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Efficacy Evaluation of Anti-wrinkle Products in Japan

  • Masaki Hitoshi
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.29 no.2 s.43
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    • pp.67-77
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    • 2003
  • Two categories of cosmetic products, cosmetics and quasi-drugs, have been established by the Ministry of Health, Labor and Welfare (MHLW) in Japan. Japanese pharmaceutical law has defined that products categorized as cosmetics do not exhibit any effects on human skin. In fact, cosmetic products are not permitted to claim any efficacy. On the other hand, products in the quasi-drug category can claim several efficacies such as anti-inflammatory effects, whitening/lightning effects, hair growth effects and so on. Unfortunately, the Japanese MHLW has not yet approved the efficacy of anti-aging/anti-wrinkle effects as a claim point. However, the population is aging, and the demand for anti-aging/anti-wrinkle products is increasing year by year. Japanese cosmetic companies have proposed to the MHLW that anti-aging/anti-wrinkle agents be approved as a claim concept of a quasi-drug. However, unified evaluation methods for anti-aging/anti-wrinkle effects have not been established. Currently, each company evaluates the efficacy of products/materials using their own original methods. Thus, to request approval of the MHLW, the establishment of a unified evaluation method is needed. Consequently, the Japan Cosmetic Industry Association (JCIA) has established a task force to develop guidelines for evaluating anti-wrinkle effects in 1998. In conclusion, the JCIA would like to adopt visual and image analysis scales to evaluate the anti-wrinkle effects objectively. Generally, wrinkles are roughly classified into three groups as fine wrinkles, linear deep wrinkles and crow's feet. However, academic societies of dermatology or cosmetics have not yet established a definition of wrinkles in Japan. Thus, in advance of setting up an evaluation method, the definition of wrinkles f3r evaluation must be decided. Wrinkles are defined by the task force of the JCIA as follows; furrows that people can recognize visually and that appear on the forehead, the corners of the eyes and the backs of the neck with aging. In addition, furrows are emphasized by exposure to solar light and by dry conditions. Visual evaluation is the most sensitive method and can be applied to most types of wrinkles. However, visual evaluation is hard to express digitally as results. Besides, in the case of image analysis, comparisons of data obtained from distinct examinations can not be done, because data from image analysis are relative values. Thus, to enhance the reliability of the evaluations, the adoption of an objective scale was required. The principle of the evaluation method is to analyze images taken from silicone replicas of wrinkle areas using several parameters, such as the proportion of the wrinkle $area({\%})$, the mean depth of the wrinkles (mm), the mean depth of the deepest wrinkle (m) and the deepest point on the deepest wrinkle. Lights are shown on the skin replica from an orthogonal direction of the main orientation of the wrinkle, and the resulting shadow images are quantified by the image analysis method. To increase the precision of the data or to allow comparisons of independent examinations, a scale with furrows of several depths, 200, 400, 600, 800, and $1000{\mu}m$, is adapted in the evaluation system. I will explain the guidelines established by the JCIA in the presentation.

Task-Specific and Argument Structure Effects on Verb Production in Normal Elderly Adults: Animation vs. Picture Comparisons (과제 제시 유형 및 논항 수에 따른 노년층의 동사 이름대기 수행력 차이: 애니메이션과 그림 비교)

  • Choi, Su Jin;Sung, Jee Eun
    • 재활복지
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    • v.18 no.4
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    • pp.279-293
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    • 2014
  • The purpose of the study was to investigate the effects of task presentation methods (animation vs. picture) on verb naming abilities as a function of verb argument structures for normal elderly adults. Participants were categorized into the two groups: animation group(n=21) vs. picture group(n=21). Data for the animation group were from obtained from Sung and Choi (2012). Percent of accuracy for the verb naming task served as a dependent measure for statistical analyses. After the years of education was controlled as a covariate, a two-way mixed ANOVA was performed with the group as a between-subject factor and the argument structure(1-, 2-, and 3-place) as a within-subject factor. Results revealed that there was a significant interaction between the group and argument structure, whereas there were no main effects for either of the factors. The animation group performed better than the picture group for one-place verb, whereas the opposite pattern was observed for the three-place verbs. The results suggested that the presentation methods are one of the critical factors that influenced verb naming abilities in elderly adults.

