• Title/Summary/Keyword: comparable study

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A Ternary Polymeric Matrix System for Controlled Drug Delivery of Highly Soluble Drug with High Drug Loading : Diltiazem Hydrochloride (염산 딜티아젬의 방출을 제어하기 위한 삼중 폴리머 매트릭스 시스템)

  • Kim, Hyun-Jo;Fassihi, Reza
    • Journal of Pharmaceutical Investigation
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    • v.31 no.1
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    • pp.19-25
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    • 2001
  • The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

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Toughness of Electric Insulator (애자의 Toughness)

  • 오경영;이준근;장성도
    • Journal of the Korean Ceramic Society
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    • v.19 no.3
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    • pp.229-235
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    • 1982
  • This paper deals with the electric insulator in terms of its toughness. The toughness is determined by the notched beam test and it is found that the toughness of electric insulator largely depends on the porosity as well as crystalline phases. This study also indicates that the Korean electric insulators have improved its toughness for last seven years and the recent products show comparable properties with imported insulator.

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Top Emission Organic EL Devices Having Metal-Doped Cathode Interface Layer

  • Kido, Junji
    • 한국정보디스플레이학회:학술대회논문집
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    • 2002.08a
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    • pp.1081-1081
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    • 2002
  • Top emission organic EL devices were fabricated by using metal-doped cathode interface layer to achieve low drive voltages. Also, facing-targets-type sputtering was used to sputter indium-tin oxide layer on top of organic active layer. The devices fabricated in this study showed reasonably high external quantum efficiency of about 1 % which is comparable to that of bottom-emission-type devices.

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Radioiodine internal dose coefficients specific for Koreans

  • Tae-Eun Kwon;Yoonsun Chung;Choonsik Lee
    • Nuclear Engineering and Technology
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    • v.56 no.7
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    • pp.2732-2739
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    • 2024
  • This study developed internal dose coefficients for radioiodine, tailored to the Korean population, by incorporating the Korean biokinetic model along with the Korean S values. The observed differences in dose coefficients for Koreans compared to the International Commission on Radiological Protection (ICRP) reference values noticeably varied depending on physical half-lives of iodine isotopes. For longer-lived isotopes such as I-125 and I-129, significant differences in thyroid dose coefficients were observed, with ratios (Korean/ICRP) from 0.30 to 0.55, indicating that actual doses for Koreans can be considerably lower than those evaluated based on the ICRP data. However, for short-lived iodine isotopes, such as I-131, the thyroid dose coefficients were comparable to the ICRP reference values (ratio = 0.95-0.98). These comparable dose coefficients resulted from the lower thyroidal iodine uptake in the Korean model being almost entirely offset by the higher thyroid self-absorption S values in the Korean phantoms. Additionally, this study delves into the substantial differences in absorbed dose coefficients for non-thyroidal regions and effective dose coefficients, which arose not only from physiological/anatomical variability but also technical differences in phantom design. The use of Korean-specific dose coefficients is advisable particularly in scenarios predicting elevated doses, yielding a more precise and clinically relevant dose assessment.

Anti-inflammatory and anti-noceceptive action of the crude extracts of Costus specious on rodents

  • Alam, Ashraful;Subhan, Nusrat;Awal, Abdul;Alam, Shohidul;Akramudau, Kazi
    • Advances in Traditional Medicine
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    • v.8 no.3
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    • pp.243-251
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    • 2008
  • The effect of alcoholic extracts of Costus specious (Family: Zingiberaceae) was evaluated in experimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg of C. specious extracts were used for the above study. Crude extracts of C. specious (300 mg/kg dose) showed maximum time needed for the response against thermal stimuli ($7.242\;{\pm}\;0.532\;s$) which is comparable to diclofenac sodium ($8.471\;{\pm}\;0.25\;s$) in the hot plate test. The MPH (Maximum Possible Analgesia) has been found to be 14.285 for 300 mg/kg dose of the crude extract while the MPH for diclofenac was 15.857 after 60 min of administration in the hot tail-flick method. The crude extract at 300 and 200 mg/kg doses showed significant reduction in acetic acid induced writhings in mice with a maximum effect of 59.661% reduction at 300 mg/kg dose which is comparable to standard diclofenac sodium (73.4%). Alcoholic extract of C. specious showed significant inhibition in serotonin and egg albumin induced hind paw oedema in rats at 100, 200 and 300 mg/kg of the crude extracts respectively (Serotonin induced edema 44.22; 53.75; 58.51%; egg albumin induced edema - 41.317; 53.892; 59.880% inhibition after 4 h respectively). The antiinflammatory effects showed by the extract were comparable to that of standard indomethacin 5 mg/kg (Serotonin induced edema 77.56%; egg albumin induced edema 77.844% inhibition after 4 h). These results suggest that the extract possesses both the anti-inflammatory and analgesic activity on mice and rat model.

