of physical and mental health for older women.

• 감성과학
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• 제9권spc3호
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• pp.277-286
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• 2006

본 연구는 일본의 도시공간을 중심으로 D/H와 둘러싸인감이 어느 정도 관련성이 있는지 평가하였다. 동일 샘플에 대해 D/H의 각도 순위와 실험자가 느끼는 실제공간의 둘러싸인감 순위를 순위상관분석을 통해 평가한 결과 42개의 전체샘플(0.49), 25개의 내부공간 샘플(0.63), 17개의 외부공간 샘플(0.59)의 상관성이 낮은 것으로 분석되었다. 따라서 D/H의 각도로 현대의 공간을 설명하는 것은 한계성이 있는 것으로 분석되었다. 이러한 결과는 현대도시는 공간구조가 복잡한 요소로 구성되어 있어 과거의 D/H와 둘러싸인감 이론을 바탕으로 공간을 평가하는 것은 한계성이 있다. 따라서 앞으로 둘러싸인감을 평가하기 위해서는 새로운 평가모델이 구축되어야 할 것이며 도시공간과 둘러싸인감의 영향에 관한 연구가 필요하다.

• 정보관리학회지
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• 제31권3호
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• pp.153-179
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• 2014

이 연구의 목적은 공동연구 네트워크에서 연구자의 영향력과 입지를 분석하는데 사용되는 중심성 지수들의 특징에 대해서 고찰하는 것이다. 전통적인 이진 네트워크 중심성 지수로는 연결정도중심성, 매개중심성, 근접중심성, 페이지랭크를 다루었고, 공동연구 네트워크에서의 중심성을 측정하기 위해서 개발되었거나 사용된 가중 네트워크 중심성 지수로는 삼각매개중심성, 평균연관성, 가중페이지랭크, 공동연구 h-지수와 공동연구 hs-지수, 복합연결정도중심성, c-지수에 대해서 살펴보았으며, 새로운 지수로 제곱근합 지수 SSR을 제안하였다. 이들 12종의 중심성 지수를 건축학, 문헌정보학, 마케팅 분야의 세 가지 공동연구 네트워크에 적용해본 결과 각 지수들의 특성과 지수 간 관계를 파악할 수 있었다. 분석 결과 공동연구 네트워크에서 공동연구 범위와 공동연구 강도를 모두 고려하기 위해서는 가중 네트워크 중심성 지수를 사용해야 하는 것으로 나타났다. 특히 공동연구 범위와 강도를 모두 고려하는 전역중심성을 측정하기 위해서는 삼각매개중심성 지수를 사용하고, 지역중심성을 측정하기 위해서는 SSR 지수를 사용하는 것이 바람직하다고 제안하였다.

• 정보처리학회논문지A
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• 제14A권1호
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• pp.1-14
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• 2007

그리드 네트워크에서 MPI를 사용하여 지리적으로 산재된 컴퓨팅 자원을 활용하여 복잡한 문제를 해결하기 위한 MPICH-G2는 사설 IP 클러스터를 지원하지 못한다는 단점을 가지고 있다. MPICH-G2의 경우에는 모든 계산노드가 외부에 노출되어 악의적인 보안 침해의 가능성이 높아지게 된다. MPICH-GP는 NAT와 프락시를 병용하여 사설 IP 클러스터의 문제를 해결한다. 사설 IP 클러스터의 프론트 노드에 프락시를 두고, 이를 통해 내부 계산 노드로의 통신 링크를 중계한다. 따라서 사설 IP 클러스터와 공인 IP 클러스터가 혼재된 네트워크에서도 적정한 경로를 설정하고 성공적으로 MPI 작업을 수행할 수 있다. 본 논문에서는 MPICH-GP의 성능을 기존의 MPICH-G2와 비교하였다. 그리드 환경에서 MPICH-GP는 MPICH-G2의 80% 이상의 성능을 보이며, RANK 관리기법을 적용한 경우는 95% 이상의 성능을 나타낸다.