The Impact of Cognitive Workload on Driving Performance and Visual Attention in Younger and Older Drivers (인지부하가 시각주의와 운전수행도에 미치는 영향에 관한 연령대별 분석)

  • Son, Joonwoo;Park, Myoungouk
    • Transactions of the Korean Society of Automotive Engineers
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    • v.21 no.4
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    • pp.62-69
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    • 2013
  • Visual demands associated with in-vehicle display usage and text messaging distract a driver's visual attention from the roadway. To minimize eyes-off-the-road demands, voice interaction systems are widely introduced. Under cognitively distracted condition, however, awareness of the operating environment will be degraded although the driver remains oriented to the roadway. It is also know that the risk of inattentive driving varies with age, thus systematic analysis of driving risks is required for the older drivers. This paper aims to understand the age-related driving performance degradation and visual attention changes under auditory cognitive demand which consists of three graded levels of cognitive complexity. In this study, two groups, aged 25-35 and 60-69, engaged in a delayed auditory recall task, so called N-back task, while driving a simulated highway. Comparisons of younger and older drivers' driving performance including mean speed, speed variability and standard deviation of lane position, and gaze dispersion changes, which consist of x-axis and y-axis of visual attention, were conducted. As a result, it was observed that gaze dispersion decreased with each level of demand, demonstrating that these indices can correctly rank order cognitive workload. Moreover, gaze dispersion change patterns were quite consistent in younger and older age groups. Effects were also observed on driving performance measures, but they were subtle, nonlinear, and did not effectively differentiate the levels of cognitive workload.

The Effect of Balance Exercise on Various Support Surfaces on the Gross Motor Function and Balance Ability of Children with Cerebral Palsy (다양한 지지면에서 균형운동이 경직성 뇌성마비 양하지마비 아동의 대동작기능 및 균형능력에 미치는 효과)

  • Lee, Eun-Jung;Song, Ju-Min
    • Journal of the Korean Society of Physical Medicine
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    • v.7 no.3
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    • pp.357-365
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    • 2012
  • Purpose : The present study has been performed to find the effects on gross motor function and balance ability of applying a balance exercise program consisting of motions able to stimulate balance-related sensory systems on various support surfaces along with goal-oriented upper extremity tasks to enhance the balance ability. Methods : 10children diagnosed as having spastic diplegia were selected as the subject for this study, of whom 5children were randomly assigned to a control group (CG) and the remainder to a balance exercise group (BEG) to perform the upper extremity task on various support surfaces. Each intervention was executed 30minutes per session with 2sessions a week for 12weeks. To make comparisons before and after intervention, gross motor function measure; standing; demention D(GMFM;D), walking/running/jumping ;demention E (GMFM;E) and pediatric balance scale (PBS) were evaluated. Results : The CG showed a significant difference (p<.05) in GMFM;E. BEG showed a significant difference (p<.05) in GMFM;D as well as GMFM;E and in PBS before and after intervention. BEG showed a significant improvement (p<.05) in GMFM;D and the PBS compared with the CG whereas it did not indicate any statistically significant difference in GMFM;E. Conclusion : According to the results of this study, it has been shown that a balance exercise accompanied by upper extremity task on various support surfaces had an effect on improvement in the gross motor function and the balance ability of children with spastic diplegic cerebral palsy.