Usefulness of the Clock Drawing Test as a Cognitive Screening Instrument for Mild Cognitive Impairment and Mild Dementia: an Evaluation Using Three Scoring Systems

  • Kim, Sangsoon;Jahng, Seungmin;Yu, Kyung-Ho;Lee, Byung-Chul;Kang, Yeonwook
    • Dementia and Neurocognitive Disorders
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    • v.17 no.3
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    • pp.100-109
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    • 2018
  • Background and Purpose: Although the clock drawing test (CDT) is a widely used cognitive screening instrument, there have been inconsistent findings regarding its utility with various scoring systems in patients with mild cognitive impairment (MCI) or dementia. The present study aimed to identify whether patients with MCI or dementia exhibited impairment on the CDT using three different scoring systems, and to determine which scoring system is more useful for detecting MCI and mild dementia. Methods: Patients with amnestic mild cognitive impairment (aMCI), vascular mild cognitive impairment (VaMCI), mild Alzheimer's disease (AD), mild vascular dementia (VaD), and cognitively normal older adults (CN) were included. All participants were administered the CDT, the Korean-Mini Mental State Examination (K-MMSE), and the Clinical Dementia Rating scale. The CDT was scored using the 3-, 5-, and 15-point scoring systems. Results: On all three scoring systems, all patient groups demonstrated significantly lower scores than the CN. However, while there were no significant differences among patients with aMCI, VaMCI, and AD, those with VaD exhibited the lowest scores. Area under the Receiver Operating Characteristic curves revealed that the three CDT scoring systems were comparable with the K-MMSE in differentiating aMCI, VaMCI, and VaD from CN. In differentiating AD from CN, however, the CDT using the 15-point scoring system demonstrated the most comparable discriminability with K-MMSE. Conclusions: The results demonstrated that the CDT is a useful cognitive screening tool that is comparable with the Mini-Mental State Examination, and that simple CDT scoring systems are sufficient for differentiating patients with MCI and mild dementia from CN.

Experimental Study on Dynamic Characteristics of Cable-Stayed Bridge (사장교의 동특성분석에 관한 실험적 연구)

  • 황학주;김상효;전귀현;박기태;신주환
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 1994.04a
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    • pp.209-216
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    • 1994
  • Recently, cable-supported long-span bridge are widely constructed due to improved quality of cable and development of design and construction techniques. In this study, an existing cable-stayed bridge, Dolsan Bridge, has been evaluated based on the cable forces measured using vibration method. And the finite element model using in this study for the dynamic analysis has been found to be quite comparable with dynamic mode shapes and natural frequencies estimated from experimental data induced by ambient traffic excitations.

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Effect of Endurance Exercise during Dexamethasone Treatment on the Attenuation of Atrophied Hindlimb Muscle Induced by Dexamethasone in Rats (Dexamethasone 치료기간중의 지구력 운동이 dexamethasone에 의해 유발된 쥐의 뒷다리근 위축경감에 미치는 영향)