• Journal of Pharmaceutical Investigation
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• 제24권2호
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• pp.95-104
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• 1994

Inclusion complexes of ketoconazole(KT) with ${\alpha}^_$, ${\beta}^_$cyclodextrin(CD) and $dimethy1-{\beta}-cyclodextrin$ (CD) and $dimethy1-{\beta}-cyclodextrin(DM{\beta}CD)$ as nasal absorption enhancer were prepared in 1: 2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability$(P_{app}\;:\;cm/sec\;{\time}\;1O^{-5}{\pm}S.E.)$, corrected by surface area of absorption, was $5.10{\pm}0.3(N,\; KT-DM{\beta}CD)$ )> $4.13{\pm}0.4(N,\;KT-{\beta}-CD)$ )> $3.52{\pm}0.2(N,\;KT-{\alpha}-CD)$ )> $2.76{\pm}0.3(J,\; KT-DM{\beta}CD)$ )> $2.61{\pm}0.5(J,\;KT-{\beta}-CD)$ )> $2.42{\pm}0.4(J,\;KT-{\alpha}-CD)$ at pH 4.0. The in crease in permeability of $KT-DM{\beta}CD$ inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of $KT-DM{\beta}CD$ inclusion complex after nasal administration was more rapid than those of ketoconazole alone and $KT-DM{\beta}CD$ inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal $KT-DM{\beta}CD$ inclusion complex in rats. The present results suggest that $KT-DM{\beta}CD$ inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.26-51
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• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제22권4호
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• pp.7-17
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• 2016

Purpose: As our population ages and becomes an elderly society the number of elderly care hospitals is rapidly increasing. Because physical functions and spatial perception in the elderly decrease with age, these hospitals require more systematic and intelligent space designs. The design of these spaces are even more complex because they must accommodate medical programs to treat various different diseases and ailments and also because there are many first time patients and irregular short term patients that seek out outpatient treatment services. Also by analyzing the spatial configuration systems and systematic relationships between each of the functional spaces of the outpatient treatment service departments for hospitals specialized in care for the elderly by focusing on the hallway and corridor systems of these hospitals, the according characteristics and trends were examined. Methods: Based on preceding research, the types of hallway and corridor systems of these hospitals were categorized into five types, including gallery corridors, middle corridors, hall-type, mixed type and cyclic type corridors, and into six types according to function including by medical diagnosis, patient registration, examination, administration and convenience and shared common space to derive any interconnecting relationships between the corridor systems. Also by comprehensively examining the types and combined utilization of the corridor types and the integration and the intelligibility of the space syntax, any trends within the corridor system were derived. The elderly care hospitals examined in this research study were twelve hospitals that opened after the year 2000 in Korea with more that 150 sick beds with areas larger than $1000m^2$ and with all outpatient medical service related rooms located entirely on a single floor of the hospital. Results: The following results could be confirmed based on this research study. 1) The spaces where medical diagnosis and examination occurred were adjacent, and the movement lines for first time patients and re-visiting patients were taken into consideration by separating the treatment space. 2) This research study confirmed that the larger the size of the hospital was, there were more detailed categorizations of treatment services and that there was a tendency for treatment areas to be separated and independent from examination areas. 3) There was a tendency for integration and intelligibility to decrease the more complex and diverse the combination of hall types designed into the corridor systems of these hospitals was. cyclic type corridors dramatically decreased the intelligibility of the corridor systems of these hospitals. 4) The priority rank of these spaces were confirmed to be highest in the order of registration, diagnosis, examination, treatment, administration and shared common spaces. However it was confirmed for the local integration that the diagnosis scope had the highest priority rank. Implications: There were exceptional cases confirmed where the number of unit spaces did not have an absolute effect on integration and intelligibility. These results can be interpreted to mean that this can be overcome through efficient architectural planning.

• 한국산학기술학회논문지
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• 제16권6호
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• pp.4308-4321
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• 2015

단지설계는 대상의 프로그램과 대상지역이 입지하고 있는 환경적 특성에 따라 원형의 공간이 차별화하여 계획되며, 그와 함께 시대의 변화와 발전에 따라 변형되어 나타나는 전형의 공간이 복합되어 구축 및 형상화 된다. 특히 국내와 같이 전 국토의 70%가량이 경사지형을 이루고 있는 지역에서는 시대적 흐름에 따라 경사를 이용하는 계획 개념이 지속적으로 적용되어 왔으며, 꾸준히 경사지를 해석하고 접근하는 설계 전략이 모색되어 왔다. 본 연구에서 대상으로 하여 살펴보고 있는 태권도 공원의 경우 또한 설계과정에서 제출한 6개의 안은 계획가에 따라 각각의 안이 가지는 가치에 차이가 있으며, 이에따라 지형과 공간을 이용하는 전략 또한 차별화되고 있음을 확인할 수 있었다. 특히, 지형조건에 따른 작가별 차별화되는 접근전략, 위계에 따라 구현되는 건축 및 외부공간의 관계, 건축가의 철학적 이해, 지역을 상징화하는 개념으로서의 설계전략 등은 본 연구에서 의미 있게 살펴본 주요 설계 전략으로 의의를 가지며, 이를 통해 구릉지 설계전략을 구체화하는 가능성을 확인할 수 있었다.