Age-related Bimanual Coordination Impairments in Elderly People: a Systematic Review and Meta-analysis (건강한 노인의 양손 협응성 변화 패턴: 체계적 문헌고찰 및 메타분석 연구)

  • Kim, Rye Kyeong;Kang, Nyeonju
    • Korean Journal of Applied Biomechanics
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    • v.31 no.4
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    • pp.259-269
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    • 2021
  • Objective: The purpose of this systematic review and meta-analysis was to investigate age-related bimanual coordination functions in older adults. Method: Thirteen studies that compared bimanual coordination functions in older adults with those in healthy young adults qualified for this meta-analysis. We additionally categorized 21 total comparisons from the 13 qualified studies into two types of task-related moderator variables: (1) kinematic versus kinetic movements and (2) symmetry versus asymmetry movements. Results: Random effects model meta-analysis found that older adults revealed significant bimanual coordination impairments as compared with young adults (Hedges's g = -0.771; p < .0001; I2 = 74.437%). We additionally confirmed specific bimanual coordination deficits using two moderator variables: 1) kinematic (Hedges's g = -0.884; p < .0001; I2 = 0.000%) and kinetic (Hedges's g = -0.666; p = .023; I2 = 86.170%). 2) symmetry (Hedges's g = -0.712; p = .001; I2 = 74.291%) and asymmetry (Hedges's g = -0.817; p < .0001; I2 = 76.322%). The moderator variable analysis indicated older adults indicated bimanual coordination deficits in the upper extremities than healthy young adults while performing kinematic bimanual coordination tasks and asymmetry coordination tasks. Conclusion: These findings suggest that developing motor rehabilitation programs based on asymmetric bimanual movement task for enhancing interlimb coordination functions of older adults may be crucial for increasing their independence in everyday activities. Given that elderly revealed the deficits in lower extremities coordination when older adults perform gait, posture, and balance, future studies should estimate lower limb coordination functions in elderly people.

TREATMENT OF ECHOLALIA IN CHILDREN WITH AUTISM (자폐아동의 반향어 치료)

  • Chung, Bo-In
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.9 no.1
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    • pp.47-53
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    • 1998
  • The purpose of this study was to investigate the possibility of providing familiar tasks as a treatment option to decrease echolalia. Two comparisons were made:One was to compare ‘conversation condition’ and ‘task performance condition.’ and the other was to compare ‘task performance alone condition’ and ‘task performance along with contingency of reinforcement condition.’ Two echolalic children aged 12 and 13 years participated in the experiment and A-B-A-B-BC-B-BC design was used, in which A was conversation only, B was task performance, and C was task performance along with contingency of reinforcement. In the A condition, the therapist asked easy and short questions to the child;in the B condition the child was given familiar tasks with short instruction, and in BC condition, each child was reinforced for his performance on given tasks, in which immediate echolalia was controlled through his hands being held down for 5 seconds. Delayed echolalia was recorded without any intervention being given. Each child was put into each of the 7 treatment conditions. With a 15 minutes session, each child went through 5 to 6 sessions per day for 2 weeks. The mean echolalia(immediate) rates across the 7 treatment conditions were:For child 1, A(99%)-B(65%)-A(95%)-B(10%)-BC(7%)-B(6%)- BC(7%) and for child 2, A(67%)-B(62%)-A(63%)-B(35%)-BC(8%)-B(4%)-BC(0%). As to the generalization of the treatment effect of immediate echolalia to the untreated delayed echolalia, there was shown a drastic reduction of delayed echolalia in child 2:A(35%)-B(57%)-A(56%)-B(40%)-BC(8%)-B(5%)-BC(9%). Child l’s delayed echolalia was negligible(mean=3%) pre-and post treatments. In conclusion, the results of this study clearly show that providing a task performance setting with familiar tasks can certainly be helpful for minimizing echolalic response, and along with the use of the contingency of reinforcement technique it can further not only correct echolalic behavior to a negligible degree but also help the echolalic child generalize its treatment effect to the child’ overall language improvement.

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The Importance of Smoking Definitions for the Study of Adolescent Smoking Behavior