  • 최명애
    • Journal of Korean Academy of Nursing
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    • v.28 no.4
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    • pp.893-907
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    • 1998
  • The purpose of this study was to determine the effect of regular exercise during dexamethasone injection on the body weight, weight of hindlimb muslces, myofibrillar protein content and glutamine synthetase activity. 180-200g female Wistar rats were divided into four groups : control, exercise, dexamethasone injection (dexa), and exercise during dexamethasone injection(D+E) group. The dexa group received daily subcutaneous injection of dexamethasone at a dose of 4mg/kg body weight for 7 days. The exercise group ran on a treadmill for 60min/day(20minutes every 4 hours) at 10m/min and a 10$^{\circ}$grade. The control group received daily subcutaneous injection of normal saline at a dose of 4mg/kg body weight for 7 days. The D+E group ran on a treadmill for 60min/day(20minutes every 4 hours) at 10m/min and a 10$^{\circ}$ grade during dexamethasone injection. Body weight of the control group increased significantly from days of experiment, that of the dexa group decreased significantly from day 4 of the experiment resulting in a 82.4% decrease compared to the first day of the experiment. Body weight of the D+E group decreased significantly from day 5 of experiment resulting in a 81.77% decrease comprared to the first day of the experiment. Body weights, muscle weight and myofibrillar protein content of the plantaris and gastrocnemius decreased significantly and muscle weight of the soleus tended to decrease with dexamethasone injection. Glutamine synthetase activity of the hindlimb muscles increased significantly with the dexamethasone injection. The relative weight of the soleus was comparable to the control group and that of plantaris decreased significantly and that of gastrocnemius tended to decrease compared to that of the control in the dexa group. Body weight and muscle weight of the plantaris and gastrocnemius of the excrcise group were comparable to the control group, and the muscle weight of soleus showed a tendencey to increase. The relative weight of the soleus increased significantly and that of the plantaris and gastrocnemius were comparable to the control in the exercise group. Myofibrillar protein content of the soleus and plantaris increased significantly and there was no change of GS activity of the hindlimb muscles compared to the control in the exercise group. Body weight of the D+E group was comparable to the dexa group, muscle weight of the plantaris increased significantly and that of the soleus and gastrocnemius showed a tendency to increase. The relative weight of the hindlimb muscles increased significantly. Myofibrillar protein content of the soleus and plantaris increased significantly and that of the gastrocnemius tended to increase compared to the dexa group. Body weight and muscle weight of the plantaris and gastrocnemius of the D+E group did not recover to that of the control group. Muscle weight of the soleus recovered to that of the control group. The relative weight and of myofibrillar protein content of the hindlimb muscles recovered to that of the control group. From these results, it is suggested that regular exercise during dexamethasone injection might attenuate the muscle atrophy of the hindlimb muscles.

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Reconstruction of Post-Glacial Environmental Changes in Yeongjong-do Island Based on Palynological Evidences (화분분석에 기초한 후빙기 영종도의 환경변화)

  • PARK, Ji-hoon;PARK, Kyeong
    • Journal of The Geomorphological Association of Korea
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    • v.19 no.2
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    • pp.173-185
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    • 2012
  • Authors performed pollen analysis in deposits at a coastal plain at Yeongjong-do Island located in Incheon, South Korea. Sampling site (7.2 m a.s.l.) belongs to the cool temperate deciduous broad-leaf forest. Environmental changes since 8,900 yrs B.P. reconstructed from pollen analysis are as follows; JS-I stage (c.a. 8,900~8,500 yrs B.P. ) was cool temperate northern mixed-forest which is comparable to the early PostGlacial pollen stage RI in Japan, in which Pinus and Quercus were dominant and Abies and Picea were also found. At that time, climate was relatively cooler and dryer than today. JS-II stage (sometime between 8,500~4,000 yrs B.P.) was Pinus-dominant coniferous forest, which is comparable to the mid-Post-Glacial pollen stage RII. Mixed forest of Pinus, Quercus and Carpinus was dominant in JS-III stage (c.a. 4,000 yrs B.P). We assumed that JS-II and JS-III stage were relatively warmer and more humid than JS-I stage, and were more like present conditions. JS-IV stage (sometime between 4,000~900 yrs B.P.) was Pinus-dominant coniferous forest which is comparable to the late Post-Glacial pollen stage RIII. JS-V stage (c.a. 900 yrs B.P. ~present) was second growth Pinus-dominant coniferous forest stage. During the last stage, non-arboreal pollen was more common than arboreal pollen and Fagopyrum appeared among the herbaceous plant, which indicates that it is comparable to the RIIIb stage which was the age of human interference. From the JS-V stage, humans in the study site started agricultural activities.