  • Park Sun-Hee;June Kyung-Ja
    • Journal of Korean Academy of Nursing
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    • v.36 no.4
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    • pp.612-620
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    • 2006
  • Purpose. Smoking is the leading cause of death and smoking initiation rarely occurs after adolescence. Thus research on adolescent smoking is crucial. A consistent definition of smoking is important because inconsistent definitions make comparisons across studies an arduous task. Thus, the aim of the study was to suggest future research directions for smoking definitions after examining pitfalls in the literature. Methods. In this study the literature on adolescent smoking in the U.S. and South Korea was examined, and three types of smoking definitions were identified. Limitations in the studies are identified and future research directions are suggested. Results. In the U.S. literature, smoking definitions can be categorized into three groups: definitions based on stage models, smoking trajectories, and definitions derived from specific data. In the South Korean literature, various levels of smoking have not been differentiated. Conclusions. While the literature does not provide a definitive answer regarding the definition of smoking, it suggests three issues to consider for future research. First, multiple measures of smoking are more desirable than a one-time measure. Second, theory- or trajectory-based smoking definitions are more desirable than definitions derived from available data. Finally, regularity and amount of cigarette use should be incorporated in defining smoking behavior.

Multiple-Shot Person Re-identification by Features Learned from Third-party Image Sets

  • Zhao, Yanna;Wang, Lei;Zhao, Xu;Liu, Yuncai
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.9 no.2
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    • pp.775-792
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    • 2015
  • Person re-identification is an important and challenging task in computer vision with numerous real world applications. Despite significant progress has been made in the past few years, person re-identification remains an unsolved problem. This paper presents a novel appearance-based approach to person re-identification. The approach exploits region covariance matrix and color histograms to capture the statistical properties and chromatic information of each object. Robustness against low resolution, viewpoint changes and pose variations is achieved by a novel signature, that is, the combination of Log Covariance Matrix feature and HSV histogram (LCMH). In order to further improve re-identification performance, third-party image sets are utilized as a common reference to sufficiently represent any image set with the same type. Distinctive and reliable features for a given image set are extracted through decision boundary between the specific set and a third-party image set supervised by max-margin criteria. This method enables the usage of an existing dataset to represent new image data without time-consuming data collection and annotation. Comparisons with state-of-the-art methods carried out on benchmark datasets demonstrate promising performance of our method.

The Influence of Liquid Atomization Models on Diesel Sprays (디젤분무에 대한 액체미립화모델들의 영향)

  • 이성혁;유홍선;홍기배
    • Transactions of the Korean Society of Automotive Engineers
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    • v.8 no.6
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    • pp.22-30
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    • 2000
  • The present article deals with comparisons of published liquid breakup models for diesel sprays to analyze the influence of breakup models on various spray parameters. The three different models tested in this study are the surface wave instability (Wave) model, the Taylor analogy breakup (TAB) model, and the drop drag model(DDM). The numerical results using these models are compared with several experimental data to assess the prediction capabilities of breakup models. Additional task in this study is to investigate effects of the breakup time constant in the Wave model on the spray parameters because the spray behavior is sensitive to the breakup time constant. It is seen that there is uncertainly about the breakup time constant indicating that the suitable acceptance of the constant is important, and the TAB model generally shows significant under-prediction of Sauter Mean Diameter(SMD). In addition, it may be indicated that differences between the DDM and Wave model are not significant, showing that the DDM may be suitable for air-assisted atomization rather than pressure atomization.

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Slab panel vertical support and tensile membrane action in fire

  • Abu, Anthony K.;Burgess, Ian W.;Plank, Roger J.
    • Steel and Composite Structures
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    • v.8 no.3
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    • pp.217-230
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    • 2008
  • The increasing use of performance-based approaches in structural fire engineering design of multi-storey composite buildings has prompted the development of various tools to help quantify the influence of tensile membrane action in composite slabs at elevated temperatures. One simplified method which has emerged is the Bailey-BRE membrane action method. This method predicts slab capacities in fire by analysing rectangular slab panels supported on edges which resist vertical deflection. The task of providing the necessary vertical support, in practice, requires protecting a panel's perimeter beams to achieve temperatures of no more than $620^{\circ}C$ at the required fire resistance time. Hence, the integrity of this support becomes critical as the slab and the attached beams deflect, and large deflections of the perimeter beams may lead to a catastrophic failure of the structure. This paper presents a finite element investigation into the effects of vertical support along slab panel boundaries on the slab behaviour in fire. It examines the development of the membrane mechanism for various degrees of edge-beam protection, and makes comparisons with predictions of the membrane action design method and various acceptance criteria.